Does sex influence the response to intravenous thrombolysis in ischemic stroke?: Answers from safe implementation of treatments in stroke-international stroke thrombolysis register

Stroke

Volumn 44, Issue 12, 2013, Pages 3401-3406

  Lorenzano, Svetlana ^a   Ahmed, Niaz ^b   Falcou, Anne ^a   Mikulik, Robert ^c   Tatlisumak, Turgut ^d   Roffe, Christine ^e   Wahlgren, Nils ^b   Toni, Danilo ^a  

^a POLICLINICO UMBERTO I   (Italy)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e KEELE UNIVERSITY   (United Kingdom)

Author keywords

Outcome assessment (health care); Sex; Stroke; Thrombolytic therapy; Tissue plasminogen activator

Indexed keywords

ACETYLSALICYLIC ACID; ALTEPLASE; ANTICOAGULANT AGENT; ANTIHYPERTENSIVE AGENT; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CONFIDENCE INTERVAL; CONFOUNDING VARIABLE; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFICACY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANKIN SCALE; RISK ASSESSMENT; SEX DIFFERENCE; SURVIVAL; TREATMENT OUTCOME;

OUTCOME ASSESSMENT (HEALTH CARE); SEX; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR;

ADMINISTRATION, INTRAVENOUS; AGED; AGED, 80 AND OVER; BODY WEIGHT; BRAIN ISCHEMIA; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; REGISTRIES; SEX FACTORS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84889259141     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.002908     Document Type: Article

References (23)

1. Reeves MJ, Bushnell CD, Howard G, Gargano JW, Duncan PW, Lynch G, et al. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol. 2008;7:915-926.
2. Bousser MG. Stroke in women: the 1997 Paul Dudley White International Lecture. Circulation. 1999;99:463-467.
3. Di Carlo A, Lamassa M, Baldereschi M, Pracucci G, Basile AM, Wolfe CD, et al; European BIOMED Study of Stroke Care Group. Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospitalbased registry. Stroke. 2003;34:1114-1119.
4. Roquer J, Campello AR, Gomis M. Sex differences in first-ever acute stroke. Stroke. 2003;34:1581-1585.
5. Kapral MK, Fang J, Hill MD, Silver F, Richards J, Jaigobin C, et al. Sex differences in stroke care and outcomes: results from the registry of the Canadian Stroke Network. Stroke. 2005;36:809-814.
6. Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke. 2005;36:62-65.
7. Kent DM, Buchan AM, Hill MD. The sex effect in stroke thrombolysis: of CASES, controls, and treatment-effect modification. Neurology. 2008;71:1080-1083.
8. Hill MD, Kent DM, Hinchey J, Rowley H, Buchan AM, Wechsler LR, et al; PROACT-2 Investigators. Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study. Stroke. 2006;37:2322-2325.
9. Elkind MS, Prabhakaran S, Pittman J, Koroshetz W, Jacoby M, Johnston KC; GAIN Americas Investigators. Sex as a predictor of outcomes in patients treated with thrombolysis for acute stroke. Neurology. 2007;68:842-848.
10. Wahlgren N, Ahmed N, Dávalos A, Ford GA, Grond M, Hacke W, et al; SITS-MOST Investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet. 2007;369:275-282.
11. SITS-ISTR. Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register. https://sitsinternational.org. Accessed July 19, 2011.
12. Lyden P, Lu M, Jackson C, Marler J, Kothari R, Brott T, et al. Underlying structure of the National Institutes of Health Stroke Scale: results of a factor analysis. NINDS tPA Stroke Trial Investigators. Stroke. 1999;30:2347-2354.
13. Berger C, Fiorelli M, Steiner T, Schäbitz WR, Bozzao L, Bluhmki E, et al. Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic? Stroke. 2001;32:1330-1335.
14. van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19:604-607.
15. Savitz SI, Schlaug G, Caplan L, Selim M. Arterial occlusive lesions recanalize more frequently in women than in men after intravenous tissue plasminogen activator administration for acute stroke. Stroke. 2005;36:1447-1451.
16. Jovanovi DR, Besla-Bumbasirevi Lj, Budimki M, Pekmezovi T, Zivkovi M, Kosti VS; SETIS Investigation Group. Do women benefit more from systemic thrombolysis in acute ischemic stroke? A Serbian experience with thrombolysis in ischemic stroke (SETIS) study. Clin Neurol Neurosurg. 2009;111:729-732.
17. Förster A, Gass A, Kern R, Wolf ME, Ottomeyer C, Zohsel K, et al. Gender differences in acute ischemic stroke: etiology, stroke patterns and response to thrombolysis. Stroke. 2009;40:2428-2432.
18. Meseguer E, Mazighi M, Labreuche J, Arnaiz C, Cabrejo L, Slaoui T, et al. Outcomes of intravenous recombinant tissue plasminogen activator therapy according to gender: a clinical registry study and systematic review. Stroke. 2009;40:2104-2110.
19. Shah SH, Liebeskind DS, Saver JL, Starkman S, Vinuela F, Duckwiler G, et al. Influence of gender on outcomes after intra-arterial thrombolysis for acute ischemic stroke. Neurology. 2006;66:1745-1746.
20. Arnold M, Kappeler L, Nedeltchev K, Brekenfeld C, Fischer U, Keserue B, et al. Recanalization and outcome after intra-arterial thrombolysis in middle cerebral artery and internal carotid artery occlusion: does sex matter? Stroke. 2007;38:1281-1285.
21. Wahlgren N, Ahmed N, Eriksson N, Aichner F, Bluhmki E, Dávalos A, et al; Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy Investigators. Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST). Stroke. 2008;39:3316-3322.
22. Mazya M, Egido JA, Ford GA, Lees KR, Mikulik R, Toni D, et al; SITS Investigators. Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: Safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score. Stroke. 2012;43:1524-1531.
23. Niessen F, Hilger T, Hoehn M, Hossmann KA. Differences in clot preparation determine outcome of rt-PA treatment in experimental thromboembolic stroke. Stroke. 2003;34:2019-2024.