A single-blind randomized controlled trial to evaluate the effect of 6 months of progressive aerobic exercise training in patients with uraemic restless legs syndrome

Nephrology Dialysis Transplantation

Volumn 28, Issue 11, 2013, Pages 2834-2840

  Giannaki, Christoforos D ^a,b   Hadjigeorgiou, Georgios M ^b,c   Karatzaferi, Christina ^b,c   Maridaki, Maria D ^d   Koutedakis, Yiannis ^b,c   Founta, Paraskevi ^e   Tsianas, Nikolaos ^e   Stefanidis, Ioannis ^b,c   Sakkas, Giorgos K ^b,c  

^a UNIVERSITY OF NICOSIA   (Cyprus)

^b INFORMATION TECHNOLOGIES INSTITUTE   (Greece)

^c UNIVERSITY OF THESSALY   (Greece)

^d UNIVERSITY OF ATHENS   (Greece)

^e General Hospital of Trikala   (Greece)

Author keywords

Depression; Exercise with no resistance; Haemodialysis; Sleep disorder; Sleep quality

Indexed keywords

ADULT; AEROBIC EXERCISE; ARTICLE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE SEVERITY; EXERCISE INTENSITY; FEMALE; FUNCTIONAL STATUS; HEMODIALYSIS; HUMAN; INTERMETHOD COMPARISON; MALE; MIDDLE AGED; PATIENT SAFETY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; RESTLESS LEGS SYNDROME; SINGLE BLIND PROCEDURE; SLEEP QUALITY; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

DEPRESSION; EXERCISE WITH NO RESISTANCE; HAEMODIALYSIS; SLEEP DISORDER; SLEEP QUALITY;

CASE-CONTROL STUDIES; EXERCISE; EXERCISE THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; QUESTIONNAIRES; RENAL DIALYSIS; RESTLESS LEGS SYNDROME; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD; SLEEP STAGES;

EID: 84890041084     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gft288     Document Type: Article

References (30)

1. Murtagh FE, Addington-Hall J, Higginson IJ. The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis 2007; 14: 82-99
2. Giannaki CD, Sakkas GK, Karatzaferi C et al. Evidence of increased muscle atrophy and impaired quality of life parameters in patients with uremic restless legs syndrome. PLoS One 2011; 6: e25180
3. Mucsi I, Molnar MZ, Ambrus C et al. Restless legs syndrome, insomnia and quality of life in patients on maintenance dialysis. Nephrol Dial Transplant 2005; 20: 571-577
4. Unruh ML, Levey AS, D'Ambrosio C et al. Restless legs symptoms among incident dialysis patients: association with lower quality of life and shorter survival. Am J Kidney Dis 2004; 43: 900-909
5. La Manna G, Pizza F, Persici E et al. Restless legs syndrome enhances cardiovascular risk and mortality in patients with end-stage kidney disease undergoing long-term haemodialysis treatment. Nephrol Dial Transplant 2011; 26: 1976-1983
6. Giannaki CD, Zigoulis P, Karatzaferi C et al. Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. J Clin Sleep Med 2013; 9: 147-153
7. Garcia-Borreguero D, Allen RP, Benes H et al. Augmentation as a treatment complication of restless legs syndrome: concept and management. Mov Disord 2007; 22: S476-SS84
8. Sakkas GK, Hadjigeorgiou GM, Karatzaferi C et al. Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study. ASAIO J 2008; 54: 185-190
9. Allen RP, Picchietti D, Hening WA et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003; 4: 101-119
10. Walters AS, LeBrocq C, Dhar A et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003; 4: 121-132
11. Heyward V. Assessing Cardiorespiratory Fitness, 3rd ed. Heyward: Human Kinetics, 1998
12. Gkizlis V, Giannaki CD, Karatzaferi C et al. Uremic versus idiopathic restless legs syndrome: impact on aspects related to quality of life. ASAIO J 2012; 58: 607-611
13. Zung WW. A self-rating depression scale. Arch Gen Psychiatry 1965; 12: 63-70
14. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14: 540-545
15. Daugirdas JT. Second generation logarithmic estimates of singlepool variable volume Kt/V: an analysis of error. J Am Soc Nephrol 1993; 4: 1205-1213
16. Giannaki CD, Sakkas GK, Hadjigeorgiou GM et al. Non-pharmacological management of periodic limb movements during hemodialysis session in patients with uremic restless legs syndrome. ASAIO J 2010; 56: 538-542
17. Johansen KL, Painter P. Exercise in individuals with CKD. Am J Kidney Dis 2012; 59: 126-134
18. Esteves AM, de Mello MT, Pradella-Hallinan M et al. Effect of acute and chronic physical exercise on patients with periodic leg movements. Med Sci Sports Exerc 2009; 41: 237-242
19. von Spiczak S, Whone AL, Hammers A et al. The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study. Brain 2005; 128: 906-917
20. Walters AS, Winkelmann J, Trenkwalder C et al. Long-term follow-up on restless legs syndrome patients treated with opioids. Mov Disord 2001; 16: 1105-1109
21. Chen WC, Lim PS, Wu WC et al. Sleep behavior disorders in a large cohort of chinese (Taiwanese) patients maintained by longterm hemodialysis. Am J Kidney Dis 2006; 48: 277-284
22. Al-Jahdali HH, Al-Qadhi WA, Khogeer HA et al. Restless legs syndrome in patients on dialysis. Saudi J Kidney Dis Transpl 2009; 20: 378-385
23. Merlino G, Lorenzut S, Romano G et al. Restless legs syndrome in dialysis patients: a comparison between hemodialysis and continuous ambulatory peritoneal dialysis. Neurol Sci 2012; 33: 1311-1318
24. Jaber BL, Schiller B, Burkart JM et al. Impact of short daily hemodialysis on restless legs symptoms and sleep disturbances. Clin J Am Soc Nephrol 2011; 6: 1049-1056
25. Perl J, Unruh ML, Chan CT. Sleep disorders in end-stage renal disease: 'Markers of inadequate dialysis'? Kidney Int 2006; 70: 1687-1693
26. Gigli GL, Adorati M, Dolso P et al. Restless legs syndrome in end-stage renal disease. Sleep Med 2004; 5: 309-315
27. Parsons TL, King-Vanvlack CE. Exercise and end-stage kidney disease: functional exercise capacity and cardiovascular outcomes. Adv Chronic Kidney Dis 2009; 16: 459-481
28. Iliescu EA, Coo H, McMurray MH et al. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant 2003; 18: 126-132
29. Pai MF, Hsu SP, Yang SY et al. Sleep disturbance in chronic hemodialysis patients: the impact of depression and anemia. Ren Fail 2007; 29: 673-677
30. Trenkwalder C, Hening WA, Montagna P et al. Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Mov Disord 2008; 23: 2267-2302