Statistical Methods of Signal Detection

Pharmacovigilance: Second Edition

Volumn , Issue , 2007, Pages 249-255

  Evans, Stephen ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

'Preferred Term' and 'High Level Term' (HLT); Adverse Drug Reactions Online Information and Tracking (ADROIT); Bayesian confidence propagation neural network and WHO; Proportional reporting ratios (PRRs); Signal detection statistical methods

Indexed keywords

EID: 84889327586     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470059210.ch19     Document Type: Chapter

References (10)

1. Bate A, Lindquist M, Edwards IR, et al. (1998) A Bayesian neural network method for adverse drug reaction signal generation. Eur J Clin Pharmacol 54: 315-21.
2. DuMouchel W (1999) Bayesian data mining in large frequency tables, with an application to the FDA Spontaneous Reporting System. Am Stat 53: 177-90.
3. Evans SJW, Waller P, Davis S (1998) Proportional reporting ratios: the uses of epidemiological methods for signal generation. Pharmacoepidemiol Drug Saf 7: S102.
4. Evans SJW, Waller PC, Davis S (2001) Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports. Pharmacoepidemiol Drug Saf 10: 483-6.
5. Finney DJ (1974) Systematic signalling of adverse reactions to drugs. Meth Inf Med 13: 1-10.
6. Patwary KW (1969) Report on Statistical Aspects of the Pilot Research Project for International Drug Monitoring. Geneva: WHO.
7. Rothman KJ, Greenland S (1998) Modern Epidemiology. Philadelphia: Lippincott-Raven, pp. 76, 270.
8. Tubert-Bitter P, Bégaud B, Motide Y, et al. (1996) Comparing the toxicity of two drugs in the framework of spontaneous reporting: a confidence interval approach. J Clin Epidemiol 49: 121-3.
9. Waller PC, Coulson RA, Wood SM (1996) Regulatory pharmacovigilance in the United Kingdom: current principles and practice. Pharmacoepidemiol Drug Saf 5: 363-75.
10. Wood SM, Coulson R, Eccles S. (1994) Signal generation in the UK. In: Fracchia GN, ed., European Medicines Research. Amsterdam: IOS Press, pp. 360-3.