“My doctor has changed my pills without telling me”: impact of generic medication switches in stroke survivors

Journal of Behavioral Medicine

Volumn 37, Issue 5, 2014, Pages 890-901

  Chambers, Julie A ^a   O’Carroll, Ronan E ^a   Dennis, Martin ^b,c   Sudlow, Cathie ^b,c   Johnston, Marie ^d  

^a UNIVERSITY OF STIRLING   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Adherence; Generic substitution; Medication; Stroke; Therapeutic substitution

Indexed keywords

EID: 84889963110     PISSN: 01607715     EISSN: 15733521     Source Type: Journal    
DOI: 10.1007/s10865-013-9550-5     Document Type: Article

References (34)

1. Bailey, J. E., Wan, J. Y., Tang, J., Ghani, M. A., & Cushman, W. C. (2010). Antihypertensive medication adherence, ambulatory visits, and risk of stroke and death. Journal of General Intern Medicine,25, 495–503.
2. Braun, V., & Clarke, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology,3, 77–101.
3. Briesacher, B. A., Andrade, S. E., Fouayzi, H., & Chan, K. A. (2009). Medication adherence and the use of generic drug therapies. American Journal of Managed Care,15, 450–456.
4. Brown, I., Sheeran, P., & Reuber, M. (2009). Randomized controlled trial of an implementation intention intervention to enhance adherence with antiepileptic drug treatment. Epilepsy & Behavior,16, 634–639.
5. Bushnell, C. D., Zimmer, L. O., Pan, W., Olson, D. M., Zhao, X., Meteleve, T., et al. (2010). Persistence with stroke prevention medications 3 months after hospitalization. Archives of Neurology,67, 1456–1463.
6. Chambers, J. A., O’Carroll, R. E., Hamilton, B., Whittaker, J., Johnston, M., Sudlow, C., et al. (2011). Adherence to medication in stroke survivors: A qualitative comparison of high and low adherers. British Journal of Health Psychology,16, 592–609.
7. Duerden, M. G., & Hughes, D. A. (2010). Generic and therapeutic substitutions in the UK: Are they a good thing? British Journal of Clinical Pharmacology,70, 335–341.
8. Federman, A. D., Halm, E. A., Zhu, C., Hochman, T., & Siu, A. L. (2006). Association of income and prescription drug coverage with generic medication use among older adults with hypertension. American Journal of Managed Care,12, 611–618.
9. Ferner, R., Lenney, W., & Marriott, J. (2010). Controversy over generic substitution. British Medical Journal,340, 1341–1343.
10. Field, A. (2009). Discovering statistics using SPSS. London: Sage.
11. Fischer, B., Lehrl, S., Weber, E., Gundert-Remy, U., & Fischer, U. (1981). Cerebrovascular insufficiency and compliance with drug therapy. Zeitshift für Gerontologie,14, 145–152.
12. Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research,12, 189–198.
13. Greene, J. A. (2011). The art of medicine: The substance of the brand. Lancet,378, 120–121.
14. Håkonsen, H., Eilertsen, M., Borge, H., & Toverud, E. L. (2009). Generic substitution: Additional challenge for adherence in hypertensive patients? Current Medical Research and Opinion,25, 2515–2521.
15. Health and Social Care Information Centre, Prescribing and Primary Care Services. (2012). Prescriptions dispensed in the community: England, statistics for 2001 to 2011. National Health Service. Downloaded from www.ic.nhs.uk on October 23, 2012.
16. Heart Protection Study Collaborative Group. (2002). MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high risk individuals: A randomised placebo-controlled trial. Lancet,360, 7–22.
17. Himmel, W., Simmenroth-Nayda, A., Niebling, W., Ledig, T., Jansen, R. D., Kochen, M. M., et al. (2005). What do primary care users think about generic drugs? International Journal of Clinical Pharmacology and Therapeutics,43, 472–479.
18. Horne, R. (2004). Measuring adherence: The case for self-report. International Journal of Behavioral Medicine,11, 75.
19. Information Services Division Scotland. (2011). Prescribing and medicines: prescription cost analysis financial year-2010/11. Edinburgh: ISD.
20. Kesselheim, A. S., Misono, A. S., Lee, J. L., Stedman, M. R., Brookhart, A., Choudhry, N. K., et al. (2008). Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: A systematic review and meta-analysis. Journal of the American Medical Association,300, 2514–2526.
21. Meyer, D., Leventhal, H., & Gutmann, M. (1985). Common-sense models of illness: The example of hypertension. Health Psychology,4, 5–135.
22. MHRA (2013). Press release: MHRA issues precautionary recall of medicines manufactured by Wockhardt Ltd. Downloaded from http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON296424 on September 23, 2013.
23. National Audit Office. (2009). Prescribing savings in 2008. http://www.nao.org.uk/publications/0809/prescribing_savings_in_2008.aspx. Accessed October 23, 2012.
24. O’Carroll, R. E., Chambers, J. A., Dennis, M., Sudlow, C., & Johnston, M. (2013). Improving adherence to medication in stroke survivors: A pilot randomised controlled trial. Annals of Behavioral Medicine,46, 358–368.
25. O’Carroll, R. E., Dennis, M., Johnston, M., & Sudlow, C. (2010). Improving adherence to medication in stroke survivors (IAMSS): A randomised controlled trial: Study protocol. BMC Neurology,10, 15.
26. O’Carroll, R. E., Whittaker, J., Hamilton, B., Johnston, M., Sudlow, C., & Dennis, M. (2011). Predictors of adherence to secondary prevention medication in stroke patients. Annals of Behavioral Medicine,41, 383–390.
27. Phillips, B., Roberts, C., Rudolph, A. E., Morant, S., Aziz, F., & O’Regan, C. P. (2007). Switching statins: The impact on patient outcomes. British Journal of Cardiology,14, 280–285.
28. Scarborough, P., Peto, V., Bhatnagar, P., Kaur, A., Leal, J., & Luengo-Fernandez, R. (2009). Stroke statistics, 2009 edition. Department of Public Health, University of Oxford. Downloaded from www.heartstats.org on May 30, 2012.
29. Sudlow, C. (2008). Preventing further vascular events after a stroke or transient ischaemic attack: An update on medical management. Practical Neurology,8, 141–157.
30. Toverud, E.-L., Røise, A. K., Hogstad, G., & Wabø, I. (2011). Norwegian patients on generic antihypertensive drugs: A qualitative study of their own experiences. European Journal of Clinical Pharmacology,67, 33–38.
31. Trewby, P. N., Reddy, A. V., Trewby, C. S., Ashton, V. J., Brennan, G., & Inglis, J. (2002). Are preventive drugs preventive enough? A study of patients’ expectation of benefit from preventive drugs. Clinical Medicine,2, 527–533.
32. Tversky, A., & Kahneman, D. (1973). Availability: A heuristic for judging frequency and probability. Cognitive Psychology,5, 207–233.
33. Van Wijk, B. L., Klungel, O. H., Heerdink, E. R., & De Boer, A. (2006). Generic substitution of antihypertensives drugs: How does it affect adherence? Annals of Pharmacotherapy,40, 15–20.
34. Warlow, C., van Gijn, J., Dennis, M. S., Wardlaw, J., Bamford, J., Hankey, G., et al. (2008). Stroke: practical management (3rd ed.). Oxford: Blackwell.