Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression

Modern Pathology

Volumn 26, Issue 12, 2013, Pages 1568-1576

  Brenner, Isabel ^a   Roth, Sabine ^a   Puppe, Bernhard ^a   Wobser, Marion ^b   Rosenwald, Andreas ^a,b   Geissinger, Eva ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

Cutaneous lymphoma; IgG4; IgG4 related disease; Immunohistochemistry; Marginal zone lymphoma

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ADULT; AGED; ARTICLE; BREAST TUMOR; CD4 CD8 RATIO; CELL DIFFERENTIATION; CHILD; CLINICAL STUDY; COHORT ANALYSIS; EYE TUMOR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE LYMPHOMA; LARYNX TUMOR; LUNG TUMOR; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MARGINAL ZONE LYMPHOMA; OROPHARYNX TUMOR; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SALIVARY GLAND TUMOR; SCHOOL CHILD; SKIN LYMPHOMA; SOFT TISSUE TUMOR; STOMACH LYMPHOMA; T LYMPHOCYTE; THYMUS LYMPHOMA; THYROID TUMOR; TONSIL TUMOR; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; LYMPHOMA, B-CELL, MARGINAL ZONE; MALE; MIDDLE AGED; PLASMA CELLS; SKIN NEOPLASMS; YOUNG ADULT;

EID: 84889092645     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.106     Document Type: Article

References (34)

1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Vol. 2 (IARC: Lyon, 2008).
2. Dalle S, Thomas L, Balme B, et al. Primary cutaneous marginal zone lymphoma. Crit Rev Oncol Hematol 2010;74:156-162.
3. Takino H, Li C, Hu S, et al. Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States. Mod Pathol 2008;21:1517-1526.
4. May SA, Netto G, Domiati-Saad R, et al. Cutaneous lymphoid hyperplasia and marginal zone B-cell lymphoma following vaccination. J Am Acad Dermatol 2005;53:512-516. (Pubitemid 41195989)
5. Breton AL, Poulalhon N, Balme B, et al. Primary cutaneous marginal zone lymphoma as a complication of radiation therapy: case report and review. Dermatol Online J 2010;16:6.
6. Kempf W, Denisjuk N, Kerl K, et al. Primary cutaneous B-cell lymphomas. J Dtsch Dermatol Ges 2012;10: 12-22; quiz 3.
7. Edinger JT, Kant JA, Swerdlow SH. Cutaneous marginal zone lymphomas have distinctive features and include 2 subsets. Am J Surg Pathol 2010;34: 1830-1841.
8. Ferenczi K. Primary cutaneous marginal zone B-cell lymphomas: are they different from other extranodal marginal zone B-cell lymphomas? J Cutan Pathol 2009;36:715-717.
9. van Maldegem F, van Dijk R, Wormhoudt TA, et al. The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment. Blood 2008;112:3355-3361.
10. Gronbaek K, Ralfkiaer E, Kalla J, et al. Infrequent somatic Fas mutations but no evidence of Bcl10 mutations or t(11;18) in primary cutaneous MALTtype lymphoma. J Pathol 2003;201:134-140. (Pubitemid 37121212)
11. Hallermann C, Kaune KM, Gesk S, et al. Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. J Invest Dermatol 2004;123:213-219. (Pubitemid 38833484)
12. Espinet B, Gallardo F, Pujol RM, et al. Absence of MALT1 translocations in primary cutaneous marginal zone B-cell lymphoma. Haematologica 2004;89: ELT14.
13. Streubel B, Lamprecht A, Dierlamm J, et al. T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma. Blood 2003;101:2335-2339. (Pubitemid 36302078)
14. Streubel B, Simonitsch-Klupp I, Mullauer L, et al. Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites. Leukemia 2004;18:1722-1726. (Pubitemid 39386353)
15. Streubel B, Vinatzer U, Lamprecht A, et al. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia 2005;19:652-658. (Pubitemid 40521171)
16. Venkataraman G, Rizzo KA, Chavez JJ, et al. Marginal zone lymphomas involving meningeal dura: possible link to IgG4-related diseases. Mod Pathol 2011;24: 355-366.
17. Cheuk W, Yuen HK, Chan AC, et al. Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease. Am J Surg Pathol 2008;32:1159-1167.
18. Sato Y, Ohshima K, Ichimura K, et al. Ocular adnexal IgG4-related disease has uniform clinicopathology. Pathol Int 2008;58:465-470. (Pubitemid 351952020)
19. Sato Y, Ohshima K, Takata K, et al. Ocular adnexal IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease. J Clin Exp Hematop 2012;52:51-55.
20. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012;366:539-551.
21. Sato Y, Takata K, Ichimura K, et al. IgG4-producing marginal zone B-cell lymphoma. Int J Hematol 2008;88:428-433.
22. Sato Y, Notohara K, Kojima M, et al. IgG4-related disease: historical overview and pathology of hematological disorders. Pathol Int 2010;60:247-258.
23. Cheuk W, Yuen HK, Chan JK. Complication of IgG4-related chronic sclerosing dacryoadenitis by lymphoma. Arch Ophthalmol 2008;126:1170 author reply.
24. Sato Y, Takeuchi M, Takata K, et al. Clinicopathologic analysis of IgG4-related skin disease. Mod Pathol 2013;26:523-532.
25. Ikeda T, Oka M, Shimizu H, et al. IgG4-related skin manifestations in patients with IgG4-related disease. Eur J Dermatol 2013;23:241-245.
26. Ingen-Housz-Oro S, Ortonne N, Elhai M, et al. IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects. JAMA Dermatol 2013; doi:10.1001/jamadermatol.2013.2625 [e-pub ahead of print].
27. Kato K, Satoh T, Tanaka-Fujimoto T, et al. IgG4-positive cells in skin lesions of cutaneous and systemic plasmacytosis. Eur J Dermatol 2013;23:255-256.
28. Khosroshahi A, Carruthers MD, Deshpande V, et al. Cutaneous immunoglobulin G4-related systemic disease. Am J Med 2011;124:e7-e8.
29. Cheuk W, Lee KC, Chong LY, et al. IgG4-related Sclerosing disease: a potential new etiology of cutaneous pseudolymphoma. Am J Surg Pathol 2009;33: 1713-1719.
30. J Godfrey Heathcote NMW, Sutton Evelyn D, Valenzuela Alejandra A. IgG4-related disease manifesting as sclerosing orbital inflammation and cutaneous pseudolymphoma with crystal-storing histiocytosis. Diagn Pathol 2013;19:147-150.
31. Aalberse RC, Stapel SO, Schuurman J, et al. Immunoglobulin G4: an odd antibody. Clin Exp Allergy 2009;39:469-477.
32. Nirula A, Glaser SM, Kalled SL, et al. What is IgG4? A review of the biology of a unique immunoglobulin subtype. Curr Opin Rheumatol 2011;23:119-124.
33. Kelley TW, Parker CJ. CD4 (+)CD25 (+)Foxp3 (+) regulatory T cells and hematologic malignancies. Front Biosci (Schol Ed) 2010;2:980-992.
34. Tzankov A, Meier C, Hirschmann P, et al. Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica 2008;93:193-200. (Pubitemid 351397707)