Spectrophotometric quantification of total urinary porphyrins as a screening test for porphyrias: Threshold value revisited

Clinical Biochemistry

Volumn 46, Issue 18, 2013, Pages 1825-1829

  Wolff, Fleur ^a   Gulbis, Béatrice ^a   Cotton, Frédéric ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

Porphyria; Receiver operator curves; Screening test

Indexed keywords

AMINOLEVULINIC ACID; COPROPORPHYRIN; CREATININE; PORPHOBILINOGEN; PORPHOBILINOGEN DEAMINASE; PORPHYRIN; UROPORPHYRIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; CREATININE URINE LEVEL; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; FLAME PHOTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; PORPHYRIA; PORPHYRIA CUTANEA TARDA; PRESCHOOL CHILD; PRIORITY JOURNAL; REFERENCE VALUE; RETROSPECTIVE STUDY; SCHOOL CHILD; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY; URINE LEVEL;

PORPHYRIA; RECEIVER OPERATOR CURVES; SCREENING TEST;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHILD; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATININE; FEMALE; HUMANS; MALE; MIDDLE AGED; PORPHYRIAS; PORPHYRINS; RETROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY; YOUNG ADULT;

EID: 84889643383     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2013.08.021     Document Type: Article

References (17)

1. Elder G.H., Smith S.G., Smyth S.J. Laboratory investigation of the porphyrias. Ann Clin Biochem 1990, 27:395-412.
2. Deacon A.C., Elder G.H. ACP Best Practice No 165: front line tests for the investigation of suspected porphyria. J Clin Pathol 2001, 54:500-507.
3. Deacon A.C. Performance of screening tests for porphyria. Ann Clin Biochem 1988, 25:392-397.
4. Westerlund J., Pudek M., Schreiber W.E. A rapid and accurate spectrofluorometric method for quantification and screening of urinary porphyrins. Clin Chem 1988, 34:345-351.
5. Hindmarsh J.T., Oliveras L., Greenway D.C. Biochemical differentiation of the porphyrias. Clin Biochem 1999, 32:609-619.
6. Zuijderhoudt F.M., Dorresteijn-de Bok J., Te Velde K. Evaluation of a first-line spectrophotometric screening test for increased urine porphyrin excretion. Ann Clin Biochem 1995, 32:186-189.
7. Blake D., Poulos V., Rossi R. Diagnosis of porphyria-recommended methods for peripheral laboratories. Clin Biochem Rev 1992, 13(Suppl. 1):S1-S24.
8. McManus J., Blake D., Ratnaike S. An assay of uroporphyrinogen decarboxylase in erythrocytes. Clin Chem 1988, 34:2355-2357.
9. Rimington C. Spectral absorption coefficients of some porphyrins in the Soret-Band region. Biochem J 1960, 75:620-623.
10. Macours P., Cotton F. Improvement in HPLC separation of porphyrin isomers and application to biochemical diagnosis of porphyrias. Clin Chem Lab Med 2006, 44:1433-1440.
11. Wright D.J., Lim C.K. Simultaneous determination of hydroxymethylbilane synthase and uroporphyrinogen-III synthase in erythrocytes by high-performance liquid chromatography. Biochem J 1983, 213:85-88.
12. Long C., Smyth S.J., Woolf J., Murphy G.M., Finlay A.Y., Newcombe R.G., et al. Detection of latent variegate porphyria by fluorescence emission spectroscopy of plasma. Br J Dermatol 1993, 129:9-13.
13. Aarsand A.K., Villanger J.H., Støle E., Deybach J.C., Marschen J., To-Figueras J., et al. European specialist porphyria laboratories: diagnostic strategies, analytical quality, clinical interpretation, and reporting as assessed by an external quality assurance program. Clin Chem 2011, 57:1514-1523.
14. Hindmarsh J.T. The porphyrias, appropriate test selection. Clin Chim Acta 2003, 333:203-207.
15. Boynton S.B., Roth K.S. Rapid and accurate random urinary porphyrin quantitation. Clin Chim Acta 1994, 226:1-11.
16. Nuttall K.L., Pingree S.S., Ashwood E.R. Reference intervals for 24-hour and random urine porphyrins. Ann Clin Lab Sci 1996, 26:313-322.
17. Bossuyt P.M. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clin Chem 2003, 49:7-18.