Elucidation of essential and nonessential genes in the Haemophilus influenzae Rd cell wall biosynthetic pathway by targeted gene disruption

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 2, 2005, Pages 824-826

  Trepod, Catherine M ^a   Mott, John E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; CELL WALL; ESSENTIAL GENE; GENE DISRUPTION; GENE IDENTIFICATION; GENE TARGETING; HAEMOPHILUS INFLUENZAE; IN VITRO STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; TRANSPOSON;

CELL WALL; DNA TRANSPOSABLE ELEMENTS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; HAEMOPHILUS INFLUENZAE; MUTAGENESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 12944270422     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.2.824-826.2005     Document Type: Article

References (5)

1. Akerley, B. J., E. J. Rubin, A. Camilli, D. J. Lampe, H. M. Robertson, and J. J. Mekalanos. 1998. Systematic identification of essential genes by in vitro mariner mutagenesis. Proc. Natl. Acad. Sci. USA 95:8927-8932.
2. Akerley, B. J., E. J. Rubin, V. L. Novick, K. Amaya, N. Judson, and J. J. Mekalanos. 2002. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc. Natl. Acad. Sci. USA 99:966-971.
3. Moir, D. T., K. J. Shaw, R. S. Hare, and G. F. Vovis. 1999. Genomics and antimicrobial drug discovery. Antimicrob. Agents Chemother. 43:439-446.
4. Reich, K. A., L. Chovan, and P. Hessler. 1999. Genome scanning in Haemophilus influenzae for identification of essential genes. J. Bacteriol. 181:4961-4968.
5. Trepod, C. M., and J. E. Mott. 2004. Identification of the Haemophilus influenzae tolC gene by susceptibility profiles of insertionally inactivated efflux pump mutants. Antimicrob. Agents Chemother. 48:1416-1418.