Onset threshold of the plasma levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation

Hypertension Research

Volumn 36, Issue 12, 2013, Pages 1073-1080

  Ohkuchi, Akihide ^a   Hirashima, Chikako ^a   Takahashi, Kayo ^a   Suzuki, Hirotada ^a   Matsubara, Shigeki ^a   Suzuki, Mitsuaki ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

imminent onset; onset threshold; placental growth factor; preeclampsia; soluble fms like tyrosine kinase 1

Indexed keywords

PLACENTAL GROWTH FACTOR; PROTEIN TYROSINE KINASE; SOLUBLE FMS LIKE TYROSINE KINASE 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOMATED ELECTROCHEMILUMINESCENCE IMMUNOASSAY; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; GESTATION PERIOD; HUMAN; IMMUNOASSAY; MATERNAL HYPERTENSION; MATERNAL SERUM SCREENING TEST; PREDICTIVE VALUE; PREECLAMPSIA; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; SMALL FOR DATE INFANT;

ADULT; AGE FACTORS; BLOOD PRESSURE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYPERTENSION; IMMUNOASSAY; INFANT, NEWBORN; INFANT, SMALL FOR GESTATIONAL AGE; NEOVASCULARIZATION, PHYSIOLOGIC; PRE-ECLAMPSIA; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY PROTEINS; PREGNANCY TRIMESTER, SECOND; PREGNANCY TRIMESTER, THIRD; REFERENCE VALUES; ROC CURVE; UTERINE ARTERY; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84890055550     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2013.95     Document Type: Article

References (26)

1. Nagaya K, Fetters MD, Ishikawa M, Kubo T, Koyanagi T, Saito Y, Sameshima H, Sugimoto M, Takagi K, Chiba Y, Honda H, Mukubo M, Kawamura M, Satoh S, Neki R. Causes of maternal mortality in Japan. JAMA 2000; 283: 2661-2667
2. Yamauchi A, Minakami H, Ohkuchi A, Usui R, Idei S, Sato I. Causes of stillbirth: An analysis of 77 cases. J Obstet Gynaecol Res 1999; 25: 419-424
3. Shiozaki A, Matsuda Y, Satoh S, Saito S. Impact of fetal sex in pregnancy-induced hypertension andXin Japan. J Reprod Immunol 2011; 89: 133-139
4. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004; 350: 672-683
5. Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA, CPEP Study Group. Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 2006; 355: 992-1005
6. Lim JH, Kim SY, Park SY, Yang JH, Kim MY, Ryu HM. Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors. Obstet Gynecol 2008; 111: 1403-1409
7. Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ. Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation 2010; 122: 478-487
8. Banek CT, Gilbert JS. Approaching the threshold for predicting preeclampsia: Monitoring angiogenic balance during pregnancy. Hypertension 2011; 58: 774-775
9. Ohkuchi A, Hirashima C, Matsubara S, Takahashi K, Matsuda Y, Suzuki M. Threshold of soluble fms-like tyrosine kinase 1/placental growth factor ratio for the imminent onset of preeclampsia. Hypertension 2011; 58: 859-866
10. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649-658
11. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 2006; 12: 642-649
12. Suzuki H, Ohkuchi A, Matsubara S, Takei Y, Murakami M, Shibuya M, Suzuki M, Sato Y. Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice. Hypertension 2009; 54: 1129-1135
13. Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M. Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. Proc Natl Acad Sci USA 2011; 108: 1451-1455
14. Cnossen JS, Morris RK, ter Riet G, Mol BW, Van Der Post JA, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJ, Kleijnen J, Khan KS. Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: A systematic review and bivariable meta-Analysis. CMAJ 2008; 178: 701-711
15. Cnossen JS, Vollebregt KC, de Vrieze N, ter Riet G, Mol BW, Franx A, Khan KS, Van Der Post JA. Accuracy of mean arterial pressure and blood pressure measurements in predicting pre-eclampsia: Systematic review and meta-Analysis. BMJ 2008; 336: 1117-1120
16. Kleinrouweler CE, Wiegerinck MM, Ris-Stalpers C, Bossuyt PM, Van Der Post JA, von Dadelszen P, Mol BW, Pajkrt E, EBM CONNECT Collaboration. Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: A systematic review and meta-Analysis. BJOG 2012; 119: 778-787
17. Ohkuchi A, Hirashima C, Suzuki H, Takahashi K, Yoshida M, Matsubara S, Suzuki M. Evaluation of a new and automated electrochemiluminescence immunoassay for plasma sFlt-1 and PlGF levels in women with preeclampsia. Hypertens Res 2010; 33: 422-427
18. Ohkuchi A, Ishibashi O, Hirashima C, Takahashi K, Matsubara S, Takizawa T, Suzuki M. Plasma level of hydroxysteroid (17-b) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio. Hypertens Res 2012; 35: 1152-1158
19. Takahashi K, Ohkuchi A, Hirashima C, Matsubara S, Suzuki M. Establishing reference values for mean notch depth index, pulsatility index and resistance index in the uterine artery at 16-23 weeks' gestation. J Obstet Gynaecol Res 2012; 38: 1275-1285
20. Ohkuchi A, Minakami H, Sato I, Mori H, Nakano T, Tateno M. Predicting the risk of preeclampsia and a small-for-gestational-Age infant by quantitative assessment of the diastolic notch in uterine artery flow velocity waveforms in unselected women. Ultrasound Obstet Gynecol 2000; 16: 171-178
21. Watanabe K, Naruse K, Tanaka K, Metoki H, Suzuki Y. Outline of definition and classification of ''Pregnancy induced Hypertension (PIH)''. Hypertens Res Pregnancy 2013; 1: 3-4
22. Ogawa Y, Iwamura T, Kuriya N, Kuriya N, Nishida H, Takeuchi H, Yakada M, Itabashi K, Imura S, Isobe K. Birth size standards by gestational age for Japanese neonates. Acta Neonatol Jpn 1998; 34: 624-632
23. Confidence interval calculator [Computer Program]. Available at http://www.pedro. org.au/english/downloads/confidence-interval-calculator/. Accessed 4 Mar 2012
24. Jaeschke R, Guyatt G, Sackett DL. Users' guides to the medical literature. III. How to use an article about a diagnostic test. A. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA 1994; 271: 389-391
25. Conde-Agudelo A, Villar J, Lindheimer M. World Health Organization systematic review of screening tests for preeclampsia. Obstet Gynecol 2004; 104: 1367-1391
26. Crispi F, Llurba E, Domínguez C, Martín-Gallán P, Cabero L, Gratacós E. Predictive value of angiogenic factors and uterine artery Doppler for early-versus late-onset preeclampsia nd intrauterine growth restriction. Ultrasound Obstet Gynecol 2008; 31: 303-309