Comparative analysis of the cardiotoxicity proclivities of second generation antihistamines in an experimental model predictive of adverse clinical ECG effects

Arzneimittel-Forschung/Drug Research

Volumn 46, Issue 2, 1996, Pages 153-158

  Hey, John A ^a   Del Prado, Maurice ^a   Sherwood, Joseph ^a   Kreutner, William ^a   Egan, Robert W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

antihistamines, cardiotoxicity, nonsedating; astemizole; carebastine; CAS 50679 08 8; CAS 6844 77 9; CAS 75970 99 9; CAS 83799 24 0; CAS 83881 52 1; CAS 90729 42 3; CAS 90729 43 4; cetirizine hydrochloride; ebastine; electrocardiogram, QT interval, torsades de pointes; norastemizole; terfenadine; terfenadine carboxylate

Indexed keywords

ASTEMIZOLE; CAREBASTINE; CETIRIZINE; DRUG METABOLITE; EBASTINE; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; NORASTEMIZOLE; TERFENADINE; TERFENADINE CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BRONCHOSPASM; CARDIOTOXICITY; CONTROLLED STUDY; DRUG INHIBITION; ELECTROCARDIOGRAM; GUINEA PIG; HEART ARRHYTHMIA; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PR INTERVAL; QRS COMPLEX; QT INTERVAL; TORSADE DES POINTES;

ANIMALS; ARRHYTHMIA; BENZIMIDAZOLES; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; GUINEA PIGS; HEART DISEASES; HEART RATE; HEMODYNAMIC PROCESSES; HISTAMINE H1 ANTAGONISTS; MALE; MODELS, BIOLOGICAL; PIPERIDINES;

EID: 0029921218     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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