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Volumn , Issue , 2008, Pages 468-478

Hepatic Removal Kinetics: Importance for Quantitative Measurements of Liver Function

Author keywords

Blood concentration; Caffeine; Hepatocytes; Microcirculation; Sinusoids

Indexed keywords


EID: 84889413413     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470691861.ch5c     Document Type: Chapter
Times cited : (6)

References (107)
  • 1
    • 0025162592 scopus 로고
    • Assessment of liver function: principles and practice
    • Tygstrup N. (1990) Assessment of liver function: principles and practice. J Gastroenterol Hepatol 5, 468-482.
    • (1990) J Gastroenterol Hepatol , vol.5 , pp. 468-482
    • Tygstrup, N.1
  • 2
    • 0017176322 scopus 로고
    • Enzymatic elimination of substrates flowing through the intact liver
    • Bass L, Keiding S, Winkler K et al. (1976) Enzymatic elimination of substrates flowing through the intact liver. J Theor Biol 61, 393-409.
    • (1976) J Theor Biol , vol.61 , pp. 393-409
    • Bass, L.1    Keiding, S.2    Winkler, K.3
  • 3
    • 0017133864 scopus 로고
    • Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver
    • Keiding S, Johansen S, Winkler K et al. (1976) Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver. Am J Physiol 230, 1302-1313.
    • (1976) Am J Physiol , vol.230 , pp. 1302-1313
    • Keiding, S.1    Johansen, S.2    Winkler, K.3
  • 4
    • 0018193940 scopus 로고
    • Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver
    • Keiding S, Chiarantini E. (1978) Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver. J Pharmacol Exp Ther 205, 465-470.
    • (1978) J Pharmacol Exp Ther , vol.205 , pp. 465-470
    • Keiding, S.1    Chiarantini, E.2
  • 5
    • 0021209947 scopus 로고
    • Current models of hepatic pharmacokinetics: flow effects on kinetic constants of ethanol elimination in perfused rat liver
    • Keiding S, Priisholm K. (1984) Current models of hepatic pharmacokinetics: flow effects on kinetic constants of ethanol elimination in perfused rat liver. Biochem Pharmacol 33, 3209-3212.
    • (1984) Biochem Pharmacol , vol.33 , pp. 3209-3212
    • Keiding, S.1    Priisholm, K.2
  • 6
    • 0023735963 scopus 로고
    • Methodological limitations of the use of intrinsic hepatic clearance of ICG as a measure of liver cell function
    • Keiding S, Skak C. (1988) Methodological limitations of the use of intrinsic hepatic clearance of ICG as a measure of liver cell function. Eur J Clin Invest 18, 507-511.
    • (1988) Eur J Clin Invest , vol.18 , pp. 507-511
    • Keiding, S.1    Skak, C.2
  • 7
    • 0017137982 scopus 로고
    • The influence of dye infusion rate and hepatic plasma flow on indocyanine green clearance
    • Krarup N, Larsen JA. (1976) The influence of dye infusion rate and hepatic plasma flow on indocyanine green clearance. Scand J Clin Lab Invest 36, 183-188.
    • (1976) Scand J Clin Lab Invest , vol.36 , pp. 183-188
    • Krarup, N.1    Larsen, J.A.2
  • 8
    • 0023229514 scopus 로고
    • Effects of liver blood flow on hepatic uptake kinetics of galactose in anesthetized cats: parallel tube model
    • Greenway CV, Burczynski FJ. (1987) Effects of liver blood flow on hepatic uptake kinetics of galactose in anesthetized cats: parallel tube model. Can J Physiol Pharmacol 65, 1193-1199.
    • (1987) Can J Physiol Pharmacol , vol.65 , pp. 1193-1199
    • Greenway, C.V.1    Burczynski, F.J.2
  • 9
    • 0019952911 scopus 로고
    • Hepatic galactose elimination kinetics in the intact pig
    • Keiding S, Johansen S, Winkler K. (1982) Hepatic galactose elimination kinetics in the intact pig. Scand J Clin Lab Invest 42, 253-259.
    • (1982) Scand J Clin Lab Invest , vol.42 , pp. 253-259
    • Keiding, S.1    Johansen, S.2    Winkler, K.3
  • 10
    • 17744420506 scopus 로고
    • Ethanol elimination kinetics in human liver and pig liver in vivo
    • Keiding S, Johansen S, Midtboll I et al. (1979) Ethanol elimination kinetics in human liver and pig liver in vivo. Am J Physiol 237, E316-E324.
    • (1979) Am J Physiol , vol.237
    • Keiding, S.1    Johansen, S.2    Midtboll, I.3
  • 11
    • 0017342079 scopus 로고
    • Michaelis-Menten kinetics of phenazone elimination in the perfused pig liver
    • Andreasen B, Tonnesen K, Rabol A et al. (1977) Michaelis-Menten kinetics of phenazone elimination in the perfused pig liver. Acta Pharmacol Toxicol 40, 1-13.
    • (1977) Acta Pharmacol Toxicol , vol.40 , pp. 1-13
    • Andreasen, B.1    Tonnesen, K.2    Rabol, A.3
  • 12
    • 0024525762 scopus 로고
    • Ca2+ concentration influences the hepatic extraction of bioactive human PTH-(1-34) in rats
    • D'Amour P, Huet PM. (1989) Ca2+ concentration influences the hepatic extraction of bioactive human PTH-(1-34) in rats. Am J Physiol 256, E87-E92.
    • (1989) Am J Physiol , vol.256
    • D'Amour, P.1    Huet, P.M.2
  • 13
    • 0014590783 scopus 로고
    • Liver function and blood flow in normal man during infusion of vasopressin
    • Jacobsen KR, Ranek L, Tygstrup N. (1969) Liver function and blood flow in normal man during infusion of vasopressin. Scand J Clin Lab Invest 24, 279-284.
    • (1969) Scand J Clin Lab Invest , vol.24 , pp. 279-284
    • Jacobsen, K.R.1    Ranek, L.2    Tygstrup, N.3
  • 14
    • 0017594594 scopus 로고
    • Effect of sites of blood sampling in determination of the galactose elimination capacity
    • Tygstrup N. (1977) Effect of sites of blood sampling in determination of the galactose elimination capacity. Scand J Clin Lab Invest 37, 333-338.
    • (1977) Scand J Clin Lab Invest , vol.37 , pp. 333-338
    • Tygstrup, N.1
  • 15
    • 0013987842 scopus 로고
    • Determination of the hepatic elimination capacity (Lm) of galactose by single injection
    • Tygstrup N. (1966) Determination of the hepatic elimination capacity (Lm) of galactose by single injection. Scand J Clin Lab Invest Suppl 18, 118-125.
    • (1966) Scand J Clin Lab Invest Suppl , vol.18 , pp. 118-125
    • Tygstrup, N.1
  • 16
    • 0017095089 scopus 로고
    • Galactose elimination capacity as a prognostic index in patients with fulminant liver failure
    • Ranek L, Andreasen PB, Tygstrup N. (1976) Galactose elimination capacity as a prognostic index in patients with fulminant liver failure. Gut 17, 959-964.
    • (1976) Gut , vol.17 , pp. 959-964
    • Ranek, L.1    Andreasen, P.B.2    Tygstrup, N.3
  • 17
    • 0024358224 scopus 로고
    • Prognostic indicators of survival in patients with cirrhosis and esophageal varices, without previous bleeding
    • Merkel C, Bolognesi M, Angeli P et al. (1989) Prognostic indicators of survival in patients with cirrhosis and esophageal varices, without previous bleeding. Am J Gastroenterol 84, 717-722.
    • (1989) Am J Gastroenterol , vol.84 , pp. 717-722
    • Merkel, C.1    Bolognesi, M.2    Angeli, P.3
  • 18
    • 0025879233 scopus 로고
    • Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis.Comparison with the Pugh score
    • Merkel C, Gatta A, Zoli M et al. (1991) Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis. Comparison with the Pugh score. Dig Dis Sci 36, 1197-1203.
    • (1991) Dig Dis Sci , vol.36 , pp. 1197-1203
    • Merkel, C.1    Gatta, A.2    Zoli, M.3
  • 19
    • 0029811058 scopus 로고    scopus 로고
    • The course of galactose elimination capacity in patients with alcoholic cirrhosis: possible use as a surrogate marker for death
    • Merkel C, Marchesini G, Fabbri A et al. (1996) The course of galactose elimination capacity in patients with alcoholic cirrhosis: possible use as a surrogate marker for death. Hepatology 24, 820-823.
    • (1996) Hepatology , vol.24 , pp. 820-823
    • Merkel, C.1    Marchesini, G.2    Fabbri, A.3
  • 20
    • 57049108825 scopus 로고    scopus 로고
    • Galactose elimination capacity and prognosis of patients with liver cirrhosis-a Danish registry-based cohort study with complete long-term follow-up
    • Jepsen P, Vilstrup H, Sørensen HT et al. (2004) Galactose elimination capacity and prognosis of patients with liver cirrhosis-a Danish registry-based cohort study with complete long-term follow-up. J Hepatol 40 (Suppl. 1), 69A.
    • (2004) J Hepatol , vol.40 , Issue.1 SUPPL.
    • Jepsen, P.1    Vilstrup, H.2    Sørensen, H.T.3
  • 21
    • 0019142435 scopus 로고
    • Synthesis of urea after stimulation with amino acids: relation to liver function
    • Vilstrup H. (1980) Synthesis of urea after stimulation with amino acids: relation to liver function. Gut 21, 990-995.
    • (1980) Gut , vol.21 , pp. 990-995
    • Vilstrup, H.1
  • 22
    • 0028041023 scopus 로고
    • A rapid method for determination of hepatic amino nitrogen to urea nitrogen conversion ('the Functional Hepatic Nitrogen Clearance')
    • Hamberg O, Vilstrup H. (1994) A rapid method for determination of hepatic amino nitrogen to urea nitrogen conversion ('the Functional Hepatic Nitrogen Clearance'). Scand J Clin Lab Invest 54, 377-383.
    • (1994) Scand J Clin Lab Invest , vol.54 , pp. 377-383
    • Hamberg, O.1    Vilstrup, H.2
  • 23
    • 0026581558 scopus 로고
    • Effects of an increase in protein intake on hepatic efficacy for urea synthesis in healthy subjects and in patients with cirrhosis
    • Hamberg O, Nielsen K, Vilstrup H. (1992) Effects of an increase in protein intake on hepatic efficacy for urea synthesis in healthy subjects and in patients with cirrhosis. J Hepatol 14, 237-243.
    • (1992) J Hepatol , vol.14 , pp. 237-243
    • Hamberg, O.1    Nielsen, K.2    Vilstrup, H.3
  • 24
    • 0033038012 scopus 로고    scopus 로고
    • Hepatic amino-to urea-N clearance and forearm amino-N exchange during hypoglycemic and euglycemic hyperinsulinemia in normal man
    • Grofte T, Wolthers T, Jorgensen JO et al. (1999) Hepatic amino-to urea-N clearance and forearm amino-N exchange during hypoglycemic and euglycemic hyperinsulinemia in normal man. J Hepatol 30, 819-825.
    • (1999) J Hepatol , vol.30 , pp. 819-825
    • Grofte, T.1    Wolthers, T.2    Jorgensen, J.O.3
  • 25
    • 78651133453 scopus 로고
    • The permeability of capillaries in various organs as determined by use of the 'indicator dilution' method
    • Crone C. (1963) The permeability of capillaries in various organs as determined by use of the 'indicator dilution' method. Acta Physiol Scand 58, 292-305.
    • (1963) Acta Physiol Scand , vol.58 , pp. 292-305
    • Crone, C.1
  • 26
    • 0025300444 scopus 로고
    • Galactose removal kinetics during hypoxia in perfused pig liver: reduction of Vmax, but not of intrinsic clearance Vmax/Km
    • Keiding S, Johansen S, Tygstrup N. (1990) Galactose removal kinetics during hypoxia in perfused pig liver: reduction of Vmax, but not of intrinsic clearance Vmax/Km. Eur J Clin Invest 20, 305-309.
    • (1990) Eur J Clin Invest , vol.20 , pp. 305-309
    • Keiding, S.1    Johansen, S.2    Tygstrup, N.3
  • 27
    • 0018744750 scopus 로고
    • The physiologic basis for clearance measurements in hepatology
    • Winkler K, Bass L, Keiding S et al. (1979) The physiologic basis for clearance measurements in hepatology. Scand J Gastroenterol 14, 439-448.
    • (1979) Scand J Gastroenterol , vol.14 , pp. 439-448
    • Winkler, K.1    Bass, L.2    Keiding, S.3
  • 28
    • 0017191354 scopus 로고
    • Hepatic elimination kinetics: the influence of hepatic blood flow on clearance determination
    • Keiding S. (1976) Hepatic elimination kinetics: the influence of hepatic blood flow on clearance determination. Scand J Clin Lab Invest 36, 113-118.
    • (1976) Scand J Clin Lab Invest , vol.36 , pp. 113-118
    • Keiding, S.1
  • 30
    • 0021369535 scopus 로고
    • Caffeine: a model compound for measuring liver function
    • Renner E, Wietholtz H, Huguenin P et al. (1984) Caffeine: a model compound for measuring liver function. Hepatology 4, 38-46.
    • (1984) Hepatology , vol.4 , pp. 38-46
    • Renner, E.1    Wietholtz, H.2    Huguenin, P.3
  • 31
    • 0016566218 scopus 로고
    • Commentary: a physiological approach to hepatic drug clearance
    • Wilkinson GR, Shand DG. (1975) Commentary: a physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18, 377-390.
    • (1975) Clin Pharmacol Ther , vol.18 , pp. 377-390
    • Wilkinson, G.R.1    Shand, D.G.2
  • 32
    • 0015980243 scopus 로고
    • Clearance of antipyrine-dependence of quantitative liver function
    • Andreasen PB, Ranek L, Statland BE et al. (1974) Clearance of antipyrine-dependence of quantitative liver function. Eur J Clin Invest 4, 129-134.
    • (1974) Eur J Clin Invest , vol.4 , pp. 129-134
    • Andreasen, P.B.1    Ranek, L.2    Statland, B.E.3
  • 33
    • 0027296740 scopus 로고
    • Metabolism of antipyrine in vivo in two rat models of liver cirrhosis.Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition
    • Buters JT, Zysset T, Reichen J. (1993) Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition. Biochem Pharmacol 46, 983-991.
    • (1993) Biochem Pharmacol , vol.46 , pp. 983-991
    • Buters, J.T.1    Zysset, T.2    Reichen, J.3
  • 34
    • 0023179129 scopus 로고
    • Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man
    • Skak C, Keiding S. (1987) Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man. Liver 7, 155-162.
    • (1987) Liver , vol.7 , pp. 155-162
    • Skak, C.1    Keiding, S.2
  • 35
    • 0031837193 scopus 로고    scopus 로고
    • Sorbitol as a test substance for measurements of liver plasma flow in humans
    • Keiding S, Engsted E, Ott P. (1998) Sorbitol as a test substance for measurements of liver plasma flow in humans. Hepatology 28, 50-56.
    • (1998) Hepatology , vol.28 , pp. 50-56
    • Keiding, S.1    Engsted, E.2    Ott, P.3
  • 36
    • 0025835487 scopus 로고
    • Combined evaluation of total and functional liver plasma flows and intrahepatic shunting
    • Molino G, Avagnina P, Ballare M et al. (1991) Combined evaluation of total and functional liver plasma flows and intrahepatic shunting. Dig Dis Sci 36, 1189-1196.
    • (1991) Dig Dis Sci , vol.36 , pp. 1189-1196
    • Molino, G.1    Avagnina, P.2    Ballare, M.3
  • 37
    • 0034092479 scopus 로고    scopus 로고
    • Interpretation of simultaneous measurements of hepatic extraction fractions of indocyanine green and sorbitol: evidence of hepatic shunts and capillarization?
    • Ott P, Clemmesen O, Keiding S. (2000) Interpretation of simultaneous measurements of hepatic extraction fractions of indocyanine green and sorbitol: evidence of hepatic shunts and capillarization? Dig Dis Sci 45, 359-365.
    • (2000) Dig Dis Sci , vol.45 , pp. 359-365
    • Ott, P.1    Clemmesen, O.2    Keiding, S.3
  • 38
    • 0023730792 scopus 로고
    • Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow
    • Zeeh J, Lange H, Bosch J et al. (1988) Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow. Gastroenterology 95, 749-759.
    • (1988) Gastroenterology , vol.95 , pp. 749-759
    • Zeeh, J.1    Lange, H.2    Bosch, J.3
  • 39
    • 0019962250 scopus 로고
    • First-order clearance of plasma galactose: the effect of liver disease
    • Henderson JM, Kutner MH, Bain RP. (1982) First-order clearance of plasma galactose: the effect of liver disease. Gastroenterology 83, 1090-1096.
    • (1982) Gastroenterology , vol.83 , pp. 1090-1096
    • Henderson, J.M.1    Kutner, M.H.2    Bain, R.P.3
  • 40
    • 0023867604 scopus 로고
    • Galactose clearance measurements and liver blood flow
    • Keiding S. (1988) Galactose clearance measurements and liver blood flow. Gastroenterology 94, 477-481.
    • (1988) Gastroenterology , vol.94 , pp. 477-481
    • Keiding, S.1
  • 41
    • 0035013197 scopus 로고    scopus 로고
    • Liver kinetics of glucose analogs measured in pigs by PET: importance of dual-input blood sampling
    • Munk OL, Bass L, Roelsgaard K et al. (2001) Liver kinetics of glucose analogs measured in pigs by PET: importance of dual-input blood sampling. J Nucl Med 42, 795-801.
    • (2001) J Nucl Med , vol.42 , pp. 795-801
    • Munk, O.L.1    Bass, L.2    Roelsgaard, K.3
  • 42
    • 0034903899 scopus 로고    scopus 로고
    • Quantification of [(18)F]FDG uptake in the normal liver using dynamic PET: impact and modeling of the dual hepatic blood supply
    • Brix G, Ziegler SI, Bellemann ME et al. (2001) Quantification of [(18)F]FDG uptake in the normal liver using dynamic PET: impact and modeling of the dual hepatic blood supply. J Nucl Med 42, 1265-1273.
    • (2001) J Nucl Med , vol.42 , pp. 1265-1273
    • Brix, G.1    Ziegler, S.I.2    Bellemann, M.E.3
  • 43
    • 0033625145 scopus 로고    scopus 로고
    • Dynamic 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography of liver tumours without blood sampling
    • Keiding S, Munk OL, Schiott KM et al. (2000) Dynamic 2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography of liver tumours without blood sampling. Eur J Nucl Med 27, 407-412.
    • (2000) Eur J Nucl Med , vol.27 , pp. 407-412
    • Keiding, S.1    Munk, O.L.2    Schiott, K.M.3
  • 44
    • 0141590224 scopus 로고    scopus 로고
    • Impulse-response function of splanchnic circulation with model-independent constraints: theory and experimental validation
    • Munk OL, Keiding S, Bass L. (2003) Impulse-response function of splanchnic circulation with model-independent constraints: theory and experimental validation. Am J Physiol Gastrointest Liver Physiol 285, G671-G680.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Munk, O.L.1    Keiding, S.2    Bass, L.3
  • 45
    • 84889283914 scopus 로고    scopus 로고
    • Hepatic metabolism of glucose analogs measured by dynamic positron emission tomography and interpreted by compartment models
    • PhD thesis, Faculty of Health Sciences, University of Aarhus, Denmark
    • Munk OL. (2005) Hepatic metabolism of glucose analogs measured by dynamic positron emission tomography and interpreted by compartment models. PhD thesis, Faculty of Health Sciences, University of Aarhus, Denmark.
    • (2005)
    • Munk, O.L.1
  • 46
    • 0020321344 scopus 로고
    • Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination
    • Gjedde A. (1982) Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination. Brain Res 257, 237-274.
    • (1982) Brain Res , vol.257 , pp. 237-274
    • Gjedde, A.1
  • 47
    • 0022389649 scopus 로고
    • Graphical evaluation of bloodto-brain transfer constants from multiple-time uptake data.Generalizations
    • Patlak CS, Blasberg RG. (1985) Graphical evaluation of bloodto-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab 5, 584-590.
    • (1985) J Cereb Blood Flow Metab , vol.5 , pp. 584-590
    • Patlak, C.S.1    Blasberg, R.G.2
  • 48
    • 0031752622 scopus 로고    scopus 로고
    • Detection of cholangiocarcinoma in primary sclerosing cholangitis by positron emission tomography
    • Keiding S, Hansen SB, Rasmussen HH et al. (1998) Detection of cholangiocarcinoma in primary sclerosing cholangitis by positron emission tomography. Hepatology 28, 700-706.
    • (1998) Hepatology , vol.28 , pp. 700-706
    • Keiding, S.1    Hansen, S.B.2    Rasmussen, H.H.3
  • 49
    • 33845600792 scopus 로고    scopus 로고
    • Dynamic FDG PET is useful for detection of cholangiocarcinoma in patients with PSC listed for liver transplantation
    • Prytz H, Keiding S, Björnsson E et al. (2006) Dynamic FDG PET is useful for detection of cholangiocarcinoma in patients with PSC listed for liver transplantation. Hepatology 44, 1572-1580.
    • (2006) Hepatology , vol.44 , pp. 1572-1580
    • Prytz, H.1    Keiding, S.2    Björnsson, E.3
  • 50
    • 0026532491 scopus 로고
    • Use of the abdominal aorta for arterial input function determination in hepatic and renal PET studies
    • Germano G, Chen BC, Huang SC et al. (1992) Use of the abdominal aorta for arterial input function determination in hepatic and renal PET studies. J Nucl Med 33, 613-620.
    • (1992) J Nucl Med , vol.33 , pp. 613-620
    • Germano, G.1    Chen, B.C.2    Huang, S.C.3
  • 51
    • 0036192281 scopus 로고    scopus 로고
    • Quantification of (18)F-FDG uptake in the liver using dynamic PET
    • Munk OL, Keiding S. (2002) Quantification of (18)F-FDG uptake in the liver using dynamic PET. J Nucl Med 43, 439-441.
    • (2002) J Nucl Med , vol.43 , pp. 439-441
    • Munk, O.L.1    Keiding, S.2
  • 52
    • 17144367716 scopus 로고    scopus 로고
    • A priori identifiability of a one-compartment model with two input functions for liver blood flow measurements
    • Becker G, Müller-Schauenburg W, Spilker ME et al. (2005) A priori identifiability of a one-compartment model with two input functions for liver blood flow measurements. Phys Med Biol 50, 1393-1404.
    • (2005) Phys Med Biol , vol.50 , pp. 1393-1404
    • Becker, G.1    Müller-Schauenburg, W.2    Spilker, M.E.3
  • 53
    • 0141996420 scopus 로고    scopus 로고
    • Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography data
    • Munk OL, Keiding S, Bass L. (2003) Capillaries within compartments: microvascular interpretation of dynamic positron emission tomography data. J Theor Biol 225, 127-141.
    • (2003) J Theor Biol , vol.225 , pp. 127-141
    • Munk, O.L.1    Keiding, S.2    Bass, L.3
  • 54
    • 0642376390 scopus 로고    scopus 로고
    • Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig livers
    • Munk OL, Bass L, Feng H et al. (2003) Determination of regional flow by use of intravascular PET tracers: microvascular theory and experimental validation for pig livers. J Nucl Med 44, 1862-1870.
    • (2003) J Nucl Med , vol.44 , pp. 1862-1870
    • Munk, O.L.1    Bass, L.2    Feng, H.3
  • 55
    • 33947648326 scopus 로고    scopus 로고
    • Ammonia metabolism in cirrhosis
    • Häussinger D, Kircheisi G, Schless F (eds) Proceedings of the 12th International Symposium of Hepatic Encephalopathy and Nitrogen Metabolism. Springer Verlag
    • Sørensen M, Keiding S. (2006) Ammonia metabolism in cirrhosis. In: Häussinger D, Kircheisi G, Schless F (eds) Proceedings of the 12th International Symposium of Hepatic Encephalopathy and Nitrogen Metabolism. Springer Verlag, pp. 406-419.
    • (2006) , pp. 406-419
    • Sørensen, M.1    Keiding, S.2
  • 56
    • 33644790063 scopus 로고    scopus 로고
    • Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by PET
    • Keiding S, Sørensen M, Bender D et al. (2006) Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by PET. Hepatology 43, 42-50.
    • (2006) Hepatology , vol.43 , pp. 42-50
    • Keiding, S.1    Sørensen, M.2    Bender, D.3
  • 57
    • 0024447423 scopus 로고
    • Hepatocyte heterogeneity in glutamate metabolism and bidirectional transport in perfused rat liver
    • Haussinger D, Stoll B, Stehle T et al. (1989) Hepatocyte heterogeneity in glutamate metabolism and bidirectional transport in perfused rat liver. Eur J Biochem 185, 189-195.
    • (1989) Eur J Biochem , vol.185 , pp. 189-195
    • Haussinger, D.1    Stoll, B.2    Stehle, T.3
  • 58
    • 0026101649 scopus 로고
    • Functional hepatocyte heterogeneity in glutamate, aspartate and alpha-ketoglutarate uptake: a histoautoradiographical study
    • Stoll B, McNelly S, Buscher HP et al. (1991) Functional hepatocyte heterogeneity in glutamate, aspartate and alpha-ketoglutarate uptake: a histoautoradiographical study. Hepatology 13, 247-253.
    • (1991) Hepatology , vol.13 , pp. 247-253
    • Stoll, B.1    McNelly, S.2    Buscher, H.P.3
  • 59
    • 0024597449 scopus 로고
    • Hepatocyte heterogeneity: the coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation
    • Gumucio JJ. (1989) Hepatocyte heterogeneity: the coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation. Hepatology 9, 154-160.
    • (1989) Hepatology , vol.9 , pp. 154-160
    • Gumucio, J.J.1
  • 60
    • 0027055347 scopus 로고
    • Hepatocyte heterogeneity in the metabolism of amino acids and ammonia
    • Haussinger D, Lamers WH, Moorman AF. (1992) Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. Enzyme 46, 72-93.
    • (1992) Enzyme , vol.46 , pp. 72-93
    • Haussinger, D.1    Lamers, W.H.2    Moorman, A.F.3
  • 61
    • 0035215103 scopus 로고    scopus 로고
    • Positron emission tomography of hepatic first-pass metabolism of ammonia in pig
    • Keiding S, Munk OL, Roelsgaard K et al. (2001) Positron emission tomography of hepatic first-pass metabolism of ammonia in pig. Eur J Nucl Med 28, 1770-1775.
    • (2001) Eur J Nucl Med , vol.28 , pp. 1770-1775
    • Keiding, S.1    Munk, O.L.2    Roelsgaard, K.3
  • 62
    • 0027216716 scopus 로고
    • Hepatic blood flow distribution: consideration of gravity, liver surface, and norepinephrine on regional heterogeneity
    • Lautt WW, Schafer J, Legare DJ. (1993) Hepatic blood flow distribution: consideration of gravity, liver surface, and norepinephrine on regional heterogeneity. Can J Physiol Pharmacol 71, 128-135.
    • (1993) Can J Physiol Pharmacol , vol.71 , pp. 128-135
    • Lautt, W.W.1    Schafer, J.2    Legare, D.J.3
  • 63
    • 0018190444 scopus 로고
    • Hepatic elimination of flowing substrates: the distributed model
    • Bass L, Robinson P, Bracken AJ. (1978) Hepatic elimination of flowing substrates: the distributed model. J Theor Biol 72, 161-184.
    • (1978) J Theor Biol , vol.72 , pp. 161-184
    • Bass, L.1    Robinson, P.2    Bracken, A.J.3
  • 64
    • 0035865103 scopus 로고    scopus 로고
    • Hepatic arteriolo-portal venular shunting guarantees maintenance of nutritional microvascular supply in hepatic arterial buffer response of rat livers
    • Richter S, Vollmar B, Mucke I et al. (2001) Hepatic arteriolo-portal venular shunting guarantees maintenance of nutritional microvascular supply in hepatic arterial buffer response of rat livers. J Physiol 531, 193-201.
    • (2001) J Physiol , vol.531 , pp. 193-201
    • Richter, S.1    Vollmar, B.2    Mucke, I.3
  • 65
    • 14544300930 scopus 로고    scopus 로고
    • Hepatic microcirculation assessed by positron emission tomography of first-pass ammonia metabolism in porcine liver
    • Keiding S, Munk OL, Vilstrup H et al. (2005) Hepatic microcirculation assessed by positron emission tomography of first-pass ammonia metabolism in porcine liver. Liver Int 25, 171-176.
    • (2005) Liver Int , vol.25 , pp. 171-176
    • Keiding, S.1    Munk, O.L.2    Vilstrup, H.3
  • 66
    • 0036668697 scopus 로고    scopus 로고
    • Intrahepatic heterogeneity of hepatic venous pressure gradient in human cirrhosis
    • Keiding S, Vilstrup H. (2002) Intrahepatic heterogeneity of hepatic venous pressure gradient in human cirrhosis. Scand J Gastroenterol 37, 960-964.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 960-964
    • Keiding, S.1    Vilstrup, H.2
  • 67
    • 0017394995 scopus 로고
    • Splanchnic blood flow in patients with abdominal angina before and after arterial reconstruction.A proposal for a diagnostic test
    • Hansen HJ, Engell HC, Ring-Larsen H et al. (1977) Splanchnic blood flow in patients with abdominal angina before and after arterial reconstruction. A proposal for a diagnostic test. Ann Surg 186, 216-220.
    • (1977) Ann Surg , vol.186 , pp. 216-220
    • Hansen, H.J.1    Engell, H.C.2    Ring-Larsen, H.3
  • 68
    • 0018930582 scopus 로고
    • Importance of flow and haematocrit for metabolic function of perfused rat liver
    • Keiding S, Vilstrup H, Hansen L. (1980) Importance of flow and haematocrit for metabolic function of perfused rat liver. Scand J Clin Lab Invest 40, 355-359.
    • (1980) Scand J Clin Lab Invest , vol.40 , pp. 355-359
    • Keiding, S.1    Vilstrup, H.2    Hansen, L.3
  • 69
    • 0001082167 scopus 로고
    • Liver circulation and function
    • Brauer RW. (1963) Liver circulation and function. Physiol Rev 43, 115-213.
    • (1963) Physiol Rev , vol.43 , pp. 115-213
    • Brauer, R.W.1
  • 70
    • 0017740218 scopus 로고
    • Hepatic vasculature: a conceptual review
    • Lautt WW. (1977) Hepatic vasculature: a conceptual review. Gastroenterology 73, 1163-1169.
    • (1977) Gastroenterology , vol.73 , pp. 1163-1169
    • Lautt, W.W.1
  • 71
    • 0029119502 scopus 로고
    • Drug administration to liver patients: aspects of liver pathophysiology
    • Keiding S. (1995) Drug administration to liver patients: aspects of liver pathophysiology. Semin Liver Dis 15, 268-282.
    • (1995) Semin Liver Dis , vol.15 , pp. 268-282
    • Keiding, S.1
  • 72
    • 0013788916 scopus 로고
    • Pharmacokinetics of salicylate elimination in man
    • Levy G. (1965) Pharmacokinetics of salicylate elimination in man. J Pharm Sci 54, 959-967.
    • (1965) J Pharm Sci , vol.54 , pp. 959-967
    • Levy, G.1
  • 73
    • 0021029231 scopus 로고
    • Albumin-mediated transport of rose bengal by perfused rat liver.Kinetics of the reaction at the cell surface
    • Forker EL, Luxon BA. (1983) Albumin-mediated transport of rose bengal by perfused rat liver. Kinetics of the reaction at the cell surface. J Clin Invest 72, 1764-1771.
    • (1983) J Clin Invest , vol.72 , pp. 1764-1771
    • Forker, E.L.1    Luxon, B.A.2
  • 74
    • 0026507278 scopus 로고
    • Intrinsic hepatic clearance of indocyanine green in the pig: dependence on plasma protein concentration
    • Ott P, Keiding S, Bass L. (1992) Intrinsic hepatic clearance of indocyanine green in the pig: dependence on plasma protein concentration. Eur J Clin Invest 22, 347-357.
    • (1992) Eur J Clin Invest , vol.22 , pp. 347-357
    • Ott, P.1    Keiding, S.2    Bass, L.3
  • 75
    • 0021248970 scopus 로고
    • Effect of albumin binding on extraction of sulfobromophthalein by perfused elasmobranch liver: evidence for dissociation-limited uptake
    • Weisiger RA, Zacks CM, Smith ND et al. (1984) Effect of albumin binding on extraction of sulfobromophthalein by perfused elasmobranch liver: evidence for dissociation-limited uptake. Hepatology 4, 492-501.
    • (1984) Hepatology , vol.4 , pp. 492-501
    • Weisiger, R.A.1    Zacks, C.M.2    Smith, N.D.3
  • 76
    • 0012527385 scopus 로고
    • Dissociation from albumin: a potentially ratelimiting step in the clearance of substances by the liver
    • Weisiger RA. (1985) Dissociation from albumin: a potentially ratelimiting step in the clearance of substances by the liver. Proc Natl Acad Sci USA 82, 1563-1567.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 1563-1567
    • Weisiger, R.A.1
  • 77
    • 0027740949 scopus 로고
    • Enhancement of unbound clearance of ICG by plasma proteins, demonstrated in human subjects and interpreted without assumption of facilitating structures
    • Keiding S, Ott P, Bass L. (1993) Enhancement of unbound clearance of ICG by plasma proteins, demonstrated in human subjects and interpreted without assumption of facilitating structures. J Hepatol 19, 327-344.
    • (1993) J Hepatol , vol.19 , pp. 327-344
    • Keiding, S.1    Ott, P.2    Bass, L.3
  • 78
    • 0023607096 scopus 로고
    • Phenobarbital specifically increases the hepatocellular uptake of sulfobromophthaleinglutathione
    • Sorrentino D, Licko V, Weisiger RA et al. (1987) Phenobarbital specifically increases the hepatocellular uptake of sulfobromophthaleinglutathione. Biochem Biophys Res Commun 149, 921-926.
    • (1987) Biochem Biophys Res Commun , vol.149 , pp. 921-926
    • Sorrentino, D.1    Licko, V.2    Weisiger, R.A.3
  • 79
    • 0023949942 scopus 로고
    • Physiologically based models and strategic experiments in hepatic pharmacology
    • Bass L, Keiding S. (1988) Physiologically based models and strategic experiments in hepatic pharmacology. Biochem Pharmacol 37, 1425-1431.
    • (1988) Biochem Pharmacol , vol.37 , pp. 1425-1431
    • Bass, L.1    Keiding, S.2
  • 80
    • 0001636074 scopus 로고
    • The puzzle of rates of cellular uptake of protein-bound ligands
    • Pecile A, Rescigno A (eds) Pharmacokinetics: Mathematical Approaches to Metabolism and Distribution of Chemicals and Drugs. New York, London: Plenum Publishing
    • Pond S, Bass L. (1988) The puzzle of rates of cellular uptake of protein-bound ligands. In: Pecile A, Rescigno A (eds) Pharmacokinetics: Mathematical Approaches to Metabolism and Distribution of Chemicals and Drugs. New York, London: Plenum Publishing, pp. 245-269.
    • (1988) , pp. 245-269
    • Pond, S.1    Bass, L.2
  • 81
    • 0030791262 scopus 로고    scopus 로고
    • Nontraditional effects of protein binding and hematocrit on uptake of indocyanine green by perfused rat liver
    • Ott P, Weisiger RA. (1997) Nontraditional effects of protein binding and hematocrit on uptake of indocyanine green by perfused rat liver. Am J Physiol 273, G227-G238.
    • (1997) Am J Physiol , vol.273
    • Ott, P.1    Weisiger, R.A.2
  • 82
    • 0024797849 scopus 로고
    • Albumin enhances unidirectional fluxes of fatty acid across a lipid-water interface: theory and experiments
    • Weisiger RA, Pond SM, Bass L. (1989) Albumin enhances unidirectional fluxes of fatty acid across a lipid-water interface: theory and experiments. Am J Physiol 257, G904-G916.
    • (1989) Am J Physiol , vol.257
    • Weisiger, R.A.1    Pond, S.M.2    Bass, L.3
  • 83
    • 0026516790 scopus 로고
    • Influence of albumin on the net sinusoidal efflux of the organic anion dibromosulfophthalein from rat liver
    • Nijssen HM, Pijning T, Meijer DK et al. (1992) Influence of albumin on the net sinusoidal efflux of the organic anion dibromosulfophthalein from rat liver. Hepatology 15, 302-309.
    • (1992) Hepatology , vol.15 , pp. 302-309
    • Nijssen, H.M.1    Pijning, T.2    Meijer, D.K.3
  • 84
    • 3643108223 scopus 로고
    • The galactose elimination capacity in relation to clinical and laboratory findings in patients with cirrhosis
    • Tygstrup N. (1964) The galactose elimination capacity in relation to clinical and laboratory findings in patients with cirrhosis. Acta Med Scand 175, 291-300.
    • (1964) Acta Med Scand , vol.175 , pp. 291-300
    • Tygstrup, N.1
  • 85
    • 0025944140 scopus 로고
    • Accurate prediction of death by serial determination of galactose elimination capacity in primary biliary cirrhosis: a comparison with the Mayo model
    • Reichen J, Widmer T, Cotting J. (1991) Accurate prediction of death by serial determination of galactose elimination capacity in primary biliary cirrhosis: a comparison with the Mayo model. Hepatology 14, 504-510.
    • (1991) Hepatology , vol.14 , pp. 504-510
    • Reichen, J.1    Widmer, T.2    Cotting, J.3
  • 86
    • 0001555340 scopus 로고
    • Vascular pattern of the cirrhotic liver
    • Popper H, Elias H, Petty DE. (1952) Vascular pattern of the cirrhotic liver. Am J Clin Pathol 22, 717-729.
    • (1952) Am J Clin Pathol , vol.22 , pp. 717-729
    • Popper, H.1    Elias, H.2    Petty, D.E.3
  • 87
    • 0020364281 scopus 로고
    • Assessment of liver microcirculation in human cirrhosis
    • Huet PM, Goresky CA, Villeneuve JP et al. (1982) Assessment of liver microcirculation in human cirrhosis. J Clin Invest 70, 1234-1244.
    • (1982) J Clin Invest , vol.70 , pp. 1234-1244
    • Huet, P.M.1    Goresky, C.A.2    Villeneuve, J.P.3
  • 88
    • 0032815333 scopus 로고    scopus 로고
    • Azygos venous blood flow while fasting, postprandially, and after endoscopic variceal ligation, measured by magnetic resonance imaging
    • Sugano S, Yamamoto K, Takamura N et al. (1999) Azygos venous blood flow while fasting, postprandially, and after endoscopic variceal ligation, measured by magnetic resonance imaging. J Gastroenterol 34, 310-314.
    • (1999) J Gastroenterol , vol.34 , pp. 310-314
    • Sugano, S.1    Yamamoto, K.2    Takamura, N.3
  • 89
    • 0025837621 scopus 로고
    • Long-term effects of oral propranolol on splanchnic and systemic haemodynamics in patients with cirrhosis and oesophageal varices
    • Bendtsen F, Henriksen JH, Sorensen TI. (1991) Long-term effects of oral propranolol on splanchnic and systemic haemodynamics in patients with cirrhosis and oesophageal varices. Scand J Gastroenterol 26, 933-939.
    • (1991) Scand J Gastroenterol , vol.26 , pp. 933-939
    • Bendtsen, F.1    Henriksen, J.H.2    Sorensen, T.I.3
  • 90
    • 0018871278 scopus 로고
    • Functioning liver mass in uncomplicated and fulminant acute hepatitis
    • Ramsoe K, Andreasen PB, Ranek L. (1980) Functioning liver mass in uncomplicated and fulminant acute hepatitis. Scand J Gastroenterol 15, 65-72.
    • (1980) Scand J Gastroenterol , vol.15 , pp. 65-72
    • Ramsoe, K.1    Andreasen, P.B.2    Ranek, L.3
  • 91
    • 2342421148 scopus 로고    scopus 로고
    • Galactose elimination capacity as a prognostic marker in patients with severe acetaminophen-induced hepatotoxicity: 10 years' experience
    • Schmidt LE, Ott P, Tygstrup N. (2004) Galactose elimination capacity as a prognostic marker in patients with severe acetaminophen-induced hepatotoxicity: 10 years' experience. Clin Gastroenterol Hepatol 2, 418-424.
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 418-424
    • Schmidt, L.E.1    Ott, P.2    Tygstrup, N.3
  • 92
    • 0018917745 scopus 로고
    • Predicting outcome of paracetamol poisoning by use of 14C-aminopyrine breath test
    • Saunders JB, Wright N, Lewis KO. (1980) Predicting outcome of paracetamol poisoning by use of 14C-aminopyrine breath test. Br Med J 280, 279-280.
    • (1980) Br Med J , vol.280 , pp. 279-280
    • Saunders, J.B.1    Wright, N.2    Lewis, K.O.3
  • 93
    • 0019175880 scopus 로고
    • Aminopyrine N-demethylation: a prognostic test of liver function in patients with alcoholic liver disease
    • Schneider JF, Baker AL, Haines NW et al. (1980) Aminopyrine N-demethylation: a prognostic test of liver function in patients with alcoholic liver disease. Gastroenterology 79, 1145-1150.
    • (1980) Gastroenterology , vol.79 , pp. 1145-1150
    • Schneider, J.F.1    Baker, A.L.2    Haines, N.W.3
  • 94
    • 0024314768 scopus 로고
    • Indocyanine green intrinsic hepatic clearance as a prognostic index of survival in patients with cirrhosis
    • Merkel C, Bolognesi M, Finucci GF et al. (1989) Indocyanine green intrinsic hepatic clearance as a prognostic index of survival in patients with cirrhosis. J Hepatol 9, 16-22.
    • (1989) J Hepatol , vol.9 , pp. 16-22
    • Merkel, C.1    Bolognesi, M.2    Finucci, G.F.3
  • 95
    • 0026562356 scopus 로고
    • Aminopyrine breath test in the prognostic evaluation of patients with cirrhosis
    • Merkel C, Bolognesi M, Bellon S et al. (1992) Aminopyrine breath test in the prognostic evaluation of patients with cirrhosis. Gut 33, 836-842.
    • (1992) Gut , vol.33 , pp. 836-842
    • Merkel, C.1    Bolognesi, M.2    Bellon, S.3
  • 96
    • 0031856703 scopus 로고    scopus 로고
    • Updating prognosis of cirrhosis by Cox's regression model using Child-Pugh score and aminopyrine breath test as time-dependent covariates
    • Merkel C, Morabito A, Sacerdoti D et al. (1998) Updating prognosis of cirrhosis by Cox's regression model using Child-Pugh score and aminopyrine breath test as time-dependent covariates. Ital J Gastroenterol Hepatol 30, 276-282.
    • (1998) Ital J Gastroenterol Hepatol , vol.30 , pp. 276-282
    • Merkel, C.1    Morabito, A.2    Sacerdoti, D.3
  • 97
    • 0022541304 scopus 로고
    • Prognostic value of the aminopyrine breath test in cirrhotic patients
    • Villeneuve JP, Infante-Rivard C, Ampelas M et al. (1986) Prognostic value of the aminopyrine breath test in cirrhotic patients. Hepatology 6, 928-931.
    • (1986) Hepatology , vol.6 , pp. 928-931
    • Villeneuve, J.P.1    Infante-Rivard, C.2    Ampelas, M.3
  • 98
    • 0024202189 scopus 로고
    • Chronic hepatitis: disease factors at diagnosis predictive of mortality
    • Lashner BA, Jonas RB, Tang HS et al. (1988) Chronic hepatitis: disease factors at diagnosis predictive of mortality. Am J Med 85, 609-614.
    • (1988) Am J Med , vol.85 , pp. 609-614
    • Lashner, B.A.1    Jonas, R.B.2    Tang, H.S.3
  • 99
    • 0036142756 scopus 로고    scopus 로고
    • Preoperative galactose elimination capacity predicts complications and survival after hepatic resection
    • Redaelli CA, Dufour JF, Wagner M et al. (2002) Preoperative galactose elimination capacity predicts complications and survival after hepatic resection. Ann Surg 235, 77-85.
    • (2002) Ann Surg , vol.235 , pp. 77-85
    • Redaelli, C.A.1    Dufour, J.F.2    Wagner, M.3
  • 100
    • 0025296981 scopus 로고
    • Liver regeneration and restoration of liver function after partial hepatectomy in patients with liver tumors
    • Jansen PL, Chamuleau RA, van Leeuwen DJ et al. (1990) Liver regeneration and restoration of liver function after partial hepatectomy in patients with liver tumors. Scand J Gastroenterol 25, 112-118.
    • (1990) Scand J Gastroenterol , vol.25 , pp. 112-118
    • Jansen, P.L.1    Chamuleau, R.A.2    van Leeuwen, D.J.3
  • 101
    • 0033037874 scopus 로고    scopus 로고
    • Possible role of FDGPET in the early prediction of therapy outcome in liver metastases of colorectal cancer
    • Bender H, Bangard N, Metten N et al. (1999) Possible role of FDGPET in the early prediction of therapy outcome in liver metastases of colorectal cancer. Hybridoma 18, 87-91.
    • (1999) Hybridoma , vol.18 , pp. 87-91
    • Bender, H.1    Bangard, N.2    Metten, N.3
  • 102
    • 0038354700 scopus 로고    scopus 로고
    • PET-FDG as predictor of therapy response in patients with colorectal carcinoma
    • Dimitrakopoulou-Strauss A, Strauss LG, Rudi J. (2003) PET-FDG as predictor of therapy response in patients with colorectal carcinoma. Q J Nucl Med 47, 8-13.
    • (2003) Q J Nucl Med , vol.47 , pp. 8-13
    • Dimitrakopoulou-Strauss, A.1    Strauss, L.G.2    Rudi, J.3
  • 103
    • 10744226606 scopus 로고    scopus 로고
    • Intraoperative radiation therapy in liver tissue in a pig model: monitoring with dualmodality PET/CT
    • Antoch G, Kaiser GM, Mueller AB et al. (2004) Intraoperative radiation therapy in liver tissue in a pig model: monitoring with dualmodality PET/CT. Radiology 230, 753-760.
    • (2004) Radiology , vol.230 , pp. 753-760
    • Antoch, G.1    Kaiser, G.M.2    Mueller, A.B.3
  • 104
    • 17844385330 scopus 로고    scopus 로고
    • Assessment of liver tissue after radiofrequency ablation: findings with different imaging procedures
    • Antoch G, Vogt FM, Veit P et al. (2005) Assessment of liver tissue after radiofrequency ablation: findings with different imaging procedures. J Nucl Med 46, 520-525.
    • (2005) J Nucl Med , vol.46 , pp. 520-525
    • Antoch, G.1    Vogt, F.M.2    Veit, P.3
  • 105
    • 0023892496 scopus 로고
    • Antipyrine as a model drug to study hepatic drug-metabolizing capacity
    • Poulsen HE, Loft S. (1988) Antipyrine as a model drug to study hepatic drug-metabolizing capacity. J Hepatol 6, 374-382.
    • (1988) J Hepatol , vol.6 , pp. 374-382
    • Poulsen, H.E.1    Loft, S.2
  • 106
    • 0017149723 scopus 로고
    • Aminopyrine demethylation measured by breath analysis in cirrhosis
    • Bircher J, Kupfer A, Gikalov I et al. (1976) Aminopyrine demethylation measured by breath analysis in cirrhosis. Clin Pharmacol Ther 20, 484-492.
    • (1976) Clin Pharmacol Ther , vol.20 , pp. 484-492
    • Bircher, J.1    Kupfer, A.2    Gikalov, I.3
  • 107
    • 0027467408 scopus 로고
    • Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis
    • Lauterburg BH, Liang D, Schwarzenbach FA et al. (1993) Mitochondrial dysfunction in alcoholic patients as assessed by breath analysis. Hepatology 17, 418-422.
    • (1993) Hepatology , vol.17 , pp. 418-422
    • Lauterburg, B.H.1    Liang, D.2    Schwarzenbach, F.A.3


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