Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis

Leukemia

Volumn 27, Issue 12, 2013, Pages 2376-2379

  Bassaganyas, L ^a,b,c,d   Bea S ^e,f   Escaramis G ^a,b,c,d   Tornador, C ^a,b,c,d   Salaverria, I ^e,f   Zapata, L ^a,b,d   Drechsel, O ^a,b,d   Ferreira, P G ^a,b,d   Rodriguez Santiago, B ^g,h   Tubio, J M C ^a,b,c,d,i   Navarro, A ^e,f   Martin Garcia D ^e,f   Lopez C ^e,f   Martinez Trillos A ^e,f,j   Lopez Guillermo A ^e,f,j,k,l   Gut, M ^k   Ossowski, S ^a,b,d   Lopez Otin C ^a,b   Campo, E ^e,f   Estivill, X ^a,b,c,d  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^d HOSPITAL DEL MAR   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

^f INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^g Quantitative Genomic Medicine Laboratories   (Spain)

^h CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

ⁱ HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^j Hospital Clýnic Barcelona   (Spain)

^k Algorithm Development Group   (Spain)

^l UNIVERSITY OF OVIEDO   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CYCLOPHOSPHAMIDE; DUOXA1 PROTEIN; FLUDARABINE; FUBP1 PROTEIN; ITGA2B PROTEIN; MAU2 PROTEIN; MITOXANTRONE; ORGANIC ANION TRANSPORTER 2; PRG4 PROTEIN; PROTEIN; RITUXIMAB; SHPRH PROTEIN; U2AF2 PROTEIN; UNCLASSIFIED DRUG;

CANCER GROWTH; CHROMOSOMAL INSTABILITY; CHROMOSOME 1; CHROMOSOME 12; CHROMOSOME 6; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; DNA REPAIR; FLUORESCENCE IN SITU HYBRIDIZATION; GENOMICS; HUMAN; LETTER; MOSAICISM; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; POINT MUTATION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 6; GENOMICS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84890437212     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.127     Document Type: Letter

References (16)

1. Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature 2009; 458: 719-724.
2. Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 2011; 144: 27-40.
3. Magrangeas F, Avet-Loiseau H, Munshi NC, Minvielle S. Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients. Blood 2011; 118: 675-678.
4. Rausch T, Jones DT, Zapatka M, Stutz AM, Zichner T, Weischenfeldt J et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell 2012; 148: 59-71.
5. Kloosterman WP, Hoogstraat M, Paling O, Tavakoli-Yaraki M, Renkens I, Vermaat JS et al. Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol 2011; 12: R103.
6. Forment JV, Kaidi A, Jackson SP. Chromothripsis and cancer: causes and consequences of chromosome shattering. Nat Rev Cancer 2012; 12: 663-670.
7. Quesada V, Conde L, Villamor N, Ordonez GR, Jares P, Bassaganyas L et al. Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2011; 44: 47-52.
8. Landau DA, Carter SL, Stojanov P, McKenna A, Stevenson K, Lawrence MS et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013; 152: 714-726.
9. Edelmann J, Holzmann K, Miller F, Winkler D, Buhler A, Zenz T et al. High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood 2012; 120: 4783-4794.
10. Guarini A, Marinelli M, Tavolaro S, Bellacchio E, Magliozzi M, Chiaretti S et al. ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression. Haematologica 2012; 97: 47-55.
11. Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916.
12. Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S. From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 2010; 10: 37-50.
13. Finn WG, Kay NE, Kroft SH, Church S, Peterson LC. Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients. Am J Hematol 1998; 59: 223-229.
14. Gunnarsson R, Mansouri L, Isaksson A, Goransson H, Cahill N, Jansson M et al. Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia. Haematologica 2011; 96: 1161-1169.
15. Clark JM, Aleksiyadis K, Martin A, McNamee K, Tharmalingam T, Williams RO et al. Inhibitor of kappa B epsilon (IkappaBepsilon) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells. PLoS One 2011; 6: e24504.
16. Puente XS, Lopez-Otin C. The evolutionary biography of chronic lymphocytic leukemia. Nat Genet 2013; 45: 229-231.