Hypovascular hepatic nodules showing hypointense on the hepatobiliary-phase image of Gd-EOB-DTPA-enhanced MRI to develop a hypervascular hepatocellular carcinoma: A nationwide retrospective study on their natural course and risk factors

Digestive Diseases

Volumn 31, Issue 5-6, 2013, Pages 472-479

  Inoue, Tatsuo ^a   Hyodo, Tomoko ^b   Murakami, Takamichi ^b   Takayama, Yukihisa ^c   Nishie, Akihiro ^c   Higaki, Atsushi ^d   Korenaga, Keiko ^d,e   Sakamoto, Azusa ^f   Osaki, Yukio ^f   Aikata, Hiroshi ^g   Chayama, Kazuaki ^g   Suda, Takeshi ^h   Takano, Toru ^h   Miyoshi, Kennichi ⁱ   Koda, Masahiko ⁱ   Numata, Kazushi ^j   Tanaka, Hironori ^k   Iijima, Hiroko ^k   Ochi, Hironori ^l   Hirooka, Masashi ^l   Imai, Yasuharu ^m   Kudo, Masatoshi ^a   more..

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KAWASAKI MEDICAL SCHOOL   (Japan)

^e National Center for Global Health and Medicine   (Japan)

^f OSAKA RED CROSS HOSPITAL   (Japan)

^g HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

^h NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

ⁱ TOTTORI UNIVERSITY   (Japan)

^j YOKOHAMA CITY UNIVERSITY MEDICAL CENTER   (Japan)

^k HYOGO COLLEGE OF MEDICINE   (Japan)

^l EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^m IKEDA MUNICIPAL HOSPITAL   (Japan)

more..

Author keywords

Enhanced MRI; Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid; Hepatocellular carcinoma; Hypervascular transformation

Indexed keywords

GADOXETIC ACID;

ADULT; AGED; ARTICLE; CANCER RISK; FEMALE; FOLLOW UP; HUMAN; LIVER CELL CARCINOMA; LIVER NODULE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR;

AGED; AGED, 80 AND OVER; BILE DUCTS; CARCINOMA, HEPATOCELLULAR; DISEASE PROGRESSION; FEMALE; GADOLINIUM DTPA; HUMANS; JAPAN; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84890054120     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000355248     Document Type: Article

References (38)

1. Kudo M: Early hepatocellular carcinoma: definition and diagnosis. Liver Cancer 2013; 2: 69-72.
2. Lee JM, Yoon JH, Joo I, Woo HS: Rencet advances in CT and MR imaging for evaluation of hepatocellular carcinoma. Liver Cancer 2012; 1: 22-40.
3. Joo I, Choi BI: New paradigm for management of hepatocellular carcinoma by imaging. Liver Cancer 2012; 1: 94-109.
4. Shinmura R, Matsui O, Kadoya M, Kobayashi S, Terayama N, Sanada J, Demachi H, Gabata T: Detection of hypervascular malignant foci in borderline lesions of hepatocellular carcinoma: comparison of dynamic multi-detector row CT, dynamic MR imaging and superparamagnetic iron oxide-enhanced MR imaging. Eur Radiol 2008; 18: 1918-1924.
5. Hayashi M, Matsui O, Ueda K, Kawamori Y, Gabata T, Kadoya M: Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology 2002; 225: 143-149.
6. Matsui O, Kadoya M, Suzuki M, Inoue K, Itoh H, Ida M, Takashima T: Work in progress: dynamic sequential computed tomography during arterial portography in the detection of hepatic neoplasms. Radiology 1983; 146: 721-727.
7. Matsui O, Kadoya M, Kameyama T, Yoshikawa J, Takashima T, Nakanuma Y, Unoura M, Kobayashi K, Izumi R, Ida M, et al: Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology 1991; 178: 493-497.
8. Ueda K, Matsui O, Kawamori Y, Nakanuma Y, Kadoya M, Yoshikawa J, Gabata T, Nonomura A, Takashima T: Hypervascular hepatocellular carcinoma: evaluation of hemodynamics with dynamic CT during hepatic arteriography. Radiology 1998; 206: 161-166.
9. Hayashi M, Matsui O, Ueda K, Kawamori Y, Kadoya M, Yoshikawa J, Gabata T, Takashima T, Nonomura A, Nakanuma Y: Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol 1999; 172: 969-976.
10. Inoue E, Fujita M, Hosomi N, Sawai Y, Hashimoto T, Kuroda C, Nakano H, Sasaki Y, Ishiguro S: Double phase CT arteriography of the whole liver in the evaluation of hepatic tumors. J Comput Assist Tomogr 1998; 22: 64-68.
11. Murakami T, Takamura M, Kim T, Hori M, Federle MP, Onishi H, Tomoda K, Nakamura H: Double phase CT during hepatic arteriography for diagnosis of hepatocellular carcinoma. Eur J Radiol 2005; 54: 246-252.
12. Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, Christensen E, Pagliaro L, Colombo M, Rodes J: Clinical management of hepatocellular carcinoma: conclusions of the Barcelona-2000 EASL conference -European Association for the Study of the Liver. J Hepatol 2001; 35: 421-430.
13. Huppertz A, Balzer T, Blakeborough A, Breuer J, Giovagnoni A, Heinz-Peer G, Laniado M, Manfredi RM, Mathieu DG, Mueller D, et al: Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Radiology 2004; 230: 266-275.
14. Halavaara J, Breuer J, Ayuso C, Balzer T, Bellin MF, Blomqvist L, Carter R, Grazioli L, Hammerstingl R, Huppertz A, et al: Liver tumor characterization: comparison between liverspecific gadoxetic acid disodium-enhanced MRI and biphasic CT -a multicenter trial. J Comput Assist Tomogr 2006; 30: 345-354.
15. Kim YK, Kim CS, Han YM, Kwak HS, Jin GY, Hwang SB, Chung GH, Lee SY, Yu HC: Detection of hepatocellular carcinoma: gadoxetic acid-enhanced 3-dimensional magnetic resonance imaging versus multi-detector row computed tomography. J Comput Assist Tomogr 2009; 33: 844-850.
16. Kim SH, Lee J, Kim MJ, Jeon YH, Park Y, Choi D, Lee WJ, Lim HK: Gadoxetic acid-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma. AJR Am J Roentgenol 2009; 192: 1675-1681.
17. Inoue T, Kudo M, Komuta M, Hayaishi S, Ueda T, Takita M, Kitai S, Hatanaka K, Yada N, Hagiwara S, et al: Assessment of Gd-EOBDTPA- enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT. J Gastroenterol 2012; 47: 1036-1047.
18. Tanimoto A, Lee JM, Murakami T, Huppertz A, Kudo M, Grazioli L: Consensus report of the 2nd International Forum for Liver MRI. Eur Radiol 2009; 19(suppl 5):S975-S989.
19. Kogita S, Imai Y, Okada M, Kim T, Onishi H, Takamura M, Fukuda K, Igura T, Sawai Y, Morimoto O, et al: Gd-EOB-DTPA-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading and portal blood flow. Eur Radiol 2010; 20: 2405-2413.
20. Kitao A, Zen Y, Matsui O, Gabata T, Kobayashi S, Koda W, Kozaka K, Yoneda N, Yamashita T, Kaneko S, et al: Hepatocellular carcinoma: signal intensity at gadoxetic acidenhanced MR imaging -correlation with molecular transporters and histopathologic features. Radiology 2010; 256: 817-826.
21. Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Okazaki N, Takayasu K, Kosuge T, Motoo Y, Yamazaki S, Hasegawa H: Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990; 336: 1150-1153.
22. Kumada T, Toyoda H, Tada T, Sone Y, Fujimori M, Ogawa S, Ishikawa T: Evolution of hypointense hepatocellular nodules observed only in the hepatobiliary phase of gadoxetate disodium-enhanced MRI. AJR Am J Roentgenol 2011; 197: 58-63.
23. Akai H, Matsuda I, Kiryu S, Tajima T, Takao H, Watanabe Y, Imamura H, Kokudo N, Akahane M, Ohtomo K: Fate of hypointense lesions on Gd-EOB-DTPA-enhanced magnetic resonance imaging. Eur J Radiol 2012; 81: 2973-2977.
24. Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Amemiya F, Enomoto N, Matsuda M, Fujii H, et al: Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease. J Magn Reson Imaging 2011; 34: 88-94.
25. Takayama Y, Nishie A, Nakayama T, Asayama Y, Ishigami K, Kakihara D, Ushijima Y, Fujita N, Hirakawa M, Honda H: Hypovascular hepatic nodule showing hypointensity in the hepatobiliary phase of gadoxetic acid-enhanced MRI in patients with chronic liver disease: prediction of malignant transformation. Eur J Radiol 2012; 81: 3072-3078.
26. Kobayashi S, Matsui O, Gabata T, Koda W, Minami T, Ryu Y, Kozaka K, Kitao A: Relationship between signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOBDTPA)- enhanced MR imaging and prognosis of borderline lesions of hepatocellular carcinoma. Eur J Radiol 2012; 81: 3002-3009.
27. Hyodo T, Murakami T, Imai Y, Okada M, Hori M, Kagawa Y, Kogita S, Kumano S, Kudo M, Mochizuki T: Hypovascular nodules in patients with chronic liver disease: risk factors for development of hypervascular hepatocellular carcinoma. Radiology 2013; 266: 480-490.
28. Higaki A, Ito K, Tamada T, Teruki S, Yamamoto A, Higashi H, Kanki A, Sato T, Noda Y: High-risk nodules detected in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MR imaging in cirrhosis or chronic hepatitis: incidence and predictive factors for hypervascular transformation, preliminary results. J Magn Reson Imaging 2013; 37: 1377-1383.
29. Takechi M, Tsuda T, Yoshioka S, Murata S, Tanaka H, Hirooka M, Mochizuki T: Risk of hypervascularization in small hypovascular hepatic nodules showing hypointense in the hepatobiliary phase of gadoxetic acid-enhanced MRI in patients with chronic liver disease. Jpn J Radiol 2012; 30: 743-751.
30. Sano K, Ichikawa T, Motosugi U, Sou H, Muhi AM, Matsuda M, Nakano M, Sakamoto M, Nakazawa T, Asakawa M, et al: Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR imaging. Radiology 2011; 261: 834-844.
31. Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Nakagawa H, Asaoka Y, Sato T, Masuzaki R, Kondo Y, et al: Radiofrequency ablation for hepatocellular carcinoma: 10- year outcome and prognostic factors. Am J Gastroenterol 2012; 107: 569-577, quiz 578.
32. Wood TF, Rose DM, Chung M, Allegra DP, Foshag LJ, Bilchik AJ: Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann Surg Oncol 2000; 7: 593-600.
33. Cho YK, Rhim H, Noh S: Radiofrequency ablation versus surgical resection as primary treatment of hepatocellular carcinoma meeting the Milan criteria: a systematic review. J Gastroenterol Hepatol 2011; 26: 1354-1360.
34. Nishida N, Goel A: Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review. Curr Genomics 2011; 12: 130-137.
35. Nishida N, Kudo M, Nagasaka T, Ikai I, Goel A: Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. Hepatology 2012; 56: 994-1003.
36. Nishida N, Kudo M: Recent advancements in comprehensive genetic analyses for human hepatocellular carcinoma. Oncology 2013; 84(suppl 1):93-97.
37. Ohtomo K, Baron RL, Dodd GD 3rd, Federle MP, Ohtomo Y, Confer SR: Confluent hepatic fibrosis in advanced cirrhosis: evaluation with MR imaging. Radiology 1993; 189: 871-874.
38. Kim T, Baron RL, Nalesnik MA: Infarcted regenerative nodules in cirrhosis: CT and MR imaging findings with pathologic correlation. AJR Am J Roentgenol 2000; 175: 1121-1125.