메뉴 건너뛰기




Volumn 4, Issue 5, 2013, Pages 192-205

Teriflunomide in relapsing multiple sclerosis: Therapeutic utility

Author keywords

Disease modifying therapy; Efficacy; Immunomodulator; Relapsing multiple sclerosis; Safety; Teriflunomide

Indexed keywords

ACTIVATED CARBON; BETA INTERFERON; BETA1A INTERFERON; COLESTYRAMINE; LEFLUNOMIDE; PLACEBO; TERIFLUNOMIDE;

EID: 84890189341     PISSN: 20406223     EISSN: 20406231     Source Type: Journal    
DOI: 10.1177/2040622313492810     Document Type: Article
Times cited : (28)

References (51)
  • 1
    • 84993703372 scopus 로고    scopus 로고
    • Effect of teriflunomide on immune responses to seasonal influenza vaccination in patients with relapsing multiple sclerosis: results from the TERIVA study
    • P925.
    • Bar-Or A. Freedman M. Kremenchutzky M. Menguy-Vacheron F. Bauer D. Jodl S. et al. (2012) Effect of teriflunomide on immune responses to seasonal influenza vaccination in patients with relapsing multiple sclerosis: results from the TERIVA study. Mult Scler 18: 279–508 P925.
    • (2012) Mult Scler , vol.18 , pp. 279-508
    • Bar-Or, A.1    Freedman, M.2    Kremenchutzky, M.3    Menguy-Vacheron, F.4    Bauer, D.5    Jodl, S.6
  • 2
    • 84876587586 scopus 로고    scopus 로고
    • Effect of teriflunomide on lymphocyte and neutrophil levels in patients with relapsing multiple sclerosis: results from the TEMSO study
    • P439.
    • Comi G. Benzerdjeb H. Wang L. Truffinet P. O'Connor P. (2012) Effect of teriflunomide on lymphocyte and neutrophil levels in patients with relapsing multiple sclerosis: results from the TEMSO study. Mult Scler 18: 279–508 P439.
    • (2012) Mult Scler , vol.18 , pp. 279-508
    • Comi, G.1    Benzerdjeb, H.2    Wang, L.3    Truffinet, P.4    O'Connor, P.5
  • 3
    • 84857334051 scopus 로고    scopus 로고
    • Extension of a phase III trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: safety outcomes with up to 4 years of follow-up
    • Comi G. O'Connor P. Wolinsky J. Confavreux C. Kappos L. Olsson T. et al. (2011) Extension of a phase III trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: safety outcomes with up to 4 years of follow-up. Mult Scler 17: S182.
    • (2011) Mult Scler , vol.17 , pp. S182
    • Comi, G.1    O'Connor, P.2    Wolinsky, J.3    Confavreux, C.4    Kappos, L.5    Olsson, T.6
  • 4
    • 84860199056 scopus 로고    scopus 로고
    • Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years
    • Confavreux C. Li D. Freedman M. Truffinet P. Benzerdjeb H. Wang D. et al. (2012) Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years. Mult Scler 18: 1278–1289.
    • (2012) Mult Scler , vol.18 , pp. 1278-1289
    • Confavreux, C.1    Li, D.2    Freedman, M.3    Truffinet, P.4    Benzerdjeb, H.5    Wang, D.6
  • 5
    • 84857288430 scopus 로고    scopus 로고
    • Long-term safety and tolerability of teriflunomide in multiple sclerosis: 9-year follow-up of a phase II study
    • Confavreux C. O'Connor P. Freedman M. Benzerdjeb H. Wang D. Bar-Or A. (2011) Long-term safety and tolerability of teriflunomide in multiple sclerosis: 9-year follow-up of a phase II study. Mult Scler 17: S409.
    • (2011) Mult Scler , vol.17 , pp. S409
    • Confavreux, C.1    O'Connor, P.2    Freedman, M.3    Benzerdjeb, H.4    Wang, D.5    Bar-Or, A.6
  • 7
    • 84899464227 scopus 로고    scopus 로고
    • TERACLES study design: teriflunomide as adjunctive therapy with interferon-beta in patients with relapsing multiple sclerosis
    • Poster presentation at the Fourth Cooperative Meeting of CMSC and ACTRIMS San Diego, CA, USA, P9.
    • Freedman M. Cheng S. Truffinet P. Wamil B. Confavreux C. Comi G. et al. (2012 a) TERACLES study design: teriflunomide as adjunctive therapy with interferon-beta in patients with relapsing multiple sclerosis. Poster presentation at the Fourth Cooperative Meeting of CMSC and ACTRIMS, 30 May–2 June 2012, San Diego, CA, USA, P9.
    • (2012)
    • Freedman, M.1    Cheng, S.2    Truffinet, P.3    Wamil, B.4    Confavreux, C.5    Comi, G.6
  • 8
    • 84993825319 scopus 로고    scopus 로고
    • Hair thinning associated with teriflunomide therapy is manageable
    • Poster presentation at the Fourth Cooperative Meeting of CMSC and ACTRIMS San Diego, CA, USA
    • Freedman M. Confavreux C. Comi G. Kappos L. Olsson T. Miller A. et al. (2012 b) Hair thinning associated with teriflunomide therapy is manageable. Poster presentation at the Fourth Cooperative Meeting of CMSC and ACTRIMS, 30 May–2 June 2012, San Diego, CA, USA, P7.
    • (2012) , pp. P7
    • Freedman, M.1    Confavreux, C.2    Comi, G.3    Kappos, L.4    Olsson, T.5    Miller, A.6
  • 9
    • 84890234607 scopus 로고    scopus 로고
    • Gastrointestinal symptoms infrequently lead to discontinuation of teriflunomide therapy
    • Poster presentation at the Fourth Cooperative Meeting of CMSC and ACTRIMS San Diego, CA, USA
    • Freedman M. Delhay J. Benamor M. (2012 c) Gastrointestinal symptoms infrequently lead to discontinuation of teriflunomide therapy. Poster presentation at the Fourth Cooperative Meeting of CMSC and ACTRIMS, 30 May–2 June 2012, San Diego, CA, USA, P8.
    • (2012) , pp. P8
    • Freedman, M.1    Delhay, J.2    Benamor, M.3
  • 10
    • 84890226744 scopus 로고    scopus 로고
    • Teriflunomide increases the proportion of patients free from disease activity in the TEMSO phase III study
    • Freedman M. O'Connor P. Wolinsky J. Confavreux C. Comi G. Kappos L. et al. (2012 d) Teriflunomide increases the proportion of patients free from disease activity in the TEMSO phase III study. Neurology 78: PD5.007.
    • (2012) Neurology , vol.78 , pp. PD5.007
    • Freedman, M.1    O'Connor, P.2    Wolinsky, J.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 12
    • 84863567558 scopus 로고    scopus 로고
    • Teriflunomide added to interferon-beta in relapsing multiple sclerosis: a randomized phase II trial
    • Freedman M. Wolinsky J. Wamil B. Confavreux C. Comi G. Kappos L. et al. (2012 e) Teriflunomide added to interferon-beta in relapsing multiple sclerosis: a randomized phase II trial. Neurology 78: 1877–1885.
    • (2012) Neurology , vol.78 , pp. 1877-1885
    • Freedman, M.1    Wolinsky, J.2    Wamil, B.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 13
    • 84993829867 scopus 로고    scopus 로고
    • Genzyme Corporation
    • Cambridge, MA: Genzyme Corporation
    • Genzyme Corporation (2012) Aubagio Prescribing Information. Cambridge, MA: Genzyme Corporation.
    • (2012) Aubagio Prescribing Information
  • 15
    • 79952735730 scopus 로고    scopus 로고
    • Sustained disease-activity-free status in patients with relapsing–remitting multiple sclerosis treated with cladribine tablets in the CLARITY study: a post-hoc and subgroup analysis
    • Giovannoni G. Cook S. Rammohan K. Rieckmann P. Sorensen P. Vermersch P. et al. (2011) Sustained disease-activity-free status in patients with relapsing–remitting multiple sclerosis treated with cladribine tablets in the CLARITY study: a post-hoc and subgroup analysis. Lancet Neurol 10: 329–337.
    • (2011) Lancet Neurol , vol.10 , pp. 329-337
    • Giovannoni, G.1    Cook, S.2    Rammohan, K.3    Rieckmann, P.4    Sorensen, P.5    Vermersch, P.6
  • 16
    • 79953016820 scopus 로고    scopus 로고
    • Pathophysiology of multiple sclerosis and the place of teriflunomide
    • Gold R. Wolinsky J. (2011) Pathophysiology of multiple sclerosis and the place of teriflunomide. Acta Neurol Scand 124: 75–84.
    • (2011) Acta Neurol Scand , vol.124 , pp. 75-84
    • Gold, R.1    Wolinsky, J.2
  • 17
    • 60049089535 scopus 로고    scopus 로고
    • Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the natalizumab safety and efficacy in relapsing–remitting multiple sclerosis (AFFIRM) study
    • Havrdova E. Galetta S. Hutchinson M. Stefoski D. Bates D. Polman C. et al. (2009) Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the natalizumab safety and efficacy in relapsing–remitting multiple sclerosis (AFFIRM) study. Lancet Neurol 8: 254–260.
    • (2009) Lancet Neurol , vol.8 , pp. 254-260
    • Havrdova, E.1    Galetta, S.2    Hutchinson, M.3    Stefoski, D.4    Bates, D.5    Polman, C.6
  • 18
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing–remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • IFNB Multiple Sclerosis Study Group
    • IFNB Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing–remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43: 655–661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 19
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs L. Cookfair D. Rudick R. Herndon R. Richert J. Salazar A. et al. (1996) Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 39: 285–294.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.1    Cookfair, D.2    Rudick, R.3    Herndon, R.4    Richert, J.5    Salazar, A.6
  • 20
    • 84155165587 scopus 로고    scopus 로고
    • The socioeconomic consequences of multiple sclerosis: a controlled national study
    • Jennum P. Wanscher B. Frederiksen J. Kjellberg J. (2012) The socioeconomic consequences of multiple sclerosis: a controlled national study. Eur Neuropsychopharmacol 22: 36–43.
    • (2012) Eur Neuropsychopharmacol , vol.22 , pp. 36-43
    • Jennum, P.1    Wanscher, B.2    Frederiksen, J.3    Kjellberg, J.4
  • 21
    • 0030177981 scopus 로고    scopus 로고
    • Management of relapsing / remitting multiple sclerosis with copolymer 1 (Copaxone)
    • Johnson K. (1996) Management of relapsing / remitting multiple sclerosis with copolymer 1 (Copaxone). Mult Scler 1: 325–326.
    • (1996) Mult Scler , vol.1 , pp. 325-326
    • Johnson, K.1
  • 22
    • 84993829841 scopus 로고    scopus 로고
    • Pregnancy outcomes from the teriflunomide clinical development program: retrospective analysis of the teriflunomide clinical trial database
    • S30.005.
    • Jung Henson L. Stüve O. Kieseier B. Benamor M. Benzerdjeb H. (2013) Pregnancy outcomes from the teriflunomide clinical development program: retrospective analysis of the teriflunomide clinical trial database. Neurology 80: 1001–112005, S30.005.
    • (2013) Neurology , vol.80 , pp. 1001-112005
    • Jung Henson, L.1    Stüve, O.2    Kieseier, B.3    Benamor, M.4    Benzerdjeb, H.5
  • 23
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L. Radue E. O'Connor P. Polman C. Hohlfeld R. Calabresi P. et al. (2010) A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 362: 387–401.
    • (2010) N Engl J Med , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.2    O'Connor, P.3    Polman, C.4    Hohlfeld, R.5    Calabresi, P.6
  • 25
    • 84890235150 scopus 로고    scopus 로고
    • The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells
    • Li L. Liu J. Ringheim G. Delohery T. Jones C. (2011) The effects of teriflunomide on lymphocyte subpopulations in human peripheral blood mononuclear cells. Mult Scler 17: S422.
    • (2011) Mult Scler , vol.17 , pp. S422
    • Li, L.1    Liu, J.2    Ringheim, G.3    Delohery, T.4    Jones, C.5
  • 26
    • 84856211605 scopus 로고    scopus 로고
    • Pharmacokinetics of oral teriflunomide, a novel oral disease-modifying agent under investigation for the treatment of multiple sclerosis
    • Limsakun T. Menguy-Vacheron F. (2010 a) Pharmacokinetics of oral teriflunomide, a novel oral disease-modifying agent under investigation for the treatment of multiple sclerosis. Neurology 74: P05.032.
    • (2010) Neurology , vol.74 , pp. P05.032
    • Limsakun, T.1    Menguy-Vacheron, F.2
  • 27
    • 80053535646 scopus 로고    scopus 로고
    • Effects of cholestyramine on the elimination of teriflunomide in healthy male volunteers
    • Limsakun T. Menguy-Vacheron F. (2010 b) Effects of cholestyramine on the elimination of teriflunomide in healthy male volunteers. Mult Scler 16: P11.
    • (2010) Mult Scler , vol.16 , pp. P11
    • Limsakun, T.1    Menguy-Vacheron, F.2
  • 28
    • 79960989910 scopus 로고    scopus 로고
    • Multiple sclerosis: pathogenesis and treatment
    • Loma I. Heyman R. (2011) Multiple sclerosis: pathogenesis and treatment. Curr Neuropharmacol 9: 409–416.
    • (2011) Curr Neuropharmacol , vol.9 , pp. 409-416
    • Loma, I.1    Heyman, R.2
  • 29
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis
    • McDonald W. Compston A. Edan G. Goodkin D. Hartung H. Lublin F. et al. (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 50: 121–127.
    • (2001) Ann Neurol , vol.50 , pp. 121-127
    • McDonald, W.1    Compston, A.2    Edan, G.3    Goodkin, D.4    Hartung, H.5    Lublin, F.6
  • 30
    • 62149096116 scopus 로고    scopus 로고
    • Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis
    • Merrill J. Hanak S. Pu S. Liang J. Dang C. Iglesias-Bregna D. et al. (2009) Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. J Neurol 256: 89–103.
    • (2009) J Neurol , vol.256 , pp. 89-103
    • Merrill, J.1    Hanak, S.2    Pu, S.3    Liang, J.4    Dang, C.5    Iglesias-Bregna, D.6
  • 31
    • 84890183590 scopus 로고    scopus 로고
    • Impact of relapses with sequelae on disability, health-related quality of life, and fatigue in a population with relapsing forms of multiple sclerosis (RMS) using data from TEMSO, a pivotal phase III teriflunomide trial
    • Miller A. Lublin F. O'Connor P. Tanio C. Dive-Pouletty C. (2012 a) Impact of relapses with sequelae on disability, health-related quality of life, and fatigue in a population with relapsing forms of multiple sclerosis (RMS) using data from TEMSO, a pivotal phase III teriflunomide trial. Neurology 78: P07.082.
    • (2012) Neurology , vol.78 , pp. P07.082
    • Miller, A.1    Lublin, F.2    O'Connor, P.3    Tanio, C.4    Dive-Pouletty, C.5
  • 32
    • 84993817421 scopus 로고    scopus 로고
    • Effect of teriflunomide on relapses with sequelae and relapse leading to hospitalization in a population with relapsing forms of multiple sclerosis: results from the TEMSO study
    • Miller A. Lublin F. O'Connor P. Wolinsky J. Comi G. Kappos L. et al. (2012 b) Effect of teriflunomide on relapses with sequelae and relapse leading to hospitalization in a population with relapsing forms of multiple sclerosis: results from the TEMSO study. Neurology 78: S30.003.
    • (2012) Neurology , vol.78 , pp. S30.003
    • Miller, A.1    Lublin, F.2    O'Connor, P.3    Wolinsky, J.4    Comi, G.5    Kappos, L.6
  • 33
    • 84993759834 scopus 로고    scopus 로고
    • Clinical and MRI outcomes from a phase III trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses
    • American Academy of Neurology 63rd Annual Meeting Honolulu, HI
    • Miller A. O'Connor P. Wolinsky J. Confavreux C. Comi G. Kappos L. et al. (2011) Clinical and MRI outcomes from a phase III trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses. In American Academy of Neurology 63rd Annual Meeting, 9–16 April 2011, Honolulu, HI, S41.002.
    • (2011) , pp. S41.002
    • Miller, A.1    O'Connor, P.2    Wolinsky, J.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 34
    • 84868013737 scopus 로고    scopus 로고
    • Pre-specified subgroup analyses of a placebo-controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis
    • Miller A. O'Connor P. Wolinsky J. Confavreux C. Kappos L. Olsson T. et al. (2012 c) Pre-specified subgroup analyses of a placebo-controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis. Mult Scler 18: 1625–1632.
    • (2012) Mult Scler , vol.18 , pp. 1625-1632
    • Miller, A.1    O'Connor, P.2    Wolinsky, J.3    Confavreux, C.4    Kappos, L.5    Olsson, T.6
  • 35
    • 84890187516 scopus 로고    scopus 로고
    • Rapid elimination procedure of teriflunomide with cholestyramine or activated charcoal
    • Fourth Cooperative Meeting of CMSC and ACTRIMS San Diego, CA, USA
    • Miller A. Turpault S. Menguy-Vacheron F. (2012 d) Rapid elimination procedure of teriflunomide with cholestyramine or activated charcoal. In Fourth Cooperative Meeting of CMSC and ACTRIMS, 30 May–2 June 2012, San Diego, CA, USA, P10.
    • (2012) , pp. P10
    • Miller, A.1    Turpault, S.2    Menguy-Vacheron, F.3
  • 36
    • 84885237877 scopus 로고    scopus 로고
    • Teriflunomide efficacy and safety in patients with relapsing multiple sclerosis: results from TOWER, a second pivotal phase 3 placebo-controlled study
    • Miller A. Kappos L. Comi G. Confavreux C. Freedman M. Olsson T. et al. (2013) Teriflunomide efficacy and safety in patients with relapsing multiple sclerosis: results from TOWER, a second pivotal phase 3 placebo-controlled study. Neurology 80: S01.004.
    • (2013) Neurology , vol.80 , pp. S01.004
    • Miller, A.1    Kappos, L.2    Comi, G.3    Confavreux, C.4    Freedman, M.5    Olsson, T.6
  • 37
    • 77951442188 scopus 로고    scopus 로고
    • Economic burden of multiple sclerosis: a systematic review of the literature
    • Naci H. Fleurence R. Birt J. Duhig A. (2010) Economic burden of multiple sclerosis: a systematic review of the literature. Pharmaco Economics 28: 363–379.
    • (2010) Pharmaco Economics , vol.28 , pp. 363-379
    • Naci, H.1    Fleurence, R.2    Birt, J.3    Duhig, A.4
  • 38
    • 33645799680 scopus 로고    scopus 로고
    • A phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
    • O'Connor P. Li D. Freedman M. Bar-Or A. Rice G. Confavreux C. et al. (2006) A phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 66: 894–900.
    • (2006) Neurology , vol.66 , pp. 894-900
    • O'Connor, P.1    Li, D.2    Freedman, M.3    Bar-Or, A.4    Rice, G.5    Confavreux, C.6
  • 39
    • 84890172879 scopus 로고    scopus 로고
    • Effect of teriflunomide on relapses leading to healthcare resource use: results from the TEMSO study
    • P250.
    • O'Connor P. Lublin F. Wolinsky J. Comi G. Kappos L. Freedman M. et al. (2011 a) Effect of teriflunomide on relapses leading to healthcare resource use: results from the TEMSO study. Mult Scler 17(Suppl. 17): S95, P250.
    • (2011) Mult Scler , vol.17 , pp. S95
    • O'Connor, P.1    Lublin, F.2    Wolinsky, J.3    Comi, G.4    Kappos, L.5    Freedman, M.6
  • 41
    • 84857248654 scopus 로고    scopus 로고
    • Extension of a phase III trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: clinical and MRI data 5 years after initial randomisation
    • P924.
    • O'Connor P. Wolinsky J. Confavreux C. Comi G. Kappos L. Olsson T. et al. (2011 c) Extension of a phase III trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: clinical and MRI data 5 years after initial randomisation. Mult Scler 17(Suppl. 17): S414, P924.
    • (2011) Mult Scler , vol.17 , pp. S414
    • O'Connor, P.1    Wolinsky, J.2    Confavreux, C.3    Comi, G.4    Kappos, L.5    Olsson, T.6
  • 42
    • 34547211016 scopus 로고    scopus 로고
    • Drug interactions due to cytochrome P450
    • Ogu C. Maxa J. (2000) Drug interactions due to cytochrome P450. Proc (Bayl Univ Med Cent) 13: 421–423.
    • (2000) Proc (Bayl Univ Med Cent) , vol.13 , pp. 421-423
    • Ogu, C.1    Maxa, J.2
  • 44
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing–remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS / MRI Study Group and the IFNB Multiple Sclerosis Study Group
    • Paty D. Li D. (1993) Interferon beta-1b is effective in relapsing–remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS / MRI Study Group and the IFNB Multiple Sclerosis Study Group. Neurology 43: 662–667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.1    Li, D.2
  • 45
    • 78650368131 scopus 로고    scopus 로고
    • Teriflunomide treatment reduces infiltration of macrophages, T cells and B cells and increases survival of oligodendrocytes in the spinal cord of the Dark Agouti rat model of experimental allergic encephalomyelitis
    • Petty M. Lee L. Liang J. Ying X. Torino M. Oliver J. et al. (2010) Teriflunomide treatment reduces infiltration of macrophages, T cells and B cells and increases survival of oligodendrocytes in the spinal cord of the Dark Agouti rat model of experimental allergic encephalomyelitis. Neurology 74: A415.
    • (2010) Neurology , vol.74 , pp. A415
    • Petty, M.1    Lee, L.2    Liang, J.3    Ying, X.4    Torino, M.5    Oliver, J.6
  • 46
    • 0001353603 scopus 로고    scopus 로고
    • Prevention of Relapses and Disability by Interferon Beta-1a Subcutaneously in Multiple Sclerosis Study Group. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing / remitting multiple sclerosis
    • PRISMS
    • PRISMS (1998) Prevention of Relapses and Disability by Interferon Beta-1a Subcutaneously in Multiple Sclerosis Study Group. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing / remitting multiple sclerosis. Lancet 352: 1498–1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 47
    • 84890133589 scopus 로고    scopus 로고
    • Teriflunomide attentuates immunopathological changes in the Dark Agouti rat model of experimental autoimmune encephalomyelitis
    • P448
    • Ringheim G. Lee L. Laws-Ricker L. Delohery T. Colletti N. Soos T. et al. (2011) Teriflunomide attentuates immunopathological changes in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Mult Scler 17: S187, P448.
    • (2011) Mult Scler , vol.17 , pp. S187
    • Ringheim, G.1    Lee, L.2    Laws-Ricker, L.3    Delohery, T.4    Colletti, N.5    Soos, T.6
  • 48
    • 84993700737 scopus 로고    scopus 로고
    • sanofi-aventis
    • US LLC. 2012. Bridgewater, NJ: sanofi-aventis
    • sanofi-aventis. (2012) Arava Prescribing Information. US LLC. 2012. Bridgewater, NJ: sanofi-aventis.
    • (2012) Arava Prescribing Information
  • 49
    • 84901715475 scopus 로고    scopus 로고
    • Evaluation of patient satisfaction from the TENERE study: a comparison of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis
    • Vermersch P. Czlonkowska A. Grimaldi L. Confavreux C. Comi G. Kappos L. et al. (2012) Evaluation of patient satisfaction from the TENERE study: a comparison of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis. J Neurol 259(Suppl. 1): 1–236.
    • (2012) J Neurol , vol.259 , pp. 1-236
    • Vermersch, P.1    Czlonkowska, A.2    Grimaldi, L.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 50
    • 84890186035 scopus 로고    scopus 로고
    • Metabolism comparison between leflunomide and teriflunomide in humans
    • Wang L. van Horn R. Turpault S. Zeng Z. (2011) Metabolism comparison between leflunomide and teriflunomide in humans. Eur J Neurol 18(Suppl. 2): 268.
    • (2011) Eur J Neurol , vol.18 , pp. 268
    • Wang, L.1    van Horn, R.2    Turpault, S.3    Zeng, Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.