Human tracheobronchial basal cells: Normal versus remodeling/repairing phenotypes in vivo and in vitro

American Journal of Respiratory Cell and Molecular Biology

Volumn 49, Issue 6, 2013, Pages 1127-1134

  Ghosh, Moumita ^a   Ahmad, Shama ^a   Jian, Abhilasha ^a   Li, Bilan ^a   Smith, Russell W ^a   Helm, Karen M ^b   Seibold, Max A ^a   Groshong, Steven D ^a   White, Carl W ^a   Reynolds, Susan D ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Basal cell; Clonogenic frequency; Phenotypic plasticity; Remodeling; Stem cell

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALPHA6 INTEGRIN; CD151 ANTIGEN; CYTOKERATIN 5; MUCIN 5B; TETRASPANIN; THROMBOPLASTIN;

ARTICLE; BASAL CELL; BASEMENT MEMBRANE; CADAVER; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CELL STRAIN 3T3; CLONOGENESIS; COMPARATIVE STUDY; EPITHELIUM BASAL CELL; FEEDER CELL; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMAN TRACHEOBRONCHIAL EPITHELIAL BASAL CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MITOSIS INDEX; MORPHOMETRICS; PHENOTYPE;

ALDEHYDE DEHYDROGENASE; ANTIGENS, CD151; BRONCHI; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CLONE CELLS; EPITHELIAL CELLS; HOMEOSTASIS; HUMANS; INTEGRIN ALPHA6; KERATINS; PHENOTYPE; REGENERATION; THROMBOPLASTIN; TRACHEA;

EID: 84890025100     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0049OC     Document Type: Article

References (33)

1. Engelhardt JF, Schlossberg H, Yankaskas JR, Dudus L. Progenitor cells of the adult human airway involved in submucosal gland development. Development 1995;121:2031-2046.
2. Rock JR, Onaitis MW, Rawlins EL, Lu Y, Clark CP, Xue Y, Randell SH, Hogan BL. Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA 2009;106:12771-12775.
3. Hajj R, Baranek T, Le Naour R, Lesimple P, Puchelle E, Coraux C. Basal cells of the human adult airway surface epithelium retain transit-amplifying cell properties. Stem Cells 2007;25:139-148.
4. Dvorak A, Tilley AE, Shaykhiev R, Wang R, Crystal RG. Do airway epithelium air-liquid cultures represent the in vivo airway epithelium transcriptome? Am J Respir Cell Mol Biol 2011;44:465-473.
5. Cole BB, Smith RW, Jenkins KM, Graham BB, Reynolds PR, Reynolds SD. Tracheal basal cells: a facultative progenitor cell pool. Am J Pathol 2010;177:362-376.
6. Hutton E, Paladini RD, Yu QC, Yen M, Coulombe PA, Fuchs E. Functional differences between keratins of stratified and simple epithelia. J Cell Biol 1998;143:487-499.
7. Omary MB, Ku NO. Cell biology: skin care by keratins. Nature 2006;441:296-297.
8. Ghosh M, Helm KM, Smith RW, Giordanengo MS, Li B, Shen H, Reynolds SD. A single cell functions as a tissue-specific stem cell and the in vitro niche-forming cell. Am J Respir Cell Mol Biol 2011;45:459-469.
9. Hegab AE, Ha VL, Gilbert JL, Zhang KX, Malkoski SP, Chon AT, Darmawan DO, Bisht B, Ooi AT, Pellegrini M, et al. A novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells 2011;29:1283-1293.
10. Avril-Delplanque A, Casal I, Castillon N, Hinnrasky J, Puchelle E, Péault B. Aquaporin-3 expression in human fetal airway epithelial progenitor cells. Stem Cells 2005;23:992-1001.
11. Rao LV, Mackman N. Factor VIIa and tissue factor: from cell biology to animal models. Thromb Res 2010;125:S1-S3.
12. Dupuit F, Gaillard D, Hinnrasky J, Mongodin E, De Bentzmann S, Copreni E, Puchelle E. Differentiated and functional human airway epithelium regeneration in tracheal xenografts. Am J Physiol Lung Cell Mol Physiol 2000;278:L165-L176.
13. Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. Tissue factor signals airway epithelial basal cell survival via coagulation and par1/2. Am J Respir Cell Mol Biol 2013;48:94-104.
14. Rock JR, Gao X, Xue Y, Randell SH, Kong YY, Hogan BL. Notchdependent differentiation of adult airway basal stem cells. Cell Stem Cell 2011;8:639-648.
15. Kumar PA, Hu Y, Yamamoto Y, Hoe NB, Wei TS, Mu D, Sun Y, Joo LS, Dagher R, Zielonka EM, et al. Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection. Cell 2011;147:525-538.
16. Brechbuhl HM, Ghosh M, Smith MK, Smith RW, Li B, Hicks DA, Cole BB, Reynolds PR, Reynolds SD. β-catenin dosage is a critical determinant of tracheal basal cell fate determination. Am J Pathol 2011;179:367-379.
17. Ghosh M, Brechbuhl HM, Smith RW, Li B, Hicks DA, Titchner T, Runkle CM, Reynolds SD. Context-dependent differentiation of multipotential keratin 14-expressing tracheal basal cells. Am J Respir Cell Mol Biol 2011;45:403-410.
18. Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol 2004;164:577-588.
19. Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol 2004;286:L643-L649.
20. Bernacki SH, Nelson AL, Abdullah L, Sheehan JK, Harris A, Davis CW, Randell SH. Mucin gene expression during differentiation of human airway epithelia in vitro: MUC4 and MUC5B are strongly induced. Am J Respir Cell Mol Biol 1999;20:595-604.
21. 2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death. Am J Respir Crit Care Med 2009;179:816-826.
22. Fulcher ML, Gabriel S, Burns KA, Yankaskas JR, Randell SH. Welldifferentiated human airway epithelial cell cultures. Methods Mol Med 2005;107:183-206.
23. Widdicombe JH, Sachs LA, Morrow JL, Finkbeiner WE. Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function. Biotechniques 2005;39:249-255.
24. Eirew P, Stingl J, Raouf A, Turashvili G, Aparicio S, Emerman JT, Eaves CJ. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med 2008;14:1384-1389.
25. Lindvall C, Evans NC, Zylstra CR, Li Y, Alexander CM, Williams BO. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem 2006;281:35081-35087.
26. Stingl J, Eaves CJ, Zandieh I, Emerman JT. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Res Treat 2001;67:93-109.
27. Smith RW, Hicks DA, Reynolds SD. Roles for β-catenin and doxycycline in the regulation of respiratory epithelial cell frequency and function. Am J Respir Cell Mol Biol 2012;46:115-124.
28. Cole BB, Smith RW, Jenkins KM, Graham BB, Reynolds PR, Reynolds SD. Tracheal basal cells: a facultative progenitor cell pool. Am J Pathol 2010;177:362-376.
29. Taswell C. Limiting dilution assays for the determination of immunocompetent cell frequencies: I. Data analysis. J Immunol 1981;126:1614-1619.
30. Seibold MA, Smith RW, Urbanek C, Groshong SD, Cosgrove GP, Brown KK, Schwarz MI, Schwartz DA, Reynolds SD. The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium. PLoS ONE 2013;8:e58658.
31. Moreb JS. Aldehyde dehydrogenase as a marker for stem cells. Curr Stem Cell Res Ther 2008;3:237-246.
32. Hegab AE, Ha VL, Darmawan DO, Gilbert JL, Ooi AT, Attiga YS, Bisht B, Nickerson DW, Gomperts BN. Isolation and in vitro characterization of basal and submucosal gland duct stem/progenitor cells from human proximal airways. Stem Cells Transl Med 2012;1:719-724.
33. Evans MJ, Van Winkle LS, Fanucchi MV, Plopper CG. Cellular and molecular characteristics of basal cells in airway epithelium. Exp Lung Res 2001;27:401-415.