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Volumn 18, Issue 4, 2013, Pages 445-459

Emerging tyrosine kinase inhibitors for head and neck cancer

Author keywords

Clinical development; Head and neck cancer; Squamous cell cancer; Tyrosine kinase inhibitors

Indexed keywords

AFATINIB; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DACOMITINIB; DASATINIB; DOCETAXEL; ERLOTINIB; EVEROLIMUS; FAMITINIB; FLUOROURACIL; FORETINIB; GEFITINIB; HYDROXYUREA; LAPATINIB; METHOTREXATE; PACLITAXEL; PANITUMUMAB; PLACEBO; PLATINUM; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TEMSIROLIMUS; UNCLASSIFIED DRUG; VANDETANIB;

EID: 84888872017     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.2013.842976     Document Type: Review
Times cited : (9)

References (102)
  • 2
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917
    • Int J Cancer 2010 , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 3
    • 14744287576 scopus 로고    scopus 로고
    • Human papillomavirus (HPV) in head and neck cancer
    • Syrjanen S. Human papillomavirus (HPV) in head and neck cancer. J Clin Virol 2005;32(Suppl 1):S59-S66
    • J Clin Virol 2005 , vol.32 , Issue.1 SUPPL.
    • Syrjanen, S.1
  • 4
    • 0347915672 scopus 로고    scopus 로고
    • Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers
    • Smith EM, Ritchie JM, Summersgill KF, et al. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer J Int Du Cancer 2004;108:766-72
    • Int J Cancer J Int du Cancer 2004 , vol.108 , pp. 766-772
    • Smith, E.M.1    Ritchie, J.M.2    Summersgill, K.F.3
  • 5
    • 84873606312 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer 1975-2009, featuring the burden and trends in Human Papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels
    • Jemal A, Simard EP, Dorell C, et al. Annual report to the nation on the status of cancer, 1975-2009, featuring the burden and trends in Human Papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst 2013;105(3):175-201
    • J Natl Cancer Inst 2013 , vol.105 , Issue.3 , pp. 175-201
    • Jemal, A.1    Simard, E.P.2    Dorell, C.3
  • 6
    • 84864316654 scopus 로고
    • Tumor stage human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: An Italian validation study
    • Jul
    • Granata R, Miceli R, Orlandi E, et al. Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study. Ann Oncol 2012 Jul;23(7):1823-7
    • (1823) Ann Oncol 2012 , vol.23 , pp. 7
    • Granata, R.1    Miceli, R.2    Orlandi, E.3
  • 7
    • 77954190940 scopus 로고    scopus 로고
    • Human papillomavirus and survival of patients with oropharyngeal cancer
    • Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24-35
    • N Engl J Med 2010 , vol.363 , pp. 24-35
    • Ang, K.K.1    Harris, J.2    Wheeler, R.3
  • 9
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354(6):567-78
    • N Engl J Med 2006 , vol.354 , Issue.6 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 10
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008;359(11):1116-27
    • N Engl J Med 2008 , vol.359 , Issue.11 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 11
    • 34247603668 scopus 로고    scopus 로고
    • Quality of life research in head and neck cancer: A review of the current state of the science
    • Murphy BA, Ridner S, Wells N, Dietrich M. Quality of life research in head and neck cancer: a review of the current state of the science. Crit Rev Oncol Hematol 2007;62:251-67
    • Crit Rev Oncol Hematol 2007 , vol.62 , pp. 251-267
    • Murphy, B.A.1    Ridner, S.2    Wells, N.3    Dietrich, M.4
  • 13
    • 77949599482 scopus 로고    scopus 로고
    • The role of the head and neck surgeon in contemporary multidisciplinary treatment programs for advanced head and neck cancer
    • Wong RJ, Shah JP. The role of the head and neck surgeon in contemporary multidisciplinary treatment programs for advanced head and neck cancer. Curr Opin Otolaryngol Head Neck Surg 2010;18(2):79-82
    • Curr Opin Otolaryngol Head Neck Surg 2010 , vol.18 , Issue.2 , pp. 79-82
    • Wong, R.J.1    Shah, J.P.2
  • 14
    • 73249120866 scopus 로고    scopus 로고
    • Evidence-based organ-sparing radiotherapy in head and neck cancer
    • Dirix P, Nuyts S. Evidence-based organ-sparing radiotherapy in head and neck cancer. Lancet Oncol 2010;11(1):85-91
    • Lancet Oncol 2010 , vol.11 , Issue.1 , pp. 85-91
    • Dirix, P.1    Nuyts, S.2
  • 15
    • 33646886144 scopus 로고    scopus 로고
    • Advances in the treatment of locally advanced non-nasopharyngeal squamous cell carcinoma of the head and neck region
    • Psyrri A, Fountzilas G. Advances in the treatment of locally advanced non-nasopharyngeal squamous cell carcinoma of the head and neck region. Med Oncol 2006;23:1-15
    • Med Oncol 2006 , vol.23 , pp. 1-15
    • Psyrri, A.1    Fountzilas, G.2
  • 16
    • 2442655601 scopus 로고    scopus 로고
    • The expanding role of systemic therapy in head and neck cancer
    • Cohen EE, Lingen MW, Vokes EE. The expanding role of systemic therapy in head and neck cancer. J Clin Oncol 2004;22:1743-52
    • J Clin Oncol 2004 , vol.22 , pp. 1743-1752
    • Cohen, E.E.1    Lingen, M.W.2    Vokes, E.E.3
  • 17
    • 0025807080 scopus 로고    scopus 로고
    • Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer
    • The Department of Veterans Affairs Laryngeal Cancer Study Group
    • The Department of Veterans Affairs Laryngeal Cancer Study Group. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med 1991;324(24):1685-90
    • N Engl J Med 1991 , vol.324 , Issue.24 , pp. 1685-1690
  • 18
    • 66949128922 scopus 로고    scopus 로고
    • Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients
    • Pignon JP, le Mâtre A, Maillard E, et al. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 2009;92(1):4-14
    • Radiother Oncol 2009 , vol.92 , Issue.1 , pp. 4-14
    • Pignon, J.P.1    Le Mâtre, A.2    Maillard, E.3
  • 19
    • 84875711689 scopus 로고    scopus 로고
    • Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: The TREMPLIN randomized phase II study
    • Lefebvre JL, Pointreau Y, Rolland F, et al. Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. J Clin Oncol 2013;31(7):853-9
    • J Clin Oncol 2013 , vol.31 , Issue.7 , pp. 853-859
    • Lefebvre, J.L.1    Pointreau, Y.2    Rolland, F.3
  • 20
    • 80053368876 scopus 로고    scopus 로고
    • A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC) [abstract]
    • Ang KK, Zhang Q, Rosenthal DI, et al. A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC) [abstract]. Proc Am Soc Clin Oncol 2011;29:550
    • Proc Am Soc Clin Oncol 2011 , vol.29 , pp. 550
    • Ang, K.K.1    Zhang, Q.2    Rosenthal, D.I.3
  • 21
    • 84872610898 scopus 로고    scopus 로고
    • Is the combination of Cetuximab with chemo-radiotherapy regimens worthwhile in the treatment of locally advanced head and neck cancer? A review of current evidence
    • Numico G, Franco P, Cristofano A, et al. Is the combination of Cetuximab with chemo-radiotherapy regimens worthwhile in the treatment of locally advanced head and neck cancer? A review of current evidence. Crit Rev Oncol Hematol 2013;85:112-20
    • Crit Rev Oncol Hematol 2013 , vol.85 , pp. 112-120
    • Numico, G.1    Franco, P.2    Cristofano, A.3
  • 22
    • 84876079071 scopus 로고    scopus 로고
    • Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: A randomized phase II trial
    • Martins RG, Parvathaneni U, Bauman JE, et al. Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial. J Clin Oncol 2013;31(11):1415-21
    • J Clin Oncol 2013 , vol.31 , Issue.11 , pp. 1415-1421
    • Martins, R.G.1    Parvathaneni, U.2    Bauman, J.E.3
  • 23
    • 77955906810 scopus 로고    scopus 로고
    • Fourth-quarter and full-year 2009 results
    • Indianapolis, Indiana:2010 available at (last accessed 20th Sept 2013)
    • Eli Lilly and Co. Fourth-quarter and full-year 2009 results. Indianapolis, Indiana: 2010 available at http://newsroom.lilly.com/ releasedetail.cfm?ReleaseID=441003 (last accessed 20th Sept 2013) 24. Bristol-Myers Squibb Fourth Quarter Earnings 2009 Results. 2010
    • (2010) Bristol-Myers Squibb Fourth Quarter Earnings 2009 Results , vol.24
    • Lilly, E.1    Co2
  • 25
    • 84888872478 scopus 로고    scopus 로고
    • LLY: Growth challenged over the near-term
    • Chicago IL:2010
    • Zeng G. LLY: growth challenged over the near-term. Zacks Equity Research; Chicago, IL: 2010
    • Zacks Equity Research
    • Zeng, G.1
  • 26
    • 75649110453 scopus 로고    scopus 로고
    • Should cetuximab replace cisplatin in head and neck cancer
    • Rowan K. Should cetuximab replace cisplatin in head and neck cancer? J Natl Cancer Inst 2010;102(2):74-6
    • J Natl Cancer Inst 2010 , vol.102 , Issue.2 , pp. 74-76
    • Rowan, K.1
  • 27
    • 0033978407 scopus 로고    scopus 로고
    • How do head and neck cancer patients prioritize treatment outcomes before initiating treatment
    • ListMA, Stracks J,Colangelo L, et al.How do head and neck cancer patients prioritize treatment outcomes before initiating treatment? J Clin Oncol 2000;18(4):877-84
    • J Clin Oncol 2000 , vol.18 , Issue.4 , pp. 877-884
    • List, M.A.1    Stracks, J.2    Colangelo, L.3
  • 28
    • 0033025369 scopus 로고    scopus 로고
    • Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy: Progression from reversible to irreversible inhibitors
    • Fry DW. Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy: progression from reversible to irreversible inhibitors. Pharmacol Ther 1999;82:207-18
    • Pharmacol Ther 1999 , vol.82 , pp. 207-218
    • Fry, D.W.1
  • 29
    • 0037029703 scopus 로고    scopus 로고
    • Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 ("Iressa")
    • Magne N, Fischel JL, Dubreuil A, et al. Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 ("Iressa"). Br J Cancer 2002;86:1518-23
    • Br J Cancer 2002 , vol.86 , pp. 1518-1523
    • Magne, N.1    Fischel, J.L.2    Dubreuil, A.3
  • 30
    • 0242425890 scopus 로고    scopus 로고
    • Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer
    • Shintani S, Li C, Mihara M, et al. Enhancement of tumor radioresponse by combined treatment with gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, is accompanied by inhibition of DNA damage repair and cell growth in oral cancer. Int J Cancer J Int Du Cancer 2003;107:1030-7
    • Int J Cancer J Int du Cancer 2003 , vol.107 , pp. 1030-1037
    • Shintani, S.1    Li, C.2    Mihara, M.3
  • 31
    • 0141599428 scopus 로고    scopus 로고
    • Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
    • Stamos J, Sliwkowski MX, Eigenbrot C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J Biol Chem 2002;277(48):46265-72
    • J Biol Chem 2002 , vol.277 , Issue.48 , pp. 46265-46272
    • Stamos, J.1    Sliwkowski, M.X.2    Eigenbrot, C.3
  • 32
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from 'never smokers' and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004;101(36):13306-11
    • Proc Natl Acad Sci USA 2004 , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 33
    • 33749035470 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
    • Sok JC, Coppelli FM, Thomas SM, et al. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res 2006;12(17):5064-73
    • Clin Cancer Res 2006 , vol.12 , Issue.17 , pp. 5064-5073
    • Sok, J.C.1    Coppelli, F.M.2    Thomas, S.M.3
  • 34
    • 79960389739 scopus 로고    scopus 로고
    • Biology of vascular endothelial growth factor and its receptors in head and neck cancer: Beyond angiogenesis
    • Christopoulos A, Ahn SM, Klein JD, et al. Biology of vascular endothelial growth factor and its receptors in head and neck cancer: beyond angiogenesis. Head Neck 2011;33:1220-9
    • Head Neck 2011 , vol.33 , pp. 1220-1229
    • Christopoulos, A.1    Ahn, S.M.2    Klein, J.D.3
  • 35
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Rosen F, Stadler WM, et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003;21(10):1980-7
    • J Clin Oncol 2003 , vol.21 , Issue.10 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3
  • 36
    • 28544432807 scopus 로고    scopus 로고
    • Phase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Kane MA, List MA, et al. Phase II trial of gefitinib 250 mg daily in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 2005;11(23):8418-24
    • Clin Cancer Res 2005 , vol.11 , Issue.23 , pp. 8418-8424
    • Cohen, E.E.1    Kane, M.A.2    List, M.A.3
  • 37
    • 64649097892 scopus 로고    scopus 로고
    • Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected]
    • Stewart JS, Cohen EE, Licitra L, et al. Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected]. J Clin Oncol 2009;27(11):1864-71
    • J Clin Oncol 2009 , vol.27 , Issue.11 , pp. 1864-1871
    • Stewart, J.S.1    Cohen, E.E.2    Licitra, L.3
  • 38
    • 84876073132 scopus 로고    scopus 로고
    • Phase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: An eastern cooperative oncology group trial
    • Argiris A, Ghebremichael M, Gilbert J, et al. Phase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: an eastern cooperative oncology group trial. J Clin Oncol 2013;31(11):1405-14
    • J Clin Oncol 2013 , vol.31 , Issue.11 , pp. 1405-1414
    • Argiris, A.1    Ghebremichael, M.2    Gilbert, J.3
  • 39
    • 84865184491 scopus 로고    scopus 로고
    • Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Perez CA, Song H, Raez LE, et al. Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck. Oral Oncol 2012;48(9):887-92
    • Oral Oncol 2012 , vol.48 , Issue.9 , pp. 887-892
    • Perez, C.A.1    Song, H.2    Raez, L.E.3
  • 40
    • 42149109105 scopus 로고    scopus 로고
    • A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy
    • Ma B, Hui EP, King A, et al. A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy. Cancer Chemother Pharmacol 2008;62(1):59-64
    • Cancer Chemother Pharmacol 2008 , vol.62 , Issue.1 , pp. 59-64
    • Ma, B.1    Hui, E.P.2    King, A.3
  • 41
    • 47549095907 scopus 로고    scopus 로고
    • Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma
    • Chua DT, Wei WI, Wong MP, et al. Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma. Head Neck 2008;30(7):863-7
    • Head Neck 2008 , vol.30 , Issue.7 , pp. 863-867
    • Chua, D.T.1    Wei, W.I.2    Wong, M.P.3
  • 42
    • 36849051467 scopus 로고    scopus 로고
    • Phase i trial of gefitinib in combination with radiation or chemoradiation for patients with locally advanced squamous cell head and neck cancer
    • Chen C, Kane M, Song J, et al. Phase I trial of gefitinib in combination with radiation or chemoradiation for patients with locally advanced squamous cell head and neck cancer. J Clin Oncol 2007;25(31):4880-6
    • J Clin Oncol 2007 , vol.25 , Issue.31 , pp. 4880-4886
    • Chen, C.1    Kane, M.2    Song, J.3
  • 43
    • 77951782182 scopus 로고    scopus 로고
    • Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer
    • Van Waes C, Allen CT, Citrin D, et al. Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 2010;77(2):447-54
    • Int J Radiat Oncol Biol Phys 2010 , vol.77 , Issue.2 , pp. 447-454
    • Van Waes, C.1    Allen, C.T.2    Citrin, D.3
  • 44
    • 65649133997 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy/gefitinib followed by concurrent chemotherapy/radiation therapy/gefitinib for patients with locally advanced squamous carcinoma of the head and neck
    • Hainsworth JD, Spigel DR, Burris HA III, et al. Neoadjuvant chemotherapy/gefitinib followed by concurrent chemotherapy/radiation therapy/gefitinib for patients with locally advanced squamous carcinoma of the head and neck. Cancer 2009;115(10):2138-46
    • Cancer 2009 , vol.115 , Issue.10 , pp. 2138-2146
    • Hainsworth, J.D.1    Spigel, D.R.2
  • 45
    • 80051781911 scopus 로고    scopus 로고
    • Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: A phase II randomized double-blind placebo-controlled study
    • Gregoire V, Hamoir M, Chen C, et al. Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: a phase II, randomized, double-blind, placebo-controlled study. Radiother Oncol 2011;100(1):62-9
    • Radiother Oncol 2011 , vol.100 , Issue.1 , pp. 62-69
    • Gregoire, V.1    Hamoir, M.2    Chen, C.3
  • 46
    • 84867890910 scopus 로고    scopus 로고
    • Single-arm phase II study of multiagent concurrent chemoradiotherapy and gefitinib in locoregionally advanced squamous cell carcinoma of the head and neck
    • Rodriguez CP, Adelstein DJ, Rybicki LA, et al. Single-arm phase II study of multiagent concurrent chemoradiotherapy and gefitinib in locoregionally advanced squamous cell carcinoma of the head and neck. Head Neck 2012;34(11):1517-23
    • Head Neck 2012 , vol.34 , Issue.11 , pp. 1517-1523
    • Rodriguez, C.P.1    Adelstein, D.J.2    Rybicki, L.A.3
  • 47
    • 77954737028 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer
    • Cohen EE, Haraf DJ, Kunnavakkam R, et al. Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol 2010;28(20):3336-43
    • J Clin Oncol 2010 , vol.28 , Issue.20 , pp. 3336-3343
    • Cohen, E.E.1    Haraf, D.J.2    Kunnavakkam, R.3
  • 48
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, et al. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004;22(1):77-85
    • J Clin Oncol 2004 , vol.22 , Issue.1 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3
  • 49
    • 34250208469 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: A Princess Margaret Hospital phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study
    • Siu LL, Soulieres D, Chen EX, et al. Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Princess Margaret Hospital phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study. J Clin Oncol 2007;25(16):2178-83
    • J Clin Oncol 2007 , vol.25 , Issue.16 , pp. 2178-2183
    • Siu, L.L.1    Soulieres, D.2    Chen, E.X.3
  • 50
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
    • Burtness B, Goldwasser MA, Flood W, et al. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 2005;23(34):8646-54
    • J Clin Oncol 2005 , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3
  • 51
    • 41949113428 scopus 로고    scopus 로고
    • Final results of a phase II study of erlotinib, docetaxel and cisplatin in patients with recurrent/metastatic head and neck cancer
    • abstract 6013
    • Kim ES, Kies MS, Glisson BS, et al. Final results of a phase II study of erlotinib, docetaxel and cisplatin in patients with recurrent/metastatic head and neck cancer. J Clin Oncol 2007;25(18 Suppl):abstract 6013
    • J Clin Oncol 2007 , vol.25 , Issue.18 SUPPL.
    • Kim, E.S.1    Kies, M.S.2    Glisson, B.S.3
  • 52
    • 62349097073 scopus 로고    scopus 로고
    • Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A phase I/II study
    • Cohen EE, Davis DW, Karrison TG, et al. Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. Lancet Oncol 2009;10(3):247-57
    • Lancet Oncol 2009 , vol.10 , Issue.3 , pp. 247-257
    • Cohen, E.E.1    Davis, D.W.2    Karrison, T.G.3
  • 53
    • 84888878744 scopus 로고    scopus 로고
    • Phase II trial of everolimus and erlotinib in patients with platinum-resistant recurrent and/or metastatic head and neck squamous cell carcinoma. Head and Neck Cancer 6067
    • abstract 6067
    • Massarelli E, Ginsberg LE, Lin H, et al. Phase II trial of everolimus and erlotinib in patients with platinum-resistant recurrent and/or metastatic head and neck squamous cell carcinoma. Head and Neck Cancer 6067. J Clin Oncol 2013;31(Suppl):abstract 6067
    • J Clin Oncol 2013 , Issue.SUPPL. , pp. 31
    • Massarelli, E.1    Ginsberg, L.E.2    Lin, H.3
  • 54
    • 84875722517 scopus 로고    scopus 로고
    • A phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic platinum-refractory head and neck squamous cell carcinoma
    • Bauman JE, Arias-Pulido H, Lee SJ, et al. A phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinoma. Oral Oncol 2013;49(5):461-7
    • Oral Oncol 2013 , vol.49 , Issue.5 , pp. 461-467
    • Bauman, J.E.1    Arias-Pulido, H.2    Lee, S.J.3
  • 55
    • 77957195929 scopus 로고    scopus 로고
    • Phase I/II study of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck
    • Herchenhorn D, Dias FL, Viegas CM, et al. Phase I/II study of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 2010;78(3):696-702
    • Int J Radiat Oncol Biol Phys 2010 , vol.78 , Issue.3 , pp. 696-702
    • Herchenhorn, D.1    Dias, F.L.2    Viegas, C.M.3
  • 56
    • 33846841515 scopus 로고    scopus 로고
    • Phase i study of the EGFR tyrosine kinase inhibitor erlotinib in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN)
    • abstract 5545
    • Savvides P, Agarwala SS, Greskovich J, et al. Phase I study of the EGFR tyrosine kinase inhibitor erlotinib in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN). J Clin Oncol 2006;24(18 Suppl):abstract 5545
    • J Clin Oncol 2006 , vol.24 , Issue.18 SUPPL.
    • Savvides, P.1    Agarwala, S.S.2    Greskovich, J.3
  • 57
    • 79953874343 scopus 로고    scopus 로고
    • A phase I/II study of erlotinib in combination with chemoradiation in patients with surgically resected locally advanced squamous head and neck cancer (HNSCC)
    • abstract TPS266
    • Arias de la Vega F, Herruzo I, de las Heras M, et al. A phase I/II study of erlotinib in combination with chemoradiation in patients with surgically resected locally advanced squamous head and neck cancer (HNSCC). J Clin Oncol 2010;28(15 Suppl):abstract TPS266
    • J Clin Oncol 2010 , Issue.15 SUPPL. , pp. 28
    • Arias De La Vega, F.1    Herruzo, I.2    De Las Heras, M.3
  • 58
    • 80053352822 scopus 로고    scopus 로고
    • Combined modality treatment with chemotherapy, radiation therapy, bevacizumab, and erlotinib in patients with locally advanced squamous carcinoma of the head and neck: A phase II trial of the Sarah Cannon oncology research consortium
    • Hainsworth JD, Spigel DR, Greco FA, et al. Combined modality treatment with chemotherapy, radiation therapy, bevacizumab, and erlotinib in patients with locally advanced squamous carcinoma of the head and neck: a phase II trial of the Sarah Cannon oncology research consortium. Cancer J 2011;17(5):267-72
    • Cancer J 2011 , vol.17 , Issue.5 , pp. 267-272
    • Hainsworth, J.D.1    Spigel, D.R.2    Greco, F.A.3
  • 59
    • 84857734054 scopus 로고    scopus 로고
    • Prospective trial of synchronous bevacizumab erlotinib and concurrent chemoradiation in locally advanced head and neck cancer
    • Yoo DS, Kirkpatrick JP, Craciunescu O, et al. Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer. Clin Cancer Res 2012;18(5):1404-14
    • Clin Cancer Res 2012 , vol.18 , Issue.5 , pp. 1404-1414
    • Yoo, D.S.1    Kirkpatrick, J.P.2    Craciunescu, O.3
  • 60
    • 84888858033 scopus 로고    scopus 로고
    • Neoadjuvant erlotinib, erlotinib-sulindac, or placebo: A randomized, double-blind biomarker modulation study in operable head and neck squamous cell carcinoma (HNSCC)
    • abstract 6051
    • Bauman JE, Gross ND, Gooding WE, et al. Neoadjuvant erlotinib, erlotinib-sulindac, or placebo: a randomized, double-blind biomarker modulation study in operable head and neck squamous cell carcinoma (HNSCC). J Clin Oncol 2013;31(Suppl):abstract 6051
    • J Clin Oncol 2013 , Issue.SUPPL. , pp. 31
    • Bauman, J.E.1    Gross, N.D.2    Gooding, W.E.3
  • 61
    • 84888881916 scopus 로고    scopus 로고
    • A phase I/II study of erlotinib as adjuvant therapy in patients treated by chemoradiation therapy (CRT) for locally advanced SCCHN. Head & Neck Cancer 5562
    • abstract
    • Soulieres D, Fortin B, Winquist E. A phase I/II study of erlotinib as adjuvant therapy in patients treated by chemoradiation therapy (CRT) for locally advanced SCCHN. Head & Neck Cancer 5562. J Clin Oncol 2010;28(15 Suppl):abstract 5562
    • J Clin Oncol 2010 , Issue.15 SUPPL. , pp. 5562
    • Soulieres, D.1    Fortin, B.2    Winquist, E.3
  • 62
    • 84859873106 scopus 로고    scopus 로고
    • A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck
    • De Souza JA, Davis DW, Zhang Y, et al. A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 2012;18(8):2336-43
    • Clin Cancer Res 2012 , vol.18 , Issue.8 , pp. 2336-2343
    • De Souza, J.A.1    Davis, D.W.2    Zhang, Y.3
  • 63
    • 61449122062 scopus 로고    scopus 로고
    • Phase i study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck
    • Harrington K, El-Hariry I, Bourhis J, et al. Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck. J Clin Oncol 2009;27(7):1100-7
    • (2009) J Clin Oncol , vol.27 , Issue.7 , pp. 1100-1107
    • Harrington, K.1    El-Hariry, I.2    Bourhis, J.3
  • 64
    • 84876106601 scopus 로고    scopus 로고
    • Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: Rationale for future randomised trials in human papilloma virus-negative disease
    • Harrington K, Berrier A, Robinson M, et al. Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease. Eur J Cancer 2013;49(7):1609-18
    • Eur J Cancer 2013 , vol.49 , Issue.7 , pp. 1609-1618
    • Harrington, K.1    Berrier, A.2    Robinson, M.3
  • 65
    • 80052029219 scopus 로고    scopus 로고
    • Effects of lapatinib monotherapy: Results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck
    • Del Campo JM, Hitt R, Sebastian P, et al. Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck. Br J Cancer 2011;105(5):618-27
    • Br J Cancer 2011 , vol.105 , Issue.5 , pp. 618-627
    • Del Campo, J.M.1    Hitt, R.2    Sebastian, P.3
  • 66
    • 84871330978 scopus 로고    scopus 로고
    • EORTC 24051: Unexpected side effects in a phase i study of TPF induction chemotherapy followed by chemoradiation with lapatinib a dual EGFR/ErbB2 inhibitor in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinoma
    • Lalami Y, Specenier PM, Awada A, et al. EORTC 24051: unexpected side effects in a phase I study of TPF induction chemotherapy followed by chemoradiation with lapatinib, a dual EGFR/ErbB2 inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinoma. Radiother Oncol 2012;105(2):238-40
    • Radiother Oncol 2012 , vol.105 , Issue.2 , pp. 238-240
    • Lalami, Y.1    Specenier, P.M.2    Awada, A.3
  • 67
    • 84878848479 scopus 로고    scopus 로고
    • Updated results of a randomized open-label phase II study exploring BIBW 2992 versus cetuximab in patients with platinum refractory metastatic/recurrent head and neck cancer (SCCHN)
    • Seiwert T, Fayatte J, Del Campo J, et al. Updated results of a randomized open-label phase II study exploring BIBW 2992 versus cetuximab in patients with platinum refractory metastatic/recurrent head and neck cancer (SCCHN). Ann Oncol 2010;21(Suppl 8):viii 316
    • Ann Oncol 2010 , vol.21 , Issue.SUPPL. 8 , pp. 8-316
    • Seiwert, T.1    Fayatte, J.2    Del Campo, J.3
  • 68
    • 84888043119 scopus 로고    scopus 로고
    • A randomized, open-label, phase II study of afatinib versus cetuximab in patients (pts) with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): Analysis of stage 2 (S2) following crossover
    • abstract 6001
    • Cupissol D, Seiwert TY, Fayette J, et al. A randomized, open-label, phase II study of afatinib versus cetuximab in patients (pts) with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): analysis of stage 2 (S2) following crossover. J Clin Oncol 2013;31(Suppl):abstract 6001
    • J Clin Oncol 2013 , vol.31 , Issue.SUPPL.
    • Cupissol, D.1    Seiwert, T.Y.2    Fayette, J.3
  • 69
    • 84874569165 scopus 로고    scopus 로고
    • A phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck
    • Razak AR, Soulières D, Laurie SA, et al. A phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck. Ann Oncol 2013;24(3):761-9
    • Ann Oncol 2013 , vol.24 , Issue.3 , pp. 761-769
    • Razak, A.R.1    Soulières, D.2    Laurie, S.A.3
  • 70
    • 84896727505 scopus 로고    scopus 로고
    • Evaluation of potential predictive markers of efficacy of dacomitinib in patients (pts) with recurrent/metastatic SCCHN from a phase II trial
    • abstract 6041
    • Audet ML, Allo G, Weng X, et al. Evaluation of potential predictive markers of efficacy of dacomitinib in patients (pts) with recurrent/metastatic SCCHN from a phase II trial. J Clin Oncol 2013;31(Suppl):abstract 6041
    • J Clin Oncol 2013 , vol.31 , Issue.SUPPL.
    • Audet, M.L.1    Allo, G.2    Weng, X.3
  • 72
    • 84888860748 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits migration and invasion of human melanoma cells and is a promising therapeutic agent for metastatic melanoma [abstract 1380]
    • Washington DC
    • Buettner RR, Nam S, Lee F, Jove R. Dasatinib (BMS-354825) inhibits migration and invasion of human melanoma cells and is a promising therapeutic agent for metastatic melanoma [abstract 1380]. 97th AACR; Washington, DC; 2006
    • (2006) 97th AACR
    • Buettner, R.R.1    Nam, S.2    Lee, F.3    Jove, R.4
  • 73
    • 79955487784 scopus 로고    scopus 로고
    • Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma
    • Brooks HD, Glisson BS, Bekele BN, et al. Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma. Cancer 2011;117(10):2112-19
    • Cancer 2011 , vol.117 , Issue.10 , pp. 2112-2119
    • Brooks, H.D.1    Glisson, B.S.2    Bekele, B.N.3
  • 74
    • 84888878564 scopus 로고    scopus 로고
    • Exelixis
    • 3 Jun 2004
    • Exelixis, Press release 3 Jun 2004
    • Press Release
  • 75
    • 84888883207 scopus 로고    scopus 로고
    • Exelixis
    • 22 Dec 2006
    • Exelixis, Press release 22 Dec 2006
    • Press Release
  • 76
    • 84888861500 scopus 로고    scopus 로고
    • Exelixis
    • 27 Jun 2008
    • Exelixis, Press release 27 Jun 2008
    • Press Release
  • 77
    • 84875025156 scopus 로고    scopus 로고
    • A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC)
    • abstract 4108
    • Yau TC, Sukeepaisarnjaroen W, Chao Y, et al. A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC). J Clin Oncol 2012;30(Suppl):abstract 4108
    • J Clin Oncol 2012 , vol.30 , Issue.SUPPL.
    • Yau, T.C.1    Sukeepaisarnjaroen, W.2    Chao, Y.3
  • 78
    • 84879554465 scopus 로고    scopus 로고
    • Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    • Seiwert T, Sarantopoulos J, Kallender H, et al. Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Invest New Drugs 2013;31(2):417-24
    • Invest New Drugs 2013 , vol.31 , Issue.2 , pp. 417-424
    • Seiwert, T.1    Sarantopoulos, J.2    Kallender, H.3
  • 79
    • 84880709088 scopus 로고    scopus 로고
    • A phase II, multicenter, open-label, single-arm trial of famitinib in patients with advanced recurrent and/or metastatic nasopharyngeal carcinoma (NPC) after two previous treatment regimens
    • abstract 6026
    • Huang Y, Zhang L, Pan J, et al. A phase II, multicenter, open-label, single-arm trial of famitinib in patients with advanced recurrent and/or metastatic nasopharyngeal carcinoma (NPC) after two previous treatment regimens. J Clin Oncol 2013;31(Suppl):abstract 6026
    • J Clin Oncol 2013 , vol.31 , Issue.SUPPL.
    • Huang, Y.1    Zhang, L.2    Pan, J.3
  • 80
    • 84888865180 scopus 로고    scopus 로고
    • Onyx
    • 26 Mar 2001 2nd Ann BioPartner N America (Vancouver)
    • Onyx, Press release 26 Mar 2001 82. 2nd Ann BioPartner N America (Vancouver), 2004
    • (2004) Press Release , vol.82
  • 81
    • 84888863481 scopus 로고    scopus 로고
    • Bayer
    • 28 Oct 2005
    • Bayer, Press release 28 Oct 2005
    • Press Release
  • 82
    • 34548504810 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma
    • Elser C, Siu LL, Winquist E, et al. Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma. J Clin Oncol 2007;25(24):3766-73
    • J Clin Oncol 2007 , vol.25 , Issue.24 , pp. 3766-3773
    • Elser, C.1    Siu, L.L.2    Winquist, E.3
  • 83
    • 77954754601 scopus 로고    scopus 로고
    • Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420
    • Williamson SK, Moon J, Huang CH, et al. Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: southwest Oncology Group Study S0420. J Clin Oncol 2010;28(20):3330-5
    • J Clin Oncol 2010 , vol.28 , Issue.20 , pp. 3330-3335
    • Williamson, S.K.1    Moon, J.2    Huang, C.H.3
  • 84
    • 84877135784 scopus 로고    scopus 로고
    • Final results of a phase II study of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic or recurrent squamous cell cancer of the head and neck (SCCHN)
    • abstract 5592
    • Blumenschein GR, Glisson BS, Lu C, et al. Final results of a phase II study of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic or recurrent squamous cell cancer of the head and neck (SCCHN). J Clin Oncol 2012;30(Suppl):abstract 5592
    • J Clin Oncol 2012 , vol.30 , Issue.SUPPL.
    • Blumenschein, G.R.1    Glisson, B.S.2    Lu, C.3
  • 85
    • 84867043532 scopus 로고    scopus 로고
    • A phase II study of sorafenib in combination with cisplatin and 5-fluorouracil in the treatment of recurrent or metastatic nasopharyngeal carcinoma
    • abstract 5538
    • Xue Yu Q, Pan J, et al. A phase II study of sorafenib in combination with cisplatin and 5-fluorouracil in the treatment of recurrent or metastatic nasopharyngeal carcinoma. J Clin Oncol 2012;30(Suppl):abstract 5538
    • J Clin Oncol 2012 , vol.30 , Issue.SUPPL.
    • Xue Yu, Q.1    Pan, J.2
  • 86
    • 84888056957 scopus 로고    scopus 로고
    • Cetuximab with or without sorafenib in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN)
    • abstract 6047
    • Gilbert J, Schell MJ, Zhao X, et al. Cetuximab with or without sorafenib in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol 2013;31(Suppl):abstract 6047
    • J Clin Oncol 2013 , vol.31 , Issue.SUPPL.
    • Gilbert, J.1    Schell, M.J.2    Zhao, X.3
  • 87
    • 77956056104 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate in head and neck squamous cell carcinoma
    • Choong NW, Kozloff MF, Taber D, et al. Phase II study of sunitinib malate in head and neck squamous cell carcinoma. Invest New Drugs 2010;28:677-83
    • Invest New Drugs 2010 , vol.28 , pp. 677-683
    • Choong, N.W.1    Kozloff, M.F.2    Taber, D.3
  • 88
    • 73949143686 scopus 로고    scopus 로고
    • Phase II Study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC
    • Machiels H, Henry S, Zanetta S, et al. Phase II Study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01. J Clin Oncol 2010;28:21-8
    • (2006) J Clin Oncol 2010 , vol.28 , pp. 21-28
    • MacHiels, H.1    Henry, S.2    Zanetta, S.3
  • 89
    • 84888884530 scopus 로고    scopus 로고
    • AstraZeneca
    • 4 Jul 2005 & 26 Feb 2007
    • AstraZeneca, Press releases 4 Jul 2005 & 26 Feb 2007
    • Press Releases
  • 90
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-55
    • Cancer Res 2002 , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 91
    • 36348941014 scopus 로고    scopus 로고
    • Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima) in combination with radiotherapy in EGFR-positive and EGFR-null human head and neck tumor xenografts
    • Gustafson DL, Frederick B, Merz AL, Raben D. Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima) in combination with radiotherapy in EGFR-positive and EGFR-null human head and neck tumor xenografts. Cancer Chemother Pharmacol 2008;61(2):179-88
    • Cancer Chemother Pharmacol 2008 , vol.61 , Issue.2 , pp. 179-188
    • Gustafson, D.L.1    Frederick, B.2    Merz, A.L.3    Raben, D.4
  • 92
    • 79953314675 scopus 로고
    • Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro
    • Sano D, Matsumoto F, Valdecanas DR, et al. Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro. Clin Cancer Res 2011;17(7):1815-27
    • (1815) Clin Cancer Res 2011 , vol.17 , pp. 7
    • Sano, D.1    Matsumoto, F.2    Valdecanas, D.R.3
  • 93
    • 75749151167 scopus 로고    scopus 로고
    • Phase i evaluation of vandetanib with radiation therapy (RT) ± cisplatin in previously untreated advanced head and neck squamous cell carcinoma (HNSCC)
    • abstract 6016
    • Papadimitrakopoulou V, Frank SJ, Blumenschein GR. Phase I evaluation of vandetanib with radiation therapy (RT) ± cisplatin in previously untreated advanced head and neck squamous cell carcinoma (HNSCC). J Clin Oncol 2009;27(15 Suppl):abstract 6016
    • J Clin Oncol 2009 , vol.27 , Issue.SUPPL. , pp. 15
    • Papadimitrakopoulou, V.1    Frank, S.J.2    Blumenschein, G.R.3
  • 94
    • 84880049211 scopus 로고    scopus 로고
    • A randomized phase II study of docetaxel with or without vandetanib in recurrent or metastatic squamous cell carcinoma of head and neck (SCCHN)
    • Epub ahead of print
    • Limaye S, Riley S, Zhao S, et al. A randomized phase II study of docetaxel with or without vandetanib in recurrent or metastatic squamous cell carcinoma of head and neck (SCCHN). Oral Oncol 2013; Epub ahead of print 97.
    • Oral Oncol 2013 , pp. 97
    • Limaye, S.1    Riley, S.2    Zhao, S.3
  • 95
    • 84874914651 scopus 로고    scopus 로고
    • Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: Preclinical and clinical studies
    • Shin DM, Zhang H, Saba NF, et al. Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies. Clin Cancer Res 2013;19:1244-56
    • Clin Cancer Res 2013 , vol.19 , pp. 1244-1256
    • Shin, D.M.1    Zhang, H.2    Saba, N.F.3
  • 96
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • Vermorken JB, Trigo J, Hitt R, et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol 2007;25(16):2171-7
    • J Clin Oncol 2007 , vol.25 , Issue.16 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3
  • 98
    • 79960991414 scopus 로고    scopus 로고
    • Role of EGFR family receptors in proliferation of squamous carcinoma cells induced by wound healing fluids of head and neck cancer patients
    • Licitra L, Perrone F, Tamborini E, et al. Role of EGFR family receptors in proliferation of squamous carcinoma cells induced by wound healing fluids of head and neck cancer patients. Ann Oncol 2011;22(8):1886-93.
    • Ann Oncol 2011 , vol.22 , Issue.8 , pp. 1886-1893
    • Licitra, L.1    Perrone, F.2    Tamborini, E.3
  • 99
    • 84880672773 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor therapy in head and neck squamous cell carcinoma: Focus on potential molecular mechanisms of drug resistance
    • Boeckx C, Baay M, Wouters A, et al. Anti-epidermal growth factor receptor therapy in head and neck squamous cell carcinoma: focus on potential molecular mechanisms of drug resistance. Oncologist 2013;18:850-64
    • Oncologist 2013 , vol.18 , pp. 850-864
    • Boeckx, C.1    Baay, M.2    Wouters, A.3
  • 100
    • 84878861605 scopus 로고    scopus 로고
    • Molecular markers of response and resistance to EGFR inhibitors in head and neck cancers
    • Box C, Zimmermann M, Eccles S. Molecular markers of response and resistance to EGFR inhibitors in head and neck cancers. Front Biosci 2013;18:520-42
    • Front Biosci 2013 , vol.18 , pp. 520-542
    • Box, C.1    Zimmermann, M.2    Eccles, S.3
  • 101
    • 76149106147 scopus 로고    scopus 로고
    • Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients
    • Chung CH, Seeley EH, Roder H, et al. Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients. Cancer Epidemiol Biomarkers Prev 2010;19:358-65
    • Cancer Epidemiol Biomarkers Prev 2010 , vol.19 , pp. 358-365
    • Chung, C.H.1    Seeley, E.H.2    Roder, H.3
  • 102
    • 84888870286 scopus 로고    scopus 로고
    • Identification of a gene expression profile associated with progression-free survival (PFS) in relapsed or metastatic (RM) head and neck squamous cell cancer (HNSCC) patients (pts) treated with first-line cetuximab and platinum therapy
    • abstract 6027
    • Bossi P, De Cecco L, Perrone F, et al. Identification of a gene expression profile associated with progression-free survival (PFS) in relapsed or metastatic (RM) head and neck squamous cell cancer (HNSCC) patients (pts) treated with first-line cetuximab and platinum therapy. J Clin Oncol 2013;31(Suppl):abstract 6027
    • J Clin Oncol 2013 , vol.31 , Issue.SUPPL.
    • Bossi, P.1    De Cecco, L.2    Perrone, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.