The genus Vitex: A review

Pharmacognosy Reviews

Volumn 7, Issue 14, 2013, Pages 188-198

  Rani, Anita ^a   Sharma, Anupam ^b  

^a LR Institute of Pharmacy   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Diterpenoides; essential oils; flavonoids; iridoid glycosides; vitex agnus castus

Indexed keywords

ALKALOID DERIVATIVE; ALPHA TOCOPHEROL; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ASCORBIC ACID; BETA EUDESMOL; BICYCLOGERMACRENE; BUTYLATED HYDROXYANISOLE; CARBON TETRACHLORIDE; CARYOPHYLLENE OXIDE; DITERPENOID; ECDYSTEROID; ESSENTIAL OIL; FLAVONE; FLAVONOID; IRIDOID; LIGNAN DERIVATIVE; PLANT GLYCOSIDE; PLANT MEDICINAL PRODUCT; POLYPHENOL; RESVERATROL; SILYMARIN; SODIUM SELENITE; SULFORHODAMINE B; TANNIN DERIVATIVE; TERPENE DERIVATIVE; TRIS( 2,4 DI TERT BUTYLPHENYL)PHOSPHATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITETRIFOLINE E; VITEX AGNUS CASTUS EXTRACT;

AGING; ALTERNATIVE MEDICINE; AMENORRHEA; ANALGESIC ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIDIARRHEAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMALARIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ANXIETY DISORDER; BACILLUS SUBTILIS; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMICAL COMPOSITION; CYTOTOXICITY; DERMATOPHYTE; DRUG CAPSULE; DRUG FORMULATION; ESCHERICHIA COLI; ETHNOPHARMACOLOGY; FLOWER; FLOWER COLOR; FRUIT; HERBAL MEDICINE; HUMAN; HYPERPROLACTINEMIA; IN VITRO STUDY; IN VIVO STUDY; LIVER INJURY; MASTALGIA; MEDICINAL PLANT; MENOPAUSAL SYNDROME; MENSTRUAL CYCLE; MICROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PHYTOCHEMISTRY; PLANT LEAF; PLANT STRUCTURES; PLASMODIUM FALCIPARUM; PREMENSTRUAL SYNDROME; REVIEW; SCAVENGING SYSTEM; SEDATION; SINGLE DRUG DOSE; SYMPTOM; TOXICOLOGY; TRADITIONAL MEDICINE; VITEX; VITEX AGNUS CASTUS;

EID: 84889572030     PISSN: 09737847     EISSN: 09762787     Source Type: Journal    
DOI: 10.4103/0973-7847.120522     Document Type: Review

References (108)

1. Ganapaty S, Vidyadhar KN. Phytoconstituents and biological activities of Vitex: A review. J Nat Rem 2005;5:75-95. (Pubitemid 41264231)
2. Ono M, Yamasaki T, Konoshita M, Ikeda T, Okawa M, Kinjo J, et al. Five new diterpenoids, viteagnusins A-E, from The fruit of Vitex agnus-castus. Chem Pharm Bull (Tokyo) 2008;56:1621-4.
3. Azhar-Ul-Haq, Malik A, Anis I, Khan SB, Ahmed E, Ahmed Z, et al. Enzyme inhibiting lignans from Vitex negundo. Chem Pharm Bull (Tokyo) 2004;52:1269-72. (Pubitemid 41364441)
4. Hu Y, Hou TT, Xin HL, Zhang QY, Zheng HC, Rahman K, et al. Estrogen-like activity of volatile components from Vitex rotundifolia L. Indian J Med Res 2007;126:68-72. (Pubitemid 350020551)
5. Kiuchi F, Matsuo K, Ito M, Qui TK, Honda G. New norditerpenoids with Trypanocidal activity from Vitex Trifolia. Chem Pharm Bull (Tokyo) 2004;52:1492-4. (Pubitemid 41364435)
6. Costa MR, Ribeiro CG, Santos-Filho SD, Neves RF, Fonseca AS, Bernardo-Filho M, et al. An aqueous extract of Vitex agnus-castus alters The labeling of blood constituents with Technetium-99m. Braz Arch Biol Technol 2007;50:183-8.
7. Azarnia M, Ejtemaei-Mehr S, Shakoor A, Ansari A. Effects of Vitex agnus-castus on mice fetus Development. Acta Med Iran 2007;45:264-70.
8. Carmichael AR. Can Vitex agnus castus be used for The Treatment of mastalgia- What is The current evidence- Evid Based Complement Alternat Med 2008;5:247-50.
9. Dugoua JJ, Seely D, Perri D, Koren G, Mills E. Safety and efficacy of chastetree (Vitex agnus-castus) during pregnancy and lactation. Can J Clin Pharmacol 2008;15:e74-9. (Pubitemid 351162491)
10. Azadbakht M, Baheddini A, Shorideh SM, Naserzadeh A. Effect of Vitex agnus-castus L. leaf and fruit flavonoidal extracts on serum prolactin concentration. J Med Plants 2005;4:56-61.
11. Jignesh P, Samir S, Shrikalp D, Gaurang S. Evaluation of The antiasthmatic activity of leaves of Vitex negundo. Asian J Pharm Clin Res 2009;2:81-6.
12. Bansod MS, Harle UN. Vitex negundo l.: Phytochemical costituets, Traditioal uses ad pharmacological properties: Comprehesive review. Pharmacologyonline 2009;1:286-02.
13. Tandon VR, Gupta RK. Vitex negundo Linn. (VN) leaf extract as an adjuvant Therapy To standard anti-inflammatory drugs. Indian J Med Res 2006;124:447-50. (Pubitemid 46592127)
14. Gautam LN, Shrestha SL, Wagle P, Tamrakar BM. Chemical constituents from Vitex negundo (Linn.) of Nepalese origin. Sci World 2008;6:27-32.
15. Patil A. Medicinal uses of Vitex negundo Linn. Indian Pat Appl. CODEN: INXXBQ IN 2003MU00761 A 20060616, 2006.
16. Biswal S, Murthy PN, Sahu J, Mohapatra AK, Sahoo P, Sarangi C, et al. Biological activities of Vitex negundo Linn: An overview. Pharmbit 2008;17:17-25.
17. Ono M, Yamamoto M, Yanaka T, Ito Y, Nohara T. Ten new labdane-type diterpenes from The fruit of Vitex rotundifolia. Chem Pharm Bull (Tokyo) 2001;49:82-6. (Pubitemid 32128099)
18. Ono M, Masuoka C, Ito Y, Yoshimitsu H, Nohara T. Studies on The constituents from The fruits of Vitex rotundifolia. Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 2000;42:445-50.
19. Hu Y, Zhang Q, Xin H, Qin LP, Lu BR, Rahman K, et al. Association between chemical and genetic variation of Vitex rotundifolia populations from different locations in China: Its implication for quality control of medicinal plants. Biomed Chromatogr 2007;21:967-75. (Pubitemid 47272332)
20. Ono M, Ito Y, Nohara T. Four new halimane-type diterpenes, vitetrifolins D-G, from The fruit of Vitex Trifolia. Chem Pharm Bull (Tokyo) 2001;49:1220-2. (Pubitemid 32847540)
21. Li W-X, Cui C-B, Cai B, Yao X-S. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex Trifolia L. J Asian Nat Prod Res 2005;7:95-105. (Pubitemid 40139364)
22. Li W-X, Cui C-B, Cai B, Wang H-Y, Yao X-S. Flavonoids from Vitex Trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells. J Asian Nat Prod Res 2005;7:615-26. (Pubitemid 40909330)
23. Assunta H. Vitex agnus castus chaste Tree berry/Monk's pepper: What's in a name- Aust Center Complement Med 2006;25:888.
24. Healthnotes Resource Page. Vitex agnus-castus, 2006, Available from: http: www.healthnotes.com. [Last accessed 2008 May 10].
25. Mahady GB, Dietz, B., Engle J, Michel J., Sagraves R. Chasteberry (Vitex agnus castus). Encyclopedia of dietary supplements, published by Marcel Dekker, Inc. 01/28/2005, 95-103.
26. Bornhorst HL. Growing native Hawaiian plants: A how-to guide for The gardener. Honolulu: The Bess Press, 1996; 26-27.
27. Edward FG. Vitex Trifolia 'Variegata' - Variegated Vitex. Fact Sheet FPS-611, 1999; 1-3.
28. Brattstroem A. Use of Vitex agnus castus extracts for preparing a medicament. PCT Int. Appl. CODEN: PIXXD2 WO 2009027086 A2 20090305, 2009. pp. 41.
29. Hajdú Z, Hohmann J, Forgo P, Martinek T, Dervarics M, Zupko I, et al. Diterpenoids and flavonoids from The fruits of Vitex agnus-castus and antioxidant activity of The fruit extracts and Their constituents. Phytother Res 2007;21:391-4. (Pubitemid 46595988)
30. Senatore F, Napolitano F, Ozcan M. Chemical composition and antibacterial activity of essential oil from fruits of Vitex agnus-castus L. (Verbenaceae) growing in Turkey. J Essential Oil-Bearing Plants 2003;6:185-90.
31. Sarer E, Gokbulut A. Determination of caffeic and chlorogenic acids in The leaves and fruits of Vitex agnus-castus. Turk J Pharm Sci 2008;5:167-74.
32. Ibrahim NA, Shalaby AS, Farag RS, Elbaroty GS, Nofal SM, Hassan EM. Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruits growing in Egypt. Nat Prod Res 2008;22:537-46. (Pubitemid 351560235)
33. Jarry H, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V. Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones. Planta Med 2003;69:945-7. (Pubitemid 38005452)
34. Diaz F, Chávez D, Lee D, Mi Q, Chai HB, Tan GT, et al. Cytotoxic flavone analogues of vitexicarpin, a constituent of The leaves of Vitex negundo. J Nat Prod 2003;66:865-7. (Pubitemid 36782101)
35. Chandramu C, Manohar RD, Krupadanam DG, Dashavantha RV. Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytother Res 2003;17:129-34. (Pubitemid 36262260)
36. Nagarsekar KS, Nagarsenker MS, Kulkarni SR. Evaluation of composition and antimicrobial activity of supercritical fluid extract of leaves of Vitex negundo. Indian J Pharm Sci 2010;72:641-3.
37. Sathiamoorthy B, Gupta P, Kumar M, Chaturvedi AK, Shukla PK, Maurya R. New antifungal flavonoid glycoside from Vitex negundo. Bioorg Med Chem Lett 2007;17:239-42. (Pubitemid 46001577)
38. Arif Lodhi M, Iqbal Choudhary M, Malik A, Ahmad S. Alpha-Chymotrypsin inhibition studies on The lignans from Vitex negundo Linn. J Enzyme Inhib Med Chem 2008;23:400-5. (Pubitemid 351935062)
39. Vinuchakkaravarthy T, Kumaravel KP, Ravichandran S, Velmurugan D. Active compound from The leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A(2) Through molecular docking. Bioinformation 2011;7:199-206.
40. Rooban BN, Sasikala V, Sahasranamam V, Abraham A. Analysis on The alterations of lens proteins by Vitex negundo in selenite cataract models. Mol Vis 2011;17:1239-48.
41. Sundaram R, Naresh R, Shanthi P, Sachdanandam P. Antihyperglycemic effect of iridoid glucoside, isolated from The leaves of Vitex negundo in streptozotocin-induced diabetic rats with special reference To glycoprotein components. Phytomedicine 2012;19:211-6.
42. Hoang VL. Chemical composition of Vitex Trifolia L. Tap Chi Duoc Hoc 2003;113-4.
43. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from The fruits of Vitex rotundifolia. J Nat Prod 2002;65:537-41. (Pubitemid 34456939)
44. Ko WG, Kang TH, Lee SJ, Kim YC, Lee BH. Rotundifuran, a labdane Type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells. Phytother Res 2001;15:535-7. (Pubitemid 32906441)
45. Ko WG, Kang TH, Lee SJ, Kim NY, Kim YC, Sohn DH, et al. Polymethoxy flavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Food Chem Toxicol 2000;38:861-5. (Pubitemid 32786704)
46. Kim MG, Kim YG, Lee HS, Lee SU, Noh MC, Song HY. Furan labdane diterpenes from Vitex rotundifolia fruits as cholesterol acyltransferase inhibitors. Repub. Korean Kongkae Taeho Kongbo 2003;56:415-7.
47. Kobayakawa J, Sato-Nishimori F, Moriyasu M, Matsukawa Y. G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). Cancer Lett 2004;208:59-64. (Pubitemid 38501784)
48. Kim NU, Lee YS. Cosmetic composition containing Vitex rotundifolia extract with antioxidant effect. Repub. Korean Kongkae Taeho Kongbo CODEN: KRXXA7 KR 2008090745 A 20081009, 2008
49. El-Sayed MM, El-Hashash MM, Mohamed MA, Korany TM. Cytotoxic activity of Vitex Trifolia purpurea extracts. J Egypt Soc Parasitol 2011;41:409-16.
50. Xin H, Hu Y, Zhang Q, Huang B, Zheng HH, Qin L. Study on chemical constituents in fruits of Vitex Trifolia. Acad J Sec Mil Med Univ 2006;27:1038-40.
51. Chen H, Cheng W, Feng Y, Gu K, Yang L, Zhang Y. Studies on flavonoid constituents of Vitex Trifolia L. var. simplicifolia cham. Tianran Chanwu Yanjiu Yu Kaifa 2008;20:582-4.
52. Alam G, Gandjar IG, Hakim L, Timmerman H, Verpoorte R, Wahyuono S. Tracheospasmolytic activity of vitetrifolin-E isolated from The leaves of Vitex Trifolia L. Indonesian J Pharm 2003;14:188-94.
53. Chowwanapoonpohn S, Baramee A. Antimalarial activity in vitro of some natural extracts from Vitex Trifolia. J Sci 2000;27:9-13
54. Manjunatha BK, Vidya SM. Hepatoprotective Activity of Vitex Trifolia against carbon Tetrachloride-induced hepatic damage. Indian J Pharm Sci 2008;70:241-5.
55. Gokaraju GR, Gokaraju RR, Gottumukkala VS, Somepalli V. Pharmaceutically active extracts of Vitex leucoxylon, a process of extracting The same and a method of Treating diabetes and inflammatory diseases Therewith. PCT Int. Appl. CODEN: PIXXD2 WO 2007029263 A1 20070315, 2007.
56. Shukla P, Shukla P, Mishra SB, Gopalakrishna B. Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn. Indian J Pharmacol 2010;42:409-11.
57. Sridhar C, Subbaraju GV, Venkateswarlu Y, Venugopal RT. New acylated iridoid glucosides from Vitex altissima. J Nat Prod 2004;67:2012-6. (Pubitemid 40092547)
58. Sridhar C, Rao KV, Subbaraju GV. Flavonoids, Triterpenoids and a lignan from Vitex altissima. Phytochemistry 2005;66:1707-12. (Pubitemid 41026625)
59. Ata A, Mbong N, Iverson CD, Samarasekera R. Minor chemical constituents of Vitex pinnata. Nat Prod Commun 2009;4:1-4.
60. Gallo MB, Vieira PC, Fernandes JB, da Silva MF, Salimena-Pires FR. Compounds from Vitex polygama active against kidney diseases. J Ethnopharmacol 2008;115:320-2. (Pubitemid 350266264)
61. Cabral C, Goncalves MJ, Cavaleiro C, Salgueiro L, Antunes T, Sevinate-Pinto I, et al. Vitex ferruginea Schumach. et. Thonn. subsp. amboniensis (Gurke) Verdc.: Glandular Trichomes micromorphology, composition and antifungal activity of The essential oils. J Essential Oil Res 2007;20:86-90. (Pubitemid 351288140)
62. Rodriguez-Lopez V, Figueroa-Suarez MZ, Rodriguez T, Aranda E. Insecticidal activity of Vitex mollis. Fitoterapia 2007;78:37-9. (Pubitemid 44932126)
63. Suleiman MM, Yusuf S. Antidiarrheal activity of The fruits of Vitex doniana in laboratory animals. Pharm Biol 2008;46:387-92. (Pubitemid 351882313)
64. Agbafor KN, Nwachukwu N. Phytochemical analysis and antioxidant property of leaf extracts of Vitex doniana and Mucuna pruriens. Biochem Res Int 2011;45:93-99.
65. Suksamrarn A, Kumpun S, Yingyongnarongkul BE. Ecdysteroids of Vitex scabra stem bark. J Nat Prod 2002;65:1690-2. (Pubitemid 35386808)
66. Zanatta L, de Sousa E, Cazarolli LH, Junior AC, Pizzolatti MG, Szpoganicz B, et al. Effect of crude extract and fractions from Vitex megapotamica leaves on hyperglycemia in alloxan-diabetic rats. J Ethnopharmacol 2007;109:151-5. (Pubitemid 44821681)
67. Chouhan CS, Sridevi K, Singh NK, Singh SK. Anti-inflammatory activity of ethanol extract of Vitex glabrata leaves. Pak J Pharm Sci 2012;25:131-4.
68. Sridevi VK, Chouhan HS, Singh NK, Singh SK. Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon Tetrachloride-induced liver damage in rats. Nat Prod Res 2012;26:1135-40.
69. Deng Y, Chin YW, Chai HB, de Blanco EC, Kardono LB, Riswan S, et al. Phytochemical and bioactivity studies on constituents of The leaves of Vitex Quinata. Phytochem Lett 2011;4:213-7.
70. Atmaca M, Kumru S, Tezcan E. Fluoxetine versus Vitex agnus castus extract in The Treatment of premenstrual dysphoric disorder. Hum Psychopharmacol 2003;18:191-5. (Pubitemid 36526944)
71. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D. Chaste Tree (Vitex agnus-castus): Pharmacology and clinical indications. Phytomedicine 2003;10:348-57. (Pubitemid 36597173)
72. Roemheld-Hamm B. Chasteberry. Am Fam Physician 2005;72:821-4. (Pubitemid 41254252)
73. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: A systematic review of adverse events. Drug Saf 2005;28:319-32. (Pubitemid 40545767)
74. Tandon V, Gupta RK. Histomorphological changes induced by Vitex negundo in albino rats. Ind J Pharm 2004;36:176-7. (Pubitemid 38787075)
75. Owolabi MA, Abass MM, Emeka PM, Jaja SI, Nnoli M, Dosa BO. Biochemical and histologic changes in rats after prolonged administration of The crude aqueous extract of The leaves of Vitex grandifolia. Pharmacognosy Res 2010;2:273-8.
76. Novak J, Draxler L, Goehler I, Franz CM. Essential oil composition of Vitex agnus-castus-comparison of accessions and different plant organs. Flav Frag J 2005;20:186-92. (Pubitemid 40347959)
77. Kuruuzum-Uz A, Ströch K, Demirezer LO, Zeeck A. Glucosides from Vitex agnus-castus. Phytochemistry 2003;63:959-64. (Pubitemid 36987623)
78. Li SH, Zhang HJ, Qiu SX, Niu XM, Santarsiero BD, Mesecar AD, et al. Vitexlactam A, a novel labdane diterpene lactam from The fruits of Vitex agnus-castus. Tetrahedron Lett 2002;43:5131-4. (Pubitemid 34686884)
79. Ono M, Eguchi K, Konoshita M, Furusawa C, Sakamoto J, Yasuda S, et al. A new diterpenoid glucoside and Two new diterpenoids from The fruit of Vitex agnus-castus. Chem Pharm Bull (Tokyo) 2011;59:392-6.
80. Cengiz M, Bardakci Z, Erdogan Y, Olgun A. Analysis of fatty acids obtained from The fruit of Vitex agnus-castus. Int J Chem 2003;13:127-31.
81. Dayal R, Singh V. A comparative study of volatile constituents of Vitex negundo leaves. J Med Aroma Plant Sci 2000;22:639-40.
82. Kaul PN, Rao BR, Bhattacharya AK, Singh K, Syamasundar KV, Ramesh S. Essential oil composition of Vitex negundo L. flowers. J Essential Oil Res 2005;17:483-4. (Pubitemid 41633670)
83. Xie J, Sun B, Yu M. Analysis of volatiles in The leaf and stem of fragrant plant vitex negundo l. var. heterophylla (franch) rehd. Food and Fermentation Ind 2005;31:100-3.
84. Khokra SL, Prakash O, Jain S, Aneja KR, Dhingra Y. Essential oil composition and antibacterial studies of Vitex negundo Linn. Extracts. Indian J Pharm Sci 2008;70:522-6.
85. Singh AK, Naqvi AA. Vitex negundo Linn.-leaf volatiles from north Indian plains and lower Himalayan region. Indian Perfumer 2004;48:415-20.
86. Lal S, Prakash O, Jain S, Ali M. Volatile constituents of The fruits of Vitex negundo Linn. J Essential Oil-Bearing Plants 2007;10:247-50. (Pubitemid 47152944)
87. Azhar-ul H, Malik A, Khan SB. Flavonoid glycoside and long chain ester from The roots of Vitex negundo. Polish J Chem 2004;78:1851-6. (Pubitemid 39468534)
88. Ono M, Nishida Y, Masuoka C, Li JC, Okawa M, Ikeda T, et al. Lignan derivatives and a norditerpene from The seeds of Vitex negundo. J Nat Prod 2004;67:2073-5. (Pubitemid 40092558)
89. Zheng CJ, Tang WZ, Huang BK, Han T, Zhang QY, Zhang H, et al. Bioactivity-guided fractionation for analgesic properties and constituents of Vitex negundo L. seeds. Phytomedicine 2009;16:560-7.
90. Xu R, Xu X. Natural health promotion plant alkaloid from Vitex negundo, and its preparation method. Faming Zhuanli Shenqing Gongkai Shuomingshu, 5 CODEN: CNXXEV CN 1683380 A 20051019, 2005.
91. Barreto LC, Carvalho EF, Filho MS, Ferreira CP, Xavier HS. Molluscicidal activity of The extracts and aucubin from Vitex gardneriana Schauer (Verbenaceae) on embryos of Biomphalaria glabrata. Latin Am J Pharmacy 2007;26:339-43. (Pubitemid 47492596)
92. Barreto LC, Xavier HS, Barbosa-Filho JM, Braz-Filho R. Glycosylated ecdysteroid and iridoid from Vitex gardneriana Schauer (Verbenaceae). Braz J Pharmacog 2005;15:51-4.
93. Santos TC, Schripsema J, Monache FD, Leitao SG. Iridoids from Vitex cymosa. J Braz Chem Soc 2001;12:763-6.
94. Thuy TT, Ripperger H, Sung TV, Adam G. Study on chemical constituents of Vitex leptobotrys. II. Chalcones and alkaloid. Viet J Chem 2000;38:1-7.
95. Suksamrarn A, Promrangsan N, Jintasirikul A. Highly oxygenated ecdysteroids from Vitex canescens root bark. Phytochemistry 2000;53:921-4. (Pubitemid 30233124)
96. Yamasaki T, Kawabata T, Masuoka C, Kinjo J, Ikeda T, Nohara T, et al. Two new lignan glucosides from The fruit of Vitex cannabifolia. J Nat Med 2008;62:47-51. (Pubitemid 351176898)
97. Gu Q, Zhang XM, Zhou J, Qiu SX, Chen JJ. One new dihydrobenzofuran lignan from Vitex Trifolia. J Asian Nat Prod Res 2008;10:499-502. (Pubitemid 351883084)
98. Ono M, Sawamura H, Ito Y, Mizuki K, Nohara T. Diterpenoids from The fruits of Vitex Trifolia. Phytochemistry 2000;55:873-7.
99. Gu Q, Zhang X, Jiang Z, Chen J, Zhou J. Chemical constituents from fruits of Vitex Trifolia Chin Trad Herbal Drugs 2007;38:656-9. (Pubitemid 47050036)
100. Kawazoe K, Yutani A, Tamemoto K, Yuasa S, Shibata H, Higuti T, et al. Phenylnaphthalene compounds from The subterranean part of Vitex rotundifolia and Their antibacterial activity against methicillin-resistant Staphylococcus aureus. J Nat Prod 2001;64:588-91. (Pubitemid 32488673)
101. Jang S, Kim Y, Kim M, Kim K, Yun S. Essential oil composition from leaves, flowers, stems, and fruits of Vitex rotundifolia L. fil. J Korean Soc Agri Chem biotechnol 2002;45:101-7.
102. Suksamrarn A, Kumpun S, Kirtikara K, Yingyongnarongkul B, Suksamrarn S. Iridoids with anti-inflammatory activity from Vitex peduncularis. Planta Med 2002;68:72-3. (Pubitemid 34113595)
103. Nebie RH, Yameogo RT, Belanger A, Sib FS. Chemical composition of essential oils of Vitex diversifolia Bak. from Burkina Faso. J Essential Oil Res 2005;17:276-7. (Pubitemid 41633755)
104. Cheng W, Chen H, Zhang Y, Qin X, Gu K. Chemical constituents of Vitex quinata. Tianran Chanwu Yanjiu Yu Kaifa 2007;19:244-6.
105. Agbede JO, Ibitoye AA. Chemical composition of black plum (Vitex doniana): An under-utilized fruit. J Food Agric Environ 2007;5:95-6. (Pubitemid 46853070)
106. Sinlaparaya D, Duanghakiang P, Panichajakul S. Enhancement of 20-hydroxyecdysone production in cell suspension cultures of Vitex glabrata R. Br. by precursors feeding. Afr J Biotechnol 2007;6:1639-42. (Pubitemid 47195799)
107. Nyiligira E, Viljoen AM, Baser KH, Ozek T, Vuuren SF. Essential oil composition and in vitro antimicrobial and anti-inflammatory activity of South African Vitex species. J Bot 2004;70:611-7. (Pubitemid 40059690)
108. Nyiligira E, Viljoen AM, Van Heerden FR, Van Zyl RL, Van Vuuren SF, Steenkamp PA. Phytochemistry and in vitro pharmacological activities of South African Vitex (Verbenaceae) species. J Ethnopharmacol 2008;119:680-5.