Fragmented QRS complexes on 12-lead ECG: A marker of cardiac sarcoidosis as detected by gadolinium cardiac magnetic resonance imaging

Annals of Noninvasive Electrocardiology

Volumn 14, Issue 4, 2009, Pages 319-326

  Homsi, Mohamed ^a   Alsayed, Lamaan ^a   Safadi, Bilal ^a   Mahenthiran, Jo ^a   Das, Mithilesh K ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac sarcoidosis; Diagnosis; Electrocardiography; Gadolinium; Magnetic resonance; Sarcoidosis

Indexed keywords

GADOLINIUM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ELECTROCARDIOGRAPHY; FEMALE; FRAGMENTED QRS COMPLEX; HEART BUNDLE BRANCH BLOCK; HEART SARCOIDOSIS; HUMAN; IMAGE ENHANCEMENT; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; Q WAVE; QRS COMPLEX; SARCOIDOSIS;

BUNDLE-BRANCH BLOCK; CARDIOMYOPATHIES; CONTRAST MEDIA; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; GADOLINIUM; HUMANS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBSERVER VARIATION; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; SARCOIDOSIS; SENSITIVITY AND SPECIFICITY;

EID: 70350647603     PISSN: 1082720X     EISSN: 1542474X     Source Type: Journal    
DOI: 10.1111/j.1542-474X.2009.00320.x     Document Type: Article

References (29)

1. Matsui Y, Iwai K, Tachibana T, et al. Clinicopathological study of fatal myocardial sarcoidosis. Ann NY Acad Sci 1976 278 : 455 469.
2. Roberts WC, McAllister HA Jr., Ferrans VJ. Sarcoidosis of the heart. A clinicopathologic study of 35 necropsy patients (group 1) and review of 78 previously described necropsy patients (group 11). Am J Med 1977 63 : 86 108.
3. Sharma OP, Maheshwari A, Thaker K. Myocardial sarcoidosis. Chest 1993 103 : 253 258.
4. Silverman KJ, Hutchins GM, Bulkley BH. Cardiac sarcoid: A clinicopathologic study of 84 unselected patients with systemic sarcoidosis. Circulation 1978 58 : 1204 1211.
5. Uemura A, Morimoto S, Hiramitsu S, et al. Histologic diagnostic rate of cardiac sarcoidosis: Evaluation of endomyocardial biopsies. Am Heart J 1999 138 : 299 302.
6. Hiraga H, Yuwai K, Hiroe M, et al. Guideline for diagnosis of cardiac sarcoidosis: Study report on diffuse pulmonary diseases from the Japanese Ministry of Health and Welfare. Japanese Ministry of Health and Welfare 1993 : 23 24.
7. Doherty MJ, Kumar SK, Nicholson AA, et al. Cardiac sarcoidosis: The value of magnetic resonance imaging in diagnosis and assessment of response to treatment. Respir Med 1998 92 : 697 699.
8. Shimada T, Shimada K, Sakane T, et al. Diagnosis of cardiac sarcoidosis and evaluation of the effects of steroid therapy by gadolinium-DTPA-enhanced magnetic resonance imaging.[see comment]. Am J Med 2001 110 : 520 527.
9. Tadamura E, Yamamuro M, Kubo S, et al. Effectiveness of delayed enhanced MRI for identification of cardiac sarcoidosis: Comparison with radionuclide imaging.[see comment]. Am J Roentgenol 2005 185 : 110 115.
10. Vignaux O, Dhote R, Duboc D, et al. Detection of myocardial involvement in patients with sarcoidosis applying T2-weighted, contrast-enhanced, and cine magnetic resonance imaging: Initial results of a prospective study. J Comput Assist Tomogr 2002 26 : 762 767.
11. Vignaux O, Dhote R, Duboc D, et al. Clinical significance of myocardial magnetic resonance abnormalities in patients with sarcoidosis: A 1-year follow-up study.[see comment]. Chest 2002 122 : 1895 1901.
12. Smedema JP, Snoep G, van Kroonenburgh MP, et al. Evaluation of the accuracy of gadolinium-enhanced cardiovascular magnetic resonance in the diagnosis of cardiac sarcoidosis.[see comment]. J Am Coll Cardiol 2005 45 : 1683 1690.
13. Gardner PI, Ursell PC, Fenoglio JJ Jr., et al. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts. Circulation 1985 72 : 596 611.
14. Varriale P, Chryssos BE. The RSR' complex not related to right bundle branch block: Diagnostic value as a sign of myocardial infarction scar. Am Heart J 1992 123 : 369 376.
15. Das MK, Khan B, Jacob S, et al. Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease. Circulation 2006 113 : 2495 2501.
16. Das MK, Suradi H, Maskoun W, et al. Fragmented wide QRS on a 12-lead ECG: A sign of myocardial scar and poor prognosis. Circ Arrhythmia Electrophysiol 2008 CIRCEP.107.763284.
17. Boglioli LR, Taff ML, Funke S, et al. Sudden death due to sarcoid heart disease. J Forensic Sci 1998 43 : 1072 1073.
18. Chapelon-Abric C, de Zuttere D, Duhaut P, et al. Cardiac sarcoidosis: A retrospective study of 41 cases. Medicine 2004 83 : 315 334.
19. Kato Y, Morimoto S, Uemura A, et al. Efficacy of corticosteroids in sarcoidosis presenting with atrioventricular block. Sarcoidosis Vasc Diffuse Lung Dis 2003 20 : 133 137.
20. Larsen F, Pehrsson SK, Hammar N, et al. ECG-abnormalities in Japanese and Swedish patients with sarcoidosis. A comparison. Sarcoidosis Vasc Diffuse Lung Dis 2001 18 : 284 288.
21. Sekiguchi M, Yazaki Y, Isobe M, et al. Cardiac sarcoidosis: Diagnostic, prognostic, and therapeutic considerations. Cardiovasc Drugs Ther 1996 10 : 495 510.
22. Mori M, Hanon S, Rachko M. Case report: Cardiac sarcoidosis presenting with ventricular arrhythmias: Case report and review of the literature. Int J Cardiol 2007 120 : e21 e23.
23. Ramachandran V, Stevens MP, Amin M, et al. Bi-fascicular block on EKG as the initial presenting sign of cardiac sarcoidosis. Int J Cardiol 2007 118 : e1 e2.
24. Tandri H, Bomma C, Calkins H. Unusual presentation of cardiac sarcoidosis. Congest Heart Fail 2007 13 : 116 118.
25. Wagner A, Mahrholdt H, Holly TA, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: An imaging study.[see comment]. Lancet 2003 361 : 374 379.
26. Ellis WS, Auslander DM, Lesh MD. Fractionated electrograms from a computer model of heterogeneously uncoupled anisotropic ventricular myocardium. Circulation 1995 92 : 1619 1626.
27. Flowers NC, Horan LG, Thomas JR, et al. The anatomic basis for high-frequency components in the electrocardiogram. Circulation 1969 39 : 531 539.
28. Lesh MD, Spear JF, Simson MB. A computer model of the electrogram: What causes fractionation? J Electrocardiol 1988 21 (Suppl S69 S73.
29. Schick TD, Powers SR, Jr. Spectral analysis of the high-frequency electrocardiogram in contusive myocardial injury. Ann Biomed Eng 1978 6 : 154 160.