Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1β-dependent pathway

Matrix Biology

Volumn 32, Issue 7-8, 2013, Pages 443-451

  Bantsimba Malanda, Claudie ^a,b   Cottet, Justine ^a   Netter, Patrick ^a   Dumas, Dominique ^a   Mainard, Didier ^a   Magdalou, Jacques ^a   Vincourt, Jean Baptiste ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b INSERM   (France)

Author keywords

Chondrocytes; Collagen; Endocytosis; Metalloprotease; MMP13; Osteoarthritis

Indexed keywords

ARSENOSOBENZENE; CELL PENETRATING PEPTIDE; CHONDROCALCIN; COLLAGENASE 3; INTERLEUKIN 1BETA; PROCOLLAGEN C PROTEINASE; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; PROTEIN; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; ARTICULAR CARTILAGE; BIOSYNTHESIS; CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL PERMEABILIZATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME RELEASE; EXPLANT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERNALIZATION; MOLECULAR MECHANICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

VERTEBRATA;

BOVINE SERUM ALBUMIN; BSA; CHONDROCYTES; COL; COLLAGEN; ENDOCYTOSIS; GAG; GLYCOSAMINOGLYCAN; HORSERADISH PEROXIDASE; HRP; IL-1Β; IL1-RI; INTERLEUKIN-1 RECEPTOR I; INTERLEUKIN-1BETA; MATRIX METALLOPROTEASE-13; METALLOPROTEASE; MMP13; OSTEOARTHRITIS; PAO; PARAFORMALDEHYDE; PFA; PHENYLARSINE OXIDE;

ANTIBODIES, MONOCLONAL; ARSENICALS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CARTILAGE, ARTICULAR; CHONDROCYTES; COLLAGEN TYPE II; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1BETA; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; PROTEIN ENGINEERING; SIGNAL TRANSDUCTION;

EID: 84889081382     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2013.06.002     Document Type: Article

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