메뉴 건너뛰기




Volumn 15, Issue 6, 2013, Pages 509-516

Latest developments in the biology and management of uveal melanoma

Author keywords

Biology; Mutations; Prognosis; Therapy; Uveal melanoma

Indexed keywords

ALPHA INTERFERON; BIOLOGICAL MARKER; BRCA1 ASSOCIATED PROTEIN 1; BRCA1 PROTEIN; CARBOPLATIN; CARMUSTINE; CISPLATIN; CIXUTUMUMAB; DACARBAZINE; EVEROLIMUS; FOTEMUSTINE; GANETESPIB; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERFERON; INTERLEUKIN 2; IPILIMUMAB; MELPHALAN; PASIREOTIDE; RECOMBINANT ALPHA2B INTERFERON; SELUMETINIB; SOTRASTAURIN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VINCRISTINE SULFATE; VORINOSTAT; YTTRIUM 90;

EID: 84890099122     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-013-0348-y     Document Type: Note
Times cited : (19)

References (79)
  • 1
    • 80052494912 scopus 로고    scopus 로고
    • Uveal melanoma: Trends in incidence, treatment, and survival
    • 10.1016/j.ophtha.2011.01.040 21704381 10.1016/j.ophtha.2011.01.040
    • Singh AD, Turell ME, Topham AK. Uveal melanoma: trends in incidence, treatment, and survival. Ophthalmology. 2011;118(9):1881-5. doi: 10.1016/j.ophtha.2011.01.040.
    • (2011) Ophthalmology , vol.118 , Issue.9 , pp. 1881-1885
    • Singh, A.D.1    Turell, M.E.2    Topham, A.K.3
  • 2
    • 58849120434 scopus 로고    scopus 로고
    • Positive interaction between light iris color and ultraviolet radiation in relation to the risk of uveal melanoma: A case-control study
    • 10.1016/j.ophtha.2008.09.040 19091418 10.1016/j.ophtha.2008.09.040
    • Schmidt-Pokrzywniak A, Jockel KH, Bornfeld N, Sauerwein W, Stang A. Positive interaction between light iris color and ultraviolet radiation in relation to the risk of uveal melanoma: a case-control study. Ophthalmology. 2009;116(2):340-8. doi: 10.1016/j.ophtha.2008.09.040.
    • (2009) Ophthalmology , vol.116 , Issue.2 , pp. 340-348
    • Schmidt-Pokrzywniak, A.1    Jockel, K.H.2    Bornfeld, N.3    Sauerwein, W.4    Stang, A.5
  • 3
    • 21244442007 scopus 로고    scopus 로고
    • Occupational risks for uveal melanoma results from a case-control study in nine European countries
    • 10.1007/s10552-004-5029-6 15953986 10.1007/s10552-004-5029-6
    • Lutz JM, Cree I, Sabroe S, Kvist TK, Clausen LB, Afonso N, et al. Occupational risks for uveal melanoma results from a case-control study in nine European countries. Cancer Causes Control. 2005;16(4):437-47. doi: 10.1007/s10552-004-5029-6.
    • (2005) Cancer Causes Control , vol.16 , Issue.4 , pp. 437-447
    • Lutz, J.M.1    Cree, I.2    Sabroe, S.3    Kvist, T.K.4    Clausen, L.B.5    Afonso, N.6
  • 4
    • 3042658337 scopus 로고    scopus 로고
    • Sunlight exposure and pathogenesis of uveal melanoma
    • 10.1016/j.survophthal.2004.04.009 15231397 10.1016/j.survophthal.2004.04. 009
    • Singh AD, Rennie IG, Seregard S, Giblin M, McKenzie J. Sunlight exposure and pathogenesis of uveal melanoma. Surv Ophthalmol. 2004;49(4):419-28. doi: 10.1016/j.survophthal.2004.04.009.
    • (2004) Surv Ophthalmol , vol.49 , Issue.4 , pp. 419-428
    • Singh, A.D.1    Rennie, I.G.2    Seregard, S.3    Giblin, M.4    McKenzie, J.5
  • 5
    • 14844331438 scopus 로고    scopus 로고
    • Metastatic uveal melanoma
    • 10.1016/j.ohc.2004.07.003 10.1016/j.ohc.2004.07.003
    • Singh AD, Borden EC. Metastatic uveal melanoma. Ophthalmol Clin N Am. 2005;18(1):143-50. doi: 10.1016/j.ohc.2004.07.003.
    • (2005) Ophthalmol Clin N Am , vol.18 , Issue.1 , pp. 143-150
    • Singh, A.D.1    Borden, E.C.2
  • 6
    • 55749112322 scopus 로고    scopus 로고
    • The biology and management of uveal melanoma
    • 18706273 10.1007/s11912-008-0066-z 1:CAS:528:DC%2BD1cXhtFKntLvI
    • Sato T, Han F, Yamamoto A. The biology and management of uveal melanoma. Curr Oncol Rep. 2008;10(5):431-8.
    • (2008) Curr Oncol Rep , vol.10 , Issue.5 , pp. 431-438
    • Sato, T.1    Han, F.2    Yamamoto, A.3
  • 7
    • 33746290776 scopus 로고    scopus 로고
    • Treatment of primary intraocular melanoma
    • 10.1586/14737140.6.4.493 16613538 10.1586/14737140.6.4.493
    • Damato B. Treatment of primary intraocular melanoma. Expert Rev Anticancer Ther. 2006;6(4):493-506. doi: 10.1586/14737140.6.4.493.
    • (2006) Expert Rev Anticancer Ther , vol.6 , Issue.4 , pp. 493-506
    • Damato, B.1
  • 8
    • 14844329883 scopus 로고    scopus 로고
    • Uveal melanoma: Proton beam irradiation
    • 10.1016/j.ohc.2004.08.002 10.1016/j.ohc.2004.08.002
    • Gragoudas ES, Marie LA. Uveal melanoma: proton beam irradiation. Ophthalmol Clin N Am. 2005;18(1):111-8. doi: 10.1016/j.ohc.2004.08.002.
    • (2005) Ophthalmol Clin N Am , vol.18 , Issue.1 , pp. 111-118
    • Gragoudas, E.S.1    Marie, L.A.2
  • 9
    • 77957575098 scopus 로고    scopus 로고
    • Posterior uveal melanoma in young patients treated with proton beam therapy
    • 10.1097/IAE.0b013e3181cfdfad 20224468 10.1097/IAE.0b013e3181cfdfad
    • Vavvas D, Kim I, Lane AM, Chaglassian A, Mukai S, Gragoudas E. Posterior uveal melanoma in young patients treated with proton beam therapy. Retina. 2010;30(8):1267-71. doi: 10.1097/IAE.0b013e3181cfdfad.
    • (2010) Retina , vol.30 , Issue.8 , pp. 1267-1271
    • Vavvas, D.1    Kim, I.2    Lane, A.M.3    Chaglassian, A.4    Mukai, S.5    Gragoudas, E.6
  • 10
    • 84868239872 scopus 로고    scopus 로고
    • Epidemiology and management of uveal melanoma
    • 10.1016/j.hoc.2012.08.004 10.1016/j.hoc.2012.08.004
    • Yonekawa Y, Kim IK. Epidemiology and management of uveal melanoma. Hematol Oncol Clin N Am. 2012;26(6):1169-84. doi: 10.1016/j.hoc.2012.08.004.
    • (2012) Hematol Oncol Clin N Am , vol.26 , Issue.6 , pp. 1169-1184
    • Yonekawa, Y.1    Kim, I.K.2
  • 11
    • 0142200859 scopus 로고    scopus 로고
    • Very long-term prognosis of patients with malignant uveal melanoma
    • 10.1167/iovs.03-0538
    • Kujala E, Makitie T, Kivela T. Very long-term prognosis of patients with malignant uveal melanoma. Investig Ophthalmol Vis Sci. 2003;44(11):4651-9.
    • (2003) Investig Ophthalmol Vis Sci , vol.44 , Issue.11 , pp. 4651-4659
    • Kujala, E.1    Makitie, T.2    Kivela, T.3
  • 12
    • 84874086891 scopus 로고    scopus 로고
    • Molecular pathology of uveal melanoma
    • 10.1038/eye.2012.255 10.1038/eye.2012.255 1:CAS:528:DC%2BC3sXislOrs7o%3D
    • Coupland SE, Lake SL, Zeschnigk M, Damato BE. Molecular pathology of uveal melanoma. Eye (Lond). 2013;27(2):230-42. doi: 10.1038/eye.2012.255.
    • (2013) Eye (Lond) , vol.27 , Issue.2 , pp. 230-242
    • Coupland, S.E.1    Lake, S.L.2    Zeschnigk, M.3    Damato, B.E.4
  • 13
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • 10.1038/nature00766 12068308 10.1038/nature00766 1:CAS:528: DC%2BD38XkvVagsLo%3D
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-54. doi: 10.1038/nature00766.
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3    Stephens, P.4    Edkins, S.5    Clegg, S.6
  • 14
    • 0028086086 scopus 로고
    • Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi
    • 8043423 10.1111/j.1365-2133.1994.tb08460.x 1:CAS:528:DyaK2MXnsFSnsQ%3D%3D
    • Carr J, Mackie RM. Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi. Br J Dermatol. 1994;131(1):72-7.
    • (1994) Br J Dermatol , vol.131 , Issue.1 , pp. 72-77
    • Carr, J.1    Mackie, R.M.2
  • 15
    • 0141842689 scopus 로고    scopus 로고
    • Absence of BRAF and NRAS mutations in uveal melanoma
    • 14522897 1:CAS:528:DC%2BD3sXnvVSjtLk%3D
    • Cruz 3rd F, Rubin BP, Wilson D, Town A, Schroeder A, Haley A, et al. Absence of BRAF and NRAS mutations in uveal melanoma. Cancer Res. 2003;63(18):5761-6.
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 5761-5766
    • Cruz III, F.1    Rubin, B.P.2    Wilson, D.3    Town, A.4    Schroeder, A.5    Haley, A.6
  • 18
    • 59049107421 scopus 로고    scopus 로고
    • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    • 10.1038/nature07586 19078957 10.1038/nature07586
    • Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature. 2009;457(7229):599-602. doi: 10.1038/nature07586.
    • (2009) Nature , vol.457 , Issue.7229 , pp. 599-602
    • Van Raamsdonk, C.D.1    Bezrookove, V.2    Green, G.3    Bauer, J.4    Gaugler, L.5    O'Brien, J.M.6
  • 19
    • 78651446131 scopus 로고    scopus 로고
    • Mutations in GNA11 in uveal melanoma
    • 10.1056/NEJMoa1000584 21083380 10.1056/NEJMoa1000584 This article first reported mutations in GNA11 in uveal melanoma and modeled its role in activation of the MAPK pathway
    • •• Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, et al. Mutations in GNA11 in uveal melanoma. N Engl J Med. 2010;363(23):2191-9. doi: 10.1056/NEJMoa1000584. This article first reported mutations in GNA11 in uveal melanoma and modeled its role in activation of the MAPK pathway.
    • (2010) N Engl J Med , vol.363 , Issue.23 , pp. 2191-2199
    • Van Raamsdonk, C.D.1    Griewank, K.G.2    Crosby, M.B.3    Garrido, M.C.4    Vemula, S.5    Wiesner, T.6
  • 20
    • 0034969317 scopus 로고    scopus 로고
    • MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma
    • 10.1002/1096-9896(200106)194:2<201: AID-PATH840>3.0.CO;2-O 11400149 10.1002/1096-9896(200106)194:2<201: AID-PATH840>3.0.CO;2-O 1:CAS:528:DC%2BD3MXks1Klsrg%3D
    • El-Shabrawi Y, Ardjomand N, Radner H, Ardjomand N. MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma. J Pathol. 2001;194(2):201-6. doi: 10.1002/1096-9896(200106)194:2<201::AID-PATH840>3. 0.CO;2-O.
    • (2001) J Pathol , vol.194 , Issue.2 , pp. 201-206
    • El-Shabrawi, Y.1    Ardjomand, N.2    Radner, H.3    Ardjomand, N.4
  • 21
    • 0030995996 scopus 로고    scopus 로고
    • Uveal melanoma. Comparison of the prognostic value of fibrovascular loops, mean of the ten largest nucleoli, cell type, and tumor size
    • 9160022 10.1016/S0161-6420(97)30234-6 1:STN:280:DyaK2szgtlKqug%3D%3D
    • McLean IW, Keefe KS, Burnier MN. Uveal melanoma. Comparison of the prognostic value of fibrovascular loops, mean of the ten largest nucleoli, cell type, and tumor size. Ophthalmology. 1997;104(5):777-80.
    • (1997) Ophthalmology , vol.104 , Issue.5 , pp. 777-780
    • McLean, I.W.1    Keefe, K.S.2    Burnier, M.N.3
  • 22
    • 84874058850 scopus 로고    scopus 로고
    • The pathology of ocular cancer
    • 10.1038/eye.2012.237 10.1038/eye.2012.237 1:CAS:528:DC%2BC3sXislOrsLY%3D
    • Eagle Jr RC. The pathology of ocular cancer. Eye (Lond). 2013;27(2):128-36. doi: 10.1038/eye.2012.237.
    • (2013) Eye (Lond) , vol.27 , Issue.2 , pp. 128-136
    • Eagle Jr., R.C.1
  • 23
    • 69149096505 scopus 로고    scopus 로고
    • The 7th edition AJCC staging system for eye cancer: An international language for ophthalmic oncology
    • 10.1043/1543-2165-133.8.1197 19653708
    • Finger PT. The 7th edition AJCC staging system for eye cancer: an international language for ophthalmic oncology. Arch Pathol Lab Med. 2009;133(8):1197-8. doi: 10.1043/1543-2165-133.8.1197.
    • (2009) Arch Pathol Lab Med , vol.133 , Issue.8 , pp. 1197-1198
    • Finger, P.T.1
  • 24
    • 84874100935 scopus 로고    scopus 로고
    • Prognostication in eye cancer: The latest tumor, node, metastasis classification and beyond
    • 10.1038/eye.2012.256 10.1038/eye.2012.256 1:STN:280: DC%2BC3s3jslGitw%3D%3D
    • Kivela T, Kujala E. Prognostication in eye cancer: the latest tumor, node, metastasis classification and beyond. Eye (Lond). 2013;27(2):243-52. doi: 10.1038/eye.2012.256.
    • (2013) Eye (Lond) , vol.27 , Issue.2 , pp. 243-252
    • Kivela, T.1    Kujala, E.2
  • 25
    • 0025611594 scopus 로고
    • Nonrandom chromosomal abnormalities in primary uveal melanoma
    • 2231772 10.1093/jnci/82.22.1765 1:STN:280:DyaK3M%2FjvFeqtA%3D%3D
    • Prescher G, Bornfeld N, Becher R. Nonrandom chromosomal abnormalities in primary uveal melanoma. J Natl Cancer Inst. 1990;82(22):1765-9.
    • (1990) J Natl Cancer Inst , vol.82 , Issue.22 , pp. 1765-1769
    • Prescher, G.1    Bornfeld, N.2    Becher, R.3
  • 26
    • 0029874486 scopus 로고    scopus 로고
    • Prognostic implications of monosomy 3 in uveal melanoma
    • 8622452 10.1016/S0140-6736(96)90736-9 1:STN:280:DyaK283gs1Ciuw%3D%3D
    • Prescher G, Bornfeld N, Hirche H, Horsthemke B, Jockel KH, Becher R. Prognostic implications of monosomy 3 in uveal melanoma. Lancet. 1996;347(9010):1222-5.
    • (1996) Lancet , vol.347 , Issue.9010 , pp. 1222-1225
    • Prescher, G.1    Bornfeld, N.2    Hirche, H.3    Horsthemke, B.4    Jockel, K.H.5    Becher, R.6
  • 27
    • 79551508872 scopus 로고    scopus 로고
    • Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens
    • 10.1016/j.ophtha.2010.05.023 20869116 10.1016/j.ophtha.2010.05.023
    • Shields CL, Ganguly A, Bianciotto CG, Turaka K, Tavallali A, Shields JA. Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens. Ophthalmology. 2011;118(2):396-401. doi: 10.1016/j.ophtha.2010.05.023.
    • (2011) Ophthalmology , vol.118 , Issue.2 , pp. 396-401
    • Shields, C.L.1    Ganguly, A.2    Bianciotto, C.G.3    Turaka, K.4    Tavallali, A.5    Shields, J.A.6
  • 28
    • 84861992419 scopus 로고    scopus 로고
    • Chromosome 3 status in uveal melanoma: A comparison of fluorescence in situ hybridization and single-nucleotide polymorphism array
    • 10.1167/iovs.11-9027 10.1167/iovs.11-9027 1:CAS:528:DC%2BC38XhtlGgs7rK
    • Singh AD, Aronow ME, Sun Y, Bebek G, Saunthararajah Y, Schoenfield LR, et al. Chromosome 3 status in uveal melanoma: a comparison of fluorescence in situ hybridization and single-nucleotide polymorphism array. Investig Ophthalmol Vis Sci. 2012;53(7):3331-9. doi: 10.1167/iovs.11-9027.
    • (2012) Investig Ophthalmol Vis Sci , vol.53 , Issue.7 , pp. 3331-3339
    • Singh, A.D.1    Aronow, M.E.2    Sun, Y.3    Bebek, G.4    Saunthararajah, Y.5    Schoenfield, L.R.6
  • 29
    • 77958149836 scopus 로고    scopus 로고
    • Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma
    • 10.1167/iovs.09-5083 10.1167/iovs.09-5083
    • Lake SL, Coupland SE, Taktak AF, Damato BE. Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma. Investig Ophthalmol Vis Sci. 2010;51(10):4884-91. doi: 10.1167/iovs.09-5083.
    • (2010) Investig Ophthalmol Vis Sci , vol.51 , Issue.10 , pp. 4884-4891
    • Lake, S.L.1    Coupland, S.E.2    Taktak, A.F.3    Damato, B.E.4
  • 30
    • 5644251671 scopus 로고    scopus 로고
    • Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death
    • 10.1158/0008-5472.CAN-04-1750 15492234 10.1158/0008-5472.CAN-04-1750 1:CAS:528:DC%2BD2cXosFyntrs%3D
    • Onken MD, Worley LA, Ehlers JP, Harbour JW. Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res. 2004;64(20):7205-9. doi: 10.1158/0008-5472.CAN-04-1750.
    • (2004) Cancer Res , vol.64 , Issue.20 , pp. 7205-7209
    • Onken, M.D.1    Worley, L.A.2    Ehlers, J.P.3    Harbour, J.W.4
  • 31
    • 77956149503 scopus 로고    scopus 로고
    • Association between gene expression profile, proliferation and metastasis in uveal melanoma
    • 10.3109/02713683.2010.493265 20795869 10.3109/02713683.2010.493265 1:CAS:528:DC%2BC3cXhtVylsrfJ
    • Onken MD, Worley LA, Harbour JW. Association between gene expression profile, proliferation and metastasis in uveal melanoma. Curr Eye Res. 2010;35(9):857-63. doi: 10.3109/02713683.2010.493265.
    • (2010) Curr Eye Res , vol.35 , Issue.9 , pp. 857-863
    • Onken, M.D.1    Worley, L.A.2    Harbour, J.W.3
  • 32
    • 77954355725 scopus 로고    scopus 로고
    • An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma
    • 10.2353/jmoldx.2010.090220 20413675 10.2353/jmoldx.2010.090220 1:CAS:528:DC%2BC3cXhtVehurrK This article provided validation of gene expression profiling data and their utility in prognostication
    • •• Onken MD, Worley LA, Tuscan MD, Harbour JW. An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma. J Mol Diagn. 2010;12(4):461-8. doi: 10.2353/jmoldx.2010.090220. This article provided validation of gene expression profiling data and their utility in prognostication.
    • (2010) J Mol Diagn , vol.12 , Issue.4 , pp. 461-468
    • Onken, M.D.1    Worley, L.A.2    Tuscan, M.D.3    Harbour, J.W.4
  • 33
    • 84876178516 scopus 로고    scopus 로고
    • The DecisionDx-UM gene expression profile test provides risk stratification and individualized patient care in uveal melanoma
    • doi: 10.1371/currents.eogt.af8ba80fc776c8f1ce8f5dc485d4a618
    • Harbour JW, Chen R. The DecisionDx-UM gene expression profile test provides risk stratification and individualized patient care in uveal melanoma. PLoS Curr. 2013;5. doi: 10.1371/currents.eogt.af8ba80fc776c8f1ce8f5dc485d4a618.
    • (2013) PLoS Curr , vol.5
    • Harbour, J.W.1    Chen, R.2
  • 34
    • 78649700287 scopus 로고    scopus 로고
    • Frequent mutation of BAP1 in metastasizing uveal melanomas
    • 10.1126/science.1194472 21051595 10.1126/science.1194472 1:CAS:528:DC%2BC3cXhsVyrsbbI
    • Harbour JW, Onken MD, Roberson ED, Duan S, Cao L, Worley LA, et al. Frequent mutation of BAP1 in metastasizing uveal melanomas. Science. 2010;330(6009):1410-3. doi: 10.1126/science.1194472.
    • (2010) Science , vol.330 , Issue.6009 , pp. 1410-1413
    • Harbour, J.W.1    Onken, M.D.2    Roberson, E.D.3    Duan, S.4    Cao, L.5    Worley, L.A.6
  • 35
    • 84865461263 scopus 로고    scopus 로고
    • BAP1 cancer syndrome: Malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs
    • 10.1186/1479-5876-10-179 22935333 10.1186/1479-5876-10-179 1:CAS:528:DC%2BC38XhvVShsr7M
    • Carbone M, Ferris LK, Baumann F, Napolitano A, Lum CA, Flores EG, et al. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med. 2012;10:179. doi: 10.1186/1479-5876-10-179.
    • (2012) J Transl Med , vol.10 , pp. 179
    • Carbone, M.1    Ferris, L.K.2    Baumann, F.3    Napolitano, A.4    Lum, C.A.5    Flores, E.G.6
  • 36
    • 84856023369 scopus 로고    scopus 로고
    • Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers
    • 10.1136/jmedgenet-2011-100156 21941004 10.1136/jmedgenet-2011-100156 1:CAS:528:DC%2BC38XhvVClsr4%3D
    • Abdel-Rahman MH, Pilarski R, Cebulla CM, Massengill JB, Christopher BN, Boru G, et al. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. J Med Genet. 2011;48(12):856-9. doi: 10.1136/jmedgenet-2011-100156.
    • (2011) J Med Genet , vol.48 , Issue.12 , pp. 856-859
    • Abdel-Rahman, M.H.1    Pilarski, R.2    Cebulla, C.M.3    Massengill, J.B.4    Christopher, B.N.5    Boru, G.6
  • 37
    • 84856023489 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
    • 10.1158/1078-0432.CCR-11-0946 22038994 10.1158/1078-0432.CCR-11-0946 1:CAS:528:DC%2BC38XhtVGqsr4%3D This study showed histone deacetylase inhibitors as a class are capable of inducing grown inhibition in uveal melanoma
    • •• Landreville S, Agapova OA, Matatall KA, Kneass ZT, Onken MD, Lee RS, et al. Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Clin Cancer Res. 2012;18(2):408-16. doi: 10.1158/1078-0432.CCR-11-0946. This study showed histone deacetylase inhibitors as a class are capable of inducing grown inhibition in uveal melanoma.
    • (2012) Clin Cancer Res , vol.18 , Issue.2 , pp. 408-416
    • Landreville, S.1    Agapova, O.A.2    Matatall, K.A.3    Kneass, Z.T.4    Onken, M.D.5    Lee, R.S.6
  • 38
    • 84880835793 scopus 로고    scopus 로고
    • Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma
    • 10.1002/cam4.61 23634288 10.1002/cam4.61 1:CAS:528:DC%2BC3sXlsV2lurk%3D
    • Metz CH, Scheulen M, Bornfeld N, Lohmann D, Zeschnigk M. Ultradeep sequencing detects GNAQ and GNA11 mutations in cell-free DNA from plasma of patients with uveal melanoma. Cancer Med. 2013;2(2):208-15. doi: 10.1002/cam4.61.
    • (2013) Cancer Med , vol.2 , Issue.2 , pp. 208-215
    • Metz, C.H.1    Scheulen, M.2    Bornfeld, N.3    Lohmann, D.4    Zeschnigk, M.5
  • 39
    • 84863895005 scopus 로고    scopus 로고
    • Pyrophosphorolysis-activated polymerization detects circulating tumor DNA in metastatic uveal melanoma
    • 10.1158/1078-0432.CCR-12-0309 22645051 10.1158/1078-0432.CCR-12-0309 1:CAS:528:DC%2BC38XhtVelur3L
    • Madic J, Piperno-Neumann S, Servois V, Rampanou A, Milder M, Trouiller B, et al. Pyrophosphorolysis-activated polymerization detects circulating tumor DNA in metastatic uveal melanoma. Clin Cancer Res. 2012;18(14):3934-41. doi: 10.1158/1078-0432.CCR-12-0309.
    • (2012) Clin Cancer Res , vol.18 , Issue.14 , pp. 3934-3941
    • Madic, J.1    Piperno-Neumann, S.2    Servois, V.3    Rampanou, A.4    Milder, M.5    Trouiller, B.6
  • 40
    • 79957573755 scopus 로고    scopus 로고
    • Prognostic relevance of circulating tumor cells in metastatic uveal melanoma
    • 10.1159/000328283 21625180 10.1159/000328283 1:STN:280: DC%2BC3MnpvFOqtA%3D%3D
    • Schuster R, Bechrakis NE, Stroux A, Busse A, Schmittel A, Thiel E, et al. Prognostic relevance of circulating tumor cells in metastatic uveal melanoma. Oncology. 2011;80(1-2):57-62. doi: 10.1159/000328283.
    • (2011) Oncology , vol.80 , Issue.1-2 , pp. 57-62
    • Schuster, R.1    Bechrakis, N.E.2    Stroux, A.3    Busse, A.4    Schmittel, A.5    Thiel, E.6
  • 41
    • 77955700927 scopus 로고    scopus 로고
    • Tyrosinase mRNA levels in the blood of uveal melanoma patients: Correlation with the number of circulating tumor cells and tumor progression
    • 10.1097/CMR.0b013e32833906e3 20442676 10.1097/CMR.0b013e32833906e3 1:CAS:528:DC%2BC3cXosFGjt7o%3D
    • Pinzani P, Mazzini C, Salvianti F, Massi D, Grifoni R, Paoletti C, et al. Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression. Melanoma Res. 2010;20(4):303-10. doi: 10.1097/CMR.0b013e32833906e3.
    • (2010) Melanoma Res , vol.20 , Issue.4 , pp. 303-310
    • Pinzani, P.1    Mazzini, C.2    Salvianti, F.3    Massi, D.4    Grifoni, R.5    Paoletti, C.6
  • 42
    • 33947246637 scopus 로고    scopus 로고
    • Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma
    • 10.1158/1078-0432.CCR-06-2329 17317826 10.1158/1078-0432.CCR-06-2329 1:CAS:528:DC%2BD2sXhvF2hsb4%3D
    • Schuster R, Bechrakis NE, Stroux A, Busse A, Schmittel A, Scheibenbogen C, et al. Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma. Clin Cancer Res. 2007;13(4):1171-8. doi: 10.1158/1078-0432.CCR-06-2329.
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1171-1178
    • Schuster, R.1    Bechrakis, N.E.2    Stroux, A.3    Busse, A.4    Schmittel, A.5    Scheibenbogen, C.6
  • 43
    • 84874729378 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 as a predictive biomarker for metastatic uveal melanoma in humans
    • 10.1167/iovs.12-10228 10.1167/iovs.12-10228 1:CAS:528: DC%2BC3sXjt1ertbo%3D
    • Frenkel S, Zloto O, Pe'er J, Barak V. Insulin-like growth factor-1 as a predictive biomarker for metastatic uveal melanoma in humans. Investig Ophthalmol Vis Sci. 2013;54(1):490-3. doi: 10.1167/iovs.12-10228.
    • (2013) Investig Ophthalmol Vis Sci , vol.54 , Issue.1 , pp. 490-493
    • Frenkel, S.1    Zloto, O.2    Pe'er, J.3    Barak, V.4
  • 44
    • 79851498472 scopus 로고    scopus 로고
    • The dynamics of serum tumor markers in predicting metastatic uveal melanoma (part 1)
    • 21273622 1:CAS:528:DC%2BC3MXisVamsL8%3D
    • Barak V, Kaiserman I, Frenkel S, Hendler K, Kalickman I, Pe'er J. The dynamics of serum tumor markers in predicting metastatic uveal melanoma (part 1). Anticancer Res. 2011;31(1):345-9.
    • (2011) Anticancer Res , vol.31 , Issue.1 , pp. 345-349
    • Barak, V.1    Kaiserman, I.2    Frenkel, S.3    Hendler, K.4    Kalickman, I.5    Pe'er, J.6
  • 46
    • 79959592222 scopus 로고    scopus 로고
    • Surveillance testing for metastasis from primary uveal melanoma and effect on patient survival
    • 10.1016/j.ajo.2011.03.004. 21601175 10.1016/j.ajo.2011.03.004 e1
    • Augsburger JJ, Correa ZM, Trichopoulos N. Surveillance testing for metastasis from primary uveal melanoma and effect on patient survival. Am J Ophthalmol. 2011;152(1):5-9 e1. doi: 10.1016/j.ajo.2011.03.004.
    • (2011) Am J Ophthalmol , vol.152 , Issue.1 , pp. 5-9
    • Augsburger, J.J.1    Correa, Z.M.2    Trichopoulos, N.3
  • 47
    • 84930765575 scopus 로고    scopus 로고
    • Surveillance options for patients with uveal melanoma following definitive management
    • 10.1200/EdBook-AM.2013.33.382 10.1200/EdBook-AM.2013.33.382
    • Francis JH, Patel SP, Gombos DS, Carvajal RD. Surveillance options for patients with uveal melanoma following definitive management. Am Soc Clin Oncol Educ Book. 2013;2013:382-7. doi: 10.1200/EdBook-AM.2013.33.382.
    • (2013) Am Soc Clin Oncol Educ Book , vol.2013 , pp. 382-387
    • Francis, J.H.1    Patel, S.P.2    Gombos, D.S.3    Carvajal, R.D.4
  • 48
    • 84872322509 scopus 로고    scopus 로고
    • Radiation-related cancer risk associated with surveillance imaging for metastasis from choroidal melanoma
    • 10.1001/jamaophthalmol.2013.564 23307209 10.1001/jamaophthalmol.2013.564
    • Wen JC, Sai V, Straatsma BR, McCannel TA. Radiation-related cancer risk associated with surveillance imaging for metastasis from choroidal melanoma. JAMA Ophthalmol. 2013;131(1):56-61. doi: 10.1001/jamaophthalmol.2013.564.
    • (2013) JAMA Ophthalmol , vol.131 , Issue.1 , pp. 56-61
    • Wen, J.C.1    Sai, V.2    Straatsma, B.R.3    McCannel, T.A.4
  • 50
    • 70350574114 scopus 로고    scopus 로고
    • Adjuvant interferon therapy for patients with uveal melanoma at high risk of metastasis
    • 10.1016/j.ophtha.2009.04.044 19744725 10.1016/j.ophtha.2009.04.044
    • Lane AM, Egan KM, Harmon D, Holbrook A, Munzenrider JE, Gragoudas ES. Adjuvant interferon therapy for patients with uveal melanoma at high risk of metastasis. Ophthalmology. 2009;116(11):2206-12. doi: 10.1016/j.ophtha.2009.04. 044.
    • (2009) Ophthalmology , vol.116 , Issue.11 , pp. 2206-2212
    • Lane, A.M.1    Egan, K.M.2    Harmon, D.3    Holbrook, A.4    Munzenrider, J.E.5    Gragoudas, E.S.6
  • 51
    • 43649087573 scopus 로고    scopus 로고
    • Adjuvant intra-arterial hepatic fotemustine for high-risk uveal melanoma patients
    • 10.1097/CMR.0b013e32830317de 18477897 10.1097/CMR.0b013e32830317de 1:CAS:528:DC%2BD1cXlvVCltLw%3D
    • Voelter V, Schalenbourg A, Pampallona S, Peters S, Halkic N, Denys A, et al. Adjuvant intra-arterial hepatic fotemustine for high-risk uveal melanoma patients. Melanoma Res. 2008;18(3):220-4. doi: 10.1097/CMR.0b013e32830317de.
    • (2008) Melanoma Res , vol.18 , Issue.3 , pp. 220-224
    • Voelter, V.1    Schalenbourg, A.2    Pampallona, S.3    Peters, S.4    Halkic, N.5    Denys, A.6
  • 52
    • 0019863870 scopus 로고
    • Prognosis in metastatic choroidal melanoma
    • 7244714 10.1097/00007611-198105000-00017 1:STN:280:DyaL3M3is1Wntg%3D%3D
    • Bedikian AY, Kantarjian H, Young SE, Bodey GP. Prognosis in metastatic choroidal melanoma. South Med J. 1981;74(5):574-7.
    • (1981) South Med J , vol.74 , Issue.5 , pp. 574-577
    • Bedikian, A.Y.1    Kantarjian, H.2    Young, S.E.3    Bodey, G.P.4
  • 53
    • 70349736165 scopus 로고    scopus 로고
    • Surgical management of liver metastases from uveal melanoma: 16 years' experience at the Institut Curie
    • 10.1016/j.ejso.2009.02.016 19329272 10.1016/j.ejso.2009.02.016 1:STN:280:DC%2BD1MnptlSmtw%3D%3D
    • Mariani P, Piperno-Neumann S, Servois V, Berry MG, Dorval T, Plancher C, et al. Surgical management of liver metastases from uveal melanoma: 16 years' experience at the Institut Curie. Eur J Surg Oncol. 2009;35(11):1192-7. doi: 10.1016/j.ejso.2009.02.016.
    • (2009) Eur J Surg Oncol , vol.35 , Issue.11 , pp. 1192-1197
    • Mariani, P.1    Piperno-Neumann, S.2    Servois, V.3    Berry, M.G.4    Dorval, T.5    Plancher, C.6
  • 54
    • 68049111254 scopus 로고    scopus 로고
    • Long-term survival of uveal melanoma patients after surgery for liver metastases
    • 10.1136/bjo.2008.153684 19429579 10.1136/bjo.2008.153684 1:STN:280:DC%2BD1MrgslKitQ%3D%3D
    • Frenkel S, Nir I, Hendler K, Lotem M, Eid A, Jurim O, et al. Long-term survival of uveal melanoma patients after surgery for liver metastases. Br J Ophthalmol. 2009;93(8):1042-6. doi: 10.1136/bjo.2008.153684.
    • (2009) Br J Ophthalmol , vol.93 , Issue.8 , pp. 1042-1046
    • Frenkel, S.1    Nir, I.2    Hendler, K.3    Lotem, M.4    Eid, A.5    Jurim, O.6
  • 55
    • 2442671910 scopus 로고    scopus 로고
    • Ocular melanoma metastatic to the liver: The role of surgery in multimodality therapy
    • 14993017 10.1245/ASO.2004.12.928
    • Helton WS. Ocular melanoma metastatic to the liver: the role of surgery in multimodality therapy. Ann Surg Oncol. 2004;11(3):242-4.
    • (2004) Ann Surg Oncol , vol.11 , Issue.3 , pp. 242-244
    • Helton, W.S.1
  • 56
    • 33645288846 scopus 로고    scopus 로고
    • Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: Experience in 101 patients
    • 10.1093/annonc/mdl009 16469752 10.1093/annonc/mdl009 1:STN:280: DC%2BD287mslSktg%3D%3D
    • Peters S, Voelter V, Zografos L, Pampallona S, Popescu R, Gillet M, et al. Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients. Ann Oncol. 2006;17(4):578-83. doi: 10.1093/annonc/mdl009.
    • (2006) Ann Oncol , vol.17 , Issue.4 , pp. 578-583
    • Peters, S.1    Voelter, V.2    Zografos, L.3    Pampallona, S.4    Popescu, R.5    Gillet, M.6
  • 57
    • 79954601182 scopus 로고    scopus 로고
    • A phase III random assignment trial comparing percutaneous hepatic perfusion with melphalan (PHP-mel) to standard of care for patients with hepatic metastases from metastatic ocular or cutaneous melanoma
    • Pingpank JF, Hughes MS, Faries MB, Zager JS, Alexander HR, Royal R, et al. A phase III random assignment trial comparing percutaneous hepatic perfusion with melphalan (PHP-mel) to standard of care for patients with hepatic metastases from metastatic ocular or cutaneous melanoma. J Clin Oncol. 2010;28(18 Suppl), LBA8512.
    • (2010) J Clin Oncol , vol.28 , Issue.18 SUPPL.
    • Pingpank, J.F.1    Hughes, M.S.2    Faries, M.B.3    Zager, J.S.4    Alexander, H.R.5    Royal, R.6
  • 58
    • 23744445248 scopus 로고    scopus 로고
    • Chemoembolization of the hepatic artery with BCNU for metastatic uveal melanoma: Results of a phase II study
    • 16034309 10.1097/00008390-200508000-00011
    • Patel K, Sullivan K, Berd D, Mastrangelo MJ, Shields CL, Shields JA, et al. Chemoembolization of the hepatic artery with BCNU for metastatic uveal melanoma: results of a phase II study. Melanoma Res. 2005;15(4):297-304.
    • (2005) Melanoma Res , vol.15 , Issue.4 , pp. 297-304
    • Patel, K.1    Sullivan, K.2    Berd, D.3    Mastrangelo, M.J.4    Shields, C.L.5    Shields, J.A.6
  • 59
    • 0023687302 scopus 로고
    • Regression of ocular melanoma metastatic to the liver after hepatic arterial chemoembolization with cisplatin and polyvinyl sponge
    • 3398202 10.1001/jama.1988.03410070102037 1:STN:280:DyaL1c3os12kug%3D%3D
    • Mavligit GM, Charnsangavej C, Carrasco CH, Patt YZ, Benjamin RS, Wallace S. Regression of ocular melanoma metastatic to the liver after hepatic arterial chemoembolization with cisplatin and polyvinyl sponge. JAMA. 1988;260(7):974-6.
    • (1988) JAMA , vol.260 , Issue.7 , pp. 974-976
    • Mavligit, G.M.1    Charnsangavej, C.2    Carrasco, C.H.3    Patt, Y.Z.4    Benjamin, R.S.5    Wallace, S.6
  • 60
    • 78049443606 scopus 로고    scopus 로고
    • Hepatic artery chemoembolization in patients with ocular melanoma metastatic to the liver: Response, survival, and prognostic factors
    • 10.1097/COC.0b013e3181b4b065 19935383 10.1097/COC.0b013e3181b4b065
    • Gupta S, Bedikian AY, Ahrar J, Ensor J, Ahrar K, Madoff DC, et al. Hepatic artery chemoembolization in patients with ocular melanoma metastatic to the liver: response, survival, and prognostic factors. Am J Clin Oncol. 2010;33(5):474-80. doi: 10.1097/COC.0b013e3181b4b065.
    • (2010) Am J Clin Oncol , vol.33 , Issue.5 , pp. 474-480
    • Gupta, S.1    Bedikian, A.Y.2    Ahrar, J.3    Ensor, J.4    Ahrar, K.5    Madoff, D.C.6
  • 61
    • 56749158015 scopus 로고    scopus 로고
    • Immunoembolization of malignant liver tumors, including uveal melanoma, using granulocyte-macrophage colony-stimulating factor
    • 10.1200/JCO.2008.16.0705 18838710 10.1200/JCO.2008.16.0705 1:CAS:528:DC%2BD1MXhslCltg%3D%3D
    • Sato T, Eschelman DJ, Gonsalves CF, Terai M, Chervoneva I, McCue PA, et al. Immunoembolization of malignant liver tumors, including uveal melanoma, using granulocyte-macrophage colony-stimulating factor. J Clin Oncol. 2008;26(33):5436-42. doi: 10.1200/JCO.2008.16.0705.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5436-5442
    • Sato, T.1    Eschelman, D.J.2    Gonsalves, C.F.3    Terai, M.4    Chervoneva, I.5    McCue, P.A.6
  • 62
    • 84872686775 scopus 로고    scopus 로고
    • Radioembolization as locoregional therapy of hepatic metastases in uveal melanoma patients
    • 10.1007/s00270-012-0373-5 22526099 10.1007/s00270-012-0373-5 1:STN:280:DC%2BC38rnsVCmtg%3D%3D
    • Klingenstein A, Haug AR, Zech CJ, Schaller UC. Radioembolization as locoregional therapy of hepatic metastases in uveal melanoma patients. Cardiovasc Intervent Radiol. 2013;36(1):158-65. doi: 10.1007/s00270-012-0373-5.
    • (2013) Cardiovasc Intervent Radiol , vol.36 , Issue.1 , pp. 158-165
    • Klingenstein, A.1    Haug, A.R.2    Zech, C.J.3    Schaller, U.C.4
  • 63
    • 0028853939 scopus 로고
    • Treatment of uveal melanoma metastatic to the liver: A review of the M. D. Anderson Cancer Center experience and prognostic factors
    • 8635073 10.1002/1097-0142(19951101)76:9<1665: AID-CNCR2820760925>3. 0.CO;2-J 1:CAS:528:DyaK28XjtFCi
    • Bedikian AY, Legha SS, Mavligit G, Carrasco CH, Khorana S, Plager C, et al. Treatment of uveal melanoma metastatic to the liver: a review of the M. D. Anderson Cancer Center experience and prognostic factors. Cancer. 1995;76(9):1665-70.
    • (1995) Cancer , vol.76 , Issue.9 , pp. 1665-1670
    • Bedikian, A.Y.1    Legha, S.S.2    Mavligit, G.3    Carrasco, C.H.4    Khorana, S.5    Plager, C.6
  • 64
    • 0038177899 scopus 로고    scopus 로고
    • Phase II evaluation of temozolomide in metastatic choroidal melanoma
    • 10.1097/01.cmr.0000056231.78713.e2 12777987 10.1097/00008390-200306000- 00013 1:CAS:528:DC%2BD3sXksVamt7o%3D
    • Bedikian AY, Papadopoulos N, Plager C, Eton O, Ring S. Phase II evaluation of temozolomide in metastatic choroidal melanoma. Melanoma Res. 2003;13(3):303-6. doi: 10.1097/01.cmr.0000056231.78713.e2.
    • (2003) Melanoma Res , vol.13 , Issue.3 , pp. 303-306
    • Bedikian, A.Y.1    Papadopoulos, N.2    Plager, C.3    Eton, O.4    Ring, S.5
  • 65
    • 23744493073 scopus 로고    scopus 로고
    • Randomized trial of dacarbazine versus bleomycin, vincristine, lomustine and dacarbazine (BOLD) chemotherapy combined with natural or recombinant interferon-alpha in patients with advanced melanoma
    • 16034308 10.1097/00008390-200508000-00010 1:CAS:528:DC%2BD2MXmtlSqtLw%3D
    • Vuoristo MS, Hahka-Kemppinen M, Parvinen LM, Pyrhonen S, Seppa H, Korpela M, et al. Randomized trial of dacarbazine versus bleomycin, vincristine, lomustine and dacarbazine (BOLD) chemotherapy combined with natural or recombinant interferon-alpha in patients with advanced melanoma. Melanoma Res. 2005;15(4):291-6.
    • (2005) Melanoma Res , vol.15 , Issue.4 , pp. 291-296
    • Vuoristo, M.S.1    Hahka-Kemppinen, M.2    Parvinen, L.M.3    Pyrhonen, S.4    Seppa, H.5    Korpela, M.6
  • 66
    • 0038402749 scopus 로고    scopus 로고
    • Bleomycin, vincristine, lomustine and dacarbazine (BOLD) in combination with recombinant interferon alpha-2b for metastatic uveal melanoma
    • 12736111 10.1016/S0959-8049(03)00132-1 1:CAS:528:DC%2BD3sXjsVaru78%3D
    • Kivela T, Suciu S, Hansson J, Kruit WH, Vuoristo MS, Kloke O, et al. Bleomycin, vincristine, lomustine and dacarbazine (BOLD) in combination with recombinant interferon alpha-2b for metastatic uveal melanoma. Eur J Cancer. 2003;39(8):1115-20.
    • (2003) Eur J Cancer , vol.39 , Issue.8 , pp. 1115-1120
    • Kivela, T.1    Suciu, S.2    Hansson, J.3    Kruit, W.H.4    Vuoristo, M.S.5    Kloke, O.6
  • 67
    • 0026733236 scopus 로고
    • Interleukin-2 therapy for metastatic uveal melanoma
    • 1419309 10.1016/0959-8049(92)90266-5 1:STN:280:DyaK3s%2FktVKhtQ%3D%3D
    • Dorval T, Fridman WH, Mathiot C, Pouillart P. Interleukin-2 therapy for metastatic uveal melanoma. Eur J Cancer. 1992;28A(12):2087.
    • (1992) Eur J Cancer , vol.28 , Issue.12 , pp. 2087
    • Dorval, T.1    Fridman, W.H.2    Mathiot, C.3    Pouillart, P.4
  • 68
    • 84856739604 scopus 로고    scopus 로고
    • Ipilimumab in pretreated patients with metastatic uveal melanoma: Safety and clinical efficacy
    • 10.1007/s00262-011-1089-0 21833591 10.1007/s00262-011-1089-0 1:CAS:528:DC%2BC38Xkt1WhsQ%3D%3D
    • Danielli R, Ridolfi R, Chiarion-Sileni V, Queirolo P, Testori A, Plummer R, et al. Ipilimumab in pretreated patients with metastatic uveal melanoma: safety and clinical efficacy. Cancer Immunol Immunother. 2012;61(1):41-8. doi: 10.1007/s00262-011-1089-0.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.1 , pp. 41-48
    • Danielli, R.1    Ridolfi, R.2    Chiarion-Sileni, V.3    Queirolo, P.4    Testori, A.5    Plummer, R.6
  • 69
    • 84885464333 scopus 로고    scopus 로고
    • Ipilimumab in pretreated metastastic uveal melanoma patients. Results of the Dutch Working group on Immunotherapy of Oncology (WIN-O)
    • 10.3109/0284186X.2013.786839 23607756
    • Kelderman S, van der Kooij MK, van den Eertwegh AJ, Soetekouw PM, Jansen RL, van den Brom RR, et al. Ipilimumab in pretreated metastastic uveal melanoma patients. Results of the Dutch Working group on Immunotherapy of Oncology (WIN-O). Acta Oncol. 2013. doi: 10.3109/0284186X.2013.786839.
    • (2013) Acta Oncol
    • Kelderman, S.1    Van Der Kooij, M.K.2    Van Den Eertwegh, A.J.3    Soetekouw, P.M.4    Jansen, R.L.5    Van Den Brom, R.R.6
  • 70
    • 84872085988 scopus 로고    scopus 로고
    • Ipilimumab activity in advanced uveal melanoma
    • 10.1097/CMR.0b013e32835b554f 23211837 10.1097/CMR.0b013e32835b554f 1:CAS:528:DC%2BC38XhvFSns7jM
    • Khattak MA, Fisher R, Hughes P, Gore M, Larkin J. Ipilimumab activity in advanced uveal melanoma. Melanoma Res. 2013;23(1):79-81. doi: 10.1097/CMR.0b013e32835b554f.
    • (2013) Melanoma Res , vol.23 , Issue.1 , pp. 79-81
    • Khattak, M.A.1    Fisher, R.2    Hughes, P.3    Gore, M.4    Larkin, J.5
  • 71
    • 84864371119 scopus 로고    scopus 로고
    • Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: A phase 1 dose-escalation trial
    • 10.1016/S1470-2045(12)70269-3 22805292 10.1016/S1470-2045(12)70269-3 1:CAS:528:DC%2BC38XhtFajsLjF
    • Falchook GS, Lewis KD, Infante JR, Gordon MS, Vogelzang NJ, DeMarini DJ, et al. Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial. Lancet Oncol. 2012;13(8):782-9. doi: 10.1016/S1470-2045(12)70269-3.
    • (2012) Lancet Oncol , vol.13 , Issue.8 , pp. 782-789
    • Falchook, G.S.1    Lewis, K.D.2    Infante, J.R.3    Gordon, M.S.4    Vogelzang, N.J.5    Demarini, D.J.6
  • 72
    • 79960719395 scopus 로고    scopus 로고
    • A phase II study of gefitinib in patients with metastatic melanoma
    • 10.1097/CMR.0b013e3283471073 21738104 10.1097/CMR.0b013e3283471073 1:CAS:528:DC%2BC3MXos1amtrg%3D
    • Patel SP, Kim KB, Papadopoulos NE, Hwu WJ, Hwu P, Prieto VG, et al. A phase II study of gefitinib in patients with metastatic melanoma. Melanoma Res. 2011;21(4):357-63. doi: 10.1097/CMR.0b013e3283471073.
    • (2011) Melanoma Res , vol.21 , Issue.4 , pp. 357-363
    • Patel, S.P.1    Kim, K.B.2    Papadopoulos, N.E.3    Hwu, W.J.4    Hwu, P.5    Prieto, V.G.6
  • 73
    • 58849127864 scopus 로고    scopus 로고
    • Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate
    • 10.1158/1078-0432.CCR-08-2243 19118061 10.1158/1078-0432.CCR-08-2243 1:CAS:528:DC%2BD1MXhs1eqsw%3D%3D
    • Hofmann UB, Kauczok-Vetter CS, Houben R, Becker JC. Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate. Clin Cancer Res. 2009;15(1):324-9. doi: 10.1158/1078-0432.CCR-08- 2243.
    • (2009) Clin Cancer Res , vol.15 , Issue.1 , pp. 324-329
    • Hofmann, U.B.1    Kauczok-Vetter, C.S.2    Houben, R.3    Becker, J.C.4
  • 74
    • 53749097317 scopus 로고    scopus 로고
    • O-Mel-Inib: A Cancero-pole Nord-Ouest multicenter phase II trial of high-dose imatinib mesylate in metastatic uveal melanoma
    • 10.1007/s10637-008-9143-2 10.1007/s10637-008-9143-2 1:CAS:528: DC%2BD1cXht1amsrvJ
    • Penel N, Delcambre C, Durando X, Clisant S, Hebbar M, Negrier S, et al. O-Mel-Inib: a Cancero-pole Nord-Ouest multicenter phase II trial of high-dose imatinib mesylate in metastatic uveal melanoma. Investig New Drugs. 2008;26(6):561-5. doi: 10.1007/s10637-008-9143-2.
    • (2008) Investig New Drugs , vol.26 , Issue.6 , pp. 561-565
    • Penel, N.1    Delcambre, C.2    Durando, X.3    Clisant, S.4    Hebbar, M.5    Negrier, S.6
  • 75
    • 84869384537 scopus 로고    scopus 로고
    • A pilot study of sunitinib malate in patients with metastatic uveal melanoma
    • 10.1097/CMR.0b013e328358b373 23114504 10.1097/CMR.0b013e328358b373 1:CAS:528:DC%2BC38XhsF2nt7fP
    • Mahipal A, Tijani L, Chan K, Laudadio M, Mastrangelo MJ, Sato T. A pilot study of sunitinib malate in patients with metastatic uveal melanoma. Melanoma Res. 2012;22(6):440-6. doi: 10.1097/CMR.0b013e328358b373.
    • (2012) Melanoma Res , vol.22 , Issue.6 , pp. 440-446
    • Mahipal, A.1    Tijani, L.2    Chan, K.3    Laudadio, M.4    Mastrangelo, M.J.5    Sato, T.6
  • 76
    • 84879715898 scopus 로고    scopus 로고
    • Phase II study of selumetinib versus temozolomide in gnaq/Gna11 mutant uveal melanoma
    • •• Carvajal RD, Sosman JA, Quevedo F, Milhem MM, Joshua AM, Kudchadkar RR, et al. Phase II study of selumetinib versus temozolomide in gnaq/Gna11 mutant uveal melanoma. J Clin Oncol. 2013;31(18 Suppl), CRA9003. This is the first prospective, randomized phase II study to demonstrate an improvement in progression-free survival in uveal melanoma patients receiving a MEK inhibitor.
    • (2013) J Clin Oncol , vol.31 , Issue.18 SUPPL.
    • Carvajal, R.D.1    Sosman, J.A.2    Quevedo, F.3    Milhem, M.M.4    Joshua, A.M.5    Kudchadkar, R.R.6
  • 77
    • 84877642623 scopus 로고    scopus 로고
    • Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death
    • 10.1158/1535-7163.MCT-12-1020 23443802 10.1158/1535-7163.MCT-12-1020 1:CAS:528:DC%2BC3sXntlSitrw%3D
    • Ambrosini G, Musi E, Ho AL, de Stanchina E, Schwartz GK. Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death. Mol Cancer Ther. 2013;12(5):768-76. doi: 10.1158/1535-7163.MCT-12-1020.
    • (2013) Mol Cancer Ther , vol.12 , Issue.5 , pp. 768-776
    • Ambrosini, G.1    Musi, E.2    Ho, A.L.3    De Stanchina, E.4    Schwartz, G.K.5
  • 78
    • 84863671580 scopus 로고    scopus 로고
    • Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype
    • 10.1371/journal.pone.0040439 22808163 10.1371/journal.pone.0040439 1:CAS:528:DC%2BC38XhtVGmtrnF
    • Ho AL, Musi E, Ambrosini G, Nair JS, Deraje Vasudeva S, de Stanchina E, et al. Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype. PLoS One. 2012;7(7):e40439. doi: 10.1371/journal.pone.0040439.
    • (2012) PLoS One , vol.7 , Issue.7 , pp. 40439
    • Ho, A.L.1    Musi, E.2    Ambrosini, G.3    Nair, J.S.4    Deraje Vasudeva, S.5    De Stanchina, E.6
  • 79
    • 84865096605 scopus 로고    scopus 로고
    • Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner
    • 10.1158/1078-0432.CCR-11-3227 22733540 10.1158/1078-0432.CCR-11-3227 1:CAS:528:DC%2BC38Xht1ajs7fI This study shows MEK activity can be enhanced with the addition of phosphatidylinositol 3-kinase inhibitors in vitro
    • •• Khalili JS, Yu X, Wang J, Hayes BC, Davies MA, Lizee G, et al. Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. This study shows MEK activity can be enhanced with the addition of phosphatidylinositol 3-kinase inhibitors in vitro.
    • (2012) Clin Cancer Res , vol.18 , Issue.16 , pp. 4345-4355
    • Khalili, J.S.1    Yu, X.2    Wang, J.3    Hayes, B.C.4    Davies, M.A.5    Lizee, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.