Within-lesion differences in quantitative MRI parameters predict contrast enhancement in multiple sclerosis

Journal of Magnetic Resonance Imaging

Volumn 38, Issue 6, 2013, Pages 1454-1461

  Jurcoane, Alina ^a   Wagner, Marlies ^a   Schmidt, Christoph ^a   Mayer, Christoph ^a   Gracien, Rene Maxime ^a   Hirschmann, Marc ^a   Deichmann, Ralf ^a   Volz, Steffen ^a   Ziemann, Ulf ^a,b   Hattingen, Elke ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

blood brain barrier; magnetization transfer ratio; multiple sclerosis; proton density; quantitative magnetic resonance imaging; T1 mapping

Indexed keywords

CONTRAST MEDIUM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; INTERMETHOD COMPARISON; MAGNETIZATION TRANSFER RATIO; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON DENSITY; QUANTITATIVE ANALYSIS; RADIOLOGICAL PARAMETERS; REFERENCE VALUE; T1 RELAXATION TIME; WHITE MATTER;

BLOOD BRAIN BARRIER; MAGNETIZATION TRANSFER RATIO; MULTIPLE SCLEROSIS; PROTON DENSITY; QUANTITATIVE MAGNETIC RESONANCE IMAGING; T1 MAPPING;

ADULT; AGED; BRAIN; CONTRAST MEDIA; FEMALE; GADOLINIUM; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NEURONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84890100659     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.24107     Document Type: Article

References (41)

1. Barkhof F,. The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin Neurol 2002; 15: 239-245.
2. Kappos L, Moeri D, Radue EW, et al. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Gadolinium MRI Meta-analysis Group. Lancet 1999; 353: 964-969.
3. Barnes D, McDonald WI, Landon DN, Johnson G,. The characterization of experimental gliosis by quantitative nuclear magnetic resonance imaging. Brain 1988; 111 (Pt 1): 83-94.
4. Mottershead JP, Schmierer K, Clemence M, et al. High field MRI correlates of myelin content and axonal density in multiple sclerosis-a post-mortem study of the spinal cord. J Neurol 2003; 250: 1293-1301.
5. Schmierer K, Scaravilli F, Altmann DR, Barker GJ, Miller DH,. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol 2004; 56: 407-415.
6. Seewann A, Vrenken H, van der Valk P, et al. Diffusely abnormal white matter in chronic multiple sclerosis: imaging and histopathologic analysis. Arch Neurol 2009; 66: 601-609.
7. Davies GR, Altmann DR, Hadjiprocopis A, et al. Increasing normal-appearing gray and white matter magnetisation transfer ratio abnormality in early relapsing-remitting multiple sclerosis. J Neurol 2005; 252: 1037-1044.
8. Traboulsee A, Dehmeshki J, Peters KR, et al. Disability in multiple sclerosis is related to normal appearing brain tissue MTR histogram abnormalities. Mult Scler 2003; 9: 566-573.
9. Larsson HB, Frederiksen J, Kjaer L, Henriksen O, Olesen J,. In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn Reson Med 1988; 7: 43-55.
10. Griffin CM, Chard DT, Parker GJ, Barker GJ, Thompson AJ, Miller DH,. The relationship between lesion and normal appearing brain tissue abnormalities in early relapsing remitting multiple sclerosis. J Neurol 2002; 249: 193-199.
11. Vrenken H, Geurts JJG, Knol DL, et al. Whole-brain T1 mapping in multiple sclerosis: global changes of normal-appearing gray and white matter. Radiology 2006; 240: 811-820.
12. Manfredonia F, Ciccarelli O, Khaleeli Z, et al. Normal-appearing brain t1 relaxation time predicts disability in early primary progressive multiple sclerosis. Arch Neurol 2007; 64: 411-415.
13. Papadopoulos K, Tozer DJ, Fisniku L, et al. TI-relaxation time changes over five years in relapsing-remitting multiple sclerosis. Mult Scler 2010; 16: 427-433.
14. van Waesberghe JH, Kamphorst W, De Groot CJ, et al. Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability. Ann Neurol 1999; 46: 747-754.
15. Barnes D, Munro PM, Youl BD, Prineas JW, McDonald WI,. The longstanding multiple sclerosis lesion. A quantitative MRI and electron microscopic study. Brain 1991; 114: 1271-1280.
16. Ferguson B, Matyszak MK, Esiri MM, Perry VH,. Axonal damage in acute multiple sclerosis lesions. Brain 1997; 120 (Pt 3): 393-399.
17. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mörk S, Bö L,. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338: 278-285.
18. Kuhlmann T, Lingfeld G, Bitsch A, Schuchardt J, Brück W,. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 2002; 125 (Pt 10): 2202-2212.
19. Plumb J, McQuaid S, Mirakhur M, Kirk J,. Abnormal endothelial tight junctions bin active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol 2002; 12: 154-169.
20. Leech S, Kirk J, Plumb J, McQuaid S,. Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis. Neuropathol Appl Neurobiol 2007; 33: 86-98.
21. D'Aversa TG, Eugenin EA, Lopez L, Berman JW,. Myelin basic protein induces inflammatory mediators from primary human endothelial cells and blood-brain-barrier disruption: implications for the pathogenesis of multiple sclerosis. Neuropathol Appl Neurobiol 2012 [Epub ahead of print].
22. Katz D, Taubenberger JK, Cannella B, McFarlin DE, Raine CS, McFarland HF,. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann Neurol 1993; 34: 661-669.
23. Brück W, Bitsch A, Kolenda H, Brück Y, Stiefel M, Lassmann H,. Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann Neurol 1997; 42: 783-793.
24. Volz S, Nöth U, Deichmann R,. Correction of systematic errors in quantitative proton density mapping. Magn Reson Med 2012; 68: 74-85.
25. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292-302.
26. Kurtzke JF,. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983; 33: 1444-1452.
27. Preibisch C, Deichmann R,. T-1 mapping using spoiled FLASH-EPI hybrid sequences and varying flip angles. Magn Reson Imaging 2009; 62: 240-246.
28. Howarth C, Hutton C, Deichmann R,. Improvement of the image quality of T1-weighted anatomical brain scans. Neuroimage 2006; 29: 930-937.
29. Venkatesan R, Lin WL, Haacke EM,. Accurate determination of spin-density and T-1 in the presence of RF-field inhomogeneities and flip-angle miscalibration. Magn Reson Med 1998; 40: 592-602.
30. Volz S, Noth U, Rotarska-Jagiela A, Deichmann R,. A fast B1-mapping method for the correction and normalization of magnetization transfer ratio maps at 3 T. Neuroimage 2010; 49: 3015-3026.
31. Warntjes JBM, Dahlqvist O, Lundberg P,. Novel method for rapid, simultaneous T-1, T-2(*), and proton density quantification. Magn Reson Med 2007; 57: 528-537.
32. Jenkinson M, Beckmann CF, Behrens TE, Woolrich MW, Smith SM,. FSL. Neuroimage 2012; 62: 782-790.
33. Preibisch C, Deichmann R,. Influence of RF spoiling on the stability and accuracy of T1 mapping based on spoiled FLASH with varying flip angles. Magn Reson Med 2009; 61: 125-135.
34. van Walderveen MA, Kamphorst W, Scheltens P, et al. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 1998; 50: 1282-1288.
35. Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM,. White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis. J Neurol 2002; 249: 1279-1286.
36. Griffin CM, Parker GJ, Barker GJ, Thompson AJ, Miller DH,. MTR and T1 provide complementary information in MS NAWM, but not in lesions. Mult Scler 2000; 6: 327-331.
37. Karampekios S, Papanikolaou N, Papadaki E, et al. Quantification of magnetization transfer rate and native T1 relaxation time of the brain: correlation with magnetization transfer ratio measurements in patients with multiple sclerosis. Neuroradiology 2005; 47: 189-196.
38. Popescu BF, Lucchinetti CF,. Meningeal and cortical grey matter pathology in multiple sclerosis. BMC Neurol 2012; 7; 12: 11.
39. Lucchinetti CF, Popescu BF, Bunyan RF, et al. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med 2011; 365: 2188-2197.
40. Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM,. MRI brain T1 relaxation time changes in MS patients increase over time in both the white matter and the cortex. J Neuroimaging 2003; 13: 234-239.
41. Janardhan V, Suri S, Bakshi R,. Multiple sclerosis: hyperintense lesions in the brain on nonenhanced T1-weighted MR images evidenced as areas of T1 shortening. Radiology 2007; 244: 823-831.