An analysis of the safety of epidural and spinal neuraxial anesthesia in more than 100,000 consecutive major lower extremity joint replacements

Regional Anesthesia and Pain Medicine

Volumn 38, Issue 6, 2013, Pages 515-519

  Pumberger, Matthias ^a   Memtsoudis, Stavros G ^b   Stundner, Ottokar ^c   Herzog, Richard ^d   Boettner, Friedrich ^e   Gausden, Elizabeth ^e   Hughes, Alexander P ^e  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

^c Departments of Anesthesiology Pharmacology and Toxicology   (United States)

^d Radiology   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ANTICOAGULATION; ARTICLE; COMORBIDITY; DRUG SAFETY; EPIDURAL ANESTHESIA; EPIDURAL HEMATOMA; FEMALE; HIP ARTHROPLASTY; HUMAN; HYPERTENSION; JOINT PROSTHESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPINAL ANESTHESIA; SPINAL HEMATOMA; THROMBOCYTOPENIA; TOTAL KNEE REPLACEMENT;

ANESTHESIA, EPIDURAL; ANESTHESIA, SPINAL; ANTICOAGULANTS; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; HEMATOMA, EPIDURAL, SPINAL; HUMANS; INCIDENCE; PAIN, POSTOPERATIVE; PATIENT SAFETY; PLATELET AGGREGATION INHIBITORS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TREATMENT OUTCOME;

EID: 84890029586     PISSN: 10987339     EISSN: 15328651     Source Type: Journal    
DOI: 10.1097/AAP.0000000000000009     Document Type: Article

References (27)

1. Kurtz S, Ong K, Lau E, Mowat F, HalpernM. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89:780-785.
2. Choi PT, Bhandari M, Scott J, Douketis J. Epidural analgesia for pain relief following hip or knee replacement. Cochrane Database Syst Rev. 2003;3:CD003071.
3. Maurer SG, Chen AL, Hiebert R, Pereira GC, Di Cesare PE. Comparison of outcomes of using spinal versus general anesthesia in total hip arthroplasty. Am J Orthop (Belle Mead NJ). 2007;36: E101-E106.
4. Horlocker TT, Wedel DJ, Rowlingson JC, et al. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (third edition). Reg Anesth Pain Med. 2010;35:64-101.
5. Ruppen W, Derry S, McQuay H, Moore RA. Incidence of epidural hematoma, infection, and neurologic injury in obstetric patients with epidural analgesia/anesthesia. Anesthesiology. 2006;105:394-399.
6. Heller AR, Litz RJ. Why do orthopedic patients have a higher incidence of serious complications after central neuraxial blockade? Anesthesiology. 2005;102:1286.
7. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133:381S-453S.
8. Groen RJ, Ponssen H. The spontaneous spinal epidural hematoma. A study of the etiology. J Neurol Sci. 1990;98:121-138.
9. Hebl JR, Horlocker TT, Kopp SL, Schroeder DR. Neuraxial blockade in patients with preexisting spinal stenosis, lumbar disk disease, or prior spine surgery: efficacy and neurologic complications. Anesth Analg. 2010;111:1511-1519.
10. Parvizi J, Viscusi ER, Frank HG, Sharkey PF, Hozack WJ, Rothman RR. Can epidural anesthesia and warfarin be coadministered? Clin Orthop Relat Res. 2007;456:133-137.
11. Martinez-Palli G, Sala-Blanch X, Salvado E, Acosta M, Nalda MA. Epidural hematoma after epidural anesthesia in a patient with peripheral vascular disease. Case report. Reg Anesth. 1996;21:342-346.
12. Jaffe RA, Siegel LC, Schnittger I, Propst JW, Brock-Utne JG. Epidural air injection assessed by transesophageal echocardiography. Reg Anesth. 1995;20:152-155.
13. Yentis SM. Time to abandon loss of resistance to air. Anaesthesia. 1997;52:184.
14. Boukobza M, Guichard JP, Boissonet M, et al. Spinal epidural haematoma: report of 11 cases and review of the literature. Neuroradiology. 1994;36:456-459.
15. Hospital for Special Surgery. New York, NY: Hospital for special surgery quality assurance committee on deep venous thrombosis/ pulmonary embolism prophylaxis. Available at: http://www.hss.edu/ conditions-dvt-pe-prophylaxis. asp. Accessed February 1, 2013.
16. Williams-Russo P, Sharrock NE, Mattis S, et al. Randomized trial of hypotensive epidural anesthesia in older adults. Anesthesiology. 1999;91:926-935.
17. Vandermeulen EP, Van Aken H, Vermylen J. Anticoagulants and spinal-epidural anesthesia. Anesth Analg. 1994;79:1165-1177.
18. Berger JS, Roncaglioni MC, Avanzini F, Pangrazzi I, Tognoni G, Brown DL. Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials. JAMA. 2006;295:306-313.
19. Andrade C, Sandarsh S, Chethan KB, Nagesh KS. Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms. J Clin Psychiatry. 2010;71: 1565-1575.
20. Dimou J, Jithoo R, Morokoff A. Spontaneous spinal epidural haematoma in a geriatric patient on aspirin. J Clin Neurosci. 2010;17:142-144.
21. Carragee EJ, Golish SR, Scuderi GJ. A case of late epidural hematoma in a patient on clopidogrel therapy postoperatively: when is it safe to resume antiplatelet agents? Spine J. 2011;11:e1-e4.
22. Wysowski DK, Talarico L, Bacsanyi J, Botstein P. Spinal and epidural hematoma and low-molecular-weight heparin. N Engl J Med. 1998;338:1774-1775.
23. Horlocker TT, Wedel DJ, Schroeder DR, et al. Preoperative antiplatelet therapy does not increase the risk of spinal hematoma associated with regional anesthesia. Anesth Analg. 1995;80:303-309.
24. Zhong W, Chen H, You C, Li J, Liu Y, Huang S. Spontaneous spinal epidural hematoma. J Clin Neurosci. 2011;18:1490-1494.
25. Kou J, Fischgrund J, Biddinger A, Herkowitz H. Risk factors for spinal epidural hematoma after spinal surgery. Spine (Phila Pa 1976). 2002;27:1670-1673.
26. Centers for Disease Control and Prevention. Vital signs: prevalence, treatment, and control of hypertension - United States, 1999-2002 and 2005-2008. MMWR Morb Mortal Wkly Rep. 2011;60:103-108.
27. Gonzalez Della Valle A, Chiu YL, Ma Y, Mazumdar M, Memtsoudis SG. The metabolic syndrome in patients undergoing knee and hip arthroplasty: trends and in-hospital outcomes in the United States. J Arthroplasty. 2012;27:1743-1749.e1.