Posttraumatic elbow contractures: Targeting neuroinflammatory fibrogenic mechanisms

Journal of Orthopaedic Science

Volumn 18, Issue 6, 2013, Pages 869-877

  Monument, Michael J ^a   Hart, David A ^b   Salo, Paul T ^b   Befus, A Dean ^c   Hildebrand, Kevin A ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CROMOGLYCATE DISODIUM; KETOTIFEN; KETOTIFEN FUMARATE; TRANSFORMING GROWTH FACTOR BETA;

ARTHROPATHY; BIOLOGICAL MODEL; CELL HYPERPLASIA; DRUG BIOAVAILABILITY; DRUG EFFECT; ELBOW DISEASE; FIBROGENESIS; HUMAN; JOINT CAPSULE FIBROSIS; JOINT STIFFNESS; MAST CELL; MYOFIBROBLAST; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSTTRAUMATIC ELBOW CONTRACTURE; PREDICTION; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT; SIGNAL TRANSDUCTION;

ANIMALS; CONTRACTURE; ELBOW JOINT; FEMALE; FIBROBLASTS; FIBRONECTINS; FIBROSIS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; JOINT CAPSULE; MALE; RANGE OF MOTION, ARTICULAR;

EID: 84890374831     PISSN: 09492658     EISSN: 14362023     Source Type: Journal    
DOI: 10.1007/s00776-013-0447-5     Document Type: Review

References (42)

1. Cooney III, WP. Contractures of the elbow. In: Morrey BF, editor. The elbow and its disorders. Philadelphia: W.B. Saunders Company, 1993. p. 464.
2. Myden C, Hildebrand K. Elbow joint contracture after traumatic injury. J Should Elbow Surg. 2011;20:39-44.
3. Akeson WH, Amiel D, Abel MF, Garfin SR, Woo SL. Effects of immobilization on joints. Clin Orthop Rel Res 1987; 28-7.
4. Charalambous CP, Morrey BF. Posttraumatic elbow stiffness. J Bone Joint Surg. American volume 2012; 94:1428-37.
5. Morrey BF. Surgical treatment of extraarticular elbow contracture. Clin Orthop Relat Res 2000;57-4.
6. Hildebrand KA, Sutherland C, Zhang M. Rabbit knee model of post-traumatic joint contractures: the long-term natural history of motion loss and myofibroblasts. J Orthop Res. 2004;22:313-20.
7. Nesterenko S, Morrey ME, Abdel MP, An KN, Steinmann SP, Morrey BF, Sanchez-Sotelo J. New rabbit knee model of posttraumatic joint contracture: indirect capsular damage induces a severe contracture. J Orthop Res. 2009;27:1028-32.
8. Wada T, Ishii S, Usui M, Miyano S. The medial approach for operative release of post-traumatic contracture of the elbow. J Bone Joint Surg. British volume 2000;82:68-3.
9. Lindenhovius AL, Jupiter JB. The posttraumatic stiff elbow: a review of the literature. J Hand Surg [Am]. 2007;32:1605-23.
10. Higgs ZC, Danks BA, Sibinski M, Rymaszewski LA. Outcomes of open arthrolysis of the elbow without post-operative passive stretching. J Bone Joint Surg. British volume 2012;94:348-52.
11. Cohen MS, Schimmel DR, Masuda K, Hastings H II, Muehleman C. Structural and biochemical evaluation of the elbow capsule after trauma. J Should Elbow Surg 2007;16:484-90.
12. Hildebrand KA, Zhang M, van Snellenberg W, King GJ, Hart DA. Myofibroblast numbers are elevated in human elbow capsules after trauma. Clin Orthop Relat Res 2004;189-97.
13. Hildebrand KA, Zhang M, Hart DA. High rate of joint capsule matrix turnover in chronic human elbow contractures. Clin Orthop Relat Res. 2005;439:228-34.
14. Germscheid NM, Hildebrand KA. Regional variation is present in elbow capsules after injury. Clin Orthop Relat Res. 2006;450:219-24.
15. Hildebrand KA, Zhang M, Germscheid NM, Wang C, Hart DA. Cellular, matrix, and growth factor components of the joint capsule are modified early in the process of posttraumatic contracture formation in a rabbit model. Acta Orthop. 2008;79:116-25.
16. Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol. 2003;200:500-3.
17. Schollmeier G, Uhthoff HK, Sarkar K, Fukuhara K. Effects of immobilization on the capsule of the canine glenohumeral joint. A structural functional study. Clin Orthop Relat Res 1994;37-2.
18. Finsterbush A, Friedman B. Reversibility of joint changes produced by immobilization in rabbits. Clin Orthop Relat Res 1975;290-98.
19. Abdel MP, Morrey ME, Barlow JD, Kreofsky CR, An KN, Steinmann SP, Morrey BF, Sanchez-Sotelo J. Myofibroblast cells are preferentially expressed early in a rabbit model of joint contracture. J Orthop Res. 2012;30:713-9.
20. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349-63.
21. Vaughan MB, Howard EW, Tomasek JJ. Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res. 2000;257:180-9.
22. Zhang HY, Phan SH. Inhibition of myofibroblast apoptosis by transforming growth factor beta(1). Am J Respir Cell Mol Biol. 1999;21:658-65.
23. Liu W, Wang DR, Cao YL. Tgf-beta: a fibrotic factor in wound scarring and a potential target for anti-scarring gene therapy. Curr Gene Ther. 2004;4:123-36.
24. Singer AJ, Huang SS, Huang JS, McClain SA, Romanov A, Rooney J, Zimmerman T. A novel tgf-beta antagonist speeds reepithelialization and reduces scarring of partial thickness porcine burns. J Burn Care Res. 2009;30:329-34.
25. Gruber BL. Mast cells: accessory cells which potentiate fibrosis. Int Rev Immunol. 1995;12:259-79.
26. Skold CM, Ohkuni Y, Liu XD, Numerof R, Rennard SI. Co-cultured human mast cells stimulate fibroblast-mediated contraction of collagen gels. Inflammation. 2001;25:47-51.
27. Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, Laurent GJ, McAnulty RJ. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol Lung Cell Mol Physiol. 2000;278:L193-201.
28. Hildebrand KA, Zhang M, Hart DA. Joint capsule mast cells and neuropeptides are increased within four weeks of injury and remain elevated in chronic stages of posttraumatic contractures. J Orthop Res. 2008;26:1313-9.
29. Craps LP, Ney UM. Ketotifen: current views on its mechanism of action and their therapeutic implications. Respiration. 1984;45:411-21.
30. Norris AA. Pharmacology of sodium cromoglycate. Clin Exp Allergy. 1996;26(Suppl 4):5-7.
31. Monument MJ, Hart DA, Befus AD, Salo PT, Zhang M, Hildebrand KA. The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures. J Bone Joint Surg Am. 2010;92:1468-77.
32. Monument MJ, Hart DA, Befus AD, Salo PT, Zhang M, Hildebrand KA. The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures. Inflamm Res. 2012;61:285-92.
33. Gallant-Behm CL, Hildebrand KA, Hart DA. The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red duroc pigs. Wound Repair Regen. 2008;16:226-33.
34. Harunari N, Zhu KQ, Armendariz RT, Deubner H, Muangman P, Carrougher GJ, Isik FF, Gibran NS, Engrav LH. Histology of the thick scar on the female, red duroc pig: final similarities to human hypertrophic scar. Burns. 2006;32:669-77.
35. Schaffer M, Beiter T, Becker HD, Hunt TK. Neuropeptides: mediators of inflammation and tissue repair? Arch Surg. 1998;133:1107-16.
36. Foreman JC. Substance p and calcitonin gene-related peptide: effects on mast cells and in human skin. Int Arch Allergy Appl Immunol. 1987;82:366-71.
37. Jing C, Jia-Han W, Hong-Xing Z. Double-edged effects of neuropeptide substance p on repair of cutaneous trauma. Wound Repair Regen 2010;18:319-24.
38. Franceschi F, Longo UG, Ruzzini L, Morini S, Battistoni F, Dicuonzo G, Maffulli N, Denaro V. Circulating substance p levels and shoulder joint contracture after arthroscopic repair of the rotator cuff. Br J Sports Med. 2008;42:742-5.
39. Scott JR, Muangman P, Gibran NS. Making sense of hypertrophic scar: a role for nerves. Wound Repair Regen. 2007;15(Suppl 1):S27-31.
40. Schubert TE, Weidler C, Borisch N, Schubert C, Hofstadter F, Straub RH. Dupuytren's contracture is associated with sprouting of substance p positive nerve fibres and infiltration by mast cells. Ann Rheum Dis. 2006;65:414-5.
41. Miller JS, Schwartz LB. Human mast cell proteases and mast cell heterogeneity. Curr Opin Immunol. 1989;1:637-42.
42. Schwartz LB. Diagnostic value of tryptase in anaphylaxis and mastocytosis. Immunol Allergy Clin North Am. 2006;26:451-63.