Methadone and illegal drugs in hair from children with parents in maintenance treatment or suspected for drug abuse in a german community

Therapeutic Drug Monitoring

Volumn 35, Issue 6, 2013, Pages 737-752

  Pragst, Fritz ^a   Broecker, Sebastian ^a   Hastedt, Martin ^a   Herre, Sieglinde ^a   Andresen Streichert, Hilke ^b   Sachs, Hans ^c   Tsokos, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c Forensic Toxicological Centre   (Germany)

Author keywords

Cannabis passive smoking; Children exposed to drugs; Drug using parents; Hair analysis; Methadone maintenance

Indexed keywords

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; AMPHETAMINE; AMPHETAMINE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CANNABINOID; COCAINE; DIAMORPHINE; DIAZEPAM; DRUG METABOLITE; ILLICIT DRUG; METHADONE; MORPHINE 6 ACETATE; NORCOCAINE; TETRAHYDROCANNABINOLIC ACID;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; DRUG ABUSE; DRUG DEGRADATION; DRUG EXPOSURE; DRUG HAIR LEVEL; DRUG USE; FAMILY INTERACTION; FEMALE; GERMANY; HAIR ANALYSIS; HEROIN DEPENDENCE; HOME ENVIRONMENT; HUMAN; INFANT; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAINTENANCE THERAPY; MALE; MASS FRAGMENTOGRAPHY; METHADONE TREATMENT; PASSIVE SMOKING; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SIBLING; SOLID PHASE MICROEXTRACTION; TIME OF FLIGHT MASS SPECTROMETRY;

ADOLESCENT; CHILD; CHILD OF IMPAIRED PARENTS; CHILD, PRESCHOOL; CHROMATOGRAPHY, LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GERMANY; HAIR; HUMANS; INFANT; MASS SPECTROMETRY; METHADONE; PARENTS; SOLID PHASE MICROEXTRACTION; STREET DRUGS; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS;

EID: 84889241359     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31829a78c3     Document Type: Article

References (70)

1. European Monitoring Centre for Drugs and Drug Addiction. 2011 national report of the Reitox, national focal point Germany. In-depth information on drug situation 2010/2011. Available at: http://www.dhs. de/fileadmin/user-upload/ pdf/Reitox-Jahresberichte/REITOX-Report-2011-dt.pdf. Accessed December 10, 2012.
2. US Department of Health and Human Services, Bulletin for Professionals (2009). Parental substance use and the child welfare system, January 2009. Available at: http://www.childwelfare.gov/pubs/factsheets/parentalsubabuse.cfm. Accessed October 30, 2012.
3. Nurco DN, Blatchley RJ, Hanlon TE, et al. Early deviance and related risk factors in the children of narcotic addicts. Am J Drug Alcohol Abuse. 1999;25:25-45. (Pubitemid 29100792)
4. Strano Rossi S, Offidani C, Chiarotti M. Application of hair analysis to document coercive heroin administration to a child. J Anal Toxicol. 1998; 22:75-77. (Pubitemid 28110250)
5. Joya X, Fríguls B, Simó M, et al. Acute heroin intoxication in a baby chronically exposed to cocaine and heroin: a case report. J Med Case Rep. 2011;5:288.
6. Li L, Levine B, Smialek JE. Fatal methadone poisoning in children: Maryland 1992-1996. Subst Use Misuse. 2000;35:1141-1148. (Pubitemid 30418844)
7. Boroda A, Gray W. Hair analysis for drugs in child abuse. J R Soc Med. 2005;98:318-319. (Pubitemid 41039307)
8. Kintz P, Villain M, Dumestre-Toulet V, et al. Methadone as a chemical weapon: two fatal cases involving babies. Ther Drug Monit. 2005;27: 741-743. (Pubitemid 44391727)
9. Tiras S, Haas V, Chevret L, et al. Nonketotic hyperglycemic coma in toddlers after unintentional methadone ingestion. Ann Emerg Med. 2006; 48:448-451. (Pubitemid 44415159)
10. Riascos R, Kumfa P, Rojas R, et al. Fatal methadone intoxication in a child. Emerg Radiol. 2008;15:67-70. (Pubitemid 350190513)
11. Bailey JE, Campagna E, Dart RC. The underrecognized toll of prescription opioid abuse on young children. Ann Emerg Med. 2009;53:419-424.
12. Palmiere C, Staub C, La Harpe R, et al. Parental substance abuse and accidental death in children. J Forensic Sci. 2010;55:819-821.
13. Papaseit E, Corrales E, Stramesi C, et al. Postnatal methadone withdrawal syndrome: hair analysis for detecting chronic exposure. Acta Paediatr. 2010;99:162-163.
14. Kintz P, Evans J, Villain M, et al. Interpretation of hair findings in children after methadone poisoning. Forensic Sci Int. 2010;196:51-54.
15. Marcus SM. Accidental death from take home methadone maintenance doses: a report of a case and suggestions for prevention. Child Abuse Negl. 2011;35:1-2.
16. Schou H, Krogh B, Knudsen F. Unexpected cocaine intoxication in a fourteen month old child following topical administration. J Toxicol Clin Toxicol. 1987;25:419-422. (Pubitemid 18043982)
17. Ernst AA, Sanders WM. Unexpected cocaine intoxication presenting as seizures in children. Ann Emerg Med. 1989;18:774-777. (Pubitemid 19169631)
18. Havlik DM, Nolte KB. Fatal crack cocaine ingestion in an infant. Am J Forensic Med Pathol. 2000;21:245-248. (Pubitemid 30667073)
19. De Giorgio F, Rossi SS, Rainio J, et al. Cocaine found in a child's hair due to environmental exposure? Int J Legal Med. 2004;118:310-312. (Pubitemid 39390318)
20. Taguchi N, Mian M, Shouldice M, et al. Chronic cocaine exposure in a toddler revealed by hair test. Clin Pediatr (Phila). 2007;46: 272-275. (Pubitemid 46537617)
21. Garcia-Algar O, López N, Bonet M, et al. 3,4- methylenedioxymethamphetamine (MDMA) intoxication in an infant chronically exposed to cocaine. Ther Drug Monit. 2005;27:409-411. (Pubitemid 41098812)
22. Boomgaarden-Brandes K, Tobias N, Thoben M, et al. Opiate-addiction of the parents as a potential high risk factor for child maltreatment. Toxichem Krimtech. 2011;78:389-390.
23. Smith FP, Kidwell DA. Cocaine in hair, saliva, skin swabs, and urine of cocaine users' children. Forensic Sci Int. 1996;83:179-189. (Pubitemid 27042183)
24. Lewis D, Moore C, Morrissey P, et al. Determination of drug exposure using hair: application to child protective cases. Forensic Sci Int. 1997; 84:123-128. (Pubitemid 27055629)
25. Joya X, Papaseit E, Civit E, et al. Unsuspected exposure to cocaine in preschool children from a Mediterranean city detected by hair analysis. Ther Drug Monit. 2009;31:391-395.
26. Garcia-Bournissen F, Nesterenko M, Karaskov T, et al. Passive environmental exposure to cocaine in Canadian children. Paediatr Drugs. 2009; 11:30-32.
27. Papaseit E, Joya X, Velasco M, et al. Hair analysis following chronic smoked-drugs-of-abuse exposure in adults and their toddler: a case report. J Med Case Rep. 2011;5:570.
28. Mecham N, Melini J. Unintentional victims: development of a protocol for the care of children exposed to chemicals at methamphetamine laboratories. Pediatr Emerg Care. 2002;18:327-332.
29. Farst K, Reading Meyer JA, Mac Bird T, et al. Hair drug testing of children suspected of exposure to the manufacture of methamphetamine. J Forensic Legal Med. 2011;18:110-114.
30. Bassindale T. Quantitative analysis of methamphetamine in hair of children removed from clandestine laboratories-evidence of passive exposure? Forensic Sci Int. 2012;219:179-182.
31. Garcia-Bournissen F, Asrar F, Verjee Z, et al. Contamination of hair with 3,4-methylene dioxymethamphetamine (ecstasy) in 2 young girls from a meth lab. Clin Pediatr (Phila). 2008;47:186-188. (Pubitemid 351208300)
32. Pragst F, Balikova MA. State of the art in hair analysis for the detection of drug and alcohol abuse. Clin Chim Acta. 2006;370:17-49. (Pubitemid 44137285)
33. Tsanaclis L, Wicks JF. Differentiation between drug use and environmental contamination when testing for drugs in hair. Forensic Sci Int. 2008;176:19-22. (Pubitemid 351273935)
34. Cairns T., Hill VA, Schaffer M, et al. Removing and identifying drug contamination in the analysis of human hair. Forensic Sci Int. 2004;145: 109-115.
35. Broecker S, Herre S, Pragst F. General unknown screening in hair by liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Forensic Sci Int. 2012;218:68-81.
36. Peters FT, Drummer OH, Musshoff F. Validation of new methods. Forensic Sci Int. 2007;165:216-224. (Pubitemid 46073540)
37. Schmitt G, Herbold M, Peters F. Methodenvalidierung im forensischtoxikologischen Labor, Auswertung von Validierungsdaten nach den Richtlinien der GTFCh mit VALISTAT. Arvecon, Walldorf, Germany; 2009.
38. Nadulski T, Pragst F. Simple and sensitive determination of Delta(9)-tetrahydrocannabinol, cannabidiol and cannabinol in hair by combined silylation, headspace solid phase microextraction and gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;846:78-85. (Pubitemid 46149495)
39. Galloway FR, Bellet NF. Methadone conversion to EDDP during GC-MS analysis of urine samples. J Anal Toxicol. 1999;23:615-619.
40. Girod C, Staub C. Methadone and EDDP in hair from human subjects following a maintenance program: results of a pilot study. Forensic Sci Int. 2001;117:175-184. (Pubitemid 32184553)
41. Paterson S, Cordero R, McPhillips M, et al. Interindividual dose/concentration relationship for methadone in hair. J Anal Toxicol. 2003;27:20-23. (Pubitemid 36139420)
42. Cooper G, Wilson L, Reid C, et al. Comparison of Cozart microplate ELISA and GC-MS detection of methadone and metabolites in human hair. J Anal Toxicol. 2005;29:678-681. (Pubitemid 41803357)
43. Lucas AC, Bermejo AM, Tabernero MJ, et al. Use of solid-phase microextraction (SPME) for the determination of methadone and EDDP in human hair by GC-MS. Forensic Sci Int. 2000;107:225-232. (Pubitemid 30019293)
44. Tsanaclis L, Wicks JF. Patterns in drug use in the United Kingdom as revealed through analysis of hair in a large population sample, Forensic Sci Int. 2007;170:121-128
45. Langrod J, Lowinson J, Ruiz P. Methadone treatment and physical complaints: a clinical analysis. Int J Addict. 1981;16:947-952. (Pubitemid 12222843)
46. Caflisch C, Figner B, Eich D. Biperiden for excessive sweating from methadone. Am J Psychiatry. 2003;160:386-387.
47. Al-Adwani A, Basu N. Methadone and excessive sweating. Addiction. 2004;99:259.
48. Fucci N, De Giovanni N. Methadone in hair and sweat from patients in long-term maintenance therapy. Ther Drug Monit. 2007;29:452-454. (Pubitemid 47220463)
49. Yegles M, Wennig R. Opioids testing in hair. In: Kintz P, ed. Analytical and Practical Aspects of Drug Testing in Hair. Boca Raton, FL: CRC Taylor & Francis; 2007:73-94.
50. Rothe M, Pragst F. Solvent optimization for the direct extraction of opiates from hair samples. J Anal Toxicol. 1995;19:236-240.
51. Musshoff F, Lachenmeier K, Wollersen H, et al. Opiate concentrations in hair from subjects in a controlled heroin-maintenance program and from opiate-associated fatalities. J Anal Toxicol. 2005;29:345-352. (Pubitemid 41191703)
52. LeBeau MA, Montgomery MA. Considerations on the utility of hair analysis for cocaine. J Anal Toxicol. 2009;33:343-344.
53. Pragst F, Sachs H, Kintz P. Hair analysis for cocaine continues to be a valuable tool in forensic and clinical toxicology. J Anal Toxicol. 2010; 34:354-355.
54. Welp EA, Bosman I, Langendam MW, et al. Amount of self-reported illicit drug use compared to quantitative hair test results in communityrecruited young drug users in Amsterdam. Addiction. 2003;98:987-994. (Pubitemid 36808265)
55. Tassiopoulos K, Bernstein J, Heeren T, et al. Hair testing and self-report of cocaine use by heroin users. Addiction. 2004;99:590-597. (Pubitemid 38561422)
56. Vignali C, Stramesi C, Vecchio M, et al. Hair testing and self-report of cocaine use. Forensic Sci Int. 2012;215:77-80.
57. Ropero-Miller JD, Huestis MA, Stout PR. Cocaine analytes in human hair: evaluation of concentration ratios in different cocaine sources, druguser populations and surface-contaminated specimens. J Anal Toxicol. 2012;36:390-398.
58. Bourland JA, Hayes EF, Kelly RC, et al. Quantitation of cocaine, benzoylecgonine, cocaethylene, methylecgonine, and norcocaine in human hair by positive ion chemical ionization (PICI) gas chromatographytandem mass spectrometry. J Anal Toxicol. 2000;24:489-495.
59. Cairns T, Hill V, Schaffer M, et al. Levels of cocaine and its metabolites in washed hair of demonstrated cocaine users and workplace subjects. Forensic Sci Int. 2004;145:175-181. (Pubitemid 39296635)
60. Faber W, Hirner A, Kaminski M. Unusual cause of pneumomediastinum. Chirurg. 2008;79:680-681.
61. Huestis MA, Gustafson RA, Moolchan ET, et al. Cannabinoid concentrations in hair from documented cannabis users. Forensic Sci Int. 2007; 169:129-136. (Pubitemid 46829701)
62. Thorspecken J, Skopp G, Pötsch L. In vitro contamination of hair by marijuana smoke. Clin Chem. 2004;50:596-602. (Pubitemid 38297311)
63. Uhl M, Sachs H. Cannabinoids in hair: strategy to prove marijuana/hashish consumption. Forensic Sci Int. 2004;145:143-147. (Pubitemid 39296632)
64. Moore C, Rana S, Coulter C, et al. Application of two-dimensional gas chromatography with electron capture chemical ionization mass spectrometry to the detection of 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in hair. J Anal Toxicol. 2006;30:171-177. (Pubitemid 44285274)
65. Kim JY, Cheong JC, Lee JI, et al. Improved gas chromatography-negative ion chemical ionization tandem mass spectrometric method for determination of 11-nor-D9-tetrahydrocannabinol-9-carboxylic acid in hair using mechanical pulverization and bead-assisted liquid-liquid extraction. Forensic Sci Int. 2011;206:e99-e102.
66. Han E, Chung H, Song JM. Segmental hair analysis for 11-nor-D?- tetrahydrocannabinol-carboxylic acid and the patterns of cannabis use. J Anal Toxicol. 2012;36:195-200.
67. Kronstrand R, Nyström I, Josefsson M, et al. Segmental ion spray LCMS-MS analysis of benzodiazepines in hair of psychiatric patients. J Anal Toxicol. 2002;26:479-484. (Pubitemid 36206783)
68. Miller EI, Wylie FM, Oliver JS. Detection of benzodiazepines in hair using ELISA and LC-ESI-MS-MS. J Anal Toxicol. 2006;30:441-448. (Pubitemid 44371485)
69. Rust KY, Baumgartner MR, Meggiolaro N, et al. Detection and validated quantification of 21 benzodiazepines and 3 z-drugs in human hair by LC-MS/MS. Forensic Sci Int. 2012;215:64-72.
70. Marks MK, South M, Carlin JB. Reference ranges for respiratory rate measured by thermistry (12-84 months). Arch Dis Child. 1993;69:569-572. (Pubitemid 23355851)