메뉴 건너뛰기




Volumn 5, Issue , 2013, Pages 61-72

Emerging targeted combinations in the management of breast cancer

Author keywords

Breast cancer; Receptor; Targeted therapy; Tyrosine kinase

Indexed keywords

AFLIBERCEPT; ANASTROZOLE; BEVACIZUMAB; CANERTINIB; CAPECITABINE; CETUXIMAB; CYCLOPHOSPHAMIDE; DOCETAXEL; ERLOTINIB; EVEROLIMUS; FULVESTRANT; GEFITINIB; GEMCITABINE; IRINOTECAN; LAPATINIB; LETROZOLE; NERATINIB; OLAPARIB; PERTUZUMAB; PLACEBO; SORAFENIB; SUNITINIB; TAMOXIFEN; TEMSIROLIMUS; TIPIFARNIB; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNINDEXED DRUG; VANDETANIB; VATALANIB;

EID: 84889256571     PISSN: None     EISSN: 11791314     Source Type: Journal    
DOI: 10.2147/BCTT.S26771     Document Type: Review
Times cited : (4)

References (77)
  • 1
    • 0021688634 scopus 로고
    • The neu oncogene: An erb-B-related gene encoding a 185,000-Mr tumour antigen
    • Schechter AL, Stern DF, Vaidyanathan L, et al. The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature. 1984;312(5994):513-516.
    • (1984) Nature , vol.312 , Issue.5994 , pp. 513-516
    • Schechter, A.L.1    Stern, D.F.2    Vaidyanathan, L.3
  • 2
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon D, Godolphin W, Jones L, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 1989;244(4905):707-712.
    • (1989) Science , vol.244 , Issue.4905 , pp. 707-712
    • Slamon, D.1    Godolphin, W.2    Jones, L.3
  • 3
    • 66249091930 scopus 로고    scopus 로고
    • The HER-2 receptor and breast cancer: Ten years of targeted anti-HER-2 therapy and personalized medicine
    • Ross JS, Slodkowska EA, Symmans WF, Pusztai L, Ravdin PM, Hortobagyi GN. The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine. The Oncologist. 2009;14(4):320-368.
    • (2009) The Oncologist , vol.14 , Issue.4 , pp. 320-368
    • Ross, J.S.1    Slodkowska, E.A.2    Symmans, W.F.3    Pusztai, L.4    Ravdin, P.M.5    Hortobagyi, G.N.6
  • 4
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab - mechanism of action and use in clinical practice
    • Hudis CA. Trastuzumab - mechanism of action and use in clinical practice. N Engl J Med. 2007;357(1):39-51.
    • (2007) N Engl J Med , vol.357 , Issue.1 , pp. 39-51
    • Hudis, C.A.1
  • 6
    • 33845914783 scopus 로고    scopus 로고
    • 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomised controlled trial
    • Smith I, Procter M, Gelber RD, et al. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet. 2007;369(9555):29-36.
    • (2007) Lancet , vol.369 , Issue.9555 , pp. 29-36
    • Smith, I.1    Procter, M.2    Gelber, R.D.3
  • 7
    • 80053539103 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in HER2-positive breast cancer
    • Slamon D, Eiermann W, Robert N, et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med. 2011;365(14):1273-1283.
    • (2011) N Engl J Med , vol.365 , Issue.14 , pp. 1273-1283
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 8
    • 20244378677 scopus 로고    scopus 로고
    • Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
    • Agus DB, Gordon MS, Taylor C, et al. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol. 2005;23(11):2534-2543.
    • (2005) J Clin Oncol , vol.23 , Issue.11 , pp. 2534-2543
    • Agus, D.B.1    Gordon, M.S.2    Taylor, C.3
  • 9
    • 0034597662 scopus 로고    scopus 로고
    • Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3
    • Chen X, Yeung TK, Wang Z. Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3. Biochem Biophys Res Commun. 2000;277(3):757-763.
    • (2000) Biochem Biophys Res Commun , vol.277 , Issue.3 , pp. 757-763
    • Chen, X.1    Yeung, T.K.2    Wang, Z.3
  • 10
    • 77949901499 scopus 로고    scopus 로고
    • Open-label, Phase II, multicenter, randomized study of the efficacy and safety of two dose levels of pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Gianni L, Lladó A, Bianchi G, et al. Open-label, Phase II, multicenter, randomized study of the efficacy and safety of two dose levels of pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol. 2010;28(7):1131-1137.
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1131-1137
    • Gianni, L.1    Lladó, A.2    Bianchi, G.3
  • 11
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S, et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol. 2010;28(7):1138-1144.
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 12
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J, Cortés J, Kim S-B, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med. 2012;366(2):109-119.
    • (2012) N Engl J Med , vol.366 , Issue.2 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.-B.3
  • 13
    • 84872845061 scopus 로고    scopus 로고
    • Confirmatory overall survival (OS) analysis of CLEOPATRA: A randomized, double-blind, placebo-controlled Phase III study with pertuzumab (P), trastuzumab (T), and docetaxel (D) in patients (pts) with HER2-positive first-line (1L) metastatic breast cancer (MBC)
    • abstract P5-18-26
    • Swain SM, Kim SB, Cortes J, et al. Confirmatory overall survival (OS) analysis of CLEOPATRA: a randomized, double-blind, placebo-controlled Phase III study with pertuzumab (P), trastuzumab (T), and docetaxel (D) in patients (pts) with HER2-positive first-line (1L) metastatic breast cancer (MBC). Cancer Research. 2012;72(24 Suppl 3):abstract P5-18-26.
    • (2012) Cancer Research , vol.72 , Issue.24
    • Swain, S.M.1    Kim, S.B.2    Cortes, J.3
  • 14
    • 56449129810 scopus 로고    scopus 로고
    • Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
    • Lewis Phillips GD, Li G, Dugger DL, et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Research. 2008;68(22):9280-9290.
    • (2008) Cancer Research , vol.68 , Issue.22 , pp. 9280-9290
    • Lewis Phillips, G.D.1    Li, G.2    Dugger, D.L.3
  • 15
    • 77954031486 scopus 로고    scopus 로고
    • Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
    • Krop IE, Beeram M, Modi S, et al. Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol. 2010;28(16):2698-2704.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2698-2704
    • Krop, I.E.1    Beeram, M.2    Modi, S.3
  • 16
    • 84863688392 scopus 로고    scopus 로고
    • A Phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
    • Krop IE, LoRusso P, Miller KD, et al. A Phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine. J Clin Oncol. 2012;30(26):3234-3241.
    • (2012) J Clin Oncol , vol.30 , Issue.26 , pp. 3234-3241
    • Krop, I.E.1    LoRusso, P.2    Miller, K.D.3
  • 17
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma S, Miles D, Gianni L, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012;367(19):1783-1791.
    • (2012) N Engl J Med , vol.367 , Issue.19 , pp. 1783-1791
    • Verma, S.1    Miles, D.2    Gianni, L.3
  • 18
    • 84890032261 scopus 로고    scopus 로고
    • Trastuzumab emtansine in HER2-positive metastatic breast cancer: Pooled safety analysis from seven studies
    • Diéras V, Harbeck N, Budd GT, et al. Trastuzumab emtansine in HER2-positive metastatic breast cancer: pooled safety analysis from seven studies. Cancer Research. 2012;72(24 Suppl 3):P5-18-06.
    • (2012) Cancer Research , vol.72 , Issue.24
    • Diéras, V.1    Harbeck, N.2    Budd, G.T.3
  • 19
    • 84867842898 scopus 로고    scopus 로고
    • MARIANNE: A phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC)
    • (Suppl; abstr TPS102)
    • Ellis P, Barrios C, Im Y, Patre M, Branle F, Perez E. MARIANNE: A phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC). J Clin Oncol. 2011;29(Suppl; abstr TPS102).
    • (2011) J Clin Oncol , vol.29
    • Ellis, P.1    Barrios, C.2    Im, Y.3    Patre, M.4    Branle, F.5    Perez, E.6
  • 20
    • 77954726255 scopus 로고    scopus 로고
    • Emerging targeted therapies for breast cancer
    • Alvarez RH, Valero V, Hortobagyi GN. Emerging targeted therapies for breast cancer. J Clin Oncol. 2010;28(20):3366-3379.
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3366-3379
    • Alvarez, R.H.1    Valero, V.2    Hortobagyi, G.N.3
  • 21
    • 23944464495 scopus 로고    scopus 로고
    • Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer
    • Baselga J, Albanell J, Ruiz A, et al. Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer. J Clin Oncol. 2005;23(23):5323-5333.
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5323-5333
    • Baselga, J.1    Albanell, J.2    Ruiz, A.3
  • 22
    • 0042804495 scopus 로고    scopus 로고
    • Gefitinib (ZD1839) is active in acquired tamoxifen (TAM)-resistant oestrogen receptor (ER)-positive and ER-negative breast cancer: Results from a phase II study
    • (abstr 23)
    • Robertson J, Gutteridge E, Cheung K, Owers R. Gefitinib (ZD1839) is active in acquired tamoxifen (TAM)-resistant oestrogen receptor (ER)-positive and ER-negative breast cancer: results from a phase II study. Proc Am Soc Clin Oncol. 2003;22(abstr 23).
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Robertson, J.1    Gutteridge, E.2    Cheung, K.3    Owers, R.4
  • 23
    • 0042675500 scopus 로고    scopus 로고
    • Open-label, phase II, multicenter trial of ZD 1839 ('Iressa') in patients with advanced breast cancer
    • (Suppl 1; abstr 20)
    • Albain K, Elledge R, Gradishar WJ, Natale RB. Open-label, phase II, multicenter trial of ZD 1839 ('Iressa') in patients with advanced breast cancer. Breast Cancer Research And Treatment. 2002;76(S33):(Suppl 1; abstr 20).
    • (2002) Breast Cancer Research And Treatment , vol.76 , Issue.S33
    • Albain, K.1    Elledge, R.2    Gradishar, W.J.3    Natale, R.B.4
  • 24
    • 20844456577 scopus 로고    scopus 로고
    • A multicentre phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer
    • von Minckwitz G, Jonat W, Fasching P, et al. A multicentre phase II study on gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer. Breast Cancer Res Treat. 2005;89(2):165-172.
    • (2005) Breast Cancer Res Treat , vol.89 , Issue.2 , pp. 165-172
    • von Minckwitz, G.1    Jonat, W.2    Fasching, P.3
  • 25
    • 33745277110 scopus 로고    scopus 로고
    • Phase II trial of gefitinib combined with docetaxel as first-line therapy in patients with metastatic breast cancer
    • Ciardiello F, Troiani T, Caputo F, et al. Phase II trial of gefitinib combined with docetaxel as first-line therapy in patients with metastatic breast cancer. Br J Cancer. 2006;94(11):1604-1609.
    • (2006) Br J Cancer. , vol.94 , Issue.11 , pp. 1604-1609
    • Ciardiello, F.1    Troiani, T.2    Caputo, F.3
  • 26
    • 84880443548 scopus 로고    scopus 로고
    • Gefitinib in combination with weekly docetaxel in patients with metastatic breast cancer caused unexpected toxicity: Results from a randomized Phase II clinical trial
    • Engebraaten O, Edvardsen H, Løkkevik E, et al. Gefitinib in combination with weekly docetaxel in patients with metastatic breast cancer caused unexpected toxicity: results from a randomized Phase II clinical trial. ISRN Oncology. 2012;2012:8.
    • (2012) ISRN Oncology , vol.2012 , pp. 8
    • Engebraaten, O.1    Edvardsen, H.2    Løkkevik, E.3
  • 27
    • 34548537574 scopus 로고    scopus 로고
    • A Phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer
    • Smith IE, Walsh G, Skene A, et al. A Phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J Clin Oncol. 2007;25(25):3816-3822.
    • (2007) J Clin Oncol , vol.25 , Issue.25 , pp. 3816-3822
    • Smith, I.E.1    Walsh, G.2    Skene, A.3
  • 28
    • 76649143246 scopus 로고    scopus 로고
    • Randomized phase II trial of gefitinib plus anastrozole or fulvestrant in postmenopausal, metastatic breast cancer
    • Carlson R W, O'Neill A, Vidaurre T, Gomez HL, Badve S. Randomized phase II trial of gefitinib plus anastrozole or fulvestrant in postmenopausal, metastatic breast cancer. J Clin Oncol. 2009;27(15S):1013.
    • (2009) J Clin Oncol , vol.27 , Issue.15S , pp. 1013
    • Carlson, R.W.1    O'Neill, A.2    Vidaurre, T.3    Gomez, H.L.4    Badve, S.5
  • 29
    • 38749087923 scopus 로고    scopus 로고
    • Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: A dose-escalation study
    • Twelves C, Trigo JM, Jones R, et al. Erlotinib in combination with capecitabine and docetaxel in patients with metastatic breast cancer: a dose-escalation study. Eur J Cancer. 2008;44(3):419-426.
    • (2008) Eur J Cancer , vol.44 , Issue.3 , pp. 419-426
    • Twelves, C.1    Trigo, J.M.2    Jones, R.3
  • 30
    • 59449097074 scopus 로고    scopus 로고
    • A phase ii trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancer
    • Dickler MN, Rugo HS, Eberle CA, et al. A phase ii trial of erlotinib in combination with bevacizumab in patients with metastatic breast cancer. Clin Cancer Res. 2008;14(23):7878-7883.
    • (2008) Clin Cancer Res , vol.14 , Issue.23 , pp. 7878-7883
    • Dickler, M.N.1    Rugo, H.S.2    Eberle, C.A.3
  • 31
    • 34249314346 scopus 로고    scopus 로고
    • Toxicity and outcome data in a phase II study of weekly docetaxel in combination with erlotinib in recurrent and/or metastatic breast cancer (MBC)
    • Kaur H, Silverman P, Singh D, Cooper BW, Fu P, Krishnamurthi S. Toxicity and outcome data in a phase II study of weekly docetaxel in combination with erlotinib in recurrent and/or metastatic breast cancer (MBC). J Clin Oncol. 2006;24(18S):10623.
    • (2006) J Clin Oncol , vol.24 , Issue.18S
    • Kaur, H.1    Silverman, P.2    Singh, D.3    Cooper, B.W.4    Fu, P.5    Krishnamurthi, S.6
  • 32
    • 84861111904 scopus 로고    scopus 로고
    • Metronomic chemotherapy combined with bevacizumab and erlotinib in patients with metastatic HER2-negative breast cancer: Clinical and biological activity
    • Montagna E, Cancello G, Bagnardi V, et al. Metronomic chemotherapy combined with bevacizumab and erlotinib in patients with metastatic HER2-negative breast cancer: clinical and biological activity. Clin Breast Cancer. 2012;12(3):207-214.
    • (2012) Clin Breast Cancer , vol.12 , Issue.3 , pp. 207-214
    • Montagna, E.1    Cancello, G.2    Bagnardi, V.3
  • 33
    • 33144485574 scopus 로고    scopus 로고
    • N0234: Phase II study of erlotinib (OSI-774) plus gemcitabine as first-or second-line therapy for metastatic breast cancer (MBC)
    • Graham DL, Hillman DW, Hobday TJ, et al. N0234: Phase II study of erlotinib (OSI-774) plus gemcitabine as first-or second-line therapy for metastatic breast cancer (MBC). J Clin Oncol. 2005;23(16S):644.
    • (2005) J Clin Oncol , vol.23 , Issue.16S , pp. 644
    • Graham, D.L.1    Hillman, D.W.2    Hobday, T.J.3
  • 34
    • 67349246021 scopus 로고    scopus 로고
    • N0436: A phase II trial of irinotecan plus cetuximab in patients with metastatic breast cancer and prior anthracycline and/or taxane-containing therapy
    • abstr 1081
    • Hobday TJ, Stella PJ, Fitch TR, et al. N0436: a phase II trial of irinotecan plus cetuximab in patients with metastatic breast cancer and prior anthracycline and/or taxane-containing therapy. J Clin Oncol. 2008;26(Suppl):abstr 1081.
    • (2008) J Clin Oncol , vol.26
    • Hobday, T.J.1    Stella, P.J.2    Fitch, T.R.3
  • 35
    • 84864101306 scopus 로고    scopus 로고
    • TBCRC 001: Randomized phase ii study of cetuximab in combination with carboplatin in Stage IV triple-negative breast cancer
    • Carey LA, Rugo HS, Marcom PK, et al. TBCRC 001: randomized phase ii study of cetuximab in combination with carboplatin in Stage IV triple-negative breast cancer. J Clin Oncol. 2012;30(21):2615-2623.
    • (2012) J Clin Oncol , vol.30 , Issue.21 , pp. 2615-2623
    • Carey, L.A.1    Rugo, H.S.2    Marcom, P.K.3
  • 36
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer. New England Journal of Medicine. 2006;355(26):2733-2743.
    • (2006) New England Journal of Medicine , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 37
    • 84857236823 scopus 로고    scopus 로고
    • Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): A randomised, open-label, multicentre, phase 3 trial
    • Baselga J, Bradbury I, Eidtmann H, et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. The Lancet. 379(9816):633-640.
    • The Lancet , vol.379 , Issue.9816 , pp. 633-640
    • Baselga, J.1    Bradbury, I.2    Eidtmann, H.3
  • 38
    • 84866536687 scopus 로고    scopus 로고
    • Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919
    • abstract LBA671
    • Gelmon KA, Boyle F, Kaufman B, et al. Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919. J Clin Oncol. 2012;30(Suppl 15):abstract LBA671.
    • (2012) J Clin Oncol. , vol.30
    • Gelmon, K.A.1    Boyle, F.2    Kaufman, B.3
  • 39
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
    • Dec
    • Cameron D, Casey M, Press M, et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat. Dec 2008;112(3):533-543.
    • (2008) Breast Cancer Res Treat , vol.112 , Issue.3 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3
  • 40
    • 63149110733 scopus 로고    scopus 로고
    • Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer
    • February 15
    • Lin NU, Diéras V, Paul D, et al. Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer. Clinical Cancer Research. February 15, 2009;15(4):1452-1459.
    • (2009) Clinical Cancer Research , vol.15 , Issue.4 , pp. 1452-1459
    • Lin, N.U.1    Diéras, V.2    Paul, D.3
  • 41
    • 84903897183 scopus 로고    scopus 로고
    • CEREBEL (EGF111438): An open label randomized phase III study comparing the incidence of CNS metastases in patients (pts) with HER2+ Metastatic Breast Cancer (MBC), treated with Lapatinib plus Capecitabine (LC) versus Trastuzumab plus Capecitabine (TC)
    • Abstract LBA11
    • Pivot X, Semiglazov V, Żurawski B, et al. CEREBEL (EGF111438): An open label randomized phase III study comparing the incidence of CNS metastases in patients (pts) with HER2+ Metastatic Breast Cancer (MBC), treated with Lapatinib plus Capecitabine (LC) versus Trastuzumab plus Capecitabine (TC). Annals of Oncology. 2012;23(Suppl 9):Abstract LBA11.
    • (2012) Annals of Oncology , vol.23
    • Pivot, X.1    Semiglazov, V.2    Żurawski, B.3
  • 42
    • 77950497981 scopus 로고    scopus 로고
    • Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer
    • Burstein HJ, Sun Y, Dirix LY, et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J Clin Oncol. 2010;28(8):1301-1307.
    • (2010) J Clin Oncol. , vol.28 , Issue.8 , pp. 1301-1307
    • Burstein, H.J.1    Sun, Y.2    Dirix, L.Y.3
  • 43
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441(7092):424-430.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 45
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO Study
    • Bachelot T, Bourgier C, Cropet C, et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO Study. J Clin Oncol. 2012;30(22):2718-2724.
    • (2012) J Clin Oncol , vol.30 , Issue.22 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 46
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P, et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol. 2009;27(16):2630-2637.
    • (2009) J Clin Oncol , vol.27 , Issue.16 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    van Dam, P.3
  • 47
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med. 2012;366(6):520-529.
    • (2012) N Engl J Med , vol.366 , Issue.6 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 48
    • 84864773253 scopus 로고    scopus 로고
    • Everolimus for postmenopausal women with advanced breast cancer: Updated results of the BOLERO-2 phase III trial
    • abstr 559
    • Piccart-Gebhart MJ, Noguchi S, Pritchard KI, et al. Everolimus for postmenopausal women with advanced breast cancer: Updated results of the BOLERO-2 phase III trial. J Clin Oncol. 2012;30(Suppl):abstr 559.
    • (2012) J Clin Oncol , vol.30
    • Piccart-Gebhart, M.J.1    Noguchi, S.2    Pritchard, K.I.3
  • 49
    • 84872518645 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer
    • Wolff AC, Lazar AA, Bondarenko I, et al. Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer. J Clin Oncol. 2013;31(2):195-202.
    • (2013) J Clin Oncol , vol.31 , Issue.2 , pp. 195-202
    • Wolff, A.C.1    Lazar, A.A.2    Bondarenko, I.3
  • 50
    • 79959508436 scopus 로고    scopus 로고
    • Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer
    • Baselga J. Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer. Oncologist. 2011;16(Suppl 1):12-19.
    • (2011) Oncologist , vol.16 , pp. 12-19
    • Baselga, J.1
  • 51
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    • Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Research. 2008;68(15):6084-6091.
    • (2008) Cancer Research , vol.68 , Issue.15 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3
  • 52
    • 33746832533 scopus 로고    scopus 로고
    • Activation of PI3K/Akt signaling and hormone resistance in breast cancer
    • Tokunaga E, Kimura Y, Mashino K, et al. Activation of PI3K/Akt signaling and hormone resistance in breast cancer. Breast Cancer. 2006;13(2):137-144.
    • (2006) Breast Cancer , vol.13 , Issue.2 , pp. 137-144
    • Tokunaga, E.1    Kimura, Y.2    Mashino, K.3
  • 53
    • 0035132538 scopus 로고    scopus 로고
    • Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
    • End DW, Smets G, Todd AV, et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Research. 2001;61(1):131-137.
    • (2001) Cancer Research , vol.61 , Issue.1 , pp. 131-137
    • End, D.W.1    Smets, G.2    Todd, A.V.3
  • 54
    • 76749123560 scopus 로고    scopus 로고
    • Tipifarnib plus tamoxifen in tamoxifen-resistant metastatic breast cancer: A negative phase II and screening of potential therapeutic markers by proteomic analysis
    • Dalenc F, Doisneau-Sixou SF, Allal BC, et al. Tipifarnib plus tamoxifen in tamoxifen-resistant metastatic breast cancer: a negative phase II and screening of potential therapeutic markers by proteomic analysis. Clin Cancer Res. 2010;16(4):1264-1271.
    • (2010) Clin Cancer Res , vol.16 , Issue.4 , pp. 1264-1271
    • Dalenc, F.1    Doisneau-Sixou, S.F.2    Allal, B.C.3
  • 55
    • 84863990603 scopus 로고    scopus 로고
    • A phase II trial of capecitabine in combination with the farnesyltransferase inhibitor tipifarnib in patients with anthracycline-treated and taxane-resistant metastatic breast cancer: An Eastern Cooperative Oncology Group Study (E1103)
    • Li T, Guo M, Gradishar W, et al. A phase II trial of capecitabine in combination with the farnesyltransferase inhibitor tipifarnib in patients with anthracycline-treated and taxane-resistant metastatic breast cancer: an Eastern Cooperative Oncology Group Study (E1103). Breast Cancer Res Treat. 2012;134(1):345-352.
    • (2012) Breast Cancer Res Treat , vol.134 , Issue.1 , pp. 345-352
    • Li, T.1    Guo, M.2    Gradishar, W.3
  • 56
    • 63549098589 scopus 로고    scopus 로고
    • Phase II trial of the farnesyltransferase inhibitor tipifarnib plus fulvestrant in hormone receptor-positive metastatic breast cancer: New York Cancer Consortium Trial P6205
    • Li T, Christos PJ, Sparano JA, et al. Phase II trial of the farnesyltransferase inhibitor tipifarnib plus fulvestrant in hormone receptor-positive metastatic breast cancer: New York Cancer Consortium Trial P6205. Ann Oncol. 2009;20(4):642-647.
    • (2009) Ann Oncol , vol.20 , Issue.4 , pp. 642-647
    • Li, T.1    Christos, P.J.2    Sparano, J.A.3
  • 57
    • 44849087679 scopus 로고    scopus 로고
    • A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy
    • Johnston S, Semiglazov V, Manikhas G, et al. A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy. Breast Cancer Res Treat. 2008;110(2):327-335.
    • (2008) Breast Cancer Res Treat , vol.110 , Issue.2 , pp. 327-335
    • Johnston, S.1    Semiglazov, V.2    Manikhas, G.3
  • 58
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • Gelmon KA, Tischkowitz M, Mackay H, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol. 2011;12(9):852-861.
    • (2011) Lancet Oncol , vol.12 , Issue.9 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    McKay, H.3
  • 59
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet. 376(9737):235-244.
    • Lancet , vol.376 , Issue.9737 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 60
    • 80052330662 scopus 로고    scopus 로고
    • A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC)
    • abstr 1007
    • O'Shaughnessy J, Schwartzberg LS, Danso MA, et al. A randomized phase III study of iniparib (BSI-201) in combination with gemcitabine/carboplatin (G/C) in metastatic triple-negative breast cancer (TNBC). J Clin Oncol. 2011;29(Suppl 15):abstr 1007.
    • (2011) J Clin Oncol , vol.29
    • O'Shaughnessy, J.1    Schwartzberg, L.S.2    Danso, M.A.3
  • 61
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor β-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PAE, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor β-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res. 1997;57(5):963-969.
    • (1997) Cancer Res , vol.57 , Issue.5 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.E.3
  • 62
    • 33845961014 scopus 로고    scopus 로고
    • Bevacizumab: An angiogenesis inhibitor for the treatment of solid malignancies
    • Shih T, Lindley C. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clin Ther. 2006;28(11):1779-1802.
    • (2006) Clin Ther , vol.28 , Issue.11 , pp. 1779-1802
    • Shih, T.1    Lindley, C.2
  • 63
    • 77954700380 scopus 로고    scopus 로고
    • Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer
    • Miles DW, Chan A, Dirix LY, et al. Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer. J Clin Oncol. 2010;28(20):3239-3247.
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 64
    • 20044364346 scopus 로고    scopus 로고
    • Randomized Phase III Trial of Capecitabine Compared With Bevacizumab Plus Capecitabine in Patients With Previously Treated Metastatic Breast Cancer
    • Miller KD, Chap LI, Holmes FA, et al. Randomized Phase III Trial of Capecitabine Compared With Bevacizumab Plus Capecitabine in Patients With Previously Treated Metastatic Breast Cancer. J Clin Oncol. 2005;23(4):792-799.
    • (2005) J Clin Oncol , vol.23 , Issue.4 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 65
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: Randomized, double-blind, placebo-controlled, phase iii trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert NJ, Diéras V, Glaspy J, et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase iii trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol. 2011;29(10):1252-1260.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1252-1260
    • Robert, N.J.1    Diéras, V.2    Glaspy, J.3
  • 66
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 2007;357(26):2666-2676.
    • (2007) N Engl J Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 67
    • 84870622658 scopus 로고    scopus 로고
    • Final overall survival (OS) and safety analyses of RIBBON-2, a randomised phase III trial of bevacizumab (BEV) versus placebo (PL) combined with second line chemotherapy (CT) for HER2-negative-BEV-naive metastatic breast cancer (MBC)
    • abstr 100
    • Brufsky A, Hurvitz SA, Perez EA, et al. Final overall survival (OS) and safety analyses of RIBBON-2, a randomised phase III trial of bevacizumab (BEV) versus placebo (PL) combined with second line chemotherapy (CT) for HER2-negative-BEV-naive metastatic breast cancer (MBC). J Clin Oncol. 2012;30(Suppl 27):abstr 100.
    • (2012) J Clin Oncol , vol.30
    • Brufsky, A.1    Hurvitz, S.A.2    Perez, E.A.3
  • 68
    • 84876285095 scopus 로고    scopus 로고
    • Primary results of BEATRICE, a randomized phase III trial evaluating adjuvant bevacizumab-containing therapy in triple-negative breast cancer
    • Accessed May 20, 2013
    • Cameron D, Brown J, Dent R, et al. Primary results of BEATRICE, a randomized phase III trial evaluating adjuvant bevacizumab-containing therapy in triple-negative breast cancer. Cancer Research. 2012;72(24, Suppl 3). Available from: http://cancerres.aacrjournals.org/cgi/content/short/72/24_MeetingAbstracts/S6-5?rss=1. Accessed May 20, 2013.
    • (2012) Cancer Research , vol.72 , Issue.24
    • Cameron, D.1    Brown, J.2    Dent, R.3
  • 69
    • 58149335533 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336
    • Moreno-Aspitia A, Morton RF, Hillman DW, et al. Phase II trial of sorafenib in patients with metastatic breast cancer previously exposed to anthracyclines or taxanes: North Central Cancer Treatment Group and Mayo Clinic Trial N0336. J Clin Oncol. 2009;27(1):11-15.
    • (2009) J Clin Oncol , vol.27 , Issue.1 , pp. 11-15
    • Moreno-Aspitia, A.1    Morton, R.F.2    Hillman, D.W.3
  • 70
    • 84862988257 scopus 로고    scopus 로고
    • Sorafenib in combination with capecitabine: An oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer
    • Baselga J, Segalla JGM, Roché H, et al. Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer. J Clin Oncol. 2012;30(13):1484-1491.
    • (2012) J Clin Oncol , vol.30 , Issue.13 , pp. 1484-1491
    • Baselga, J.1    Segalla, J.G.M.2    Roché, H.3
  • 71
    • 77951296573 scopus 로고    scopus 로고
    • Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer
    • Barrios CH, Liu MC, Lee SC, et al. Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer. Breast Cancer Res Treat. 2010;121(1):121-131.
    • (2010) Breast Cancer Res Treat , vol.121 , Issue.1 , pp. 121-131
    • Barrios, C.H.1    Liu, M.C.2    Lee, S.C.3
  • 72
    • 77955894152 scopus 로고    scopus 로고
    • Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC)
    • abstr 18
    • Crown J, Dieras V, Staroslawska E, et al. Phase III trial of sunitinib (SU) in combination with capecitabine (C) versus C in previously treated advanced breast cancer (ABC). J Clin Oncol. 2010;28(Suppl):abstr 18.
    • (2010) J Clin Oncol , vol.28
    • Crown, J.1    Dieras, V.2    Staroslawska, E.3
  • 73
    • 84860625265 scopus 로고    scopus 로고
    • First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: Results of a prospective, randomized phase III study
    • Bergh J, Bondarenko IM, Lichinitser MR, et al. First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized phase III study. J Clin Oncol. 2012;30(9):921-929.
    • (2012) J Clin Oncol , vol.30 , Issue.9 , pp. 921-929
    • Bergh, J.1    Bondarenko, I.M.2    Lichinitser, M.R.3
  • 74
    • 18244387980 scopus 로고    scopus 로고
    • A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer
    • Miller KD, Trigo JM, Wheeler C, et al. A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer. Clin Cancer Res. 2005;11(9):3369-3376.
    • (2005) Clin Cancer Res , vol.11 , Issue.9 , pp. 3369-3376
    • Miller, K.D.1    Trigo, J.M.2    Wheeler, C.3
  • 75
    • 84861040218 scopus 로고    scopus 로고
    • Vandetanib with docetaxel as second-line treatment for advanced breast cancer: A double-blind, placebo-controlled, randomized phase II study
    • Boér K, Láng I, Llombart-Cussac A, et al. Vandetanib with docetaxel as second-line treatment for advanced breast cancer: a double-blind, placebo-controlled, randomized phase II study. Invest New Drugs. 2012;30(2):681-687.
    • (2012) Invest New Drugs , vol.30 , Issue.2 , pp. 681-687
    • Boér, K.1    Láng, I.2    Llombart-Cussac, A.3
  • 76
    • 0034655182 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    • Wood JM, Bold G, Buchdunger E, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000;60(8):2178-2189.
    • (2000) Cancer Res , vol.60 , Issue.8 , pp. 2178-2189
    • Wood, J.M.1    Bold, G.2    Buchdunger, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.