Optimization of a chondrogenic medium through the use of factorial design of experiments

BioResearch Open Access

Volumn 1, Issue 6, 2012, Pages 306-313

  Enochson, Lars ^a   Brittberg, Mats ^b,c   Lindahl, Anders ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c Kungsbacka Hospital   (Sweden)

Author keywords

articular cartilage; autonomous chondrocyte implantation; design of experiments; differentiation; media development; TGF b1; tissue engineering

Indexed keywords

DEXAMETHASONE; GLUCOSE; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CARTILAGE CELL; CASE REPORT; CELL DEDIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE OPTIMIZATION; FACTORIAL DESIGN; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RESPONSE SURFACE METHOD;

EID: 84888869982     PISSN: None     EISSN: 21647860     Source Type: Journal    
DOI: 10.1089/biores.2012.0277     Document Type: Article

References (40)

1. Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331:889-895.
2. Benya PAD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell. 1982;30:215-224.
3. Watt FM. Effect of seeding density on stability of the differentiated phenotype of pig articular chondrocytes in culture. J Cell Sci. 1988;89(Pt 3):373-378.
4. Johnstone B, Hering T, Caplan A. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 1998;238:265-272.
5. Grogan SP, Barbero A, Diaz-Romero J, et al. Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity. Arthritis Rheum. 2007;56:586-595.
6. Dehne T, Karlsson C, Ringe J, et al. Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. Arthritis Res Ther. 2009;11:R133.
7. Tallheden T, Karlsson C, Brunner A, et al. Gene expression during redifferentiation of human articular chondrocytes. Osteoarthritis Cartilage. 2004;12:525-535.
8. Haaland P. 1989. Experimental Design in Biotechnology. New York: Marcel Dekker Inc.
9. Marciset O. Multifactorial experimental design for optimizing transformation: electroporation of Streptococcus thermophilus. Biotechnol Bioeng. 1994;43:490-496.
10. Kumari P, Reddy CRK, Jha B. Comparative evaluation and selection of a method for lipid and fatty acid extraction from macroalgae. Anal Biochem. 2011;415:134-144.
11. Tye H.Application of statistical ''design of experiments''methods in drug discovery. Drug Discov Today. 2004;9:485-491.
12. Fisher RA. 1935. The Design of Experiments. Oxford: Oliver & Boyd.
13. Mandenius C-F, Brundin A. Bioprocess optimization using design-of-experiments methodology. Biotechnol Prog. 2008; 24:1191-1203.
14. Montgomery D. 2008. Design and Analysis of Experiments Hoboken, NJ: John Wiley & Sons, Inc.
15. Chen Y, Bloemen V, Impens S, et al. Characterization and optimization of cell seeding in scaffolds by factorial design: quality by design approach for skeletal tissue engineering. Tissue Eng Part C Methods. 2011;17:1-11.
16. Chen Y-L, Chen H-C, Lee H-P. Rational development of GAG-augmented chitosan membranes by fractional factorial design methodology. Biomaterials. 2006;27:2222-2232.
17. Lim M, Ye H, Drakakis E, et al. Towards information-rich bioprocessing: generation of spatio-temporal profiles through the use of design of experiments to determine optimal number and location of sensors - an example in thermal profiles. Biochem Eng J. 2008;40:1-7.
18. Chen WLK, Likhitpanichkul M, Ho A, et al. Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials. 2010;31:2489-2497.
19. Liu G, Kawaguchi H, Ogasawara T, et al. Optimal combination of soluble factors for tissue engineering of permanent cartilage from cultured human chondrocytes. J Biol Chem. 2007;282:20407-20415.
20. Gheshlaghi R, Scharer JM, Moo-Young M, et al. Medium optimization for hen egg white lysozyme production by recombinant Aspergillus niger using statistical methods. Biotechnol Bioeng. 2005;90:754-760.
21. Kuettner KE. Biochemistry of articular cartilage in health and disease. Clin Biochem. 1992;25:155-163.
22. de Crombrugghe B, Lefebvre V, Behringer R, et al. Transcriptional mechanisms of chondrocyte differentiation. Matrix Biol. 2000;19:389-394.
23. Bi W, Deng J, Zhang Z, et al. Sox9 is required for cartilage formation. Nat Genet. 1999;22:85-89.
24. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta. 1986;883:173-177.
25. Shapiro IM, Leboy PS, Tokuoka T, et al. Ascorbic acid regulates multiple metabolic activities of cartilage cells. Am J Clin Nutr. 1991;54(6 Suppl):1209S-1213S.
26. Clark AG, Rohrbaugh AL, Otterness I, et al. The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Matrix Biol. 2002;21:175-184.
27. Ibold Y, Lu? bke C, Pelz S, et al. Effect of different ascorbate supplementations on in vitro cartilage formation in porcine high-density pellet cultures. Tissue Cell. 2009;41:249-256.
28. Kisiday JD, Kurz B, DiMicco MA, et al. Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds. Tissue Eng. 2005;11:141-151.
29. Lennon D, Haynesworth S, Young R. A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells. Exp Cell Res. 1995;219:211-222.
30. Miyazono K. Positive and negative regulation of TGF-beta signaling. J Cell Sci. 2000;113(Pt 7):1101-1109.
31. Miyazaki Y. Dexamethasone inhibition of TGFb-induced cell growth and type II collagen mRNA expression through ERKintegrated AP-1 activity in cultured rat articular chondrocytes. Osteoarthritis Cartilage. 2000;8:378-385.
32. Phitak T, Pothacharoen P, Kongtawelert P. Comparison of glucose derivatives effects on cartilage degradation. BMC Musculoskelet Disord. 2010;11:162.
33. Heywood HK, Bader DL, Lee DA. Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded alginate constructs. Tissue Eng. 2006;12:3487-3496.
34. Scotti C, Osmokrovic A, Wolf F, et al. Response of human engineered cartilage based on articular or nasal chondrocytes to IL-1b and low oxygen. Tissue Eng Part A. 2012;18:362-372.
35. Bastiaansen-Jenniskens YM, Koevoet W, de Bart ACW, et al. TGFb Affects collagen cross-linking independent of chondrocyte phenotype but strongly depending on physical environment. Tissue Eng Part A. 2008;14:1059-1066.
36. van der Windt AE, Jahr H, Farrell E, et al. Calcineurin inhibitors promote chondrogenic marker expression of dedifferentiated human adult chondrocytes via stimulation of endogenous TGFbeta1 production. Tissue Eng Part A. 2010; 16:1-10.
37. Henderson JH, Welter JF, Mansour JM, et al. Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit. Tissue Eng. 2007;13:843-853.
38. Pritchett J, Baldwin SA. The effect of nitrogen source on yield and glycosylation of a human cystatin C mutant expressed in Pichia pastoris. J Ind Microbiol Biotechnol. 2004;31: 553-558.
39. Zaucke F, Dinser R, Maurer P, Cartilage oligomeric matrix protein (COMP) and collagen IX are sensitive markers for the differentiation state of articular primary chondrocytes. Biochem J. 2001;15;358(Pt 1):17-24.
40. Nelson L, Fairclough J, Archer C. Use of stem cells in the biological repair of articular cartilage. Expert Opin Biol Ther. 2010;10:43-55.