Characterization of potential degradation products in a PEGylating reagent 20kDa monomethoxy polyethylene glycol propionaldehyde by RP-HPLC, APCI-MS and NMR

Journal of Pharmaceutical and Biomedical Analysis

Volumn 89, Issue , 2014, Pages 221-226

  Zhang, Heidi ^a,b   Wilson, John ^a,c   Zhang, Jifeng ^a,d   Luo, Ying ^a  

^a AMGEN INC   (United States)

^b Novartis   (United States)

^c Arcanum Bio Inc   (United States)

^d Bioproduct Pharmaceutical Development   (United States)

Author keywords

APCI MS; MPEG aldehyde; NMR; PEGylation; RP HPLC

Indexed keywords

2,4 DINITROPHENYLHYDRAZINE; ACETALDEHYDE; ACROLEIN; BENZALDEHYDE; CROTONALDEHYDE; FORMALDEHYDE; MACROGOL; PROPIONALDEHYDE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEGRADATION; DERIVATIZATION; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCREENING; SEPARATION TECHNIQUE; ULTRAVIOLET RADIATION;

APCI-MS; MPEG-ALDEHYDE; NMR; PEGYLATION; RP-HPLC;

ACROLEIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FORMALDEHYDE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHENYLHYDRAZINES; POLYETHYLENE GLYCOLS;

EID: 84889071769     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.10.046     Document Type: Article

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