Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine

Journal of Nanobiotechnology

Volumn 11, Issue 1, 2013, Pages

  Portilho, Flávia A ^a   Cavalcanti, Cláudio E D O ^a,b,c   Miranda Vilela, Ana L ^a,d   Estevanato, Luciana L C ^a   Longo, João P F ^a   Almeida Santos, Maria D F M ^a   Bocca, Anamélia L ^a   Martins, Olímpia P ^e   Simioni, Andreza R ^e   Morais, Paulo C ^f,g   Azevedo, Ricardo B ^a   Tedesco, Antonio C ^e   Lacava, Zulmira G M ^a  

^a INSTITUTO DE CIÊNCIAS BIOLÓGICAS   (Brazil)

^b FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^c UNIVERSIDADE ESTADUAL DE CIÊNCIAS DA SAÚDE DE ALAGOAS   (Brazil)

^d Faculdades Integradas do Planalto Central FACIPLAC   (Brazil)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

^f UNIVERSITY OF BRASILIA   (Brazil)

^g HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Albumin nanospheres; Doxorubicin; Drug delivery system; Ehrlich tumor; Photodynamic therapy; Zinc phthalocyanine

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DOXORUBICIN; DRUG DELIVERY SYSTEM; INHIBITION OF TUMOR GROWTH; MORPHOLOGICAL ANALYSIS; PHOTODYNAMIC THERAPY (PDT); ZINC-PHTHALOCYANINE;

AMINO ACIDS; ANIMALS; DISEASES; DRUG DELIVERY; NANOSPHERES; PHOSPHATASES; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; UREA; ZINC;

TUMORS;

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN GLUCURONIDE; CREATININE; DOXORUBICIN; ERYTHROMYCIN ETHYLSUCCINATE; GAMMA GLUTAMYLTRANSFERASE; NANOSPHERE; PHTHALOCYANINE ZINC; UNCLASSIFIED DRUG; UREA; ZINC PHTHALOCYANINE TETRASULFONATE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; BREAST CANCER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFICACY; EHRLICH ASCITES TUMOR; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; MORPHOLOGY; MORPHOMETRICS; MOUSE; NONHUMAN; PARTICLE SIZE; PHOTODYNAMIC THERAPY; TUMOR NECROSIS; TUMOR REGRESSION; TUMOR VOLUME; UREA BLOOD LEVEL; ZETA POTENTIAL;

ANIMALIA; MUS;

ALANINE TRANSAMINASE; ALBUMINS; ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BODY WEIGHT; CARCINOMA, EHRLICH TUMOR; CREATININE; DOXORUBICIN; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; INDOLES; INJECTIONS, INTRALESIONAL; LIGHT; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NANOSPHERES; ORGANOMETALLIC COMPOUNDS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; TUMOR BURDEN; UREA;

EID: 84890295395     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/1477-3155-11-41     Document Type: Article

References (56)

1. Sibata CH, Colussi VC, Oleinick NL, Kinsella TJ. Photodynamic therapy: a new concept in medical treatment. Braz J Med Biol Res 2000, 33:869-880.
2. Simplicio FI, Maionchi F, Hioka N. Terapia fotodinâmica: aspectos farmacológicos, aplicações e avanços recentes no desenvolvimento de medicamentos. Quim Nova 2002, 25:801-807.
3. Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer 2003, 3:380-387. 10.1038/nrc1071, 12724736.
4. De Paula LB, Primo FL, Jardim DR, Morais PC, Tedesco AC. Development, characterization, and in vitro trials of chloroaluminum phthalocyanine-magnetic nanoemulsion to hyperthermia and photodynamic therapies on glioblastoma as a biological model. J Appl Phys 2012, 111:07B307-07B307-3.
5. Passos SK, de Souza PE, Soares PK, Eid DR, Primo FL, Tedesco AC, Lacava ZG, Morais PC. Quantitative approach to skin field cancerization using a nanoencapsulated photodynamic therapy agent: a pilot study. Clin Cosmet Invest Dermatol 2013, 6:51-59.
6. Kim H-J, Shin K-J, Han MK, An K, Lee J-K, Honma I, Kim H. One-pot synthesis of multifunctional mesoporous silica nanoparticle incorporated with zinc(II) phthalocyanine and iron oxide. Scr Mater 2009, 61:1137-1140.
7. Zhao B, Yin J-J, Bilski PJ, Chignell CF, Roberts JE, He Y-Y. Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles. Toxicol Appl Pharmacol 2009, 241:163-172. 10.1016/j.taap.2009.08.010, 2783992, 19695274.
8. Oleinick NL, Evans HH. The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat Res 1998, 150:S146-S156. 10.2307/3579816, 9806617.
9. Li K, Sun X, Koon H, Leung W, Fung M, Wong R, Lung M, Chang C, Mak N. Apoptosis and expression of cytokines triggered by pyropheophorbide-a methyl ester-mediated photodynamic therapy in nasopharyngeal carcinoma cells. Photodiagnosis Photodyn Ther 2006, 3:247-258.
10. Mang TS, Sullivan M, Cooper M, Loree T, Rigual N. The use of photodynamic therapy using 630 nm laser light and porfimer sodium for the treatment of oral squamous cell carcinoma. Photodiagnosis Photodyn Ther 2006, 3:272-275.
11. Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle D, Mittleman A. Photoradiation therapy for the treatment of malignant tumors. Cancer Res 1978, 38:2628-2635.
12. Kalka K, Merk H, Mukhtar H. Photodynamic therapy in dermatology. J Am Acad Dermatol 2000, 42:389-413. quiz 414-386, 10.1016/S0190-9622(00)90209-3, 10688709.
13. Marmur ES, Schmults CD, Goldberg DJ. A review of laser and photodynamic therapy for the treatment of nonmelanoma skin cancer. Dermatol Surg 2004, 30:264-271. 10.1111/j.1524-4725.2004.30083.x, 14871220.
14. Passos SK, Tedesco AC, Eid DRM, Lacava ZGM. Bowen disease treated with PDT using ALA in nanostructured vehicle and two light deliveries: a case report. J Am Acad Dermatol 2011, 64:AB141.
15. Chen B, Pogue BW, Hasan T. Liposomal delivery of photosensitising agents. Expet Opin Drug Deliv 2005, 2:477-487.
16. Wise-Milestone L, Akens MK, Lo VC, Yee AJ, Wilson BC, Whyne CM. Local treatment of mixed osteolytic/osteoblastic spinal metastases: is photodynamic therapy effective?. Breast Cancer Res treat 2012, 133:899-908. 10.1007/s10549-011-1854-y, 22058005.
17. Aziz F, Telara S, Moseley H, Goodman C, Manthri P, Eljamel MS. Photodynamic therapy adjuvant to surgery in metastatic carcinoma in brain. Photodiagnosis Photodyn Ther 2009, 6:227-230. 10.1016/j.pdpdt.2009.09.003, 19932456.
18. Ferreira SDRM, Tedesco AC, Sousa G, Zângaro RA, Silva NS, Pacheco MTT, Pacheco-Soares C. Analysis of mitochondria, endoplasmic reticulum and actin filaments after PDT with AlPcS4. Lasers Med Sci 2004, 18:207-212. 10.1007/s10103-003-0282-6, 15042425.
19. Haywood-Small SL, Vernon DI, Griffiths J, Schofield J, Brown SB. Phthalocyanine-mediated photodynamic therapy induces cell death and a G0/G1 cell cycle arrest in cervical cancer cells. Biochem Biophys Res Commun 2006, 339:569-576. 10.1016/j.bbrc.2005.11.046, 16300726.
20. Longo JP. Avaliação da aplicação da terapia fotodinâmica mediada pela alumínio-cloro-ftalocianina em formulação lipossomal sobre o câncer bucal em modelos experimentais in vivo e in vitro 2008, Brasília, DF, Brazil: Universidade de Brasília, Departamento de Patologia Molecular.
21. Simioni AR, Martins OP, Lacava ZG, Azevedo RB, Lima EC, Lacava BM, Morais PC, Tedesco AC. Cell toxicity studies of albumin-based nanosized magnetic beads. J Nanosci Nanotechnol 2006, 6:2413-2415. 10.1166/jnn.2006.511, 17037849.
22. Machado AEH. Terapia fotodinâmica: princípios, potencial de aplicação e perspectivas. Quim Nova 2000, 23:237-243.
23. Estevanato L, Cintra D, Baldini N, Portilho F, Barbosa L, Martins O, Lacava B, Miranda-Vilela AL, Tedesco AC, Bao S, et al. Preliminary biocompatibility investigation of magnetic albumin nanosphere designed as a potential versatile drug delivery system. Int J Nanomed 2011, 6:1709-1717.
24. Rocha MST, Lucci CM, Longo JO, Paulo F, Galera PD, Simioni AR, Lacava ZGM, Tedesco A, Nio C, Azevedo RB. Aluminum-chloride-phthalocyanine encapsulated in liposomes: activity against naturally occurring dog breast cancer cells. J Biomed Nanotechnol 2012, 8:251-257. 10.1166/jbn.2012.1378, 22515076.
25. Lu B, Xiong S-B, Yang H, Yin X-D, Zhao R-B. Mitoxantrone-loaded BSA nanospheres and chitosan nanospheres for local injection against breast cancer and its lymph node metastases: II: Tissue distribution and pharmacodynamics. Int J Pharm 2006, 307:175-181. 10.1016/j.ijpharm.2005.09.038, 16314056.
26. Simioni AR, Primo FL, Rodrigues MMA, Lacava ZGM, Morais PC, Tedesco AC. Preparation, characterization and in vitro toxicity test of magnetic nanoparticle-based drug delivery system to hyperthermia of biological tissues. Magnetics, IEEE Transactions 2007, 43:2459-2461.
27. Rodrigues MMA, Simioni AR, Primo FL, Siqueira-Moura MP, Morais PC, Tedesco AC. Preparation, characterization and in vitro cytotoxicity of BSA-based nanospheres containing nanosized magnetic particles and/or photosensitizer. J Magn Magn Mater 2009, 321:1600-1603.
28. Wongsagonsup R, Shobsngob S, Oonkhanond B, Varavinit S. Zeta potential (ζ) analysis for the determination of protein content in rice flour. Starch - Stärke 2005, 57:25-31.
29. Viana FAB. Guia terapêutico veterinário 2007, Gráfica Editora Cem: Minas Gerais, 2.
30. Konopka K, Goslinski T. Photodynamic therapy in dentistry. J Dent Res 2007, 86:694-707. 10.1177/154405910708600803, 17652195.
31. Kim KH, Park JJ. The effects of photodynamic therapy in upper-gastrointestinal malignant diseases. Gut Liver 2010, 4(Suppl 1):S39-S43. 2989553, 21103293.
32. Castano AP, Mroz P, Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer 2006, 6:535-545. 10.1038/nrc1894, 2933780, 16794636.
33. Smetana Z, Mendelson E, Manor J, van Lier JE, Ben-Hur E, Salzberg S, Malik Z. Photodynamic inactivation of herpes viruses with phthalocyanine derivatives. J Photochem Photobiol B 1994, 22:37-43. 10.1016/1011-1344(93)06949-4, 8151454.
34. Yu C, Wo F, Shao Y, Dai X, Chu M. Bovine serum albumin nanospheres synchronously encapsulating " gold selenium/gold" nanoparticles and photosensitizer for high-efficiency cancer phototherapy. Appl Biochem Biotechnol 2013, 169:1566-1578. 10.1007/s12010-012-0078-x, 23322252.
35. Portilho FA, Estevanato LLC, Miranda-Vilela AL, Almeida-Santos MFM, De Oliveira-Cavalcanti CE, Lacava BM, Simioni AR, Tedesco AC, Morais PC, Lacava ZGM. Investigation of a magnetohyperthermia system efficacy. J Appl Phys 2011, 109:07B307-1-07B307-3. doi:10.1063/1.3559498.
36. Miranda-Vilela AL, Peixoto RCA, Longo JPF, Cintra DOS, Portilho FA, Miranda KLC, Sartoratto PPC, Báo SN, Azevedo RB, Lacava ZGM. Dextran-functionalized magnetic fluid mediating magnetohyperthermia combined with preventive antioxidant pequi-oil supplementation: potential use against cancer. J Biomed Nanotechnol 2013, 9:1-13. doi: 10.1007/s13277-013-1447-y, 10.1166/jbn.2013.1468, 3766318, 23627064.
37. Miranda-Vilela AL, Portilho FA, de Araujo VG, Estevanato LL, Mezzomo BP, Santos M, De F, Lacava ZG. The protective effects of nutritional antioxidant therapy on Ehrlich solid tumor-bearing mice depend on the type of antioxidant therapy chosen: histology, genotoxicity and hematology evaluations. J Nutr Biochem 2011, 22:1091-1098. 10.1016/j.jnutbio.2010.09.009, 21273055.
38. Brufman G, Colajori E, Ghilezan N, Lassus M, Martoni A, Perevodchikova N, Tosello C, Viaro D, Zielinski C. Doubling epirubicin dose intensity (100 mg/m2 versus 50 mg/m2) in the FEC regimen significantly increases response rates. An international randomised phase III study in metastatic breast cancer. The epirubicin high dose (HEPI 010) study group. Ann Oncol 1997, 8:155-162. 10.1023/A:1008295427877, 9093724.
39. Danesi R, Fogli S, Gennari A, Conte P, Del Tacca M. Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs. Clin Pharmacokinet 2002, 41:431-444. 10.2165/00003088-200241060-00004, 12074691.
40. Barpe DR, Rosa DD, Froehlich PE. Pharmacokinetic evaluation of doxorubicin plasma levels in normal and overweight patients with breast cancer and simulation of dose adjustment by different indexes of body mass. Eur J Pharm Sci 2010, 41:458-463. 10.1016/j.ejps.2010.07.015, 20688160.
41. Manjanatha MG, Bishop ME, Pearce MG, Kulkarni R, Lyn-Cook LE, Ding W. Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow-cytometric peripheral blood micronucleus test, and pathway-focused gene expression profiling. Environ Mol Mutagen 2013, n/a-n/a.
42. Menna P, Salvatorelli E, Minotti G. Anthracycline degradation in cardiomyocytes: a journey to oxidative survival. Chem Res Toxicol 2009, 23:6-10.
43. Booser DJ, Hortobagyi GN. Anthracycline antibiotics in cancer therapy. Focus on drug resistance. Drugs 1994, 47:223-258. 10.2165/00003495-199447020-00002, 7512899.
44. Park SH, Lee Y, Han SH, Kwon SY, Kwon OS, Kim SS, Kim JH, Park YH, Lee JN, Bang SM, et al. Systemic chemotherapy with doxorubicin, cisplatin and capecitabine for metastatic hepatocellular carcinoma. BMC Cancer 2006, 6:3. 10.1186/1471-2407-6-3, 1352374, 16396674.
45. Nakazawa S, Itoh Y, Shimura T, Matsumoto M, Yajima K. New management of brain neoplasms. 2. Local injection of adriamycin. No Shinkei Geka 1983, 11:821-827.
46. Voulgaris S, Partheni M, Karamouzis M, Dimopoulos P, Papadakis N, Kalofonos HP. Intratumoral doxorubicin in patients with malignant brain gliomas. Am J Clin Oncol 2002, 25:60-64. 10.1097/00000421-200202000-00013, 11823699.
47. Lesniak MS, Upadhyay U, Goodwin R, Tyler B, Brem H. Local delivery of doxorubicin for the treatment of malignant brain tumors in rats. Anticancer Res 2005, 25:3825-3831. 1635000, 16312042.
48. Goldberg SN, Saldinger PF, Gazelle GS, Huertas JC, Stuart KE, Jacobs T, Kruskal JB. Percutaneous tumor ablation: increased necrosis with combined radio-frequency ablation and intratumoral doxorubicin injection in a rat breast tumor model. Radiology 2001, 220:420-427. 10.1148/radiology.220.2.r01au44420, 11477246.
49. Hughes GA. Nanostructure-mediated drug delivery. Nanomedicine 2005, 1:22-30.
50. Cseh SB. Bioquímica clínica en medicina veterinária: critérios a tener em cuenta em el laboratório. Ver Agr Prod Anim 2003, 23:177-185.
51. Quimby FW, Luong RH. Clinical chemistry of the laboratory mouse. The Mouse in Biomedical Research: Normative Biology, Husbandry, and Models. Volume III 2007, 171-216. San Diego, California, USA: Elsevier, Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL.
52. Everds NE. Ematology of the laboratory mouse. The Mouse in Biomedical Research: Normative Biology, Husbandry, and Models. Volume III 2007, 133-170. San Diego, California, USA: Elsevier, Fox JG, Barthold SW, Davisson MT, Newcomer CE, Quimby FW, Smith AL.
53. Thrall MA. Hematologia e Bioquímica Clínica Veterinária 2007, São Paulo, Brazil: Editora Roca, 1.
54. Almersjo O, Bengmark S, Engevik L, Hafstrom LO, Loughridge BP, Nilsson LA. Serum enzyme changes after hepatic dearterialization in man. Ann Surg 1968, 167:9-17. 10.1097/00000658-196801000-00002, 1387209, 4169542.
55. Association AVM AVMA Guidelines on Euthanasia. Book AVMA Guidelines on Euthanasia 2007, City, Association AVM.
56. Yanase M, Shinkai M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T. Intracellular hyperthermia for cancer using magnetite cationic liposomes: an in vivo study. Jpn J Cancer Res 1998, 89:463-469. 10.1111/j.1349-7006.1998.tb00586.x, 9617354.