Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients

Critical Care

Volumn 17, Issue 6, 2013, Pages

  Lorente, Leonardo ^a   Martín, María M ^b   Abreu González, Pedro ^c   Domínguez Rodriguez, Alberto ^a   Labarta, Lorenzo ^d   Díaz, César ^e   Solé Violán, Jordi ^f   Ferreres, José ^g   Cabrera, Judith ^a   Igeño, Jose Carlos ^b   Jiménez, Alejandro ^a  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

^d HOSPITAL SAN JORGE   (Spain)

^e HOSPITAL UNIVERSITARIO INSULAR DE GRAN CANARIA   (Spain)

^f Hospital Universitario Dr   (Spain)

^g HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; MALONALDEHYDE;

ADULT; AGED; APACHE; ARTICLE; BLOOD LEVEL; BLOODSTREAM INFECTION; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; HEMATOLOGIC DISEASE; HUMAN; KIDNEY DISEASE; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MIDDLE AGED; MORTALITY; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SEPSIS; BLOOD; CLINICAL TRIAL; INTENSIVE CARE UNIT; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; PROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX;

AGED; APACHE; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; LACTIC ACID; MALE; MALONDIALDEHYDE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PROSPECTIVE STUDIES; SEPSIS; SEVERITY OF ILLNESS INDEX;

EID: 84889859453     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc13155     Document Type: Article

References (31)

1. Rocha M, Herance R, Rovira S, Hernández-Mijares A, Victor VM. Mitochondrial dysfunction and antioxidant therapy in sepsis. Infect Disord Drug Targets 2012, 12:161-178. 10.2174/187152612800100189, 22420514.
2. Galley HF. Oxidative stress and mitochondrial dysfunction in sepsis. Br J Anaesth 2011, 107:57-64. 10.1093/bja/aer093, 21596843.
3. Galley HF. Bench-to-bedside review: targeting antioxidants to mitochondria in sepsis. Crit Care 2010, 14:230. 2945094, 20804578.
4. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990, 186:421-431.
5. Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A. Biomarkers of oxidative damage in human disease. Clin Chem 2006, 52:601-623. 10.1373/clinchem.2005.061408, 16484333.
6. Ogilvie AC, Groeneveld AB, Straub JP, Thijs LG. Plasma lipid peroxides and antioxidants in human septic shock. Intensive Care Med 1991, 17:40-44. 10.1007/BF01708408, 1645378.
7. Erdem SS, Yerlikaya FH, Çiçekler H, Gül M. Association between ischemia-modified albumin, homocysteine, vitamin B(12) and folic acid in patients with severe sepsis. Clin Chem Lab Med 2012, 50:1417-1421.
8. Gelain DP, de Bittencourt Pasquali MA, Comim MC, Grunwald MS, Ritter C, Tomasi CD, Alves SC, Quevedo J, Dal-Pizzol F, Moreira JC. Serum heat shock protein 70 levels, oxidant status, and mortality in sepsis. Shock 2011, 35:466-470. 10.1097/SHK.0b013e31820fe704, 21330950.
9. Andresen M, Regueira T, Bruhn A, Perez D, Strobel P, Dougnac A, Marshall G, Leighton F. Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock. Mediators Inflamm 2008, 2008:168652. 2430274, 18566692.
10. Toufekoula C, Papadakis V, Tsaganos T, Routsi C, Orfanos SE, Kotanidou A, Carrer DP, Raftogiannis M, Baziaka F, Giamarellos-Bourboulis EJ. Compartmentalization of lipid peroxidation in sepsis by multidrug-resistant gram-negative bacteria: experimental and clinical evidence. Crit Care 2013, 17:R6. 10.1186/cc11930, 23324310.
11. Goode HF, Cowley HC, Walker BE, Howdle PD, Webster NR. Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction. Crit Care Med 1995, 23:646-651. 10.1097/00003246-199504000-00011, 7712754.
12. Lorente L, Martín MM, Abreu-González P, Domínguez-Rodríguez A, Labarta L, Díaz C, Solé-Violán J, Ferreres J, Borreguero-León JM, Jiménez A, Morera-Fumero A. Prognostic value of malondialdehyde serum levels in severe sepsis: a multicenter study. PLoS One 2013, 8:e53741. 10.1371/journal.pone.0053741, 3544841, 23341989.
13. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G, International Sepsis Definitions Conference SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003, 2001:530-538. International Sepsis Definitions Conference.
14. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829. 10.1097/00003246-198510000-00009, 3928249.
15. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG, for the Working Group on Sepsis-related Problems of the European Society of Intensive Care Medicine The Sepsis-related Organ Failure Assessment (SOFA) score to describe organ dysfunction/failure. Intensive Care Med 1996, 22:707-710. 10.1007/BF01709751, 8844239, for the Working Group on Sepsis-related Problems of the European Society of Intensive Care Medicine.
16. Kikugawa K, Kojima T, Yamaki S, Kosugi H. Interpretation of the thiobarbituric acid reactivity of rat liver and brain homogenates in the presence of ferric ion and ethylediaminotetraacetic acid. Anal Biochem 1992, 202:249-255. 10.1016/0003-2697(92)90102-D, 1519749.
17. Harrell FE. Multivariable modelling strategies. Regression Modelling Strategies. With Applications to Linear Models, Logistic Regression, and Survival Analysis 2001, 53-85. New York, NY: Springer-Verlag, Harrell FE.
18. Ware LB, Fessel JP, May AK, Roberts LJ. Plasma biomarkers of oxidant stress and development of organ failure in severe sepsis. Shock 2011, 36:12-17. 10.1097/SHK.0b013e318217025a, 3117035, 21372753.
19. Andrades ME, Ritter C, Dal-Pizzol F. The role of free radicals in sepsis development. Front Biosci (Elite Ed) 2009, 1:277-287.
20. Andrades ME, Morina A, Spasić S, Spasojević I. Bench-to-bedside review. Sepsis from the redox point of view. Crit Care 2011, 15:230. 10.1186/cc10334, 3334726, 21996422.
21. Xing HY, Ling YL, Meng AH, Zhao XY, Huang XL. Melatonin improves vascular reactivity of endotoxemia rats. Sheng Li Xue Bao 2005, 57:367-372.
22. Sener G, Toklu H, Kapucu C, Ercan F, Erkanli G, Kaçmaz A, Tilki M, Yeǧen BC. Melatonin protects against oxidative organ injury in a rat model of sepsis. Surg Today 2005, 35:52-59.
23. Paskaloǧlu K, Sener G, Kapucu C, Ayanoǧlu-Dülger G. Melatonin treatment protects against sepsis-induced functional and biochemical changes in rat ileum and urinary bladder. Life Sci 2004, 74:1093-1104. 10.1016/j.lfs.2003.07.038, 14687650.
24. Fulia F, Gitto E, Cuzzocrea S, Reiter RJ, Dugo L, Gitto P, Barberi S, Cordaro S, Barberi I. Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: reduction by melatonin. J Pineal Res 2001, 31:343-349. 10.1034/j.1600-079X.2001.310409.x, 11703564.
25. Gitto E, Karbownik M, Reiter RJ, Tan DX, Cuzzocrea S, Chiurazzi P, Cordaro S, Corona G, Trimarchi G, Barberi I. Effects of melatonin treatment in septic newborns. Pediatr Res 2001, 50:756-760. 10.1203/00006450-200112000-00021, 11726736.
26. Sahib AS, Al-Jawad FH, Alkaisy AA. Effect of antioxidants on the incidence of wound infection in burn patients. Ann Burns Fire Disasters 2010, 23:199-205. 3188280, 21991225.
27. Srinivasan V, Pandi-Perumal SR, Spence DW, Kato H, Cardinali DP. Melatonin in septic shock: some recent concepts. J Crit Care 2010, 25:e1-e6.
28. Bourne RS, Mills GH. Melatonin: possible implications for the postoperative and critically ill patient. Intensive Care Med 2006, 32:371-379. 10.1007/s00134-005-0061-x, 16477412.
29. Escames G, Acuña-Castroviejo D, López LC, Tan DX, Maldonado MD, Sánchez-Hidalgo M, León J, Reiter RJ. Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence. J Pharm Pharmacol 2006, 58:1153-1165. 10.1211/jpp.58.9.0001, 16945173.
30. Rinaldi S, Landucci F, De Gaudio AR. Antioxidant therapy in critically septic patients. Curr Drug Targets 2009, 10:872-880. 10.2174/138945009789108774, 19799541.
31. Srinivasan V, Mohamed M, Kato H. Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent Pat Endocr Metab Immune Drug Discov 2012, 6:30-39. 10.2174/187221412799015317, 22264213.