Polyaspartic acid functionalized gold nanoparticles for tumor targeted doxorubicin delivery

Journal of Biomedical Nanotechnology

Volumn 10, Issue 1, 2014, Pages 143-153

  Khandekar, Sameera V ^a,b   Kulkarni, M G ^b   Devarajan, Padma V ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Doxorubicin; Gold nanoparticle; Ionic complexation; Polyaspartic acid

Indexed keywords

DOXORUBICIN; FUNCTIONALIZED GOLD NANOPARTICLES; GOLD NANOPARTICLES; IONIC-COMPLEXATION; MCF-7 BREAST CANCER CELLS; POLYASPARTIC ACID; SECONDARY AMINO GROUP; TUMOR TARGETED DELIVERY;

CHLORINE COMPOUNDS; DEIONIZED WATER; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GOLD; MAMMALS; METAL NANOPARTICLES; TOXICITY; TUMORS;

LOADING;

DOXORUBICIN; ELECTROLYTE; GOLD CHLORIDE; GOLD NANOPARTICLE; POLYASPARTIC ACID; POLYMER;

ABSORPTION SPECTROSCOPY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; BREAST CANCER; CELL STRAIN MCF 7; CELL VIABILITY; CELLS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; DRUG SYNTHESIS; FIBROSARCOMA; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PROTON NUCLEAR MAGNETIC RESONANCE; STATIC ELECTRICITY; SURFACE PLASMON RESONANCE; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT DURATION; TUMOR GROWTH; TUMOR VOLUME; WEIGHT CHANGE; WEIGHT REDUCTION; X RAY DIFFRACTION; ZETA POTENTIAL;

ANIMALS; DOXORUBICIN; DRUG CARRIERS; DRUG EVALUATION, PRECLINICAL; GOLD; HUMANS; MALE; MCF-7 CELLS; METAL NANOPARTICLES; MICE; NEOPLASMS; PEPTIDES;

EID: 84889007963     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1772     Document Type: Article

References (40)

1. C. R. Patra, R. Bhattacharya, D. Mukhopadhyay, and P. Mukherjee, Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer. Adv. Drug. Deliv. Rev. 62, 346 (2010).
2. X. Huang and M. A. El-Sayed, Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy. J. Adv. Res. 1, 13 (2010).
3. M. C. Daniel and D. Astruc, Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem. Rev. 104, 293 (2004).
4. M. Brust, M. Walker, D. Bethell, D. J. Schiffrin, and R. Whyman, Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid-liquid system. J. Chem. Soc. Chem. Commun. 801 (1994).
5. X. Sun, S. Dong, and E. Wang, One-step synthesis and characterization of polyelectrolyte-protected gold nanoparticles through a thermal process. Polymer 45, 2181 (2004).
6. C. Note, S. Kosmella, and J. Koetz, Poly(ethyleneimine) as reducing and stabilizing agent for the formation of gold nanoparticles in w/o microemulsions. Colloids Surf. A Physicochem. Eng. Asp. 290, 150 (2006).
7. S. Wang, J. Yana, and L. Chen, Formation of gold nanoparticles and self-assembly into dimer and trimer aggregates. Mater. Lett. 59, 1383 (2005).
8. X. Sun, S. Dong, and E. Wang, One-step polyelectrolyte-based route to well-dispersed gold nanoparticles: Synthesis and insight. Mater. Chem. Phys. 96, 29 (2006).
9. Y. Zhang, H. Peng, W. Huang, Y. Zhou, and D. Yan, Facile preparation and characterization of highly antimicrobial colloid Ag or Au nanoparticles. J. Colloid Interface Sci. 325, 371 (2008).
10. I. Hussain, M. Brust, A. J. Papworth, and A. I. Cooper, Preparation of acrylate-stabilized gold and silver hydrosols and gold-polymer composite films. Langmuir 19, 4831 (2003).
11. C. Note, J. Koetz, S. Kosmella, and B. Tiersch, Hydrophobically modified polyelectrolytes used as reducing and stabilizing agent for the formation of gold nanoparticles. Colloid Polym. Sci. 283, 334 (2005).
12. T. Sakai and P. Alexandridis, Single-step synthesis and stabilization of metal nanoparticles in aqueous pluronic block copolymer solutions at ambient temperature. Langmuir 20, 8426 (2004).
13. D. R. Bhumkar, H. M. Joshi, M. Sastry, and V. B. Pokharkar, Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin. Pharm. Res. 24, 1415 (2007).
14. S. Dhar, E. M. Reddy, A. Shiras, V. Pokharkar, and B. L. V. Prasad, Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations. Chem. Eur. J. 14, 10244 (2008).
15. E. Markovsky, H. Baabur-Cohen, L. Omer, G. Tiram, S. Ferber, P. Ofek, D. Polyak, A. Scomparin, and R. Satchi-Fainaro, Administration, distribution, metabolism and elimination of polymer therapeutics. J. Controlled Release 161, 446 (2012).
16. R. R. Patil, S. A. Guhagarkar, and P. V. Devarajan, Engineered nanocarriers of doxorubicin: A current update. Crit. Rev. Ther. Drug Carrier Syst. 25, 1 (2008).
17. S. Aryal and J. J. Grailer, Doxorubicin conjugated gold nanoparticles as water-soluble and pH-responsive anticancer drug nanocarriers. J. Mater. Chem. 19, 7879 (2009).
18. B. Asadishad, M. Vossoughi, and I. Alemzadeh, Folate-receptor-targeted delivery of doxorubicin using polyethylene glycolfunctionalized gold nanoparticles. Ind. Eng. Chem. Res. 49, 1958 (2010).
19. M. Prabhaharan, J. J. Grailer, S. Pilla, D. A. Steeber, and S. Gong, Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery. Biomaterials 30, 6065 (2009).
20. Y. Gu, J. Cheng, C. W. Man, W. Wong, and S. H. Cheng, Gold-doxorubicin conjugates for overcoming multidrug resistance. Nanomedicine: Nanotechnology, Biology and Medicine 8, 204 (2012).
21. J. D. Gibson, B. P. Khanal, and E. R. Zubarev, Paclitaxel-functionalized gold nanoparticles. J. Am. Chem. Soc. 129, 11653 (2007).
22. A. Z. Mirza and H. Shamshad, Preparation and characterization of doxorubicin functionalized gold nanoparticles. Eur. J. Med. Chem. 46, 1857 (2011).
23. L. Minati, V. Antonini, S. Torrengo, M. Dalla Sera, M. Boustta, X. Leclercq, C. Migliaresi, M. Vert, and G. Speranza, Sustained in-vitro release and cell uptake of doxorubicin adsorbed onto gold nanoparticles and covered by a polyelectrolyte complex layer. Int. J. Pharm. 438, 44 (2012).
24. M. Tomida, T. Nakato, and M. Kuramochi, Novel method of synthesizing poly(succinimide) and its copolymeric derivatives by acid-catalysed polycondensation of L-aspartic acid. Polymer 37, 4435 (1996).
25. S. A. Guhagarkar, R. V. Gaikwad, A. Samad, V. C. Malshe, and P. V. Devarajan, Polyethylene sebacate-doxorubicin nanoparticles for hepatic targeting. Int. J. Pharm. 401, 113 (2010).
26. W. Chen, B. Gua, J. Pan, W. Lua, and H. Hou, Development and evaluation of novel itraconazole-loaded intravenous nanoparticles. Int. J. Pharm. 362, 133 (2008).
27. H. Han, B. Shin, and H. Choi, Doxorubicin-encapsulated thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-acrylamide): Drug release behavior and stability in the presence of serum. Eur. J. Pharm. Biopharm. 62, 110 (2006).
28. N. Cao and S. Feng, Doxorubicin conjugated to D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS): Conjugation chemistry, characterization, in-vitro and in-vivo evaluation. Biomaterials 29, 3856 (2008).
29. X. Qi, Y. Maitani, T. Nagai, and S. Wei, Comparative pharmacokinetics and antitumor efficacy of doxorubicin encapsulated in soybean-derived sterols and poly(ethylene glycol) liposomes in mice. Int. J. Pharm. 146, 31 (1997).
30. S. Mandal, P. R. Selvakannan, S. Phadtare, R. Pasricha, and M. Sastry, Synthesis of a stable gold hydrosol by the reduction of chloroaurate ions by the amino acid, aspartic acid. Proc. Indian Acad. Sci. (Chem. Sci.) 114, 513 (2002).
31. Y. Shao, Y. Jin, and S. Dong, Synthesis of gold nanoplates by aspartate reduction of gold chloride. Chem. Commun. 7, 1104 (2004).
32. L. L. Rouhana, J. A. Jaber, and J. B. Schlenoff, Aggregation-resistant water-soluble gold nanoparticles. Langmuir 23, 12799 (2007).
33. D. M. Beniwal and P. V. Devarajan, Lipomer of doxorubicin hydrochloride for enhanced oral bioavailability. Int. J. Pharm. 423, 554 (2012).
34. M. V. Kitaeva, N. S. Melik-Nubarov, F. M. Menger, and A. A. Yaroslavovkitaeva, Doxorubicin-poly(acrylic acid) complexes: Interaction with liposomes. Langmuir 20, 6575 (2004).
35. Y. Wang, J. L. Robertson, W. B. Spillman, Jr, and R. O. Claus, Effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility. Pharm. Res. 21, 1362 (2004).
36. P. R. Harrigan, K. F. Wong, T. E. Redelmeier, J. J. Wheeler, and P. R. Cullis, Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients. Biochimica et Biophysics Acta 1149, 329 (1993).
37. A. Harada and K. Kataoka, Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethy1ene glycol) segments. Macromolecules 28, 5294 (1996).
38. S. Bennis, C. Chapey, P. Couvreur, and J. Robert, Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture. Eur. J. Cancer 30, 89 (1994).
39. H. S. Yoo, K. H. Lee, J. E. Oh, and T. G. Park, In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. J. Controlled Release 68, 419 (2000).
40. T. Akao, T. Kimura, Y. S. Hirofuji, K. Matsunaga, R. Imayoshi, J. Nagao, T. Cho, H. Matsumoto, S. Ohtono, J. Ohno, K. Taniguchi, and H. Kaminishi, A poly(γ-glutamic acid)-amphiphile complex as a novel nanovehicle for drug delivery system. J. Drug Target. 18, 550 (2010).