Prevalence and impact of constipation and bowel dysfunction induced by strong opioids: A cross-sectional survey of 520 patients with cancer pain: DYONISOS study

Journal of Medical Economics

Volumn 16, Issue 12, 2013, Pages 1423-1433

  Abramowitz, L ^a   Beziaud N ^b   Labreze, L ^c   Giardina, V ^d   Causse C ^e   Chuberre, B ^e   Allaert, F A ^f   Perrot, S ^g  

^a BICHAT HOSPITAL   (France)

^b HÔPITAL MICHALLON   (France)

^c Service d'Anatomie Pathologique   (France)

^d Nephrology Unit   (France)

^e Mundipharma SAS   (France)

^f DIJON UNIVERSITY HOSPITAL   (France)

^g HÔTEL DIEU   (France)

Author keywords

Bowel dysfunction; Opioid induced constipation; Prevalence; Quality of life

Indexed keywords

LAXATIVE; NARCOTIC ANALGESIC AGENT;

ABDOMINAL PAIN; ADULT; ARTICLE; BLOATING; CANCER PAIN; CONSTIPATION; ENTEROPATHY; EPIGASTRIC PAIN; FEMALE; FLATULENCE; GASTROESOPHAGEAL REFLUX; HEALTH ECONOMICS; HOSPITALIZATION; HUMAN; KNOWLES ECCERSLEY SCOTT SYMPTOM; LOSS OF APPETITE; MAJOR CLINICAL STUDY; MALE; PAINFUL DEFECATION; PELVIC DISEASE; PRESCRIPTION; PREVALENCE; QUALITY OF LIFE; SCORING SYSTEM; SHORT FORM 12;

AGED; ANALGESICS, OPIOID; CONSTIPATION; CROSS-SECTIONAL STUDIES; FEMALE; GASTROINTESTINAL MOTILITY; HEALTH STATUS INDICATORS; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; OPIOID-RELATED DISORDERS; PAIN; PREVALENCE; QUALITY OF LIFE; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX;

EID: 84889864122     PISSN: 13696998     EISSN: 1941837X     Source Type: Journal    
DOI: 10.3111/13696998.2013.851082     Document Type: Article

References (29)

1. World Health Organization. Cancer pain relief. Geneva: WHO, 1996
2. De Luca A, Coupar IM. Insights into opioid action in the intestinal tract. Pharmacol Therapeut 1996;69:103-15
3. De Schepper HU, Cremonini F, Park MI, et al. Opioids and the gut: Pharmacology and current clinical experience. Neurogastroenterol Motil 2004;16:383-94
4. Holzer P. Opioids and opioid receptors in the enteric nervous system: From a problem in opioid analgesia to a possible new prokinetic therapy in humans. Neurosci Lett 2004;361:192-5
5. Holzer P. Treatment of opioid-induced gut dysfunction. Exp Opin Investig Drugs 2007;16:181-94
6. Mehendale SR, Yuan CS. Opioid-induced gastrointestinal dysfunction. Dig Dis 2006;24:105-12
7. Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil 2004;16:17-28
8. Panchal SJ, Muller-Schwefe P, Wurzelmann JI. Opioid-induced bowel dysfunction: Prevalence, pathophysiology and burden. Int J Clin Pract 2007;61:1181-7
9. Meuser T, Pietruck C, Radbruch L, et al. Symptoms during cancer pain treatment following WHO-guidelines: A longitudinal follow-up study of symptom prevalence, severity and etiology. Pain 2001;93:247-57
10. Sykes NP. The relationship between opioid use and laxative use in terminally ill cancer patients. Palliative Med 1998;12:375-82
11. Knowles CH, Scott SM, Legg PE, et al. Level of classification performance of KESS (symptom scoring system for constipation) validated in a prospective series of 105 patients. Dis Colon Rectum 2002;45:842-3
12. Rentz AM, van Hanswijck de Jonge P, Leyendecker P, et al. Observational, nonintervention, multicenter study for validation of the Bowel Function Index for constipation in European countries. Curr Med Res Opin 2011;27:35-44
13. Rentz AM, Yu R, Muller-Lissner S, et al. Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation. J Med Econ 2009;12:371-83
14. Choi YS, Billings JA. Opioid antagonists: A review of their role in palliative care, focusing on use in opioid-related constipation. J Pain Symptom Manage 2002;24:71-90
15. Fallon MT. Constipation in cancer patients: Prevalence, pathogenesis, and cost-related issues. Eur J Pain 1999;3:3-7
16. Marquis P, De La Loge C, Dubois D, et al. Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire. Scand J Gastroenterol 2005;40:540-51
17. Abramowitz L, Bé ziaud N, Caussé C, et al. Further validation of the psychometric properties of the Bowel Function Index for evaluating opioid-induced constipation (OIC). J Med Econ 2013;16:1434-41
18. McMillan SC. Assessing and managing opiate-induced constipation in adults with cancer. Cancer Control 2004;11:3-9
19. Knowles CH, Eccersley AJ, Scott SM, et al. Linear discriminant analysis of symptoms in patients with chronic constipation: Validation of a new scoring system (KESS). Dis Colon Rectum 2000;43:1419-26
20. Ueberall MA, Muddddller-Lissner S, Buschmann-Kramm C, et al. The Bowel Function Index for evaluating constipation in pain patients: Definition of a reference range for a non-constipated population of pain patients. J Int Med Res 2011;39:41-50
21. McCrea GL, Miaskowski C, Stotts NA, et al. Review article: Self-report measures to evaluate constipation. Aliment Pharm Therap 2008;27:638-48
22. Coffin B, Caussé C. Constipation assessment scales in adults: A literature review including the new Bowel Function Index. Expert Rev Gastroenterol Hepatol 2011;5:601-13
23. Bell TJ, Panchal SJ, Miaskowski C, et al. The prevalence, severity, and impact of opioid-induced bowel dysfunction: Results of a US and European Patient Survey (PROBE 1). Pain Med 2009;10:35-42
24. Krakowski I, Delorme T, Vuillemin N, et al. [Observational study of the initial prescription of level 3 analgesics in cancer patients.]. Bull Cancer 2009;96:59-66
25. Cook SF, Lanza L, Zhou X, et al. Gastrointestinal side effects in chronic opioid users: Results from a population-based survey. Aliment Pharm Therap 2008;27:1224-32
26. Pappagallo M. Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg 2001;182:11S-18S
27. Candrilli SD, Davis KL, Iyer S. Impact of constipation on opioid use patterns, health care resource utilization, and costs in cancer patients on opioid therapy. J Pain Palliat Care Pharmacother 2009;23:231-41
28. Bell T, Annunziata K, Leslie JB. Opioid-induced constipation negatively impacts pain management, productivity, and health-related quality of life: Findings from the National Health and Wellness Survey. J Opioid Manag 2009;5:137-44
29. Kwong WJ, Diels J, Kavanagh S. Costs of gastrointestinal events after outpatient opioid treatment for non-cancer pain. Ann Pharmacother 2010;44:630-40