Development and validation of an indirect pulsed electrochemical detection method for monitoring the inhibition of Abl1 tyrosine kinase

Journal of Pharmaceutical and Biomedical Analysis

Volumn 90, Issue , 2014, Pages 52-57

  Chen, Hui ^a   Wang, Xu ^a   Chopra, Shruti ^a   Adams, Erwin ^a   Van Schepdael, Ann ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Abl1 tyrosine kinase; Abltide; Inhibition assay; LC InPED

Indexed keywords

ACETONITRILE; DASATINIB; GLUCONIC ACID; GLUCOSE; IMATINIB; NILOTINIB; POLYOL; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE ABL 1; SODIUM; SODIUM HYDROXIDE; SORBITOL; TRIFLUOROACETIC ACID; TROMETAMOL; UNCLASSIFIED DRUG;

ADSORPTION; ARTICLE; CATALYSIS; DRUG MONITORING; ELECTROCHEMICAL DETECTION; ELECTRODE; ENZYME ASSAY; ENZYME INHIBITION; ENZYME MECHANISM; FLOW RATE; IC 50; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; OXIDATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL NOISE RATIO;

ABL1 TYROSINE KINASE; ABLTIDE; INHIBITION ASSAY; LC-INPED;

BENZAMIDES; CALIBRATION; CHROMATOGRAPHY, LIQUID; ELECTROCHEMICAL TECHNIQUES; FUSION PROTEINS, BCR-ABL; GLUCONATES; INHIBITORY CONCENTRATION 50; LIMIT OF DETECTION; LINEAR MODELS; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; THIAZOLES;

EID: 84890179870     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.11.022     Document Type: Article

References (31)

1. Copeland R.A. Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists 2013, John Wiley & Sons, Inc., New Jersey. second ed.
2. Hu L., Jiang G., Xu S., Pan C., Zou H. Monitoring enzyme reaction and screening enzyme inhibitor based on MALDI-TOF-MS platform with a matrix of oxidized carbon nanotubes. J. Am. Soc. Mass Spectrom. 2006, 17:1616-1619.
3. Funeriu D.P., Eppinger J., Denizot L., Miyake M., Miyake J. Enzyme family-specific and activity-based screening of chemical libraries using enzyme microarrays. Nat. Biotechnol. 2005, 23:622-627.
4. Copeland R.A. Mechanistic considerations in high-throughput screening. Anal. Biochem. 2003, 320:1-12.
5. Greis K.D., Zhou S., Burt T.M., Carr A.N., Dolan E., Easwaran V., Evdokimov A., Kawamoto R., Roesgen J., Davis G.F. MALDI-TOF MS as a label-free approach to rapid inhibitor screening. J. Am. Soc. Mass Spectrom. 2006, 17:815-822.
6. Piersma S.R., Labots M., Verheul H.M., Jiménez C.R. Strategies for kinome profiling in cancer and potential clinical applications: chemical proteomics and array-based methods. Anal. Bioanal. Chem. 2010, 397:3163-3171.
7. Saglio G., Cilloni D. Abl: the prototype of oncogenic fusion proteins. Cell Mol. Life Sci. 2004, 61:2897-2911.
8. An X., Tiwari A.K., Sun Y., Ding P.R., Ashby C.R., Chen Z.S. BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review. Leuk. Res. 2010, 34:1255-1268.
9. Krishna R. Application of Pharmacokinetic Principles in Drug Development 2003, Kluwer Academic/Plenum Publishers, New York.
10. LaCourse W.R. Pulsed Electrochemical Detection in High-Performance Liquid Chromatography 1997, John Wiley & Sons, Inc., New York.
11. Adams E., Schepers R., Roets E., Hoogmartens J. Determination of neomycin sulfate by liquid chromatography with pulsed electrochemical detection. J. Chromatogr. A 1996, 741:233-240.
12. Adams E., Van Vaerenbergh G., Roets E., Hoogmartens J. Analysis of amikacin by liquid chromatography with pulsed electrochemical detection. J. Chromatogr. A 1998, 819:93-97.
13. Adams E., Schepers R., Gathu L.W., Kibaya R., Roets E., Hoogmartens J. Liquid chromatographic analysis of a formulation containing polymyxin, gramicidin and neomycin. J. Pharm. Biomed. Anal. 1997, 15:505-511.
14. Yuan Y., Chopra S., Deng X., Zhang M., Fan X., Hu C., Jin S., Van Schepdael A., Adams E. Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection. J. Chromatogr. A 2013, 1295:90-98.
15. Olson M.P., Keating L.R., LaCourse W.R. Indirect pulsed electrochemical detection of amino acids and proteins following high performance liquid chromatography. Anal. Chim. Acta 2009, 652:198-204.
16. LaCourse W.R. Pulsed electrochemical detection at noble metal electrodes in high performance liquid chromatography. Analysis 1993, 21:181-195.
17. Szunyog J., Adams E., Roets E., Hoogmartens J. Analysis of tobramycin by liquid chromatography with pulsed electrochemical detection. J. Pharm. Biomed. Anal. 2000, 23:891-896.
18. Chen H., Adams E., Van Schepdael A. LC-ESI-MS method for the monitoring of Abl1 tyrosine kinase. J. Chromatogr. B 2012, 897:17-21.
19. Chen H., Adams E., Van Schepdael A. Study of Abl1 tyrosine kinase inhibitors by liquid chromatography-electrospray ionization-mass spectrometry. Talanta 2013, 107:88-94.
20. Weber P.L., Kornfelt T., Klausen N.K., Lunte S.M. Characterization of glycopeptides from recombinant coagulation factor VIIa by high-performance liquid chromatography and capillary zone electrophoresis using ultraviolet and pulsed electrochemical detection. Anal. Biochem. 1995, 225:135-142.
21. Weber P.L., Lunte S.M. Capillary electrophoresis with pulsed amperometric detection of carbohydrates and glycopeptides. Electrophoresis 1996, 17:302-309.
22. Kerman K., Vestergaard M., Chikae M., Yamamura S., Tamiya E. Label-free electrochemical detection of the phosphorylated and non-phosphorylated forms of peptides based on tyrosine oxidation. Electrochem. Commun. 2007, 9:976-980.
23. van Riel J.A., Olieman C. Selective detection in RP-LC of Tyr-, Trp-, and sulfur-containing peptides by pulsed amperometry at platinum. Anal. Chem. 1995, 67:3911-3915.
24. Russell J.D., Dolphin J.M., Koppang M.D. Selective analysis of secondary amino acids in gelatin using pulsed electrochemical detection. Anal. Chem. 2007, 79:6615-6621.
25. U.S.FDA Guidance for Industry - Bioanalytical Method Validation 2001.
26. U.S.FDA Guidance for Industry - Analytical Procedures and Method Validation, Draft Guidance 2000.
27. U.S.FDA Guidance for Industry - Bioanalytical Method Validation, Draft Guidance 2013.
28. O'Hare T., Walters D.K., Stoffregen E.P., Jia T., Manley P.W., Mestan J., Cowan-Jacob S.W., Lee F.Y., Heinrich M.C., Deininger M.W., Druker B.J. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res. 2005, 65:4500-4505.
29. Bradeen H.A., Eide C.A., O'Hare T., Johnson K.J., Willis S.G., Lee F.Y., Druker B.J., Deininger M.W. Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations. Blood 2006, 108:2332-2338.
30. Kondo N., Nishimura S. MALDI-TOF mass-spectrometry-based versatile method for the characterization of protein kinases. Chemistry 2009, 15:1413-1421.
31. 50?. Oncologist 2011, 16:868-876.