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Journal of Molecular Catalysis B: Enzymatic

Volumn 100, Issue , 2014, Pages 1-6

Assessing biocatalysis for the synthesis of optically active tetrahydropyrazolo[1,5-α]pyrimidines (THPPs) as novel therapeutic agents

(5) Fernández Álvaro, Elena a Esquivias, Jorge a Pérez Sánchez, María b Domínguez De María, Pablo b Remuiñán Blanco, Modesto J a

a GLAXOSMITHKLINE (Spain)

b RWTH AACHEN UNIVERSITY (Germany)

Author keywords

CAL B; Enantioselective biotransformations; Tetrahydropyrazolo 1,5 pyrimidines; Therapeutic agents

Indexed keywords

CATALYSIS;

CAL-B; ENANTIOSELECTIVE; KINETIC RESOLUTION; OPTICALLY ACTIVE; PHARMACOLOGICAL AGENTS; PROOF OF CONCEPT; PROTEIN ENGINEERING; THERAPEUTIC AGENTS;

AROMATIC COMPOUNDS;

HYDROLASE; PYRAZOLOPYRIMIDINE DERIVATIVE; TETRAHYDROPYRAZOLO[1,5 ALPHA]PYRIMIDINE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; ASYMMETRIC CATALYSIS; BIOCATALYSIS; CHIRALITY; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ISOLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; PROTEIN ENGINEERING; REACTION TIME; STRUCTURE ACTIVITY RELATION; WATER CONTENT;

EID: 84890252256 PISSN: 13811177 EISSN: 18733158 Source Type: Journal
DOI: 10.1016/j.molcatb.2013.11.012 Document Type: Article

Times cited : (8)

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