Increasing the complexity of chromatin: Functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis

Nucleic Acids Research

Volumn 41, Issue 20, 2013, Pages 9284-9295

  Singh, Rajbir ^a   Mortazavi, Amir ^a   Telu, Kelly H ^a   Nagarajan, Prabakaran ^a   Lucas, David M ^a   Thomas Ahner, Jennifer M ^a   Clinton, Steven K ^a   Byrd, John C ^a   Freitas, Michael A ^a   Parthun, Mark R ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H2A; MESSENGER RNA; SMALL INTERFERING RNA;

5' UNTRANSLATED REGION; ARTICLE; CANCER TISSUE; CELL PROLIFERATION; CHROMATIN; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCUS; GENE REPLICATION; GENE REPRESSION; HISTONE H2A GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKEMOGENESIS; PRIORITY JOURNAL; TRANSLATION REGULATION; UPREGULATION;

5' UNTRANSLATED REGIONS; CARCINOGENESIS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN; DNA REPLICATION; GENE EXPRESSION REGULATION; HISTONES; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; PROTEIN ISOFORMS; URINARY BLADDER NEOPLASMS;

EID: 84890070638     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt736     Document Type: Article

References (22)

1. Malik, H.S. and Henikoff, S. (2003) Phylogenomics of the nucleosome. Nat. Struct. Biol., 10, 882-891.
2. Kouzarides, T. (2007) Chromatin modifications and their function. Cell, 128, 693-705.
3. Henikoff, S., Furuyama, T. and Ahmad, K. (2004) Histone variants, nucleosome assembly and epigenetic inheritance. Trends Genet., 20, 320-326.
4. Kamakaka, R.T. and Biggins, S. (2005) Histone variants: deviantš Genes Dev., 19, 295-310.
5. Talbert, P.B. and Henikoff, S. (2010) Histone variants - ancient wrap artists of the epigenome. Nat. Rev. Mol. Cell. Biol., 11, 264-275.
6. Wu, R.S. and Bonner, W.M. (1981) Separation of basal histone synthesis from S-phase hstone synthesis in dividing cells. Cell, 27, 321-330.
7. Marzluff, W.F., Wagner, E.J. and Duronio, R.J. (2008) Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail. Nat. Rev. Genet., 9, 843-854.
8. Albig, W., Trappe, R., Kardalinou, E., Eick, S. and Doenecke, D. (1999) The human H2A and H2B histone gene complement. Biol. Chem., 380, 7-18.
9. Boyne, M.T. II, Pesavento, J.J., Mizzen, C.A. and Kelleher, N.L. (2006) Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J. Proteome Res., 5, 248-253.
10. Talbert, P.B., Ahmad, K., Almouzni, G., Ausio, J., Berger, F., Bhalla, P.L., Bonner, W.M., Cande, W.Z., Chadwick, B.P., Chan, S.W. et al. (2012) A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin, 5, 7.
11. Su, X., Lucas, D.M., Zhang, L., Xu, H., Zabrouskov, V., Davis, M.E., Knapp, A.R., Young, D.C., Payne, P.R., Parthun, M.R. et al. (2009) Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia. Proteomics, 9, 1197-1206.
12. Wang, L., Harshman, S.W., Liu, S., Ren, C., Xu, H., Sallans, L., Grever, M., Byrd, J.C., Marcucci, G. and Freitas, M.A. (2010) Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia. Proteomics, 10, 4281-4292.
13. Livak, K.J. and Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402-408.
14. Ma, W.J., Cheng, S., Campbell, C., Wright, A. and Furneaux, H. (1996) Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem., 271, 8144-8151.
15. Ma, W.J., Chung, S. and Furneaux, H. (1997) The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA. Nucleic Acids Res., 25, 3564-3569.
16. Lebedeva, S., Jens, M., Theil, K., Schwanhausser, B., Selbach, M., Landthaler, M. and Rajewsky, N. (2011) Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol. Cell, 43, 340-352.
17. Uren, P.J., Burns, S.C., Ruan, J., Singh, K.K., Smith, A.D. and Penalva, L.O. (2011) Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites. J. Biol. Chem., 286, 37063-37066.
18. Kullmann, M., Gopfert, U., Siewe, B. and Hengst, L. (2002) ELAV/ Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev., 16, 3087-3099.
19. Meng, Z., King, P.H., Nabors, L.B., Jackson, N.L., Chen, C.Y., Emanuel, P.D. and Blume, S.W. (2005) The ELAV RNAstability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses capdependent and IRES-mediated translation. Nucleic Acids Res., 33, 2962-2979.
20. Yeh, C.H., Hung, L.Y., Hsu, C., Le, S.Y., Lee, P.T., Liao, W.L., Lin, Y.T., Chang, W.C. and Tseng, J.T. (2008) RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment. Mol. Biol. Cell, 19, 3812-3822.
21. Marzluff, W.F., Gongidi, P., Woods, K.R., Jin, J. and Maltais, L.J. (2002) The human and mouse replication-dependent histone genes. Genomics, 80, 487-498.
22. Zhang, K. and Tang, H. (2003) Analysis of core histones by liquid chromatography-mass spectrometry and peptide mapping. J. Chromatogr. B, 783, 173-179.