Progressive multifocal leukeoncephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir

Bone Marrow Transplantation

Volumn 30, Issue 12, 2002, Pages 963-966

  Osorio, S ^a   de la Camara R ^a   Golbano, N ^a   Marti, E ^a   Fedele, C G ^b   Nieto, S ^a   Manzanares, R ^a   Fernandez Ranada J M ^a  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Cidofovir; Progressive multifocal leukoencephalopathy; Stem cell transplantation

Indexed keywords

CD34 ANTIGEN; CD4 ANTIGEN; CIDOFOVIR; GADOLINIUM; OXYGEN; PREDNISONE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CYTOSINE; DRUG DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PHOSPHONIC ACID DERIVATIVE;

ADULT; ARTICLE; AUTOTRANSPLANTATION; BRONCHIOLITIS; CASE REPORT; DISEASE ASSOCIATION; DRUG INTERMITTENT THERAPY; DRUG MEGADOSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; JC VIRUS; MALE; MANTLE CELL LYMPHOMA; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; SIDE EFFECT; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; WHOLE BODY RADIATION; BRAIN; FATALITY; IMMUNE DEFICIENCY; ISOLATION AND PURIFICATION; LEUKOENCEPHALOPATHY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; REVIEW; SERODIAGNOSIS; TREATMENT FAILURE; VIROLOGY;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ANTIVIRAL AGENTS; BRAIN; COMBINED MODALITY THERAPY; CYTOSINE; FATAL OUTCOME; HIV SERONEGATIVITY; HUMANS; IMMUNOCOMPROMISED HOST; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; LYMPHOMA, MANTLE-CELL; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGANOPHOSPHORUS COMPOUNDS; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PHOSPHONIC ACIDS; TRANSPLANTATION, AUTOLOGOUS; TREATMENT FAILURE;

EID: 0036947642     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1703704     Document Type: Article

References (20)

1. Aström KE, Mancall EL, Richardson EPJ. Progressive multifocal leukoencephalopathy: a hitherto unrecognized complication of chronic lymphatic leukemia and Hodgkin's disease. Brain 1958; 81: 93-110.
2. Demeter LM. JC, BK, other polyomavirus; progressive multifocal leukoencephalopathy. In: Mandell GL, Bennett JE, Dolin R (eds). Principles and Practice of Infectious Diseases, fifth edn. Churchill Livingstone: London, 2000, pp 1645-1651.
3. Mesquita R, Parravicini C, Bjorkholm M et al. Macrophage association of polyomavirus in progressive multifocal leukoencephalopathy: an immunohistochemical and ultrastructural study. Case report. APMIS 1992; 100: 993-1000.
4. Owen RG, Patmore RD, Smith GM, Barnard DL. Cytomegalovirus-induced T-cell proliferation and the development of progressive multifocal leucoencephalopathy following bone marrow transplantation. Br J Haematol 1995; 89: 196-198.
5. O'Shaughnessy D, Goldman JM, Roddie M, Schofield JB. Dizziness and confusion after bone marrow transplantation. Br Med J 1994; 309: 262-265.
6. Seong D, Bruner JM, Lee KH et al. Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation in a patient with chronic myelogenous leukemia. Clin Infect Dis 1996; 23: 402-403.
7. Przepiorka D, Jaeckle KA, Birdwell RR et al. Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2. Bone Marrow Transplant 1997; 20: 983-987.
8. Re D, Bamborschke S, Feiden W et al. Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. Bone Marrow Transplant 1999; 23: 295-298.
9. Coppo P, Laporte JP, Aoudjhane M et al. Progressive multifocal leucoencephalopathy with peripheral demyelinating neuropathy after autologous bone marrow transplantation for acute myeloblastic leukemia (FAB5). Bone Marrow Transplant 1999; 23: 401-403.
10. Salmaggi A, Maccagnano E, Castagna A et al. Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy. Neurol Sci 2001; 22: 17-20.
11. Haider S, Nafziger D, Gutierrez JA et al. Progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia: a case report and review of reported cases. Clin Infect Dis 2000; 31: E20-E22.
12. Houston S, Roberts N, Mashinter L. Failure of cidofovir therapy in progressive multifocal leukoencephalopathy unrelated to human immunodeficiency virus. Clin Infect Dis 2001; 32: 150-152.
13. Tubridy N, Wells C, Lewis D, Schon F. Unsuccessful treatment with cidofovir and cytarabine in progressive multifocal leukoencephalopathy associated with dermatomyositis. JR Soc Med 2000; 93: 374-375.
14. Fedele CG, Ciardi M, Delia S et al. Multiplex polymerase chain reaction for the simultaneous detection and typing of polyomavirus JC, BK and SV40 DNA in clinical samples. J Virol Methods 1999; 82: 137-144.
15. De Luca A, Giancola ML, Ammassari A et al. Cidofovir added to HAART improves virological and clinical outcome in AIDS-associated progressive multifocal leukoencephalopathy. AIDS 2000; 14: F117-F121.
16. Gasnault J, Kousignian P, Kahraman M et al. Cidofovir in AIDS-associated progressive multifocal leukoencephalopathy: a monocenter observational study with clinical and JC virus load monitoring. J Neurovirol 2001; 7: 375-381.
17. De Luca A, Giancola ML, Ammassari A et al. Potent antiretroviral therapy with or without cidofovir for AIDS-associated progressive multifocal leukoencephalopathy: extended follow-up of an observational study. J Neurovirol 2001; 7: 364-368.
18. Portilla J, Boix V, Roman F et al. Progressive multifocal leukoencephalopathy treated with cidofovir in HIV-infected patients receiving highly active anti-retroviral therapy. J Infect 2000; 41: 182-184.
19. Brambilla AM, Castagna A, Novati R et al. Remission of AIDS-associated progressive multifocal leukoencephalopathy after cidofovir therapy. J Neurol 1999; 246: 723-725.
20. Lea AP, Bryson HM. Cidofovir. Drugs 1996; 52: 225-230.