A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues

Chemistry and Physics of Lipids

Volumn 177, Issue , 2014, Pages 71-90

  Benesch, Matthew G K ^a   Mannock, David A ^a   Lewis, Ruthven N A H ^a   McElhaney, Ronald N ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cholesterol; Cholesterol analogues; Dipalmitoylphosphatidylcholine; Lipid bilayer membranes; Sterol phospholipid interactions; Thermotropic phase behaviour

Indexed keywords

4 CHOLESTEN 3ALPHA OL; 5 CHOLESTEN 3ALPHA OL; ALLOCHOLESTEROL; CHOLEST 4 EN 3 ONE; CHOLEST 5 EN 3 ONE; CHOLESTEROL; CHOLESTEROL DERIVATIVE; DIPALMITOYLPHOSPHATIDYLCHOLINE; HYDROCARBON; OXOSTEROID; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DOUBLE BOND; ENTHALPY; INFRARED SPECTROSCOPY; LIPID BILAYER; MISCIBILITY; PHASE TRANSITION; PRIORITY JOURNAL; STEREOCHEMISTRY; STEROL ANALYSIS; TEMPERATURE RELATED PHENOMENA; THERMOSTABILITY; THERMOTROPIC PHASE BEHAVIOR;

1-PALMITOYL, 2-OLEOYLPHOSPHATIDYLCHOLINE; ACHOL; ACHOLONE; ALLOCHOLESTENONE (4-CHOLESTEN-3-ONE); ALLOCHOLESTEROL (4-CHOLESTEN-3Β-OL); CHOL; CHOLESTENONE (5-CHOLESTEN-3-ONE); CHOLESTEROL; CHOLESTEROL (5-CHOLESTEN-3Β-OL); CHOLESTEROL ANALOGUES; CHOLONE; DIFFERENTIAL SCANNING CALORIMETRY; DIPALMITOYLPHOSPHATIDYLCHOLINE; DPPC; DSC; EACHOL; ECHOL; ELECTRON SPIN RESONANCE; EPIALLOCHOLESTEROL (4-CHOLESTEN-3Α-OL); EPICHOLESTEROL (5-CHOLESTEN-3Α-OL); ESR; FOURIER TRANSFORM INFRARED; FTIR; L(D); L(O); L(Α); L(Β′) AND L(Β); LAMELLAR GEL PHASES WITH TILTED AND UNTILTED HYDROCARBON CHAINS, RESPECTIVELY; LAMELLAR LIQUID-CRYSTALLINE PHASE; LAMELLAR LIQUID-DISORDERED PHASE; LAMELLAR LIQUID-ORDERED PHASE; LIPID BILAYER MEMBRANES; NMR; NUCLEAR MAGNETIC RESONANCE; P(Β′); PC; PHOSPHATIDYLCHOLINE; POPC; RIPPLED GEL PHASE WITH TILTED HYDROCARBON CHAINS; SPHINGOMYELIN; SPM; STEROL/PHOSPHOLIPID INTERACTIONS; T(M); T(P); THE MAIN TRANSITION TEMPERATURE MAXIMUM; THE PRETRANSITION TEMPERATURE MAXIMUM; THE SUPERSCRIPT " BRD" APPENDED TO THIS THERMODYNAMIC PARAMETER REFERS TO THE BROAD COMPONENTS OF THE MAIN PHASE TRANSITION OF STEROL OR STEROID-CONTAINING DPPC BILAYERS; THE SUPERSCRIPT " SHP" APPENDED TO THIS THERMODYNAMIC PARAMETER REFERS TO THE SHARP COMPONENTS OF THE MAIN PHASE TRANSITION OF STEROL OR STEROID-CONTAINING DPPC BILAYERS; THE TRANSITION ENTHALPY; THE WIDTH OF THE PHASE TRANSITION AT HALF HEIGHT, INVERSELY RELATED TO THE COOPERATIVITY OF THE PHASE TRANSITION; THERMOTROPIC PHASE BEHAVIOUR; ΔH; ΔT(1/2);

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ABSORPTION; CALORIMETRY, DIFFERENTIAL SCANNING; CELL MEMBRANE; CHOLESTENONES; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHASE TRANSITION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STEREOISOMERISM; TEMPERATURE;

EID: 84890007379     PISSN: 00093084     EISSN: 18732941     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2013.11.008     Document Type: Article

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