The effects of topically applied polyNIPAM-based nanogels and their monomers on skin cyclooxygenase expression, ex vivo

Nanotoxicology

Volumn 8, Issue 1, 2014, Pages 100-106

  Abu Samah, Nor H ^a   Heard, Charles M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Acrylic acid; COX 2; Inflammation; Nanogel; NIPAM; PH; Skin; Stimulus responsive; Temperature

Indexed keywords

ACRYLAMIDE DERIVATIVE; ACRYLIC ACID; ACRYLIC ACID BUTYL ESTER; CITRIC ACID; CYCLOOXYGENASE 2; NANOGEL; NANOPARTICLE; POLY N ISOPROPYLACRYLAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DRUG EFFECT; EAR; ENZYME DENATURATION; ENZYME MODIFICATION; EPIDERMIS; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KERATINOCYTE; NONHUMAN; PH; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SKIN; SKIN PENETRATION; SWINE; TOPICAL TREATMENT; WESTERN BLOTTING;

ACRYLATES; ACRYLIC RESINS; ADMINISTRATION, TOPICAL; ANIMALS; BLOTTING, WESTERN; CYCLOOXYGENASE 2; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; SKIN; SWINE;

EID: 84890417819     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2012.754511     Document Type: Article

References (34)

1. Abdelouahab-Ouitas N, Heard C. 2010. Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw). Phytother Res 24: 333-338
2. Abu Samah NH, Heard CM. Enhanced in vitro transdermal delivery of caffeine using a temperature-And pH-sensitive nanogel, poly(NIPAM-co-AAc). International Journal of Pharmaceutics, in Press
3. Alvarez-Román R, Naik A, Kalia YN, Fessi H, Guy RH. 2004. Visualization of skin penetration using confocal laser scanning microscopy. Eur J Pharm Biopharm 58:301-316
4. Bronaugh RL. 2007. Methods for in vitro skin metabolism studies. In: Zhai H, Wilhelm K-P, Maibach HI, editors. Marzulli and Maibach's dermatotoxicology. Boca Raton: Taylor & Francis Ltd
5. Chilcott RP, Jenner J, Hotchkiss SAM, Rice P. 2001. In vitro skin absorption and decontamination of sulphur mustard: Comparison of human and pig-ear skin. J Appl Toxicol 21:279-283
6. Ghanayem BI, Maronpot RR, Matthews HB. 1985. Ethyl acrylateinduced gastric toxicity: II. Structure-Toxicity relationships and mechanism. Toxicol Appl Pharmacol 80:336-344
7. Guterres SS, Alves MP, Pohlmann AR. 2007. Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights 2:147-157
8. Hoare T, Pelton R. 2004. Highly pH and temperature responsive microgels functionalized with vinylacetic acid. Macromolecules 37:2544-2550
9. Kaneda I, Vincent B. 2004. Swelling behavior of PMMA-g-PEO microgel particles by organic solvents. J Colloid Interface Sci 274:49-54
10. Leslie Singka G, Samah NA, Zulfakar MH, Yurdasiper A, Heard CM. 2010. Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel. Eur J Pharm Biopharm 76:275-281
11. Lin C-L, Chiu W-Y, Lee C-F. 2006. Preparation, morphology, and thermoresponsive properties of poly(N-isopropylacrylamide)-based copolymer microgels. J Polym Sci A Polym Chem 44:356-370
12. Lindblad M, LesteliusM, Johansson A, Tengvall P, Thomsen P. 1997. Cell and soft tissue interactions with methyl-And hydroxyl-Terminated alkane thiols on gold surfaces. Biomaterials 18:1059-1068
13. Lindman S, Lynch I, Thulin E, Nilsson H, Dawson KA, Linse S. 2007. Systematic investigation of the thermodynamics of HSA adsorption to N-iso-propylacrylamide/N-Tert-butylacrylamide copolymer nanoparticles. Effects of particle size and hydrophobicity. Nano Lett 7:914-920
14. Lopez VC, Raghavan SL, Snowden MJ. 2004. Colloidal microgels as transdermal delivery systems. React Funct Polym 58:175-185
15. Lynch I, Blute IA, Zhmud B, Macartain P, Tosetto M, Allen LT, et al. 2005. Correlation of the adhesive properties of cells to N-isopropylacrylamide/ N-Tert-butylacrylamide copolymer surfaces with changes in surface structure using contact angle measurements, molecular simulations, and Raman spectroscopy. Chem Mater 17:3889-3898
16. Marks F, Fürstenberger G, Müller-Decker K. 1998. Arachidonic acid metabolism as a reporter of skin irritancy and target of cancer chemoprevention. Toxicol Lett 96-97:111-118
17. Naha PC, Bhattacharya K, Tenuta T, Dawson KA, Lynch I, Gracia A, et al. 2010a. Intracellular localisation, geno-And cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480). Toxicol Lett 198:134-143
18. Naha PC, Davoren M, Lyng FM, Byrne HJ. 2010b. Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. Toxicol Appl Pharmacol 246:91-99
19. Neyret S, Vincent B. 1997. The properties of polyampholyte microgel particles prepared by microemulsion polymerization. Polymer (Guildf) 38:6129-6134
20. Oh JK, Lee DI, Park JM. 2009. Biopolymer-based microgels/nanogels for drug delivery applications. Prog Polym Sci 34:1261-1282
21. Otto DP, De Villiers MM. 2009. Physicochemical principles of nanosized drug delivery systems. In: Villiers MMD, Aramwit P, Kwon GS, editors. Nanotechnology in drug delivery. New York: Springer-Verlag New York Inc
22. Pelton RH, Chibante P. 1986. Preparation of aqueous lattices with N-isopropylacrylamide. Colloids Surf 20:247-256
23. Samah NA, Williams N, Heard CM. 2010. Nanogel particulates located within diffusion cell receptor phases following topical application demonstrates uptake into and migration across skin. Int J Pharm 401:72-78
24. Scientific Committee on Emerging and Newly Identified Health Risks. 2010. Scientific basis for the definition of the term Nanomaterial. In: Directorate-General For Health & Consumers. Scientific Committee on Emerging and Newly Identified Health Risks. Brussels: European Commission
25. Shibata A, Nakagawa K, Yamanoi H, Tsuduki T, Sookwong P, Higuchi O, et al. 2010. Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice. J Nutr Biochem 21:702-709
26. Tengvall P, Lundström I, Liedberg B. 1998. Protein adsorption studies on model organic surfaces: An ellipsometric and infrared spectroscopic approach. Biomaterials 19:407-422
27. Thomas CP, Davison Z, Heard CM. 2007. Probing the skin permeation of fish oil/EPA and ketoprofen-3. Effects on epidermal COX-2 and LOX. Prostaglandins Leukot Essent Fatty Acids 76:357-362
28. Tsuda Y, Kikuchi A, Yamato M, Sakurai Y, Umezu M, Okano T. 2004. Control of cell adhesion and detachment using temperature and thermoresponsive copolymer grafted culture surfaces. J Biomed Mater Res A 69A:70-78
29. US Food and Drug Administration. 2010. Reporting format for nanotechnology-related information in CMC review. 6 June 2010 ed., Center for Drug Evaluation and Research (CDER) Office of Pharmaceutical Science
30. US Food and Drug Administration (FDA) Center for Drug Evaluation and Research. 2012. Center for drug evaluation and research meeting of the advisory committee for pharmaceutical science and clinical pharmacology. Topic 2: Nanotechnology-An update. Silver Spring: US FDA
31. Wadajkar A, Koppolu B, RahimiM,NguyenK. 2009. Cytotoxic evaluation of N-isopropylacrylamide monomers and temperature-sensitive poly(N- isopropylacrylamide) nanoparticles. J Nanopart Res 11:1375-1382
32. Zhang H, Mardyani S, Chan WCW, Kumacheva E. 2006. Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics. Biomacromolecules 7:1568-1572
33. Zondlo FM. 2002. Final report on the safety assessment of acrylates copolymer and 33 related cosmetic ingredients. Int J Toxicol 21:1-50
34. Zulfakar MH, Abdelouahab N, Heard CM. 2010. Enhanced topical delivery and ex vivo anti-inflammatory activity from a betamethasone dipropionate formulation containing fish oil. Inflamm Res 59:23-30