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It is imortant to know that SCIg is well tolerated and accetable in children
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Fasth A, Nystrom J. Safety and efficacy of subcutaneous human immunoglobulin in children with primary immunodeficiencies. Acta Paediatr Jpn 2007; 96:1474-1478. It is important to know that SCIg is well tolerated and acceptable in children.
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The quality-of-life data are imortant for convincing healthcare roviders to suort immunoglobulin relacement theraies
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Gardulf A, Nicolay U. Replacement IgG therapy and self therapy at home improve the health-related quality of life in patients with primary antibody deficiencies. Curr Opin Allergy Clin Immunol 2006; 6:434-442. The quality-of-life data are important for convincing healthcare providers to support immunoglobulin replacement therapies.
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Gardulf A, Bjo rvell H, Andersen V, et al. Lifelong treatment with gammaglobulin for primary antibody deficiencies: the patients' experiences of subcutaneous self-infusions and home therapy. J Adv Nurs 1995; 21:917-927.
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12
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Remvig L, Andersen V, Hansen NE, Karle H. Prophylactic effect of selfadministered pump-driven subcutaneous IgG infusion in patients with antibody deficiency: A triple-blind cross-over study comparing P-IgG levels of 3 g l-1 versus 6 g l-1. J Intern Med 1991; 229:73-77.
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15
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Bioavailability of gammaglobulin after subcutaneous infusions in patients with common variable immunodeficiency
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This study is ertinent to the harmacokinetic studies required by the most regulators and licensing authorities
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Waniewski J, Gardulf A, Hammarstrom L. Bioavailability of gammaglobulin after subcutaneous infusions in patients with common variable immunodeficiency. J Clin Immunol 1994; 14:90-97. This study is pertinent to the pharmacokinetic studies required by the most regulators and licensing authorities.
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Good data for convincing atients that seedy infusions are well tolerated
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Hansen S, Gustafson R, Smith CI, Gardulf A. Express subcutaneous IgG infusions: decreased time of delivery with maintained safety. Clin Immunol 2002; 104:237-241. Good data for convincing patients that speedy infusions are well tolerated.
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Hansen, S.1
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The life situations of patients with primary antibody deficiency untreated or treated with subcutaneous gammaglobulin infusions
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Gardulf A, Bjo rvell H, Gustafson R, et al. The life situations of patients with primary antibody deficiency untreated or treated with subcutaneous gammaglobulin infusions. Clin Exp Immunol 1993; 92:200-204.
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Children and adults with primary antibody deficiencies gain quality of life by subcutaneous igg self-infusions at home
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Gardulf A, Nicolay U, Math D, et al. Children and adults with primary antibody deficiencies gain quality of life by subcutaneous IgG self-infusions at home. J Allergy Clin Immunol 2004; 114:936-942.
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Gardulf A, Andersson E, Lindqvist M, et al. Rapid subcutaneous IgG replacement therapy at home for pregnant immunodeficient women. J Clin Immunol 2001; 21:150-154.
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20
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0034073949
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The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy
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The first comparitive trial: important for European Medicines agency decision on equivalence of doses
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Chapel H, Spickett GP, Ericson D, et al. The comparison of the efficacy and safety of intravenous versus subcutaneous immunoglobulin replacement therapy. J Clin Immunol 2000; 2:94-100. The first comparitive trial: important for European Medicines agency decision on equivalence of doses.
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Chapel, H.1
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21
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SCIg can be used in previously untreated patients
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Borte M, Quinti I, Soresina A, et al. Efficacy and safety of subcutaneous vivaglobin replacement therapy in previously untreated patients with primary immunodeficiency: A prospective, multicenter study. J Clin Immunol 2011; 31:952-961. SCIg can be used in previously untreated patients.
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Borte, M.1
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22
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Rapid subcutaneous immunoglobulin administration every second week results in high and stable serum immunoglobulin g levels in patients with primary antibody deficiencies
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This study confirms the equivalence data for dosing and demonstrates the various pharmacokinetic measurements available
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Gustafson R, Gardulf A, Hansen S, et al. Rapid subcutaneous immunoglobulin administration every second week results in high and stable serum immunoglobulin G levels in patients with primary antibody deficiencies. Clin Exp Immunol 2008; 152:274-279. This study confirms the equivalence data for dosing and demonstrates the various pharmacokinetic measurements available.
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23
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This study demonstrates the importance of individual IgG trough levels in infection prevention
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Lucas M, Lee M, Lortan J, et al. Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years. J Allergy Clin Immunol 2010; 125:1354-1360. This study demonstrates the importance of individual IgG trough levels in infection prevention.
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Gelfand E, Ochs HD, Shearer WT. Controversies in IgG replacement therapy in patients with antibody deficiency diseases. J Allergy Clin Immunol 2013; 131:1001-1005.
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The first ublication of self-infusion of immunoglobulin in relacement theray
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Ochs H, Lee ML, Fischer SH, et al. Self-infusion of intravenous immunoglobulin by immunodeficient patients at home. J Infect Dis 1987; 56:652-654. The first publication of self-infusion of immunoglobulin in replacement therapy.
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Chapel HBV, Delson E. Immunoglobulin replacement therapy by self-infusion at home. Clin Exp Immunol 1988; 73:160-162.
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Chapel, H.B.V.1
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32
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0042667057
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Prospective audit of adverse reactions occurring in 459 pad patients receiving ivig
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This study confirms the safety of self-infusion of therapeutic immunoglobulin in primary antibody deficiency patients
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Brennan VM, Salomé -Bentley NJ, Chapel HM. Prospective audit of adverse reactions occurring in 459 PAD patients receiving IVIg. Clin Exp Immunol 2003; 133:247-251. This study confirms the safety of self-infusion of therapeutic immunoglobulin in primary antibody deficiency patients.
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Brennan, V.M.1
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34
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The first ublication to indicate that no secial equiment is needed so imortant for cost-effectiveness
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Shapiro R. Subcutaneous immunoglobulin: rapid push vs. infusion pump in pediatrics. Pediatr Allergy Immunol 2013; 24:49-53. The first publication to indicate that no special equipment is needed, so important for cost-effectiveness.
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Shapiro, R.1
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Confirmation of reduced costs: important for healthcare providers
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Martin A, Lavoie L, Goetghebeur M, Schellenberg R. Economic benefits of subcutaneous rapid push versus intravenous immunoglobulin infusion therapy in adult patients with primary immune deficiency. Transfus Med 2013; 23:55-60.Confirmation of reduced costs: important for healthcare providers.
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Martin, A.1
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36
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Fasth A, Nystrom J. Quality of life and health-care resource utilization among children with primary immunodeficiency receiving home treatment with subcutaneous human immunoglobulin. J Clin Immunol 2008; 28:370-378.
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Chapel, H.1
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