Liver transplant tolerance and its application to the clinic: Can we exploit the high dose effect?

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Cunningham, Eithne C ^a   Sharland, Alexandra F ^a   Alex Bishop, G ^a  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; AUTOANTIGEN; CYCLOSPORIN; INTERLEUKIN 15; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 9; MAJOR HISTOCOMPATIBILITY ANTIGEN; ANTIGEN;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; DOSE RESPONSE; GENE THERAPY; GRAFT SURVIVAL; HUMAN; IMMUNOGENICITY; IMMUNOSUPPRESSIVE TREATMENT; LIVER GRAFT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; TRANSPLANTATION TOLERANCE; ANIMAL; ANIMAL MODEL; GENE TRANSFER; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; LIVER; METABOLISM; REVIEW;

ANIMALS; ANTIGENS; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNE TOLERANCE; LIVER; LIVER TRANSPLANTATION; MODELS, ANIMAL;

EID: 84888869342     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/419692     Document Type: Article

References (98)

1. Calne R. Y., Sells R. A., Pena J. R., Davis D. R., Millard P. R., Herbertson B. M., Binns R. M., Davies D. A. L., Induction of immunological tolerance by porcine liver allografts. Nature 1969 223 5205 472 476 2-s2.0-0014661390 10.1038/223472a0
2. Kamada N., Brons G., Davies H. S., Fully allogeneic liver grafting in rats induces a state of systemic nonreactivity to donor transplantation antigens. Transplantation 1980 29 5 429 431 2-s2.0-0019314128 (Pubitemid 10037391)
3. Zimmermann F. A., Davies Ff. H. S., Knoll P. P., Orthotopic liver allografts in the rat. The influence of strain combination on the fate of the graft. Transplantation 1984 37 4 406 410 2-s2.0-0021250344 (Pubitemid 14105436)
4. Qian S. G., Fung J. J., Demetris A. J., Ildstad S. T., Starzl T. E., Orthotopic liver transplantation in the mouse. Transplantation 1991 52 3 562 564 2-s2.0-0025986994
5. Kamada N., Davies H. S., Roser B., Reversal of transplantation immunity by liver grafting. Nature 1981 292 5826 840 842 2-s2.0-0019796723 (Pubitemid 11015497)
6. Subbotin V., Sun H., Aitouche A., Valdivia L. A., Fung J. J., Starzl T. E., Rao A. S., Abrogation of chronic rejection in a murine model of aortic allotransplantation by prior induction of donor-specific tolerance. Transplantation 1997 64 5 690 695 2-s2.0-0030931524 10.1097/00007890-199709150- 00005 (Pubitemid 27407094)
7. Qian S., Demetris A. J., Murase N., Rao A. S., Fung J. J., Starzl T. E., Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology 1994 19 4 916 924 2-s2.0-0028297988 10.1016/0270-9139(94)90292-5 (Pubitemid 24109354)
8. Bishop G. A., Sun J., DeCruz D. J., Rokahr K. L., Sedgwick J. D., Sheil A. G. R., Gallagher N. D., McCaughan G. W., Tolerance to rat liver allografts: III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues. Journal of Immunology 1996 156 12 4925 4931 2-s2.0-0029934768 (Pubitemid 26174481)
9. Kamada N., Wight D. G. D., Antigen-specific immunosuppression induced by liver transplantation in the rat. Transplantation 1984 38 3 217 221 2-s2.0-0021151847 (Pubitemid 14035167)
10. Wang C., Sun J., Li L., Wang L., Dolan P., Sheil A. G. R., Conversion of pancreas allograft rejection to acceptance by liver transplantation. Transplantation 1998 65 2 188 192 2-s2.0-0032570274 (Pubitemid 28099209)
11. Ramos H. C., Reyes J., Abu-Elmagd K., Zeevi A., Reinsmoen N., Tzakis A., Demetris A. J., Fung J. J., Flynn B., McMichael J., Ebert F., Starzl T. E., Weaning of immunosuppression in long-term liver transplant recipients. Transplantation 1995 59 2 212 217 2-s2.0-0028799575
12. Reyes J., Zeevi A., Ramos H., Tzakis A., Todo S., Demetris A. J., Nour B., Nalesnik M., Trucco M., Abu-Elmagd K., Fung J. J., Starzl T. E., Frequent achievement of a drug-free state after orthotopic liver transplantation. Transplantation Proceedings 1993 25 6 3315 3319 2-s2.0-0027733734 (Pubitemid 24007333)
13. Sumimoto R., Kamada N., Specific suppression of allograft rejection by soluble class I antigen and complexes with monoclonal antibody. Transplantation 1990 50 4 678 682 2-s2.0-0025131372 (Pubitemid 20358545)
14. Graeb C., Justl M., Scherer M. N., Andrassy J., Frank E., Zuelke C., Jauch K.-W., Geissler E. K., Use of an adenoviral vector to express soluble donor-major histocompatibility complex molecules capable of suppressing the immune response in rat transplant recipients. Human Immunology 2002 63 10 844 852 2-s2.0-0036776216 10.1016/S0198-8859(02)00460-3 (Pubitemid 35246764)
15. Priestley C. A., Dalchau R., Sawyer G. J., Fabre J. W., A detailed analysis of the potential of water-soluble classical class I MHC molecules for the suppression of kidney allograft rejection and in vitro cytotoxic T cell responses. Transplantation 1989 48 6 1031 1038 2-s2.0-0024787455 (Pubitemid 20018364)
16. Qian S., Fu F., Li Y., Lu L., Rao A. S., Starzl T. E., Thomson A. W., Fung J. J., Impact of donor MHC class I or class II antigen deficiency on first- and second-set rejection of mouse heart or liver allografts. Immunology 1996 88 1 124 129 2-s2.0-0029884503 (Pubitemid 26166385)
17. Sun J., McCaughan G. W., Gallagher N. D., Sheil A. G. R., Bishop G. A., Deletion of spontaneous rat liver allograft acceptance by donor irradiation. Transplantation 1995 60 3 233 236 2-s2.0-0029144580
18. Sriwatanawongsa V., Davies H. S., Calne R. Y., The essential roles of parenchymal tissues and passenger leukocytes in the tolerance induced by liver grafting in rats. Nature Medicine 1995 1 5 428 432 2-s2.0-0029071114
19. Tsui T.-Y., Deiwick A., Ko S., Schlitt H. J., Specific immunosuppression by postoperative infusion of allogeneic spleen cells: requirement of donor major histocompatibility complex expression and graft-versus-host reactivity. Transplantation 2000 69 1 25 30 2-s2.0-0034650555 (Pubitemid 30062603)
20. Yan Y., Shastry S., Richards C., Wang C., Bowen D. G., Sharland A. F., Painter D. M., McCaughan G. W., Bishop G. A., Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. Journal of Immunology 2001 166 8 5258 5264 2-s2.0-0035871831 (Pubitemid 32280743)
21. Ciancio G., Miller J., Garcia-Morales R. O., Carreno M., Burke G. W. III, Roth D., Kupin W., Tzakis A. G., Ricordi C., Rosen A., Fuller L., Esquenazi V., Six-year clinical effect of donor bone marrow infusions in renal transplant patients. Transplantation 2001 71 7 827 835 2-s2.0-0035870592 (Pubitemid 32417339)
22. Solgi G., Gadi V., Paul B., Five-year clinical effects of donor bone marrow cells infusions in kidney allograft recipients: improved graft function and higher graft survival. Chimerism 2013 4 3 87 94
23. Bertolino P., McCaughan G. W., Bowen D. G., Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunology & Cell Biology 2002 80 1 84 92 2-s2.0-0036236538 10.1046/j.0818-9641.2001.01048.x (Pubitemid 34415537)
24. Benseler V., Warren A., Vo M., Holz L. E., Tay S. S., Le Couteur D. G., Breen E., Allison A. C., Van Rooijen N., McGuffog C., Schlitt H. J., Bowen D. G., McCaughan G. W., Bertolino P., Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America 2011 108 40 16735 16740 2-s2.0-80053653657 10.1073/pnas.1112251108
25. Bowen D. G., Zen M., Holz L., Davis T., McCaughan G. W., Bertolino P., The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity. The Journal of Clinical Investigation 2004 114 5 701 712 2-s2.0-4944245002 10.1172/JCI200421593 (Pubitemid 39578761)
26. Kamada N., Shinomiya T., Clonal deletion as the mechanism of abrogation of immunological memory following liver grafting in rats. Immunology 1985 55 1 85 90 2-s2.0-0021981629 (Pubitemid 15114588)
27. Kamada N., Teramoto K., Baguerizo A., Ishikawa M., Sumimoto R., Ohkouchi Y., Cellular basis of transplantation tolerance induced by liver grafting in the rat. Extent of clonal deletion among thoracic duct lymphocytes, spleen, and lymph node cells. Transplantation 1988 46 1 165 167 2-s2.0-0023724486
28. Qian S., Lu L., Fu F., Li Y., Li W., Starzl T. E., Fung J. J., Thomson A. W., Apoptosis within spontaneously accepted mouse liver allografts. Evidence for deletion of cytotoxic T cells and implications for tolerance induction. Journal of Immunology 1997 158 10 4654 4661 2-s2.0-0031570116 (Pubitemid 127483783)
29. Steger U., Denecke C., Sawitzki B., Karim M., Jones N. D., Wood K. J., Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection. Transplantation 2008 85 9 1339 1347 2-s2.0-43449133598 10.1097/TP.0b013e31816dd64a (Pubitemid 351670486)
30. Medawar P. B., The behaviour and fate of skin autografts and skin homografts in rabbits: a report to the War Wounds Committee of the Medical Research Council. Journal of Anatomy 1944 78, part 5 176 199
31. Lehrfield J. W., Taylor A. C., The dosage phenomenon in rat skin homografts. Plastic & Reconstructive Surgery December 1953 12 6 432 438
32. Zotikov E. A., Budik V. M., Puza A., Some peculiarities in the survival time of skin homografts. Annals of the New York Academy of Sciences 1960 87 166 172
33. Henry L., Dammin G. J., Time and dose relationships in the development of immunity to skin homografts in mice. Journal of Immunology 1962 89 841 848 2-s2.0-73849153188
34. Converse J. M., Siegel W. H., Ballantyne D. L. Jr., Studies in antigenic overloading with massive skin homografts in rats. Plastic and Reconstructive Surgery 1963 31 9 15 2-s2.0-75449137048
35. Ballantyne D. L. Jr., Stetson C. A. Jr., Serologic reactions to skin homografts of various sizes in the rat. Annals of the New York Academy of Sciences 1964 120 7 14 2-s2.0-78651149844
36. Zanella G., Reif A. E., Buenviaje O. L., Asakuma R., Deterlig R. A. Jr., On prolonged survival of massive skin allografts in mice. Transplantation 1968 6 8 885 894 2-s2.0-0014349734
37. Gotjamanos T., The effect of skin allograft size on survival time following transplantation between mice differing at the H-2 locus. The Australian Journal of Experimental Biology and Medical Science 1970 48 1 1 15 2-s2.0-0014742975
38. Lappé M. A., Graff R. G., Snell G. D., The importance of target size in the destruction of skin grafts with non-H-2 incompatibility. Transplantation 1969 7 5 372 377 2-s2.0-0014516198
39. Ashman R. B., The influence of graft size on the induction of immunity versus tolerance to H-Y in H-2(k) strains of mice. Immunogenetics 1985 22 6 585 591 2-s2.0-0022404849 (Pubitemid 16232320)
40. Sun J., Sheil A. G. R., Wang C., Wang L., Rokahr K., Sharland A., Jung S.-E., Li L., Mccaughan G. W., Bishop G. A., Tolerance to rat liver allografts: IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes. Transplantation 1996 62 12 1725 1730 2-s2.0-0030457356
41. Sun J., Bishop G., Wang C., Wang L., McCaughan G., Sheil R., Quantity of donor tissue and rat allograft survival. Transplantation Proceedings 1997 29 1-2 1143 1144 2-s2.0-0030960901 10.1016/S0041-1345(96)00494-0 (Pubitemid 27126130)
42. Wang C., Sheil A. G. R., Sun J., Outcome of different models of multiorgan transplantation in rats. Microsurgery 1999 19 7 318 323 2-s2.0-0033404732 (Pubitemid 30004180)
43. Madsen J. C., Sachs D. H., Fallon J. T., Weissman N. J., Cardiac allograft vasculopathy in partially inbred miniature swine. I. Time course, pathology, and dependence on immune mechanisms. Journal of Thoracic and Cardiovascular Surgery 1996 111 6 1230 1239 2-s2.0-0029977056 10.1016/S0022-5223(96)70226-X (Pubitemid 26176082)
44. Madsen J. C., Yamada K., Allan J. S., Choo J. K., Erhorn A. E., Pins M. R., Vesga L., Slisz J. K., Sachs D. H., Transplantation tolerance prevents cardiac allograft vasculopathy in major histocompatibility complex class I-disparate miniature swine. Transplantation 1998 65 3 304 313 2-s2.0-0032519430 10.1097/00007890-199802150-00002 (Pubitemid 28095954)
45. Yamada K., Mawulawde K., Menard M. T., Shimizu A., Aretz H. T., Choo J. K., Allison K. S., Slisz J. K., Sachs D. H., Madsen J. C., Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: the effect of augmentation of donor antigen load. Journal of Thoracic and Cardiovascular Surgery 2000 119 4 709 719 2-s2.0-0034041267 (Pubitemid 30395468)
46. Nash J. R., Peters M., Bell P. R. F., Comparative survival of pancreatic islets, heart, kidney, and skin allografts in rats, with and without enhancement. Transplantation 1977 24 1 70 73 2-s2.0-0017728870 (Pubitemid 9101982)
47. Davis W. C., McKenzie I. F. C., Melvold R. W., A comparison of skin and heart graft rejection patterns in H-2 mutant mice. Transplantation 1980 29 3 189 192 2-s2.0-0018859996 (Pubitemid 10128757)
48. Mason A., Mottram P. L., Mirisklavos A., Clunie G. J. A., Mandel T. E., A comparison of cyclosporine, donor-specific transfusion, and antilymphocyte serum suppression of skin, heart, and fetal pancreatic islet allograft rejection in mice. Transplantation 1988 45 6 1155 1157 2-s2.0-0023939796
49. Zhang Z., Zhu L., Quan D., Garcia B., Ozcay N., Duff J., Stiller C., Lazarovits A., Grant D., Zhong R., Pattern of liver, kidney, heart, and intestine allograft rejection in different mouse strain combinations. Transplantation 1996 62 9 1267 1272 2-s2.0-8044242319 10.1097/00007890- 199611150-00016 (Pubitemid 27008553)
50. Jones N. D., Turvey S. E., Van Maurik A., Hara M., Kingsley C. I., Smith C. H., Mellor A. L., Morris P. J., Wood K. J., Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection. Journal of Immunology 2001 166 4 2824 2830 2-s2.0-0035865216 (Pubitemid 32173524)
51. He C., Schenk S., Zhang Q., Valujskikh A., Bayer J., Fairchild R. L., Heeger P. S., Effects of T cell frequency and graft size on transplant outcome in mice. Journal of Immunology 2004 172 1 240 247 2-s2.0-0346734192 (Pubitemid 38020477)
52. Ganbold A., Andersen S., Tay S. S., Cunningham E., Ilie V., Krishnan S., Wang C., McCaughan G. W., Sharland A. F., Bishop G. A., Expression of common gamma chain signalling cytokines and their receptors distinguishes rejection from tolerance in a rat organ transplant model. Transplant Immunology 2012 27 2-3 89 94
53. Alex Bishop G., Bertolino P. D., Bowen D. G., McCaughan G. W., Tolerance in liver transplantation. Best Practice and Research 2012 26 1 73 84 2-s2.0-84859358271 10.1016/j.bpg.2012.01.003
54. Margreiter R., Kornberger R., Koller J., Steiner E., Spielberger M., Aigner F., Schmid T., Vogel W., Can a liver graft from the same donor protect a kidney from rejection? Transplantation Proceedings 1988 20 1 522 523 2-s2.0-0023941954
55. Gonwa T. A., Nery J. R., Husberg B. S., Klintmalm G. B., Simultaneous liver and renal transplantation in man. Transplantation 1988 46 5 690 693 2-s2.0-0024206303 (Pubitemid 19017043)
56. Katznelson S., Cecka J. M., The liver neither protects the kidney from rejection nor improves kidney graft survival after combined liver and kidney transplantation from the same donor. Transplantation 1996 61 9 1403 1405 2-s2.0-0029879164 10.1097/00007890-199605150-00021 (Pubitemid 26152833)
57. Rasmussen A., Davies H. F. S., Jamieson N. V., Evans D. B., Calne R. Y., Combined transplantation of liver and kidney from the same donor protects the kidney from rejection and improves kidney graft survival. Transplantation 1995 59 6 919 921 2-s2.0-0028966356
58. Creput C., Durrbach A., Samuel D., Eschwege P., Amor M., Kriaa F., Kreis H., Benoit G., Bismuth H., Charpentier B., Incidence of renal and liver rejection and patient survival rate following combined liver and kidney transplantation. American Journal of Transplantation 2003 3 3 348 356 2-s2.0-0037355159 10.1034/j.1600-6143.2003.00050.x (Pubitemid 36407056)
59. Ruiz R., Kunitake H., Wilkinson A. H., Danovitch G. M., Farmer D. G., Ghobrial R. M., Yersiz H., Hiatt J. R., Busuttil R. W., Long-term analysis of combined liver and kidney transplantation at a single center. Archives of Surgery 2006 141 8 735 742 2-s2.0-33747602330 10.1001/archsurg.141.8.735 (Pubitemid 44268509)
60. Opelz G., Margreiter R., Döhler B., Prolongation of long-term kidney graft survival by a simultaneous liver transplant: the liver does it, and the heart does it too. Transplantation 2002 74 10 1390 1394 2-s2.0-0036852125 (Pubitemid 35379543)
61. Fong T.-L., Bunnapradist S., Jordan S. C., Selby R. R., Cho Y. W., Analysis of the United Network for Organ Sharing database comparing renal allografts and patient survival in combined liver-kidney transplantation with the contralateral allografts in kidney alone or kidney-pancreas transplantation. Transplantation 2003 76 2 348 353 2-s2.0-0042768028 10.1097/01.TP.0000071204. 03720.BB (Pubitemid 36927997)
62. Sarwal M. M., Cecka J. M., Millan M. T., Salvatierra O. Jr., Adult-size kidneys without acute tubular necrosis provide exceedingly superior long-term graft outcomes for infants and small children. Transplantation 2000 70 12 1728 1736 2-s2.0-0034722937 (Pubitemid 32064828)
63. Simpson N., Cho Y. W., Cicciarelli J. C., Selby R. R., Fong T.-L., Comparison of renal allograft outcomes in combined liver-kidney transplantation versus subsequent kidney transplantation in liver transplant recipients: analysis of UNOS database. Transplantation 2006 82 10 1298 1303 2-s2.0-33751525750 10.1097/01.tp.0000241104.58576.e6 (Pubitemid 44832912)
64. Lang M., Kahl A., Bechstein W., Neumann U., Knoop M., Frei U., Neuhaus P., Combined liver-kidney transplantation: long-term follow up in 18 patients. Transplant International 1998 11 supplement 1 S155 S159 2-s2.0-0031604033 (Pubitemid 128683531)
65. Morrissey P. E., Gordon F., Shaffer D., Madras P. N., Silva P., Sahyoun A. I., Monaco A. P., Hill T., Lewis W. D., Jenkins R. L., Combined liver-kidney transplantation in patients with cirrhosis and renal failure: effect of a positive cross-match and benefits of combined transplantation. Liver Transplantation and Surgery 1998 4 5 363 369 2-s2.0-0031666136 (Pubitemid 28413237)
66. Neumann U. P., Lang M., Moloenhauer A., Langrehr J. M., Glanemann M., Kahl A., Frei U., Bechstein W. O., Neuhaus P., Significance of a T-lymphocytotoxic crossmatch in liver and combined liver-kidney transplantation. Transplantation 2001 71 8 1163 1168 2-s2.0-0035034095 (Pubitemid 32448835)
67. Gutiérrez A., Crespo M., Mila J., Torregrosa J. V., Martorell J., Oppenheimer F., Outcome of simultaneous liver-kidney transplantation in highly sensitized, crossmatch-positive patients. Transplantation Proceedings 2003 35 5 1861 1862 2-s2.0-0042332238 10.1016/S0041-1345(03)00621-3 (Pubitemid 37093742)
68. Olausson M., Mjörnstedt L., Nordén G., Rydberg L., Mölne J., Bäckman L., Friman S., Successful combined partial auxiliary liver and kidney transplantation in highly sensitized cross-match positive recipients. American Journal of Transplantation 2007 7 1 130 136 2-s2.0-33845608554 10.1111/j.1600-6143.2006.01592.x (Pubitemid 44952865)
69. Narula J., Bennett L. E., DiSalvo T., Hosenpud J. D., Semigran M. J., Dec G. W., Outcomes in recipients of combined heart-kidney transplantation: multiorgan, same-donor transplant study of the International Society of Heart and Lung Transplantation/United Network for Organ Sharing Scientific Registry. Transplantation 1997 63 6 861 867 2-s2.0-0030937206 10.1097/00007890-199703270- 00012 (Pubitemid 27150594)
70. Vermès E., Kirsch M., Houël R., Legouvelo S., Benvenuti C., Aptecar E., Le Besnerais P., Lang P., Abbou C., Loisance D., Immunologic events and long-term survival after combined heart and kidney transplantation: a 12-year single-center experience. Journal of Heart and Lung Transplantation 2001 20 2 1084 1091 2-s2.0-0034809260 10.1016/S1053-2498(01)00308-4 (Pubitemid 32930113)
71. Luckraz H., Parameshwar J., Charman S. C., Firth J., Wallwork J., Large S., Short- and long-term outcomes of combined cardiac and renal transplantation with allografts from a single donor. Journal of Heart and Lung Transplantation 2003 22 12 1318 1322 2-s2.0-0346850966 10.1016/S1053-2498(03)00030-5 (Pubitemid 37522035)
72. Trachiotis G. D., Vega J. D., Johnston T. S., Berg A., Whelchel J., Smith A. L., Lutz J., Kanter K. R., Ten-year follow-up in patients with combined heart and kidney transplantation. Journal of Thoracic and Cardiovascular Surgery 2003 126 6 2065 2071 2-s2.0-0347994926 10.1016/j.jtcvs.2003.07.009 (Pubitemid 38020773)
73. Hermsen J. L., Nath D. S., Munoz del Rio A., Eickstaedt J. B., Wigfield C., Lindsey J. D., Edwards N. M., Combined heart-kidney transplantation: the University of Wisconsin experience. Journal of Heart and Lung Transplantation 2007 26 11 1119 1126 2-s2.0-36048934299 10.1016/j.healun.2007.08.011 (Pubitemid 350088522)
74. Raichlin E., Kushwaha S. S., Daly R. C., Kremers W. K., Frantz R. P., Clavell A. L., Rodeheffer R. J., Larson T. S., Stegall M. D., McGregor C., Pereira N. L., Edwards B. S., Combined heart and kidney transplantation provides an excellent survival and decreases risk of cardiac cellular rejection and coronary allograft vasculopathy. Transplantation Proceedings 2011 43 5 1871 1876 2-s2.0-79959431604 10.1016/j.transproceed.2011.01.190
75. Vermes E., Grimbert P., Sebbag L., Barrou B., Pouteil-Noble C., Pavie A., Obadia J. F., Loisance D., Lang P., Kirsch M., Long-term results of combined heart and kidney transplantation: a French multicenter study. Journal of Heart and Lung Transplantation 2009 28 5 440 445 2-s2.0-67349201005 10.1016/j.healun.2009.01.020
76. Rana A., Robles S., Russo M. J., Halazun K. J., Woodland D. C., Witkowski P., Ratner L. E., Hardy M. A., The combined organ effect: protection against rejection? Annals of Surgery 2008 248 5 871 879 2-s2.0-56149102371 10.1097/SLA.0b013e31817fc2b8
77. Bentley F. R., Garrison R. N., Superior results with combined kidney-pancreas transplants. American Surgeon 1992 58 2 136 140 2-s2.0-0026571016
78. Pinderski L. J., Kirklin J. K., McGiffin D., Brown R., Naftel D. C., Young K. R. Jr., Smith K., Bourge R. C., Tallaj J. A., Rayburn B. K., Benza R., Zorn G., Leon K., Wille K., Deierhoi M., George J. F., Multi-organ transplantation: is there a protective effect against acute and chronic rejection? Journal of Heart and Lung Transplantation 2005 24 11 1828 1833 2-s2.0-27844522832 10.1016/j.healun.2005.03.015 (Pubitemid 41641859)
79. Glanville A. R., Imoto E., Baldwin J. C., Billingham M. E., Theodore J., Robin E. D., The role of right ventricular endomyocardial biopsy in the long-term management of heart-lung transplant recipients. Journal of Heart Transplantation 1987 6 6 357 361 2-s2.0-0023470617 (Pubitemid 18007534)
80. Baldwin J. C., Oyer P. E., Stinson E. B., Starnes V. A., Billingham M. E., Shumway N. E., Comparison of cardiac rejection in heart and heart-lung transplantation. Journal of Heart Transplantation 1987 6 6 352 356 2-s2.0-0023492559 (Pubitemid 18007533)
81. Vricella L. A., Karamichalis J. M., Ahmad S., Robbins R. C., Whyte R. I., Reitz B. A., Lung and heart-lung transplantation in patients with end-stage cystic fibrosis: the Stanford experience. Annals of Thoracic Surgery 2002 74 1 13 18 2-s2.0-0036307665 10.1016/S0003-4975(02)03634-2 (Pubitemid 34741998)
82. Lee W. P. A., Yaremchuk M. J., Pan Y.-C., Randolph M. A., Tan C. M., Weiland A. J., Relative antigenicity of components of a vascularized limb allograft. Plastic and Reconstructive Surgery 1991 87 3 401 411 2-s2.0-0025971311
83. Henry L., Marshall D. C., Friedman E. A., Dammin G. J., Merrill J. P., The rejection of skin homografts in the normal human subject. II. Histological findings. The Journal of Clinical Investigation 1962 41 420 446 2-s2.0-0003052026
84. Cunningham E. C., Tay S. S., Wang C., Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation 2013 95 1 70 77
85. LoDuca P. A., Hoffman B. E., Herzog R. W., Hepatic gene transfer as a means of tolerance induction to transgene products. Current Gene Therapy 2009 9 2 104 114 2-s2.0-65949102083 10.2174/156652309787909490
86. Annoni A., Brown B. D., Cantore A., Sergi L. S., Naldini L., Roncarolo M.-G., In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance. Blood 2009 114 25 5152 5161 2-s2.0-73949157699 10.1182/blood-2009-04-214569
87. Sharland A., Logan G. J., Bishop A., Alexander I. E., Liver-directed gene expression using recombinant AAV 2/8 vectors-a tolerogenic strategy for gene delivery? Discovery Medicine 2010 9 49 519 527 2-s2.0-77957327230
88. Lüth S., Huber S., Schramm C., Buch T., Zander S., Stadelmann C., Brück W., Wraith D. C., Herkel J., Lohse A. W., Ectopic expression of neural autoantigen in mouse liver suppresses experimental autoimmune neuroinflammation by inducing antigen-specific Tregs. The Journal of Clinical Investigation 2008 118 10 3403 3410 2-s2.0-55849093638 10.1172/JCI32132
89. Cunningham S. C., Dane A. P., Spinoulas A., Alexander I. E., Gene delivery to the juvenile mouse liver using AAV2/8 vectors. Molecular Therapy 2008 16 6 1081 1088 2-s2.0-44049094812 10.1038/mt.2008.72 (Pubitemid 351737073)
90. Laurence J. M., Wang C., Zheng M., Cunningham S., Earl J., Tay S. S., Allen R. D. M., McCaughan G. W., Alexander I. E., Bishop G. A., Sharland A. F., Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transplantation 2009 15 2 233 241 2-s2.0-67349155841 10.1002/lt.21662
91. Adams A. B., Williams M. A., Jones T. R., Shirasugi N., Durham M. M., Kaech S. M., Wherry E. J., Onami T., Lanier J. G., Kokko K. E., Pearson T. C., Ahmed R., Larsen C. P., Heterologous immunity provides a potent barrier to transplantation tolerance. The Journal of Clinical Investigation 2003 111 12 1887 1895 2-s2.0-0042532322 10.1172/JCI200317477 (Pubitemid 38057733)
92. Madsen J. C., Superina R. A., Wood K. J., Morris P. J., Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature 1988 332 6160 161 164 2-s2.0-0023865253 (Pubitemid 18083561)
93. Sykes M., Sachs D. H., Nienhuis A. W., Pearson D. A., Moulton A. D., Bodine D. M., Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene. Transplantation 1993 55 1 197 202 2-s2.0-0027472414 (Pubitemid 23033971)
94. Geissler E. K., Wang J., Fechner J. H. Jr., Burlingham W. J., Knechtle S. J., Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle. Journal of Immunology 1994 152 2 413 421 2-s2.0-0028219512 (Pubitemid 24072944)
95. Logan G. J., Wang L., Zheng M., Ginn S. L., Coppel R. L., Alexander I. E., Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy 2009 16 2 200 210 2-s2.0-60449097497 10.1038/gt.2008.168
96. Kelly M. E., Zhuo J., Bharadwaj A. S., Chao H., Induction of immune tolerance to FIX following muscular AAV gene transfer Is AAV-dose/FIX-level dependent. Molecular Therapy 2009 17 5 857 863 2-s2.0-67349217385 10.1038/mt.2009.25
97. Bishop G. A., Sun J., Sheil A. G. R., McCaughan G. W., High-dose/activation-associated tolerance: a mechanism for allograft tolerance. Transplantation 1997 64 10 1377 1382 2-s2.0-0030776194 (Pubitemid 27513613)
98. Zinkernagel R. M., Localization dose and time of antigens determine immune reactivity. Seminars in Immunology 2000 12 3 163 171 2-s2.0-0034210006 10.1006/smim.2000.0253 (Pubitemid 30479434)