-
2
-
-
18544364628
-
Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate
-
Pascolo E, Wenz C, Lingner J, Hauel N, Priepke H, et al. (2002) Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem 277: 15566-15572.
-
(2002)
J Biol Chem
, vol.277
, pp. 15566-15572
-
-
Pascolo, E.1
Wenz, C.2
Lingner, J.3
Hauel, N.4
Priepke, H.5
-
3
-
-
13544268344
-
Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532
-
El-Daly H, Kull M, Zimmermann S, Pantic M, Waller CF, et al. (2005) Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532. Blood 105: 1742-1749.
-
(2005)
Blood
, vol.105
, pp. 1742-1749
-
-
El-Daly, H.1
Kull, M.2
Zimmermann, S.3
Pantic, M.4
Waller, C.F.5
-
4
-
-
23944516595
-
Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment
-
Ward RJ, Autexier C (2005) Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. Mol Pharmacol 68: 779-786.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 779-786
-
-
Ward, R.J.1
Autexier, C.2
-
5
-
-
84878616949
-
Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001
-
Inderberg-Suso EM, Trachsel S, Lislerud K, Rasmussen AM, Gaudernack G (2012) Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001. Oncoimmunology 1: 670-686.
-
(2012)
Oncoimmunology
, vol.1
, pp. 670-686
-
-
Inderberg-Suso, E.M.1
Trachsel, S.2
Lislerud, K.3
Rasmussen, A.M.4
Gaudernack, G.5
-
6
-
-
84856324806
-
Clinical outcome of patients with various advanced cancer types vaccinated with an optimized cryptic human telomerase reverse transcriptase (TERT) peptide: Results of an expanded phase II study
-
Kotsakis A, Vetsika EK, Christou S, Hatzidaki D, Vardakis N, et al. (2012) Clinical outcome of patients with various advanced cancer types vaccinated with an optimized cryptic human telomerase reverse transcriptase (TERT) peptide: results of an expanded phase II study. Ann Oncol 23: 442-449.
-
(2012)
Ann Oncol
, vol.23
, pp. 442-449
-
-
Kotsakis, A.1
Vetsika, E.K.2
Christou, S.3
Hatzidaki, D.4
Vardakis, N.5
-
7
-
-
84878813349
-
A multicenter randomized phase IIb efficacy study of Vx-001, a peptide-based cancer vaccine as maintenance treatment in advanced non-small-cell lung cancer: Treatment rationale and protocol dynamics
-
Georgoulias V, Douillard JY, Khayat D, Manegold C, Rosell R, et al. (2013) A multicenter randomized phase IIb efficacy study of Vx-001, a peptide-based cancer vaccine as maintenance treatment in advanced non-small-cell lung cancer: treatment rationale and protocol dynamics. Clin Lung Cancer 14: 461-465.
-
(2013)
Clin Lung Cancer
, vol.14
, pp. 461-465
-
-
Georgoulias, V.1
Douillard, J.Y.2
Khayat, D.3
Manegold, C.4
Rosell, R.5
-
9
-
-
39749163359
-
Telomerase and cancer therapeutics
-
Harley CB (2008) Telomerase and cancer therapeutics. Nat Rev Cancer 8: 167-179.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 167-179
-
-
Harley, C.B.1
-
10
-
-
79954570122
-
Chemistry in human telomere biology: Structure, function and targeting of telomere DNA/RNA
-
Xu Y (2011) Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA. Chem Soc Rev 40: 2719-2740.
-
(2011)
Chem Soc Rev
, vol.40
, pp. 2719-2740
-
-
Xu, Y.1
-
11
-
-
34248184169
-
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells
-
Yaar M, Eller MS, Panova I, Kubera J, Wee LH, et al. (2007) Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res 9: R13.
-
(2007)
Breast Cancer Res
, vol.9
-
-
Yaar, M.1
Eller, M.S.2
Panova, I.3
Kubera, J.4
Wee, L.H.5
-
12
-
-
0036352910
-
Induction of apoptosis by telomere 3' overhang-specific DNA
-
Eller MS, Puri N, Hadshiew IM, Venna SS, Gilchrest BA (2002) Induction of apoptosis by telomere 3' overhang-specific DNA. Exp Cell Res 276: 185-193.
-
(2002)
Exp Cell Res
, vol.276
, pp. 185-193
-
-
Eller, M.S.1
Puri, N.2
Hadshiew, I.M.3
Venna, S.S.4
Gilchrest, B.A.5
-
13
-
-
58249084335
-
Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: Mechanism and therapeutic potential
-
Longe HO, Romesser PB, Rankin AM, Faller DV, Eller MS, et al. (2009) Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential. Int J Cancer 124: 473-482.
-
(2009)
Int J Cancer
, vol.124
, pp. 473-482
-
-
Longe, H.O.1
Romesser, P.B.2
Rankin, A.M.3
Faller, D.V.4
Eller, M.S.5
-
14
-
-
84880302835
-
Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma
-
Pitman RT, Wojdyla L, Puri N (2013) Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma. Oncotarget 4: 761-771.
-
(2013)
Oncotarget
, vol.4
, pp. 761-771
-
-
Pitman, R.T.1
Wojdyla, L.2
Puri, N.3
-
15
-
-
84876976986
-
Novel anticancer therapeutics targeting telomerase
-
Ruden M, Puri N (2013) Novel anticancer therapeutics targeting telomerase. Cancer Treat Rev 39: 444-456.
-
(2013)
Cancer Treat Rev
, vol.39
, pp. 444-456
-
-
Ruden, M.1
Puri, N.2
-
17
-
-
84889681176
-
-
Annual Meeting 2013, Washington, DC
-
Chiappori A, Kolevska T, Burington B, Spiegel DR, Hager S, et al. (2013) A randomized Phase II STudy of the Telomerase Inhibitor Imetelstat as a Maintenance Therapy for Advanced Non-Small Cell Lung Cancer. Annual Meeting 2013, Washington, DC.
-
(2013)
A Randomized Phase II STudy of the Telomerase Inhibitor Imetelstat As a Maintenance Therapy For Advanced Non-Small Cell Lung Cancer
-
-
Chiappori, A.1
Kolevska, T.2
Burington, B.3
Spiegel, D.R.4
Hager, S.5
-
18
-
-
84889650738
-
-
Chiappori A, Bassett K, Burington B, Spiegel DR, Hager S, et al. (2013) Improved Progression Free Survival (PFS) in Patients with Short Tumor Telomere Length: Subgroup Analysis from a Randomized Phase II Study of the Telomerase Inhibitor Imetelstat as a Maintenance Therapy for Advanced NSCLC.
-
(2013)
Improved Progression Free Survival (PFS) In Patients With Short Tumor Telomere Length: Subgroup Analysis From a Randomized Phase II Study of the Telomerase Inhibitor Imetelstat As a Maintenance Therapy For Advanced NSCLC
-
-
Chiappori, A.1
Bassett, K.2
Burington, B.3
Spiegel, D.R.4
Hager, S.5
-
19
-
-
84889651866
-
-
2013 Congress of the European Hematology Association
-
Baerlocher G, Oppliger Leibundgut E, Spitzer G, Ottmann O, Olatoyosi O, et al. (2013) Imetelstat: A Novel Approach with Robust Hematologic and Molecular Responses in a Phase II Study in Patients with Essential Thrombocythemia Who are Refractory or Intolerant to Prior Therapy. 2013 Congress of the European Hematology Association.
-
(2013)
Imetelstat: A Novel Approach With Robust Hematologic and Molecular Responses In a Phase II Study In Patients With Essential Thrombocythemia Who Are Refractory Or Intolerant to Prior Therapy
-
-
Baerlocher, G.1
Oppliger Leibundgut, E.2
Spitzer, G.3
Ottmann, O.4
Olatoyosi, O.5
-
20
-
-
79960014113
-
Phase I study of imetelstat (GRN163L) in combination with paclitaxel (P) and bevacizumab (B) in patients (pts) with locally recurrent or metastatic breast cancer (MBC)
-
M Kozloff GWS, FM Benedetti, A Starr, JA Wallace, MJ Stuart, et al. (2010) Phase I study of imetelstat (GRN163L) in combination with paclitaxel (P) and bevacizumab (B) in patients (pts) with locally recurrent or metastatic breast cancer (MBC). J Clin Oncol 28: 15s.
-
(2010)
J Clin Oncol
, vol.28
-
-
Kozloff, M.G.W.S.1
Benedetti, F.M.2
Starr, A.3
Wallace, J.A.4
Stuart, M.J.5
-
21
-
-
84880052883
-
A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer
-
abstr LBA4004
-
Middleton G, Valle J, Wadsley J, Propper D, Coxon F, et al. (2013) A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer. J Clin Oncol (suppl; abstr LBA4004).
-
(2013)
J Clin Oncol
, Issue.SUPPL.
-
-
Middleton, G.1
Valle, J.2
Wadsley, J.3
Propper, D.4
Coxon, F.5
-
22
-
-
33745638729
-
Telomerase peptide vaccination: A phase I/II study in patients with non-small cell lung cancer
-
Brunsvig PF, Aamdal S, Gjertsen MK, Kvalheim G, Markowski-Grimsrud CJ, et al. (2006) Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer. Cancer Immunol Immunother 55: 1553-1564.
-
(2006)
Cancer Immunol Immunother
, vol.55
, pp. 1553-1564
-
-
Brunsvig, P.F.1
Aamdal, S.2
Gjertsen, M.K.3
Kvalheim, G.4
Markowski-Grimsrud, C.J.5
|