Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6825-6828

  Ruel, Réjean ^a,b   L'Heureux, Alexandre ^a   Thibeault, Carl ^a   Lapointe, Philippe ^a   Martel, Alain ^a,b   Qiao, Jennifer X ^a   Hua, Ji ^a   Price, Laura A ^a   Wu, Qimin ^a   Chang, Ming ^a   Zheng, Joanna ^a   Huang, Christine S ^a   Wexler, Ruth R ^a   Rehfuss, Robert ^a   Lam, Patrick Y S ^a,c  

^a BRISTOL MYERS SQUIBB   (United States)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c Lam Drug Discovery Consulting LLC   (United States)

Author keywords

Isoindolines; Piperidines; Purinergic receptors; Tetrahydroisoquinolines

Indexed keywords

AMINE; PIPERIDINE DERIVATIVE; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y1 RECEPTOR; TETRAHYDROISOQUINOLINE; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; DRUG DERIVATIVE; PIPERIDINE; PURINERGIC P2Y RECEPTOR AGONIST; TETRAHYDROISOQUINOLINE DERIVATIVE; UREA;

AMINATION; ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IN VITRO STUDY; LITHIATION; SOLUBILITY; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; ANIMAL; CHEMISTRY; DRUG EFFECT; HALF LIFE TIME; HUMAN; ISOINDOLINES; LIVER MICROSOME; METABOLISM; P2Y(1) ANTAGONISTS; PROTEIN BINDING; PURINERGIC RECEPTORS; RAT; SYNTHESIS; THROMBOCYTE;

ISOINDOLINES; P2Y(1) ANTAGONISTS; PIPERIDINES; PURINERGIC RECEPTORS; TETRAHYDROISOQUINOLINES;

ADENOSINE DIPHOSPHATE; AMINES; ANIMALS; BLOOD PLATELETS; HALF-LIFE; HUMANS; MICROSOMES, LIVER; PIPERIDINES; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; PURINERGIC P2Y RECEPTOR AGONISTS; RATS; RECEPTORS, PURINERGIC P2Y1; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84888869155     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.009     Document Type: Article

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17. The cyclic amine compounds reported herein were previously disclosed in Chao, H. J.; Tuerdi, H.; Herpin, T.; Roberge, J. Y.; Liu, Y.; Lawrence, R. M.; Rehfuss, R. P.; Clark, C. G.; Qiao, J. X.; Gungor, T.; Lam, P. Y. S.; Wang, T. C.; Ruel, R.; L'Heureux, A.; Thibeault, C.; Bouthillier, G.; Schnur, D. M. U.S. 0,261,244A1, 2005.