Fragmented QRS complexes are associated with increased left ventricular mass in patients with essential hypertension

Annals of Noninvasive Electrocardiology

Volumn 18, Issue 6, 2013, Pages 547-554

  Kadi, Hasan ^a   Kevser, Ayşe ^b   Ozturk, Ahmet ^a   Koc, Fatih ^a   Ceyhan, Koksal ^a  

^a GAZIOSMANPASA UNIVERSITY   (Turkey)

^b Cardiology   (Turkey)

Author keywords

fragmented QRS; hypertension; left ventricular hypertrophy

Indexed keywords

ADULT; ARTICLE; CARDIAC PATIENT; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; ESSENTIAL HYPERTENSION; FEMALE; HEART EJECTION FRACTION; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE SIZE; HEART VENTRICLE WALL; HUMAN; MALE; PRIORITY JOURNAL; QRS COMPLEX; R WAVE;

FRAGMENTED QRS; HYPERTENSION; LEFT VENTRICULAR HYPERTROPHY;

ELECTROCARDIOGRAPHY; FEMALE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC;

EID: 84889889329     PISSN: 1082720X     EISSN: 1542474X     Source Type: Journal    
DOI: 10.1111/anec.12070     Document Type: Article

References (33)

1. Frohlich ED, Apstein C, Chobanian AV, et al. The heart in hypertension. N Engl J Med 1992; 327: 998-1008.
2. Leonetti G, Cuspidi C,. Heart and vascular changes in hypertension. J Hypertens 1995; 13 (Suppl 2): S29-S34.
3. Ducharme A, Swedberg K, Pfeffer MA, et al. Prevention of atrial fibrillation in patients with symptomatic chronic heart failure by candesartan in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. Am Heart J 2006; 152: 86-92.
4. Jalil JE, Doering CV, Janicki JS, et al. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res 1989; 64: 1041-1050.
5. Diez J, Lopez B, Gozales A, et al. Clinical aspects of hypertensive myocardial fibrosis. Curr Opin Cardiol 2001; 16: 328-335.
6. Gonzales A, Lopez B, Diez J,. Fibrosis in hypertensive heart disease role of the angiotensin-aldosterone system. Med Clin N Am 2004; 88: 93-97.
7. Abi-Samra F, Fouad FM, Tarazi RC,. Determinants of left ventricular hypertrophy and function in hypertensive patients: An echocardiographic study. Am J Med 1983; 75 (Suppl 3A): 26-33.
8. Devereux RB, Savage DD, Sachs1, et al. Relation of hemodynamic load to left ventricular hypertrophy and performance in hypertension. Am J Cardiol 1983; 51: 171-176.
9. Campus S, Malavasi A, Ganau A,. Systolic function of the hypertrophied left ventricle. J Clin Hypertens 1987; 3: 79-87.
10. de Simone G, DiLorenzo L, Costantinue G, et al. Supernormal contractility in primary hypertension without left ventricular hypertrophy. Hypertension 1988; 11: 457-463.
11. de Simone G, DiLorenzo L, Costantinue G, et al. Hemodynamic hypertrophied left ventricular patterns in systemic hypertension. Am J Cardiol 1987; 60: 1317-1321.
12. Flowers NC, Horan LG, Thomas JR, et al. The anatomic basis for high-frequency components in the electrocardiogram. Circulation 1969; 39: 531-539.
13. Basaran Y, Tigen K, Karaahmet T, et al. Fragmented QRS complexes are associated with cardiac fibrosis and significant intraventricular systolic dyssynchrony in nonischemic dilated cardiomyopathy patients with a narrow QRS interval. Echocardiography 2011; 28: 62-68.
14. Mahenthiran J, Khan BR, Sawada SG, et al. Fragmented QRS complexes not typical of a bundle branch block: a marker of greater myocardial perfusion tomography abnormalities in coronary artery disease. J Nucl Cardiol 2007; 14 (3): 347-353.
15. Das MK, Khan B, Jacob S, et al. Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease. Circulation 2006; 113: 2495-2501.
16. Homsi M, Alsayed L, Safadi B, et al. Fragmented QRS complexes on 12-lead ECG: A marker of cardiac sarcoidosis as detected by gadolinium vardiac magnetic resonance imaging. Ann Noninvasive Electrocardiol 2009; 14: 319-326.
17. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497.
18. Feigenbaum H,. Echocardiographic Evaluation of Cardiac Chamber. In:, Feigenbaum H, (ed.): Echocardiography. 5th ed. Baltimore: Williams Wilkins, 1994, pp. 134-180.
19. Savage DD, Garrison RJ, Kannel WB, et al. The spectrum of left ventricular hypertrophy in a general population sample: The Framingham Study. Circulation 1987; 75: 26-33.
20. Devereux RB, Alonso DR, Lutas EM, et al. Echocardio-graphic assessment of left ventricular hypertrophy: Comparison to necropsy findings. Am J Cardiol 1986; 57: 450-458.
21. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989; 2: 358-367.
22. Levy D, Labib SB, Anderson KM, et al. Determinants of sensitivity and specificity of electrocardiographic criteria for left ventricular hypertrophy. Circulation 1990; 81: 815-820.
23. Levy D, Anderson KM, Savage DD, et al. Echocardiographically detected left ventricular hypertrophy: Prevalence and risk factors. The Framingham Heart Study. Ann Intern Med 1988; 108: 7-13.
24. Diez J, Lopez B, Gonzales A, et al. Clinical aspects of hypertensive myocardial fibrosis. Curr Opin Cardiol 2001; 16: 328-335.
25. Gonzalez A, Lopez B, Diez J,. Fibrosis in hypertensive heart disease role of the angiotensin-aldosterone system. Med Clin N Am 2004; 88: 83-97.
26. Rossi MA,. Connective tissue skeleton in the normal left ventricle and in hypertensive left ventricular hypertrophy and chronic chagasic myocarditis. Med Sci Monit 2001; 7: 820-832.
27. Olivetti G, Melissari M, Balbi T, et al. Myocite cellular hypertrophy is responsible for ventricular remodelling in thehypertrophic heart of middle aged individuals in the absence of heart failure. Cardiovasc Res 1994; 28: 1199-1208.
28. Rossi MA,. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens 1998; 16: 1031-1041.
29. Ciulla MM, Paliotti R, Hess DB, et al. Echocardiographic patterns of myocardial fibrosis in hypertensive patients: Endomyocardial biopsy versus ultrasonic tissue characterization. J Am Soc Echocardiogr 1997; 10: 657-664.
30. Gardner PI, Ursell PC, Fenoglio JJ Jr, et al. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation 1985; 72: 596-611.
31. Averill DB, Ferrario CM, Tarazi RC, et al. Cardiac performance in rats with renal hypertension. Circ Res 1976; 38: 280-288.
32. McLenachan JM, Dargie HJ,. Ventricular arrhythmias in hypertensive left ventricular hypertrophy. Relation to coronary artery disease, left ventricular dysfunction, and myocardial fibrosis. Am J Hypertens 1990; 3: 735-740.
33. Ganau A, Devereux RB, Roman MJ, et al. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension. J Am Coll Cardiol 1992; 19: 1550-1558.