SOX11 overexpression is a specific marker for mantle cell lymphoma and correlates with t(11;14) translocation, CCND1 expression and an adverse prognosis

Leukemia

Volumn 27, Issue 12, 2013, Pages 2388-2391

  Meggendorfer, M ^a   Kern, W ^a   Haferlach, C ^a   Haferlach, T ^a   Schnittger, S ^a  

^a MLL MUNICH LEUKEMIA LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; TRANSCRIPTION FACTOR SOX11;

AGGRESSION; B CELL LYMPHOMA; BLOOD; BURKITT LYMPHOMA; CANCER PROGNOSIS; CELL STRUCTURE; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 14; CHRONIC LYMPHATIC LEUKEMIA; GENETIC PARAMETERS; HOUSEKEEPING GENE; HUMAN; IMMUNOPHENOTYPING; LETTER; LYMPHOBLASTOMA; MANTLE CELL LYMPHOMA; ONCOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROLYMPHOCYTIC LEUKEMIA; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 14; CYCLIN D1; DNA PRIMERS; FEMALE; HUMANS; LYMPHOMA, MANTLE-CELL; MALE; MIDDLE AGED; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; SOXC TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 84890431082     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.141     Document Type: Letter

References (15)

1. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edn. International Agency for Research on Cancer IARC: Lyon, 2008.
2. Jares P, Colomer D, Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer 2007; 7: 750-762.
3. Fu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A et al. Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood 2005; 106: 4315-4321.
4. Mozos A, Royo C, Hartmann E, de JD, Baro C, Valera A et al. SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype. Haematologica 2009; 94: 1555-1562.
5. Xu W, Li JY. SOX11 expression in mantle cell lymphoma. Leuk Lymphoma 2010; 51: 1962-1967.
6. Dreyling M, Kluin-Nelemans HC, Bea S, Klapper W, Vogt N, fau-Larue MH et al. Update on the molecular pathogenesis and clinical treatment of mantle cell lymphoma: report of the 11th Annual Conference of the European Mantle Cell Lymphoma Network. Leuk Lymphoma 2013; 54: 699-707.
7. Bhattaram P, Penzo-Mendez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A et al. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 2010; 1: 9.
8. Lefebvre V, Dumitriu B, Penzo-Mendez A, Han Y, Pallavi B. Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol 2007; 39: 2195-2214.
9. Ek S, Dictor M, Jerkeman M, Jirstrom K, Borrebaeck CA. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. Blood 2008; 111: 800-805.
10. Wang X, Asplund AC, Porwit A, Flygare J, Smith CI, Christensson B et al. The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival. Br J Haematol 2008; 143: 248-252.
11. Fernandez V, Salamero O, Espinet B, Sole F, Royo C, Navarro A et al. Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma. Cancer Res 2010; 70: 1408-1418.
12. Nygren L, Baumgartner WS, Klimkowska M, Christensson B, Kimby E, Sander B. Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma. Blood 2012; 119: 4215-4223.
13. Ondrejka SL, Lai R, Smith SD, Hsi ED. Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis. Haematologica 2011; 96: 1121-1127.
14. Swerdlow SH, Williams ME. From centrocytic to mantle cell lymphoma: a clinicopathologic and molecular review of 3 decades. Hum Pathol 2002; 33: 7-20.
15. Bacher U, Kern W, Haferlach C, Alpermann T, Haferlach T, Schnittger S. Cyclin D1 (CCND1) mRNA expression assessed by real-time PCR is increased in patients with mantle cell lymphoma and contributes to diagnosis in B-cell lymphoma cases. Blood 2013; 120: 1595a.