Unsuspected exposure to cocaine in preschool children from a mediterranean city detected by hair analysis

Therapeutic Drug Monitoring

Volumn 31, Issue 3, 2009, Pages 391-395

  Joya, Xavier ^a,b   Papaseit, Esther ^a,b   Civit, Ester ^c   Pellegrini, Manuela ^d   Vall, Oriol ^a,b   Garcia Algar, Oscar ^a,b   Scaravelli, Giulia ^d   Pichini, Simona ^d  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cocaine; Hair testing; Preschool children

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE DERIVATIVE; BENZOYLECGONINE; COCAINE; OPIATE DERIVATIVE;

ARTICLE; BODY WEIGHT; CHILD; CHILD HEALTH; DRUG EXPOSURE; EMERGENCY WARD; ENVIRONMENTAL EXPOSURE; FEMALE; GAS CHROMATOGRAPHY; HAIR ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MEDITERRANEAN SEA; PARENT; PRESCHOOL CHILD; PRIORITY JOURNAL; SOUTHERN EUROPE; SPAIN;

AMPHETAMINES; CANNABIS; CHILD; COCAINE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HAIR; HUMANS; INFANT, NEWBORN; MARIJUANA ABUSE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NARCOTICS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SMOKING; SOCIAL CLASS; SPAIN; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS;

EID: 67651120015     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31819c3f2b     Document Type: Article

References (29)

1. UNODC. Annual Reports Questionnaire Data. Available at: http://www.unodc.org/pdf/research/wdr07/WDR-2007.pdf. Accessed February 2009.
2. Observatorio Español sobre Drogas (OED). Encuesta Domiciliaria sobre Abuso de Drogas en España (EDADES). Available at: http://www.pnsd.msc.es/Categoria2/observa/pdf/domiciliaria2003.pdf. Accessed February 2009.
3. Lester BM, ElSohly M, Wright LL, et al. The Maternal Lifestyle Study: drug use by meconium toxicology and maternal self-report. Pediatrics. 2001;107:309-317.
4. Pichini S, Puig C, Zuccaro P, et al. Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project". Forensic Sci Int. 2005;153:59-65.
5. Taguchi N, Mian M, Shouldice M, et al. Chronic cocaine exposure in a toddler revealed by hair test. Clin Pediatr. 2007;46:272-275.
6. Garcia-Algar O, Lopez N, Bonet M, et al. 3, 4- methylenedioxymethamphetamine (MDMA) intoxication in an infant chronically exposed to cocaine. Ther Drug Monit. 2005;27:409-411.
7. Garcia-Algar O, López-Vilchez MA, Pacifici R, et al. Acute poisoning and chronic exposure to cocaine in a child. Med Clin (Barc). 2005;125: 436-437.
8. De Giorgio F, Rossi SS, Rainio J, et al. Cocaine found in a child's hair due to environmental exposure? Int J Legal Med. 2004;118: 310-312.
9. Rosenberg NM, Meert KL, Knazik SR, et al. Occult cocaine exposure in children. Am J Dis Child. 1991;145:1430-1432.
10. Rosenberg NM, Meert KL, Marino D, et al. Occult cocaine and opiate exposure in children and associated physical findings. Pediatr Emerg Care. 1995;11:167-169.
11. Rosenberg NM, Marino D, Meert KL, et al. Comparison of cocaine and opiate exposure between young urban and suburban children. Arch Pediatr Adolesc Med. 1995;149:1362-1364.
12. Lustbader AS, Mayes LC, McGee BA, et al. Incidence of passive exposure to crack/cocaine and clinical findings in infants seen in an outpatient service. Pediatrics. 1998;102:e5.
13. Pichini S, Altieri I, Zuccaro P, et al. Drug monitoring in nonconventional biological fluids and matrices. Clin Pharmacokinet. 1996;30:211-228.
14. Lewis D, Moore C, Morrissey P, et al. Determination of drug exposure using hair: application to child protective cases. Forensic Sci Int. 1997;84: 123-128.
15. Klein J, Karaskov T, Koren G. Clinical applications of hair testing for drugs of abuse-the Canadian experience. Forensic Sci Int. 2000;107: 281-288.
16. Montagna M, Polettini A, Stramesi C, et al. Hair analysis for opiates, cocaine and metabolites. Evaluation of a method by interlaboratory comparison. Forensic Sci Int. 2002;128:79-83.
17. Henderson L, Harkey MR, Zhou C, et al. Incorporation of isotopically labeled cocaine and metabolites into human hair: 1. dose-response relationships. J Anal Toxicol. 1996;20:1-12.
18. Mott SH, Packer RJ, Soldin SJ. Neurologic manifestations of cocaine exposure in childhood. Pediatrics. 1994;93:557-560.
19. Mayes LC, Grillon C, Granger R, et al. Regulation of arousal and attention in preschool children exposed to cocaine prenatally. Ann N Y Acad Sci. 1998;846:126-143.
20. Bennett DS, Bendersky M, Lewis M. Children's intellectual and emotional-behavioral adjustment at 4 years as a function of cocaine exposure, maternal characteristics, and environmental risk. Dev Psychol. 2002;38:648-658.
21. Singer LT, Arendt R, Minnes S, et al. Cognitive and motor outcomes of cocaine-exposed infants. JAMA. 2002;287:1952-1960.
22. Hurt H, Malmud E, Betancourt L, et al. Children with in utero cocaine exposure do not differ from control subjects on intelligence testing. Arch Pediatr Adolesc Med. 1997;151:1237-1241.
23. Frank DA, Rose-Jacobs R, Beeghly M, et al. Level of prenatal cocaine exposure and 48-month IQ: importance of preschool enrichment. Neurotoxicol Teratol. 2005;27:15-28.
24. Singer LT, Minnes S, Short E, et al. Cognitive outcomes of preschool children with prenatal cocaine exposure. JAMA. 2004;291:2448-2456.
25. Linares TJ, Singer LT, Kirchner HL, et al. Mental health outcomes of cocaine-exposed children at years of age. J Pediatr Psychology. 2006;31: 85-97.
26. Shuler ME, Nair P, Kettinger L. Drug-exposed infants and development outcome. Arch Pediatr Adolesc Med. 2003;157:133-138.
27. Accornero VH, Morrow CE, Bandstra ES, et al. Behavioral outcome of preschoolers exposed prenatally to cocaine: role of maternal behavioral health. J Pediatr Psychology. 2002;27:259-269.
28. Bada HS, Das A, Bauer CR, et al. Impact of prenatal cocaine on child behavior problems through school age. Pediatrics. 2007;119:e348-e359.
29. Mieczkowsky T. Distinguishing passive contamination from active cocaine consumption: assessing the occupational exposure of narcotics officers to cocaine. Forensic Sci Int. 1997;84:87-111.