A cluster of deaths involving 5-(2-Aminopropyl)Indole (5-IT)

Journal of Analytical Toxicology

Volumn 37, Issue 8, 2013, Pages 542-546

  Kronstrand, Robert ^a,b   Roman, Markus ^a   Dahlgren, Maria ^a   Thelander, Gunilla ^a   Wikström, Maria ^a   Druid, Henrik ^a,c  

^a DEPARTMENT OF FORENSIC GENETICS AND FORENSIC TOXICOLOGY   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; 5 (2 AMINOPROPYL)INDOLE; ALIMEMAZINE; BENZOYLECGONINE; CARISOPRODOL; COCAINE; DESVENLAFAXINE; ETIZOLAM; HYDROXYZINE; INDOLE DERIVATIVE; MEPROBAMATE; METHYLPHENIDATE; NORSERTRALINE; PERPHENAZINE; PREGABALIN; RITALINIC ACID; SERTRALINE; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG; VENLAFAXINE; ZOPICLONE;

ADULT; ARTICLE; AUTOPSY; BLOOD; BODY HEIGHT; BODY WEIGHT; CLUSTER ANALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG FATALITY; DRUG INTOXICATION; DRUG LIVER LEVEL; DRUG URINE LEVEL; EPILEPSY; FEMORAL BLOOD; HEART; HUMAN; LIQUID CHROMATOGRAPHY; LUNG; MALE; SWEDEN; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VITREOUS BODY;

ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESIGNER DRUGS; FORENSIC TOXICOLOGY; GOVERNMENT REGULATION; HUMANS; INDOLES; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS; SWEDEN; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84888873307     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bkt058     Document Type: Article

References (18)

1. Carbone, P.N., Carbone, D.L., Carstairs, S.D., Luzi, S.A. (2013) Sudden cardiac death associated with methylone use. American Journal of Forensic Medicine and Pathology, 34, 26-28.
2. Kronstrand, R., Roman, M., Thelander, G., Eriksson, A. (2011) Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. Journal of Analytical Toxicology, 35, 242-247.
3. Murray, B.L., Murphy, C.M., Beuhler, M.C. (2012) Death following recreational use of designer drug "bath salts" containing 3,4-methylenedioxypyrovalerone (MDPV). Journal of Medical Toxicology, 8, 69-75.
4. Pearson, J.M., Hargraves, T.L., Hair, L.S., Massucci, C.J., Frazee, C.C. 3rd, Garg, U. et al. (2012) Three fatal intoxications due to methylone. Journal of Analytical Toxicology, 36, 444-451.
5. Warrick, B.J., Wilson, J., Hedge, M., Freeman, S., Leonard, K., Aaron, C. (2012) Lethal serotonin syndrome after methylone and butylone ingestion. Journal of Medical Toxicology, 8, 65-68.
6. Wikstrom, M., Thelander, G., Dahlgren, M., Kronstrand, R. (2013) An accidental fatal intoxication with methoxetamine. Journal of Analytical Toxicology, 37, 43-46.
7. Wikstrom, M., Thelander, G., Nystrom, I., Kronstrand, R. (2010) Two fatal intoxications with the new designer drug methedrone (4-methoxymethcathinone). Journal of Analytical Toxicology, 34, 594-598.
8. Shulgin, A.T., Shulgin, A. (1997) TIHKAL: The continuation. Transform Press, Berkeley, CA.
9. Cerletti, A., Taeschler, M., Weidmann, H. (1968) Pharmacologic studies on the structure-activity relationship of hydroxyindole alkylamines. Advances in Pharmacology, 6(Pt B), 233-246.
10. Seetohul, L.N., Maskell, P.D., De Paoli, G., Pounder, D.J. (2012) Deaths associated with new designer drug 5-IT. Br Med J, 345, e5625.
11. Druid, H., Holmgren, P. (1997) A compilation of fatal and control concentrations of drugs in postmortem femoral blood. Journal of Forensic Sciences, 42, 79-87.
12. Roman, M., Strom, L., Tell, H., Josefsson, M. (2013) Liquid chromatography/ time-of-flight mass spectrometry analysis of postmortem blood samples for targeted toxicological screening. Analytical Bioanalytical Chemistry, 405, 4107-4125.
13. Jones, A.W., Schuberth, J. (1989) Computer-aided headspace gas chromatography applied to blood-alcohol analysis: importance of online process control. Journal of Forensic Sciences, 34, 1116-1127.
14. Peters, F.T., Drummer, O.H., Musshoff, F. (2007) Validation of new methods. Forensic Science International, 165, 216-224.
15. Elliott, S.P., Brandt, S.D., Freeman, S., Archer, R.P. (2013) AMT (3-(2-aminopropyl)indole) and 5-IT (5-(2-aminopropyl)indole): an analytical challenge and implications for forensic analysis. Drug Testing and Analysis, 5, 196-202.
16. Druid, H., Strandberg, J.J., Alkass, K., Nystrom, I., Kugelberg, F.C., Kronstrand, R. (2007) Evaluation of the role of abstinence in heroin overdose deaths using segmental hair analysis. Forensic Science International, 168, 223-226.
17. Selden, T., Ahlner, J., Druid, H., Kronstrand, R. (2012) Toxicological and pathological findings in a series of buprenorphine related deaths. Possible risk factors for fatal outcome. Forensic Science International, 220, 284-290.
18. Warner-Smith, M., Darke, S., Lynskey, M., Hall, W. (2001) Heroin overdose: causes and consequences. Addiction, 96, 1113-1125.