Estrogen modulates cardiac growth through an estrogen receptor α-dependent mechanism in healthy ovariectomized mice

Molecular and Cellular Endocrinology

Volumn 382, Issue 2, 2014, Pages 909-914

  Kararigas, Georgios ^a   Nguyen, Ba Tiep ^b,c   Jarry, Hubertus ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c VIETNAM NATIONAL UNIVERSITY OF AGRICULTURE   (Viet Nam)

Author keywords

Estrogen; Estrogen receptor; Heart

Indexed keywords

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MYOCARDIN; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HEART DEVELOPMENT; HEART LEFT VENTRICLE; HEART WEIGHT; HORMONAL REGULATION; IGF1 GENE; KNOCKOUT MOUSE; MOUSE; MYOCD GENE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; UTERUS WEIGHT; WILD TYPE;

17Β-ESTRADIOL; BERKO; CON; CONTROL; E2; ER; ERKO; ERΑ KNOCKOUT; ERΒ KNOCKOUT; ESTROGEN; ESTROGEN RECEPTOR; HEART; LEFT VENTRICLE; LV; WILD-TYPE; WT;

ANIMALS; BODY WEIGHT; DIET; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; ORGAN SIZE; OVARIECTOMY; OVARY; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; UTERUS;

EID: 84890023038     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2013.11.011     Document Type: Article

References (31)

1. Anderson G.L., Limacher M., Assaf A.R., Bassford T., Beresford S.A., Black H., Bonds D., Brunner R., Brzyski R., Caan B., Chlebowski R., Curb D., Gass M., Hays J., Heiss G., Hendrix S., Howard B.V., Hsia J., Hubbell A., Jackson R., Johnson K.C., Judd H., Kotchen J.M., Kuller L., LaCroix A.Z., Lane D., Langer R.D., Lasser N., Lewis C.E., Manson J., Margolis K., Ockene J., O'Sullivan M.J., Phillips L., Prentice R.L., Ritenbaugh C., Robbins J., Rossouw J.E., Sarto G., Stefanick M.L., Van Horn L., Wactawski-Wende J., Wallace R., Wassertheil-Smoller S. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 2004, 291:1701-1712.
2. Bottner M., Christoffel J., Jarry H., Wuttke W. Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats. J. Endocrinol. 2006, 189:77-88.
3. Brown L.M., Gent L., Davis K., Clegg D.J. Metabolic impact of sex hormones on obesity. Brain Res. 2010, 1350:77-85.
4. Butera P.C. Estradiol and the control of food intake. Physiol. Behav. 2010, 99:175-180.
5. Del Parigi A., Gautier J.F., Chen K., Salbe A.D., Ravussin E., Reiman E., Tataranni P.A. Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann. NY Acad. Sci. 2002, 967:389-397.
6. Deroo B.J., Korach K.S. Estrogen receptors and human disease. J. Clin. Invest. 2006, 116:561-570.
7. He Z., Zhang S.S., Meng Q., Li S., Zhu H.H., Raquil M.A., Alderson N., Zhang H., Wu J., Rui L., Cai D., Feng G.S. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol. Cell Biol. 2012, 32:1867-1878.
8. Heine P.A., Taylor J.A., Iwamoto G.A., Lubahn D.B., Cooke P.S. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc. Natl. Acad. Sci. USA 2000, 97:12729-12734.
9. Hsia J., Langer R.D., Manson J.E., Kuller L., Johnson K.C., Hendrix S.L., Pettinger M., Heckbert S.R., Greep N., Crawford S., Eaton C.B., Kostis J.B., Caralis P., Prentice R. Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative. Arch. Intern. Med. 2006, 166:357-365.
10. Ihaka R., Gentleman R. R: a language for data analysis and graphics. J. Comput. Graph. Stat. 1996, 5:299-314.
11. Kararigas G., Becher E., Mahmoodzadeh S., Knosalla C., Hetzer R., Regitz-Zagrosek V. Sex-specific modification of progesterone receptor expression by 17beta-oestradiol in human cardiac tissues. Biol. Sex Differ. 2010, 1:2.
12. Kararigas G., Fliegner D., Gustafsson J.A., Regitz-Zagrosek V. Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophy. Physiol. Genomics 2011, 43:438-446.
13. Kararigas G., Bito V., Tinel H., Becher E., Baczko I., Knosalla C., Albrecht-Kupper B., Sipido K.R., Regitz-Zagrosek V. Transcriptome characterization of estrogen-treated human myocardium identifies Myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function. J. Am. Coll. Cardiol. 2012, 59:410-417.
14. Krege J.H., Hodgin J.B., Couse J.F., Enmark E., Warner M., Mahler J.F., Sar M., Korach K.S., Gustafsson J.A., Smithies O. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proc. Natl. Acad. Sci. USA 1998, 95:15677-15682.
15. Lubahn D.B., Moyer J.S., Golding T.S., Couse J.F., Korach K.S., Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl. Acad. Sci. USA 1993, 90:11162-11166.
16. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R.M. The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
17. Mayes J.S., Watson G.H. Direct effects of sex steroid hormones on adipose tissues and obesity. Obes. Rev. 2004, 5:197-216.
18. McMullen J.R., Shioi T., Huang W.Y., Zhang L., Tarnavski O., Bisping E., Schinke M., Kong S., Sherwood M.C., Brown J., Riggi L., Kang P.M., Izumo S. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway. J. Biol. Chem. 2004, 279:4782-4793.
19. Mendelsohn M.E., Karas R.H. The protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 1999, 340:1801-1811.
20. Mendelsohn M.E., Karas R.H. HRT and the young at heart. N. Engl. J. Med. 2007, 356:2639-2641.
21. Miller V.M., Duckles S.P. Vascular actions of estrogens: functional implications. Pharmacol. Rev. 2008, 60:210-241.
22. Murphy E. Estrogen signaling and cardiovascular disease. Circ. Res. 2011, 109:687-696.
23. Nguyen B.T., Kararigas G., Jarry H. Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice. Genes. Nutr. 2012, 8:383-390.
24. Nguyen B.T., Kararigas G., Wuttke W., Jarry H. Long-term treatment of ovariectomized mice with estradiol or phytoestrogens as a new model to study the role of estrogenic substances in the heart. Planta Med. 2012, 78:6-11.
25. Ogawa S., Chan J., Gustafsson J.A., Korach K.S., Pfaff D.W. Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity. Endocrinology 2003, 144:230-239.
26. Patten R.D., Pourati I., Aronovitz M.J., Alsheikh-Ali A., Eder S., Force T., Mendelsohn M.E., Karas R.H. 17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload. J. Cardiovasc. Fail 2008, 14:245-253.
27. Ring L.E., Zeltser L.M. Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. J. Clin. Invest. 2010, 120:2931-2941.
28. Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., Jackson R.D., Beresford S.A., Howard B.V., Johnson K.C., Kotchen J.M., Ockene J. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002, 288:321-333.
29. Smith P.J., Ornatsky O., Stewart D.J., Picard P., Dawood F., Wen W.H., Liu P.P., Webb D.J., Monge J.C. Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats. Circulation 2000, 102:2983-2989.
30. Spiteri T., Ogawa S., Musatov S., Pfaff D.W., Agmo A. The role of the estrogen receptor alpha in the medial preoptic area in sexual incentive motivation, proceptivity and receptivity, anxiety, and wheel running in female rats. Behav. Brain Res. 2012, 230:11-20.
31. van Eickels M., Patten R.D., Aronovitz M.J., Alsheikh-Ali A., Gostyla K., Celestin F., Grohe C., Mendelsohn M.E., Karas R.H. 17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction. J. Am. Coll. Cardiol. 2003, 41:2084-2092.