IgG4-related disease: Historical overview and pathology of hematological disorders: Review Article

Pathology International

Volumn 60, Issue 4, 2010, Pages 247-258

  Sato, Yasuharu ^a   Notohara, Kenji ^b   Kojima, Masaru ^c   Takata, Katsuyoshi ^a   Masaki, Yasufumi ^d   Yoshino, Tadashi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b KURASHIKI CENTRAL HOSPITAL   (Japan)

^c DOKKYO MEDICAL UNIVERSITY   (Japan)

^d KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Autoimmune pancreatitis; IgG4; Lymph node; Mucosa associated lymphoid tissue lymphoma; Ocular adnexa

Indexed keywords

C REACTIVE PROTEIN; CORTICOSTEROID; IMMUNOGLOBULIN G4; INTERLEUKIN 6;

ABDOMINAL PAIN; ANGIOFOLLICULAR LYMPH NODE HYPERPLASIA; AUTOIMMUNE PANCREATITIS; CELLULAR DISTRIBUTION; DIFFERENTIAL DIAGNOSIS; ENTERITIS; HEMATOLOGIC DISEASE; HUMAN; IMMUNOGLOBULIN G DEFICIENCY; IMMUNOGLOBULIN G4 RELATED DISEASE; IMMUNOGLOBULIN PRODUCTION; IMMUNOHISTOCHEMISTRY; LACRIMAL GLAND; LYMPH NODE; LYMPHADENOPATHY; MIKULICZ DISEASE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; OBLITERATIVE PHLEBITIS; OBSTRUCTIVE JAUNDICE; PHLEBITIS; PLASMA CELL GRANULOMA; PRIORITY JOURNAL; REVIEW; SCLEROSING CHOLANGITIS; UPREGULATION;

AUTOANTIBODIES; AUTOIMMUNE DISEASES; HEMATOLOGIC DISEASES; HUMANS; IMMUNOGLOBULIN G; LYMPHATIC DISEASES; PANCREATITIS; PLASMA CELLS; SCLEROSIS; SYNDROME;

EID: 77949660079     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2010.02524.x     Document Type: Review

References (91)

1. Bird P, Friedmann PS, Ling N et al. Subclass distribution of IgG autoantibodies in bullous pemphigoid. J Invest Dermatol 1986 86 : 21 5.
2. Flotte TJ, Baird LG. Immunoglobulin light and heavy chain isotypes in skin diseases: Restricted distribution in bullous pemphigoid and linear IgA bullous dermatosis. J Immunol 1986 136 : 491 496.
3. Jones CC, Hamilton RG, Jordon RE. Subclass distribution of human IgG autoantibodies in pemphigus. J Clin Immunol 1988 8 : 43 9.
4. Doi T, Mayumi M, Kanatsu K et al. Distribution of IgG subclasses in membranous nephropathy. Clin Exp Immunol 1984 58 : 57 62.
5. Hamano H, Kawa S, Horiuchi A et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001 344 : 732 738.
6. Hamano H, Kawa S, Ochi Y et al. Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis. Lancet 2002 359 : 1403 1404.
7. Yoshida K, Toki F, Takeuchi T et al. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci 1995 40 : 1561 1568.
8. Sarles H, Sarles JC, Muratore R et al. Chronic inflammatory sclerosis of the pancreas: An autonomous pancreatic disease? Am J Dig Dis 1961 6 : 688 698.
9. Kawaguchi K, Koike M, Tsuruta K et al. Lymphoplasmacytic sclerosing pancreatitis with cholangitis: A variant of primary sclerosing cholangitis extensively involving pancreas. Hum Pathol 1991 22 : 387 395.
10. Ectors N, Maillet B, Aerts R et al. Non-alcoholic duct destructive chronic pancreatitis. Gut 1997 41 : 263 268.
11. Wreesmann V, van Eijck CHJ, Naus DCWH et al. Inflammatory pseudotumour (inflammatory myofibroblastic tumour) of the pancreas: A report of six cases associated with obliterative phlebitis. Histopathology 2001 38 : 105 110.
12. Notohara K, Burgart LJ, Yadav D et al. Idiopathic chronic pancreatitis with periductal lymphoplasmacytic infiltration. Clinicopathologic features of 35 cases. Am J Surg Pathol 2003 27 : 1119 1127.
13. Zamboni G, Lüttges J, Capelli P et al. Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: A study on 53 resection specimens and 9 biopsy specimens. Virchows Arch 2004 445 : 552 563.
14. Kojima M, Sipos B, Klapper W et al. Autoimmune pancreatitis: Frequency, IgG4 expression, and clonality of T and B cells. Am J Surg Pathol 2007 31 : 521 528.
15. Deshpande V, Chiocca S, Finkelberg D et al. Autoimmune pancreatitis: A systemic immune complex mediated disease. Am J Surg Pathol 2006 30 : 1537 1545.
16. Kamisawa T, Funata N, Hayashi Y. Lymphoplasmacytic sclerosing pancreatitis is a pancreatic lesion of IgG4-related systemic disease. Am J Surg Pathol 2004 28 : 1114.
17. Zhang L, Notohara K, Levy MJ et al. IgG4-positive plasma cell infiltration in the diagnosis of autoimmune pancreatitis. Mod Pathol 2007 20 : 23 8.
18. Mino-Kenudson M, Smyrk TC, Deshpande V et al. Autoimmune pancreatitis: West vs. East. Mod Pathol 2008 21 (Suppl. 1 312A (abstract).
19. Okazaki K, Kawa S, Kamisawa T et al. Clinical diagnostic criteria of autoimmune pancreatitis: Revised proposal. J Gastroenterol 2006 41 : 626 631.
20. Kim KP, Kim MH, Kim JC, Lee SS, Seo DW, Lee SK. Diagnostic criteria for autoimmune chronic pancreatitis revisited. World J Gastroenterol 2006 12 : 2487 2496.
21. Otsuki M, Chung JB, Okazaki K et al. Asian diagnostic criteria for autoimmune pancreatitis: Consensus of the Japan-Korea symposium on autoimmune pancreatitis. J Gastroenterol 2008 43 : 403 408.
22. Chari ST, Smyrk TC, Levy MJ et al. Diagnosis of autoimmune pancreatitis: The Mayo Clinic experience. Clin Gastroenterol Hepatol 2006 4 : 1010 1016.
23. Frulloni L, Scattolini C, Falconi M et al. Autoimmune pancreatitis: Differences between the focal and diffuse forms in 87 patients. Am J Gastroenterol 2009 104 : 2288 2294.
24. Sugumar A, Klöppel G, Chari ST. Autoimmune pancreatitis: Pathologic subtypes and their implications for its diagnosis. Am J Gastroenterol 2009 104 : 2308 2310.
25. Clark A, Zeman RK, Choyke PL et al. Pancreatic pseudotumors associated with multifocal idiopathic fibrosclerosis. Gastrointest Radiol 1988 13 : 30 32.
26. Mitchinson MJ. The pathology of idiopathic retroperitoneal fibrosis. J Clin Pathol 1970 23 : 681 689.
27. Meyer S, Hausman R. Occlusive phlebitis in multifocal fibrosclerosis. Am J Clin Pathol 1976 65 : 274 283.
28. Mombaerts I, Goldschmeding R, Schlingemann RO et al. What is orbital pseudotumor? Surv Ophthalmol 1996 41 : 66 78.
29. Meijer S, Hausman R. Occlusive phlebitis, a diagnostic feature in Riedel's thyroiditis. Virchows Arch 1978 377 : 339 349.
30. Hamano H, Arakura N, Muraki T et al. Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis. J Gastroenterol 2006 41 : 1197 1205.
31. Kamisawa T, Funata N, Hayashi Y et al. Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis. Gut 2003 52 : 683 687.
32. Kamisawa T, Funata N, Hayashi Y et al. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol 2003 38 : 982 984.
33. Yamamoto M, Takahashi H, Sugai S et al. Clinical and pathological characteristics of Mikulicz's disease (IgG4-related plasmacytic exocrinopathy). Autoimmun Rev 2005 4 : 195 200.
34. Masaki Y, Dong L, Kurose N et al. Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: Analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis 2009 68 : 1310 1315.
35. Zen Y, Harada K, Sasaki M et al. IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis. Do they belong to a spectrum of sclerosing pancreatitis? Am J Surg Pathol 2004 28 : 1193 1203.
36. Kitagawa S, Zen Y, Harada K et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor). Am J Surg Pathol 2005 29 : 783 791.
37. Zen Y, Kasahara Y, Horita K et al. Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level. Histologic similarity to sclerosing pancreatitis. Am J Surg Pathol 2005 29 : 275 278.
38. Zen Y, Kitagawa S, Minato H et al. IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung. Hum Pathol 2005 36 : 710 717.
39. Umemura T, Zen Y, Hamano H et al. Immunoglobulin G4-hepatopathy: Association of immunoglobulin G4-bearing plasma cells in liver with autoimmune pancreatitis. Hepatology 2007 46 : 463 471.
40. Kasashima S, Zen Y, Kawashima A et al. Inflammatory abdominal aortic aneurysm: Close relationship to IgG4-related periaortitis. Am J Surg Pathol 2008 32 : 197 204.
41. Nakazawa T, Ohara H, Sano H et al. Cholangiography can discriminate sclerosing cholangitis with autoimmune pancreatitis from primary sclerosing cholangitis. Gastrointest Endosc 2004 60 : 937 944.
42. Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol 2008 14 : 3948 3955.
43. Ishida M, Hotta M, Kushima R et al. IgG4-related inflammatory aneurysm of the aortic arch. Pathol Int 2009 59 : 269 273.
44. Ito H, Kaizaki Y, Noda Y et al. IgG4-related inflammatory abdominal aortic aneurysm associated with autoimmune pancreatitis. Pathol Int 2008 58 : 421 426.
45. Li Y, Bai Y, Liu Z et al. Immunohistochemistry of IgG4 can help subclassify Hashimoto's autoimmune thyroiditis. Pathol Int 2009 59 : 636 641.
46. Ishida M, Hotta M, Kushima R et al. Multiple IgG4-related sclerosing lesions in the maxillary sinus, parotid gland and nasal septum. Pathol Int 2009 59 : 670 675.
47. Yamashita K, Haga H, Kobashi Y, Miyagawa-Hayashino A, Yoshizawa A, Manabe T. Lung involvement in IgG4-related lymphoplasmacytic vasculitis and interstitial fibrosis. Report of 3 cases and review of the literature. Am J Surg Pathol 2008 32 : 1620 1626.
48. Shrestha B, Sekiguchi H, Colby TV et al. Distinctive pulmonary histopathology with increased IgG4-positive plasma cells in patients with autoimmune pancreatitis. Report of 6 and 12 cases with similar histopathology. Am J Surg Pathol 2009 Jul 20. [Epub ahead of print W, Chan ACL, Lam WL et al. IgG4-related sclerosing mastitis: Description of a new member of the IgG4-related sclerosing diseases. Am J Surg Pathol 2009 33 : 1058 1064.
49. Cornell LD, Chicano SL, Deshpande V et al. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease. Am J Surg Pathol 2007 31 : 1586 1597.
50. Uehara T, Hamano H, Kawakami M et al. Autoimmune pancreatitis-associated prostatitis: Distinct clinicopathological entity. Pathol Int 2008 58 : 118 125.
51. Sakata N, Tashiro T, Uesugi N et al. IgG4-positive plasma cells in inflammatory abdominal aortic aneurysm: The possibility of an aortic manifestation of IgG4-related sclerosing disease. Am J Surg Pathol 2008 32 : 553 559.
52. Cheuk W, Yuen HKL, Chu SYY et al. Lymphadenopathy of IgG4-related sclerosing disease. Am J Surg Pathol 2008 32 : 671 681.
53. Sato Y, Kojima M, Takata K et al. Systemic IgG4-related lymphadenopathy: A clinical and pathologic comparison to multicentric Castleman's disease. Mod Pathol 2009 22 : 589 599.
54. Chan SK, Cheuk W, Chan KT et al. IgG4-related sclerosing pachymeningitis. A previously unrecognized form of central nervous system involvement in IgG4-related sclerosing disease. Am J Surg Pathol 2009 33 : 1249 1252.
55. Cheuk W, Lee KC, Chong LY et al. IgG4-related sclerosing disease. A potential new etiology of cutaneous pseudolymphoma. Am J Surg Pathol 2009 33 : 1713 1719.
56. Suda K, Takase M, Fukumura Y et al. Pathology of autoimmune pancreatitis and tumor-forming pancreatitis. J Gastroenterol 2007 42 (Suppl. 18 22 7.
57. Kamisawa T, Chen PY, Tu Y et al. Pancreatic cancer with a high serum IgG4 concentration. World J Gastroenterol 2006 12 : 6225 6228.
58. Ghazale A, Chari ST, Smyrk TC et al. Value of serum IgG4 in the diagnosis of autoimmune pancreatitis and in distinguishing it from pancreatic cancer. Am J Gastroenterol 2007 102 : 1646 1653.
59. Witkiewicz AK, Kennedy EP, Kennyon L et al. Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: Case report and review of the literature. Hum Pathol 2008 39 : 1548 1551.
60. Zen Y, Fujii T, Harada K et al. Th2 and regulatory immune reactions are increased in immunoglobulin G4-related sclerosing pancreatitis and cholangitis. Hepatology 2007 45 : 1538 1546.
61. Kawa S, Ota M, Yoshizawa K et al. HLA-DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the Japanese population. Gastroenterology 2002 122 : 1264 1269.
62. Aoki S, Nakazawa T, Ohara H et al. Immunohistochemical study of autoimmune pancreatitis using anti-IgG4 antibody and patients' sera. Histopathology 2005 47 : 147 158.
63. Kawa S, Kitahara K, Hamano H et al. A novel immunoglobulin-immunoglobulin interaction in autoimmunity. PloS One 2008 3 : e1637.
64. Boulanger E, Fuentes V, Meignin V et al. Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy. Ann Hematol 2006 86 : 833 840.
65. Kojima M, Miyawaki S, Takada S et al. Lymphoplasmacytic infiltrate of regional lymph node in Küttner's tumor (chronic sclerosing sialoadenitis). A report of three cases. Int J Surg Pathol 2008 16 : 263 268.
66. Frizzera G. Atypical lymphoproliferative disorders. In : Knowles DM, ed. Neoplastic Hematopathology, 2nd edn. Baltimore : Lippincott Williams & Wilkins, 2001 569 622.
67. Ioachim HL, Medeiros LJ. Ioachim's Lymph Node Pathology, 4th edn. Philadelphia, PA : Lippincott, Williams & Wilkins, 2009.
68. Moran CA, Suster S, Abbondanzo SL. Inflammatory pseudotumor of lymph nodes: A study of 25 cases with emphasis on morphological heterogeneity. Hum Pathol 1997 28 : 332 338.
69. Kojima M, Nakamura N, Tsukamoto N et al. Clinical implications of idiopathic multicentric Castleman's disease among Japanese. A report of 28 cases. Int J Surg Pathol 2008 16 : 391 398.
70. Suda T, Kanato H, Delsol G et al. HHV-8 infection status of AIDS-unrelated and AIDS-associated multicentric Castleman's disease. Pathol Int 2001 51 : 671 679.
71. Leary AG, Ikebuch Ki, Hirai Y et al. Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: Comparison with interleukin-1 alpha. Blood 1988 71 : 1759 1763.
72. Yoshizaki K, Matsuda T, Nishimoto N et al. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 1989 74 : 1360 1367.
73. Nishimoto N, Kanakura Y, Aozasa K et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman's disease. Blood 2005 106 : 2627 2632.
74. Kojima M, Hosomura Y, Itoh H et al. Reactive proliferative lesions in lymph node from rheumatoid arthritis patients. A clinicopathological study and immunohistochemical study. Acta Pathol Jpn 1990 40 : 249 254.
75. Kojima M, Nakamura S, Morishita Y et al. Reactive follicular hyperplasia in the lymph node lesions from systemic lupus erythematosus patients. A clinicopathological study of 21 cases. Pathol Int 2000 50 : 304 312.
76. Koo CH, Nathwani BN, Winberg CD, Hill LR, Rappaport H. Atypical lymphoplasmacytic and immunoblastic proliferation in lymph nodes of patients with autoimmune disease (autoimmune-disease-associated lymphadenopathy). Medicine (Baltimore) 1984 63 : 274 290.
77. Kojima M, Motoori T, Hosomura Y et al. Atypical lymphoplasmacytic and immunoblastic proliferation from rheumatoid arthritis. A case report. Pathol Res Pract 2006 202 : 51 4.
78. Attygale AD, Kyriakou C, Dupuis J et al. Histologic evolution of angioimmunoblastic T-cell lymphoma in consecutive biopsies: Clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 2007 31 : 1077 1088.
79. Sato Y, Ohshima K, Ichimura K et al. Ocular adnexal IgG4-related disease has uniform clinicopathology. Pathol Int 2008 58 : 465 470.
80. Mehta M, Jakobiec F, Fay A. Idiopathic fibroinflammatory disease of the face, eyelids, and periorbital membrane with immunoglobulin G4-positive plasma cells. Arch Pathol Lab Med 2009 133 : 1251 1255.
81. Yamamoto M, Harada S, Ohara M et al. Clinical and pathological differences between Mikulicz's disease and Sjogren's syndrome. Rheumatology (Oxford) 2005 44 : 227 234.
82. Yamamoto M, Takahashi H, Ohara M et al. A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease. Mod Rheumatol 2006 16 : 335 340.
83. Yamamoto M, Takahashi H, Naishiro Y et al. Mikulicz's disease and systemic IgG4-related plasmacytic syndrome (SIPS). Nihon Rinsho Meneki Gakkai Kaishi 2008 31 : 1 8.
84. Cheuk W, Yuen HKL, Chan ACL et al. Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: A previously undescribed complication of IgG4-related sclerosing disease. Am J Surg Pathol 2008 32 : 1159 1167.
85. Shiomi T, Yoshida Y, Horie Y et al. Acquired reactive perforating collagenosis with the histological features of IgG4-related sclerosing disease in a patient with Mikulicz's disease. Pathol Int 2009 59 : 326 331.
86. Takahashi N, Ghazale AH, Smyrk TC et al. Possible association between IgG4-associated systemic disease with or without autoimmune pancreatitis and non-Hodgkin lymphoma. Pancreas 2009 38 : 523 526.
87. Yoshino T, Akagi T. Gastric low-grade mucosa-associated lymphoid tissue lymphomas: Their histogenesis and high-grade transformation. Pathol Int 1998 48 : 323 331.
88. Inagaki H. Mucosa-associated lymphoid tissue lymphoma: Molecular pathogenesis and clinicopathological significance. Pathol Int 2007 57 : 474 484.
89. Ochoa ER, Harris NL, Pilch BZ. Marginal zone B-cell lymphoma of the salivary gland arising in chronic sclerosing sialadenitis (Küttner tumor). Am J Surg Pathol 2001 25 : 1546 1550.
90. Ohtsuka K, Hashimoto M, Suzuki Y. A review of 244 orbital tumors in Japanese patients during a 21-year period: Origins and locations. Jpn J Ophthalmol 2005 49 : 49 55.
91. Sato Y, Takata K, Ichimura K et al. IgG4-producing marginal zone B-cell lymphoma. Int J Hematol 2008 88 : 428 433.