Residence time modeling of hot melt extrusion processes

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART B, 2013, Pages 1200-1205

  Reitz, Elena ^a   Podhaisky, Helmut ^b   Ely, David ^c   Thommes, Markus ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Hot melt extrusion; Mathematical model; Residence time distribution; Twin screw extruder

Indexed keywords

XYLITOL;

AREA UNDER THE CURVE; ARTICLE; EVALUATION; FLOW RATE; HEAT; HOT MELT EXTRUSION PROCESS; MATHEMATICAL MODEL; MELTING POINT; PARAMETERS; POWDER; REPRODUCIBILITY; RESIDENCE TIME; TIME; VELOCITY; VISCOSITY;

HOT MELT EXTRUSION; MATHEMATICAL MODEL; RESIDENCE TIME DISTRIBUTION; TWIN SCREW EXTRUDER;

AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; HOT TEMPERATURE; MODELS, STATISTICAL; NORMAL DISTRIBUTION; PHARMACEUTICAL PREPARATIONS; POWDERS; PROBABILITY; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; VISCOSITY;

EID: 84889101619     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.07.019     Document Type: Article

References (19)

1. G.T. Leister, D. Geissler, and T. Twin-screw Extruders for pharmaceutical hot-melt extrusion: technology, techniques and practices D. Douroumis, Hot-Melt Extrusion Pharmaceutical Applications 2012 John Wiley & Sons Ltd.
2. K. Kolter, M. Karl, and A. Gryczke Hot-Melt Extrusion with BASF Pharma Polymers second revised and enlarged ed. 2012 BASF SE Pharma Ingredients & Services
3. Y. Gao, F.J. Muzzio, and M.G. Ierapetritou A review of the Residence Time Distribution (RTD) applications in solid unit operations Powder Technol. 228 2012 416 423
4. P.V. Danckwerts Continuous flow systems - distribution of residence times Chem. Eng. Sci. 2 1953 1 13
5. O. Levenspiel, Nonideal flow, in: N.Y. Wiley (Ed.) Chemical Reaction Engineering: An Introduction to the Design of Chemical Reactors, John Wiley & Sons, 1967.
6. T. Jager, P. Santbulte, and D.J. Vanzuilichem Residence time distribution in kneading extruders J. Food Eng. 24 1995 285 294
7. H. DeRuyck Modelling of the residence time distribution in a twin screw extruder J. Food Eng. 32 1997 375 390
8. A. Gautam, and G.S. Choudhury Screw configuration effects on residence time distribution and mixing in twin-screw extruders during extrusion of rice flour J. Food Process. Eng. 22 1999 263 285
9. G.I. Taylor Diffusion and mass transport in tubes P. Phys. Soc. Lond. B 67 1954 857 869
10. D.B. Todd Residence time distribution in twin-screw extruders Polym. Eng. Sci. 15 1975 437 443
11. R. Baron, P. Vauchel, R. Kaas, A. Arhaliass, and J. Legrand Dynamical modelling of a reactive extrusion process: focus on residence time distribution in a fully intermeshing co-rotating twin-screw extruder and application to an alginate extraction process Chem. Eng. Sci. 65 2010 3313 3321
12. J.P. Puaux, G. Bozga, and A. Ainser Residence time distribution in a corotating twin-screw extruder Chem. Eng. Sci. 55 2000 1641 1651
13. A. Lawal, and D.M. Kalyon Mechanisms of mixing in single and co-rotating twin-screw extruders Polym. Eng. Sci. 35 1995 1325 1338
14. K. Kohlgüber Co-Rotating Twin Screw Extruders 2008 Carl Hanser Verlag Munich
15. P.A. Moysey, and M.R. Thompson Modelling the solids inflow and solids conveying of single-screw extruders using the discrete element method Powder Technol. 153 2005 95 107
16. G. Shearer, and C. Tzoganakis The effects of kneading block design and operating conditions on distributive mixing in twin screw extruders Polym. Eng. Sci. 40 2000 1095 1106
17. B. Mu, and M.R. Thompson Examining the mechanics of granulation with a hot melt binder in a twin-screw extruder Chem. Eng. Sci. 81 2012 46 56
18. J. Gao, G.C. Walsh, D. Bigio, R.M. Briber, and M.D. Wetzel Residence-time distribution model for twin-screw extruders AIChe J. 45 1999 2541 2549
19. R. Mudalamane, and D.I. Bigio Experimental characterization of fill length behavior in extruders Polym. Eng. Sci. 44 2004 557 563