A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus

International Journal of Antimicrobial Agents

Volumn 42, Issue 6, 2013, Pages 513-518

  Shiu, Winnie K P ^a   Malkinson, John P ^a   Rahman, M Mukhlesur ^a,b   Curry, Jonathan ^a   Stapleton, Paul ^a   Gunaratnam, Mekala ^a   Neidle, Stephen ^a   Mushtaq, Shazad ^c   Warner, Marina ^c   Livermore, David M ^d   Evangelopoulos, Dimitrios ^e   Basavannacharya, Chandrakala ^e   Bhakta, Sanjib ^e   Schindler, Bryan D ^f   Seo, Susan M ^f   Coleman, David ^f   Kaatz, Glenn W ^f,g   Gibbons, Simon ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF EAST LONDON   (United Kingdom)

^c HPA Microbiology Services Colindale   (United Kingdom)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^e UNIVERSITY OF LONDON   (United Kingdom)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hypericum olympicum; MurE ligase; Olympicin A; Staphylococcus aureus

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; BACTERIAL PROTEIN; ENOXACIN; HYPERICUM OLYMPICUM EXTRACT; MURE LIGASE; NORA MULTIDRUG EFFLUX PUMP; PENICILLIN DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; EFFLUX PUMP INHIBITOR; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

HYPERICUM OLYMPICUM; MURE LIGASE; OLYMPICIN A; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELL LINE; CELL SURVIVAL; ENZYME INHIBITORS; HUMANS; HYPERICUM; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PLANT EXTRACTS;

EID: 84889098269     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.08.007     Document Type: Article

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