Silencing of the tandem pore domain halothane-inhibited K+ Channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane

Journal of Biological Chemistry

Volumn 288, Issue 49, 2013, Pages 35081-35092

  Chatelain, Franck C ^a   Bichet, Delphine ^a   Feliciangeli, Sylvain ^a   Larroque, Marie Madeleine ^a   Braud, Véronique M ^a   Douguet, Dominique ^a   Lesage, Florian ^a  

^a Laboratory of Excellence in Ion Channel Science and Therapeutics   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINUS; HETEROLOGOUS SYSTEMS; INTRACELLULAR RETENTION; INTRINSIC ACTIVITIES; MACROSCOPIC CURRENTS; PORE REGION;

BIOCHEMISTRY; BIOLOGY;

CELL MEMBRANES;

ASPARTIC ACID; CD161 ANTIGEN; POTASSIUM CHANNEL; PROLINE; SERINE; TANDEM PORE DOMAIN HALOTHANE INHIBITED POTASSIUM CHANNEL 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL PH; CHIMERA; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENDOPLASMIC RETICULUM; FEMALE; GENE SILENCING; INTRACELLULAR SIGNALING; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN TRANSPORT;

ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM (ER); GATING; PLASMA MEMBRANE; POTASSIUM CHANNELS; PROTEIN PHOSPHORYLATION; TRAFFICKING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL MEMBRANE; DOGS; ENDOPLASMIC RETICULUM; FEMALE; GENE SILENCING; HUMANS; INTRACELLULAR SPACE; MADIN DARBY CANINE KIDNEY CELLS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PHOSPHORYLATION; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS LAEVIS;

EID: 84890308463     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.503318     Document Type: Article

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