메뉴 건너뛰기




Volumn 58, Issue 11, 2013, Pages 3088-3093

Polypharmacy of osteoarthritis: The perfect intestinal storm

Author keywords

Arthritis; Enteropathy; Gastric acid; Nonsteroidal anti inflammatory drugs; Proton pump inhibitors; Ulcer

Indexed keywords

ACETYLSALICYLIC ACID; CIMETIDINE; FAMOTIDINE; LANSOPRAZOLE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; RANITIDINE; ROFECOXIB;

EID: 84889578648     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2777-8     Document Type: Review
Times cited : (38)

References (45)
  • 1
    • 84872319640 scopus 로고    scopus 로고
    • Epidemiology of osteoarthritis
    • 10.1016/j.rdc.2012.10.004
    • Neogi T, Zhang Y. Epidemiology of osteoarthritis. Rheumatol Dis Clin N Am. 2013;39:1-19.
    • (2013) Rheumatol Dis Clin N Am , vol.39 , pp. 1-19
    • Neogi, T.1    Zhang, Y.2
  • 2
    • 84859773681 scopus 로고    scopus 로고
    • American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip and knee
    • 10.1002/acr.21596
    • Hochber MC, Altman RD, April KT, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip and knee. Arthritis Care Res. 2012;64:465-474.
    • (2012) Arthritis Care Res , vol.64 , pp. 465-474
    • Hochber, M.C.1    Altman, R.D.2    April, K.T.3
  • 3
    • 59149099329 scopus 로고    scopus 로고
    • Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: Benefits versus risks
    • Canadian Association of Gastroenterology Consensus Group 19053986 10.1111/j.1365-2036.2008.03905.x 1:STN:280:DC%2BD1M7hs1altA%3D%3D
    • Rostom A, Moayyedi P, Hunt R, Canadian Association of Gastroenterology Consensus Group. Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks. Aliment Pharmacol Ther. 2009;29:481-496.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 481-496
    • Rostom, A.1    Moayyedi, P.2    Hunt, R.3
  • 4
    • 80053596796 scopus 로고    scopus 로고
    • Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis
    • 21745447 10.1053/j.gastro.2011.06.075 1:CAS:528:DC%2BC3MXht1Ois73O
    • Wallace JL, Syer S, Denou E, et al. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology. 2011;141:1314-1322.
    • (2011) Gastroenterology , vol.141 , pp. 1314-1322
    • Wallace, J.L.1    Syer, S.2    Denou, E.3
  • 5
    • 85046588922 scopus 로고    scopus 로고
    • Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice
    • 19574968 10.1038/ajg.2009.164
    • Lanas A, García-Rodríguez LA, Polo-Tomás M, et al. Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice. Am J Gastroenterol. 2009;104:1633-1641.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1633-1641
    • Lanas, A.1    García-Rodríguez, L.A.2    Polo-Tomás, M.3
  • 7
    • 84867619456 scopus 로고    scopus 로고
    • Exacerbation of NSAID-induced small intestinal lesions by anti-secretory drugs in rats: The role of intestinal motility
    • 22854201 10.1124/jpet.112.197475 1:CAS:528:DC%2BC38XhsFKktb3L
    • Satoh H, Amagase K, Takeuchi K. Exacerbation of NSAID-induced small intestinal lesions by anti-secretory drugs in rats: the role of intestinal motility. J Pharmacol Exp Ther. 2012;343:270-277.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 270-277
    • Satoh, H.1    Amagase, K.2    Takeuchi, K.3
  • 8
    • 33645022077 scopus 로고    scopus 로고
    • Is non-steroidal anti-inflammatory drug (NSAID) enteropathy clinically more important than NSAID gastropathy?
    • 16517800 10.1136/pgmj.2005.039586 1:CAS:528:DC%2BD28XjsFagsbs%3D
    • Adebayo D, Bjarnason I. Is non-steroidal anti-inflammatory drug (NSAID) enteropathy clinically more important than NSAID gastropathy? Postgrad Med J. 2006;82:186-191.
    • (2006) Postgrad Med J , vol.82 , pp. 186-191
    • Adebayo, D.1    Bjarnason, I.2
  • 9
    • 7044239406 scopus 로고    scopus 로고
    • Aging, the gastrointestinal tract, and risk of acid-related disease
    • Greenwald DA. Aging, the gastrointestinal tract, and risk of acid-related disease. Am J Med. 2004;117:8-13.
    • (2004) Am J Med , vol.117 , pp. 8-13
    • Greenwald, D.A.1
  • 10
    • 33744976771 scopus 로고    scopus 로고
    • Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials
    • 16740558 10.1136/bmj.332.7553.1302 1:CAS:528:DC%2BD28XntVSrtb4%3D
    • Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006;332:1302-1308.
    • (2006) BMJ , vol.332 , pp. 1302-1308
    • Kearney, P.M.1    Baigent, C.2    Godwin, J.3    Halls, H.4    Emberson, J.R.5    Patrono, C.6
  • 11
    • 0034707105 scopus 로고    scopus 로고
    • Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
    • 11087881 10.1056/NEJM200011233432103 1:CAS:528:DC%2BD3cXos1OhurY%3D
    • Bombardier C, Laine L, Reicin A, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med. 2000;343:1520-1528.
    • (2000) N Engl J Med , vol.343 , pp. 1520-1528
    • Bombardier, C.1    Laine, L.2    Reicin, A.3
  • 12
    • 0034644396 scopus 로고    scopus 로고
    • Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib long-term arthritis safety study
    • 10979111 10.1001/jama.284.10.1247 1:CAS:528:DC%2BD3cXmvFKmuro%3D
    • Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. Celecoxib long-term arthritis safety study. JAMA. 2000;284:1247-1255.
    • (2000) JAMA , vol.284 , pp. 1247-1255
    • Silverstein, F.E.1    Faich, G.2    Goldstein, J.L.3
  • 13
    • 4143087071 scopus 로고    scopus 로고
    • Ulcer formation with low dose enteric-coated aspirin and the effect of COX-2-selective inhibition: A double-blind trial
    • 10.1053/j.gastro.2004.05.001
    • Laine L, Maller ES, Yu C, Quan H, Simon T. Ulcer formation with low dose enteric-coated aspirin and the effect of COX-2-selective inhibition: a double-blind trial. Gastroenterology. 2003;127:395-402.
    • (2003) Gastroenterology , vol.127 , pp. 395-402
    • Laine, L.1    Maller, E.S.2    Yu, C.3    Quan, H.4    Simon, T.5
  • 14
    • 0032973694 scopus 로고    scopus 로고
    • Selective COX-2 inhibitors: Is the water becoming muddy?
    • 10101953 10.1016/S0165-6147(98)01283-8 1:CAS:528:DyaK1MXks1amsLs%3D
    • Wallace JL. Selective COX-2 inhibitors: is the water becoming muddy? Trends Pharmacol Sci. 1999;20:4-6.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 4-6
    • Wallace, J.L.1
  • 15
    • 0022938794 scopus 로고
    • The pathogenesis and consequence of non steroidal anti-inflammatory drug induced small intestinal inflammation in man
    • 10.3109/03009748709096722 1:STN:280:DyaL1c7is12gtQ%3D%3D
    • Bjarnason I, Zanelli G, Smith T, et al. The pathogenesis and consequence of non steroidal anti-inflammatory drug induced small intestinal inflammation in man. Scand J Rheumatol. 1987;64:55-62.
    • (1987) Scand J Rheumatol , vol.64 , pp. 55-62
    • Bjarnason, I.1    Zanelli, G.2    Smith, T.3
  • 16
    • 67650989383 scopus 로고    scopus 로고
    • GI bleeding: Problems that persist
    • 10.1016/j.gie.2008.12.247
    • McCarthy DM. GI bleeding: problems that persist. Gastrointest Endosc. 2009;7:225-228.
    • (2009) Gastrointest Endosc , vol.7 , pp. 225-228
    • McCarthy, D.M.1
  • 17
    • 35748970752 scopus 로고    scopus 로고
    • Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: A cross-sectional capsule endoscopy study
    • 17625980 10.1016/j.cgh.2007.04.031
    • Maiden L, Thjodleifsson B, Seigal A, et al. Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: a cross-sectional capsule endoscopy study. Clin Gastroenterol Hepatol. 2007;5:1040-1045.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 1040-1045
    • Maiden, L.1    Thjodleifsson, B.2    Seigal, A.3
  • 18
    • 0032510315 scopus 로고    scopus 로고
    • A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid suppression trial: Ranitidine versus omeprazole for NSAID-associated ulcer treatment (ASTRONAUT) study group
    • 9494148 10.1056/NEJM199803123381104 1:CAS:528:DyaK1cXitFars78%3D
    • Yeomans ND, Tulassay Z, Juhász L, et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid suppression trial: ranitidine versus omeprazole for NSAID-associated ulcer treatment (ASTRONAUT) study group. N Engl J Med. 1998;338:719-726.
    • (1998) N Engl J Med , vol.338 , pp. 719-726
    • Yeomans, N.D.1    Tulassay, Z.2    Juhász, L.3
  • 19
    • 7044254965 scopus 로고    scopus 로고
    • Cardioprotective effects and gastrointestinal risks of aspirin: Maintaining the delicate balance
    • 15478856 1:CAS:528:DC%2BD2cXos1ers70%3D
    • Kimmey MB. Cardioprotective effects and gastrointestinal risks of aspirin: maintaining the delicate balance. Am J Med. 2004;117:72S-78S.
    • (2004) Am J Med , vol.117
    • Kimmey, M.B.1
  • 20
    • 0026674243 scopus 로고
    • Objective evidence of aspirin use in both ulcer and non-ulcer upper and lower gastrointestinal bleeding/perforation
    • Lanas A, Sekar MC, Hirschowitz BI. Objective evidence of aspirin use in both ulcer and non-ulcer upper and lower gastrointestinal bleeding/perforation. Gastroenterology. 1992;103:8629-8637.
    • (1992) Gastroenterology , vol.103 , pp. 8629-8637
    • Lanas, A.1    Sekar, M.C.2    Hirschowitz, B.I.3
  • 21
    • 0036191305 scopus 로고    scopus 로고
    • Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding
    • 11876703 10.1046/j.1365-2036.2002.01197.x 1:STN:280: DC%2BD387ksFSktQ%3D%3D
    • Stack WA, Atherton JC, Hawkey GM, Logan RF, Hawkey CJ. Interactions between Helicobacter pylori and other risk factors for peptic ulcer bleeding. Aliment Pharmacol Ther. 2002;16:497-506.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 497-506
    • Stack, W.A.1    Atherton, J.C.2    Hawkey, G.M.3    Logan, R.F.4    Hawkey, C.J.5
  • 22
    • 84860195560 scopus 로고    scopus 로고
    • Lower GI bleeding is more common than upper among patients on dual antiplatelet therapy: Long-term follow-up of a cohort of patients commonly using PPI co-therapy
    • 22523056 10.1136/heartjnl-2012-301632
    • Casado Arroyo RC, Polo-Tomas M, Roncalés MP, Scheiman J, Lanas A. Lower GI bleeding is more common than upper among patients on dual antiplatelet therapy: long-term follow-up of a cohort of patients commonly using PPI co-therapy. Heart. 2012;98:718-723.
    • (2012) Heart , vol.98 , pp. 718-723
    • Casado Arroyo, R.C.1    Polo-Tomas, M.2    Roncalés, M.P.3    Scheiman, J.4    Lanas, A.5
  • 23
    • 0032600854 scopus 로고    scopus 로고
    • Sustained release and enteric coated NSAIDs: Are they really GI safe?
    • 10951657 1:CAS:528:DyaK1MXks1Whsr0%3D
    • Davies NM. Sustained release and enteric coated NSAIDs: are they really GI safe? J Pharm Pharm Sci. 1999;2:5-14.
    • (1999) J Pharm Pharm Sci , vol.2 , pp. 5-14
    • Davies, N.M.1
  • 24
    • 84865764270 scopus 로고    scopus 로고
    • Differences in the severity of small bowel mucosal injury based on the type of aspirin as evaluated by capsule endoscopy
    • 22749649 10.1016/j.dld.2012.05.016 1:CAS:528:DC%2BC38XpvFOktLk%3D
    • Endo H, Sakai E, Higurashi T, et al. Differences in the severity of small bowel mucosal injury based on the type of aspirin as evaluated by capsule endoscopy. Dig Liver Dis. 2012;44:833-838.
    • (2012) Dig Liver Dis , vol.44 , pp. 833-838
    • Endo, H.1    Sakai, E.2    Higurashi, T.3
  • 25
    • 84872728410 scopus 로고    scopus 로고
    • Drug resistance and pseudoresistance: An unintended consequence of enteric coating aspirin
    • 23212718 10.1161/CIRCULATIONAHA.112.117283 1:CAS:528:DC%2BC3sXhsV2rtLk%3D
    • Grosser T, Fries S, Lawson LA, Kapoor SC, Grant GR, FitzGerald GA. Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin. Circulation. 2013;127:377-385.
    • (2013) Circulation , vol.127 , pp. 377-385
    • Grosser, T.1    Fries, S.2    Lawson, L.A.3    Kapoor, S.C.4    Grant, G.R.5    Fitzgerald, G.A.6
  • 26
    • 55949135789 scopus 로고    scopus 로고
    • Prostaglandins, NSAIDs and gastric mucosal protection: Why doesn't the stomach digest itself?
    • 18923189 10.1152/physrev.00004.2008 1:CAS:528:DC%2BD1cXhtlGgtbbM
    • Wallace JL. Prostaglandins, NSAIDs and gastric mucosal protection: why doesn't the stomach digest itself? Physiol Rev. 2008;88:1547-1565.
    • (2008) Physiol Rev , vol.88 , pp. 1547-1565
    • Wallace, J.L.1
  • 27
    • 82955184551 scopus 로고    scopus 로고
    • NSAID gastropathy and enteropathy: Distinct pathogenesis likely necessitates distinct prevention strategies
    • 21627632 10.1111/j.1476-5381.2011.01509.x 1:CAS:528:DC%2BC3MXhs1yksLjI
    • Wallace JL. NSAID gastropathy and enteropathy: distinct pathogenesis likely necessitates distinct prevention strategies. Br J Pharmacol. 2012;165:67-74.
    • (2012) Br J Pharmacol , vol.165 , pp. 67-74
    • Wallace, J.L.1
  • 28
    • 84875621014 scopus 로고    scopus 로고
    • Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy
    • 23569332 10.3748/wjg.v19.i12.1861
    • Wallace JL. Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy. World J Gastroenterol. 2013;19:1861-1876.
    • (2013) World J Gastroenterol , vol.19 , pp. 1861-1876
    • Wallace, J.L.1
  • 29
    • 0028343722 scopus 로고
    • Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds
    • 8174980 10.1136/gut.35.4.455 1:CAS:528:DyaK2cXlsVykt7g%3D
    • Verdu E, Viani F, Armstrong D, et al. Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds. Gut. 1994;35:455-460.
    • (1994) Gut , vol.35 , pp. 455-460
    • Verdu, E.1    Viani, F.2    Armstrong, D.3
  • 30
    • 33644892551 scopus 로고    scopus 로고
    • Review article: Proton pump inhibitors and bacterial overgrowth
    • 16393275 10.1111/j.1365-2036.2006.02707.x 1:STN:280: DC%2BD28%2FgslShtQ%3D%3D
    • Williams C, McColl KE. Review article: proton pump inhibitors and bacterial overgrowth. Aliment Pharmacol Ther. 2006;23:3-10.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 3-10
    • Williams, C.1    McColl, K.E.2
  • 31
    • 77952744764 scopus 로고    scopus 로고
    • Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy
    • 20060064 10.1016/j.cgh.2009.12.022
    • Lombardo L, Foti M, Ruggia O, Chiecchio A. Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy. Clin Gastroenterol Hepatol. 2010;8:504-508.
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 504-508
    • Lombardo, L.1    Foti, M.2    Ruggia, O.3    Chiecchio, A.4
  • 32
    • 79952499261 scopus 로고    scopus 로고
    • Effects of long-term PPI on producing bowel symptoms and SIBO
    • 10.1111/j.1365-2362.2010.02419.x
    • Compare D, Pica L, Rocco A, et al. Effects of long-term PPI on producing bowel symptoms and SIBO. Eur Clin Invest. 2011;41:380-386.
    • (2011) Eur Clin Invest , vol.41 , pp. 380-386
    • Compare, D.1    Pica, L.2    Rocco, A.3
  • 33
    • 0038402608 scopus 로고    scopus 로고
    • Proton pump inhibitors are associated with elevation of faecal calprotectin and may affect specificity
    • 12702920
    • Poullis A, Foster R, Mendall MA, Shreeve D, Wiener K. Proton pump inhibitors are associated with elevation of faecal calprotectin and may affect specificity. Eur J Gastroenterol Hepatol. 2003;15:573-574.
    • (2003) Eur J Gastroenterol Hepatol , vol.15 , pp. 573-574
    • Poullis, A.1    Foster, R.2    Mendall, M.A.3    Shreeve, D.4    Wiener, K.5
  • 34
    • 79959340763 scopus 로고    scopus 로고
    • Faecal calprotectin: A biomarker of gastrointestinal disease in systemic sclerosis
    • 21205026 10.1111/j.1365-2796.2010.02340.x 1:CAS:528:DC%2BC3MXhtVKksrzF
    • Andreasson K, Scheja A, Saxne T, Ohlsson B, Hesselstrand R. Faecal calprotectin: a biomarker of gastrointestinal disease in systemic sclerosis. J Intern Med. 2011;270:50-57.
    • (2011) J Intern Med , vol.270 , pp. 50-57
    • Andreasson, K.1    Scheja, A.2    Saxne, T.3    Ohlsson, B.4    Hesselstrand, R.5
  • 35
    • 84857692820 scopus 로고    scopus 로고
    • Considerations for the use of proton-pump inhibitors in older adults
    • 22330952 10.4140/TCP.n.2012.114
    • Desilets AR, Asal NJ, Dunican KC. Considerations for the use of proton-pump inhibitors in older adults. Consult Pharm. 2012;27:114-120.
    • (2012) Consult Pharm , vol.27 , pp. 114-120
    • Desilets, A.R.1    Asal, N.J.2    Dunican, K.C.3
  • 36
    • 67651092059 scopus 로고    scopus 로고
    • Microscopic colitis associated with omeprazole and esomeprazole exposure
    • 19142168 10.1097/MCG.0b013e31817d3fa1 1:CAS:528:DC%2BD1MXnsFyhsb8%3D
    • Wilcox GM, Mattia AR. Microscopic colitis associated with omeprazole and esomeprazole exposure. J Clin Gastroenterol. 2009;43:551-553.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 551-553
    • Wilcox, G.M.1    Mattia, A.R.2
  • 37
    • 78649486172 scopus 로고    scopus 로고
    • Proton pump inhibitor use is associated with an increased risk for microscopic colitis: A case-control study
    • 10.1111/j.1365-2036.2010.04453.x
    • Keszthelyl D, Jansen SV, Schouten GA. Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study. Aliment Pharmacol Ther. 2010;32:1124-1128.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 1124-1128
    • Keszthelyl, D.1    Jansen, S.V.2    Schouten, G.A.3
  • 38
    • 79953232028 scopus 로고    scopus 로고
    • Microscopic colitis
    • 21303675 10.1053/j.gastro.2011.02.003
    • Pardi DS, Kelly CP. Microscopic colitis. Gastroenterology. 2011;140:1155-1165.
    • (2011) Gastroenterology , vol.140 , pp. 1155-1165
    • Pardi, D.S.1    Kelly, C.P.2
  • 39
    • 79960963240 scopus 로고    scopus 로고
    • Association between proton pump inhibitor use and anemia: A retrospective cohort study
    • 21318590 10.1007/s10620-011-1589-y 1:CAS:528:DC%2BC3MXps12ns7s%3D
    • Sarzynski E, Puttarajappa C, Xie Y, Grover M, Laird-Fick H. Association between proton pump inhibitor use and anemia: a retrospective cohort study. Dig Dis Sci. 2011;56:2349-2353.
    • (2011) Dig Dis Sci , vol.56 , pp. 2349-2353
    • Sarzynski, E.1    Puttarajappa, C.2    Xie, Y.3    Grover, M.4    Laird-Fick, H.5
  • 40
    • 84876709049 scopus 로고    scopus 로고
    • Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage
    • 23333664 10.1016/j.dld.2012.12.005 1:CAS:528:DC%2BC3sXhtFKks70%3D
    • Watanabe T, Tanigawa T, Nadatani Y, et al. Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage. Dig Liver Dis. 2013;45:390-395.
    • (2013) Dig Liver Dis , vol.45 , pp. 390-395
    • Watanabe, T.1    Tanigawa, T.2    Nadatani, Y.3
  • 41
    • 84879694274 scopus 로고    scopus 로고
    • Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding
    • 10.1111/den.12002
    • Sakai E, Endo H, Taniguchi L, et al. Factors predicting the presence of small bowel lesions in patients with obscure gastrointestinal bleeding. Dig Endosc. 2012;25:412-420. doi: 10.1111/den.12002.
    • (2012) Dig Endosc
    • Sakai, E.1    Endo, H.2    Taniguchi, L.3
  • 42
    • 0029787769 scopus 로고    scopus 로고
    • Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug
    • 8887349 1:CAS:528:DyaK28XlvFWqu7s%3D
    • Uejima M, Kinouchi T, Kataoka K, Hiraoka I, Ohnishi Y. Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug. Microbiol Immunol. 1996;40:553-560.
    • (1996) Microbiol Immunol , vol.40 , pp. 553-560
    • Uejima, M.1    Kinouchi, T.2    Kataoka, K.3    Hiraoka, I.4    Ohnishi, Y.5
  • 43
    • 7144253780 scopus 로고    scopus 로고
    • Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation
    • 1:CAS:528:DyaK1cXktFynsL4%3D
    • Kinouchi T, Kataoka K, Bing SR, et al. Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation. Micriobiol Immunol. 1998;42:347-355.
    • (1998) Micriobiol Immunol , vol.42 , pp. 347-355
    • Kinouchi, T.1    Kataoka, K.2    Bing, S.R.3
  • 44
    • 84875581463 scopus 로고    scopus 로고
    • Bifidobacteria exert a protective effect against NSAID-induced enteropathy that is dependent on lactate production
    • (abstract)
    • Syer SD, McKnight W, Aucouturier A, et al. Bifidobacteria exert a protective effect against NSAID-induced enteropathy that is dependent on lactate production. Gastroenterology. 2012;142:S-489 (abstract).
    • (2012) Gastroenterology , vol.142 , pp. 489
    • Syer, S.D.1    McKnight, W.2    Aucouturier, A.3
  • 45
    • 69749099183 scopus 로고    scopus 로고
    • Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: Involvement of lactic acid
    • 19589943 10.1152/ajpgi.90553.2008 1:CAS:528:DC%2BD1MXht1ykurnF
    • Watanabe T, Nishio H, Tanigawa T, et al. Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. Am J Physiol Gastrointest Liver Physiol. 2009;297:G506-G513.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297
    • Watanabe, T.1    Nishio, H.2    Tanigawa, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.